The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
The chemokine SDF1 regulates migration of dentate granule cells
Abstract
The dentate gyrus is the primary afferent pathway into the hippocampus, but there is little information concerning the molecular influences that govern its formation. In particular, the control of migration and cell positioning of dentate granule cells is not clear. We have characterized more fully the timing and route of granule cell migration during embryogenesis using in utero retroviral injections. Using this information, we developed an in vitro assay that faithfully recapitulates important events in dentate gyrus morphogenesis. In searching for candidate ligands that may regulate dentate granule cell migration, we found that SDF1, a chemokine that regulates cerebellar and leukocyte migration, and its receptor CXCR4 are expressed in patterns that suggest a role in dentate granule cell migration. Furthermore, CXCR4 mutant mice have a defect in granule cell position. Ectopic expression of SDF1 in our explant assay showed that it directly regulates dentate granule cell migration. Our study shows that a chemokine is necessary for the normal development of the dentate gyrus, a forebrain structure crucial for learning and memory.
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Cites
Gage, F. H. (2000) · Science · doi:10.1126/science.287.5457.1433 · Cited by 4,786
Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus
van Praag, H., Kempermann, G., & Gage, F. H. (1999) · Nature Neuroscience · doi:10.1038/6368 · Cited by 3,880
Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats
Altman, J., & Das, G. D. (1965) · Journal of Comparative Neurology · doi:10.1002/cne.901240303 · Cited by 3,592
Specification of Cerebral Cortical Areas
Rakic, P. (1988) · Science · doi:10.1126/science.3291116 · Cited by 3,127
Astrocytes give rise to new neurons in the adult mammalian hippocampus
Seri, B., Garcı́a-Verdugo, J. M., McEwen, B. S., & Alvarez-Buylla, A. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-18-07153.2001 · Cited by 1,495
Isolation of radial glial cells by fluorescent-activated cell sorting reveals a neuronal lineage
Malatesta, P., Hartfuss, E., & Götz, M. (2000) · Development · doi:10.1242/dev.127.24.5253 · Cited by 1,157
Altman, J., & Bayer, S. A. (1990) · Journal of Comparative Neurology · doi:10.1002/cne.903010304 · Cited by 819
Sorting of Striatal and Cortical Interneurons Regulated by Semaphorin-Neuropilin Interactions
Marı́n, O., Yaron, A., Bagri, A., Tessier-Lavigne, M., & Rubenstein, J. L. R. (2001) · Science · doi:10.1126/science.1061891 · Cited by 433
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Deverman, B. E., & Patterson, P. H. (2009) · Neuron · doi:10.1016/j.neuron.2009.09.002 · Cited by 865
Kucia, M., Reca, R., Miekus, K., Wanzeck, J., Wojakowski, W., Janowska‐Wieczorek, A., Ratajczak, J., & Ratajczak, M. Z. (2005) · STEM CELLS · doi:10.1634/stemcells.2004-0342 · Cited by 759
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Han, Y.-G., Spassky, N., Romaguera-Ros, M., Garcia-Verdugo, J.-M., Aguilar, A., Schneider-Maunoury, S., & Alvarez-Buylla, A. (2008) · Nature Neuroscience · doi:10.1038/nn2059 · Cited by 547
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Wang, Y., Li, G., Stanco, A., Long, J. E., Crawford, D., Potter, G. B., Pleasure, S. J., Behrens, T., & Rubenstein, J. L. R. (2011) · Neuron · doi:10.1016/j.neuron.2010.12.005 · Cited by 290
Self-citationCxcr7 controls neuronal migration by regulating chemokine responsiveness
Sánchez-Alcañiz, J. A., Haege, S., Mueller, W., Pla, R., Mackay, F., Schulz, S., López-Bendito, G., Stumm, R., & Marín, O. (2011) · Neuron · doi:10.1016/j.neuron.2010.12.006 · Cited by 290
Lazarini, F., Tham, T. N., Casanova, P., Arenzana‐Seisdedos, F., & Dubois‐Dalcq, M. (2003) · Glia · doi:10.1002/glia.10139 · Cited by 280
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BLEDNOV, Y., BERGESON, S., WALKER, D., FERREIRA, V, KUZIEL, W., & HARRIS, R. (2005) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.06.026 · Cited by 149
Schönemeier, B., Kolodziej, A., Schulz, S., Jacobs, S., Hoellt, V., & Stumm, R. (2008) · Journal of Comparative Neurology · doi:10.1002/cne.21780 · Cited by 141
Immune and nervous system CXCL12 and CXCR4: parallel roles in patterning and plasticity
Klein, R. S., & Rubin, J. B. (2004) · Trends in Immunology · doi:10.1016/j.it.2004.04.002 · Cited by 132
Seki, T., Sato, T., Toda, K., Osumi, N., Imura, T., & Shioda, S. (2014) · Journal of Comparative Neurology · doi:10.1002/cne.23460 · Cited by 60
Metadata
- Authors
- Bagri, A., Gurney, T., He, X., Zou, Y.-R., Littman, D. R., Tessier-Lavigne, M., & Pleasure, S. J.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2002-09-15
- Volume
- 129
- Issue
- 18
- Pages
- 4249-4260
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2170221117
- Cited by
- 386
- References
- 8
- FWCI
- 4.47
- Type
- journal article
- Language
- en
- Open access
- closed
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