Cxcr7 controls neuronal migration by regulating chemokine responsiveness

Sánchez-Alcañiz, Juan Antonio; Haege, Sammy; Mueller, Wiebke; Pla, Ramón; Mackay, Fabienne; Schulz, Stefan; López-Bendito, Guillermina; Stumm, Ralf; Marín, Oscar

doi:10.1016/j.neuron.2010.12.006

Cited by 294Chemokine receptors and signalingNeurogenesis and neuroplasticity mechanismsAxon Guidance and Neuronal Signaling

Cxcr7 controls neuronal migration by regulating chemokine responsiveness

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Sánchez-Alcañiz, Juan Antonio, Haege, Sammy, Mueller, Wiebke, Pla, Ramón, Mackay, Fabienne, Schulz, Stefan, López-Bendito, Guillermina, Stumm, Ralf +1 more·2011·Neuron

DOI 10.1016/j.neuron.2010.12.006

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Abstract

The chemokine Cxcl12 binds Cxcr4 and Cxcr7 receptors to control cell migration in multiple biological contexts, including brain development, leukocyte trafficking, and tumorigenesis. Both receptors are expressed in the CNS, but how they cooperate during migration has not been elucidated. Here, we used the migration of cortical interneurons as a model to study this process. We found that Cxcr4 and Cxcr7 are coexpressed in migrating interneurons, and that Cxcr7 is essential for chemokine signaling. Intriguingly, this process does not exclusively involve Cxcr7, but most critically the modulation of Cxcr4 function. Thus, Cxcr7 is necessary to regulate Cxcr4 protein levels, thereby adapting chemokine responsiveness in migrating cells. This demonstrates that a chemokine receptor modulates the function of another chemokine receptor by controlling the amount of protein that is made available for signaling at the cell surface.

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Cxcl12, expressed by cells in each tangential migration route, helps confine interneurons to those routes.
“The confinement of interneurons to each of the three routes of tangential migration involves the chemokine Cxcl12, which is expressed by cells located in each of the routes (Li et al., 2008; López-Bendito et al., 2008; Sánchez-Alcaniz et al., 2011; Stumm et al., 2007; Tiveron et al., 2006; Wang et al., 2011).”
From Development and Functional Diversification of Cortical Interneurons (2018) · cites this paper as Sánchez-Alcaniz et al., 2011
Cxcl12 acts as an attractant to keep interneurons within the IZ/SVZ and MZ until they reach appropriate maturity to begin radial migration.
“chemokine signaling via Cxcl12, which acts as an attractant to keep interneurons within the IZ/SVZ and MZ until they reach appropriate maturity to begin radial migration”
From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [973]
Cxcr7 regulates the local concentrations of Cxcl12 sensed by Cxcr4 and controls Cxcr4 protein levels.
“Cxcr7 regulates the local concentrations of Cxcl12 sensed by Cxcr4 and controls Cxcr4 protein levels”
From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [973]

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Sánchez‐Alcañiz, J. A., Pla, P., Mackay, F., López‐Bendito, G., & Marín, Ó. (2010) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2010.07.166
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CXCL12/CXCR4 signalling in neuronal cell migration
Tiveron, M.-C., & Cremer, H. (2008) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2008.06.004 · Cited by 98 · see citing works

Authors: Sánchez-Alcañiz, J. A., Haege, S., Mueller, W., Pla, R., Mackay, F., Schulz, S., López-Bendito, G., Stumm, R., & Marín, O.
Affiliations: Center for Behavioral Brain Sciences (DE)
Friedrich Schiller University Jena (DE)
Consejo Superior de Investigaciones Científicas (ES)
The Alfred Hospital (AU)
Corresponding author: Stumm, Ralf
ORCID: Pla, Ramón
Mackay, Fabienne
Schulz, Stefan
Stumm, Ralf
Venue: Neuron
Publisher: Elsevier BV
Published: 2011-01
Volume: 69
Issue: 1
Pages: 77-90
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/j.neuron.2010.12.006
OpenAlex: W2142919551
Cited by: 290
References: 61
Citations by year: 2026: 9 · 2025: 6 · 2024: 21 · 2023: 11 · 2022: 9 · 2021: 18 · 2020: 26 · 2019: 18 · 2018: 17 · 2017: 17 · 2016: 4 · 2015: 20 · 2014: 30 · 2013: 34 · 2012: 29
FWCI: 17.92
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 928 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
Funders: Ministerio de Ciencia e Innovación
Topics: Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
Keywords: CXCR7, CXCR4, CXCL12, chemokine signaling, neuronal migration, cortical interneurons, receptor co-expression, receptor protein levels, brain development
MeSH terms: Animals, Cell Movement, Cells, Cultured, Cerebral Cortex, Immunohistochemistry, Interneurons, Mice, Inbred C57BL, Mice, Transgenic, Signal Transduction, In Situ Hybridization, Receptors, CXCR4, Mice, Chemokine CXCL12, Receptors, CXCR

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Cxcr7 controls neuronal migration by regulating chemokine responsiveness

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