The DOI matches its Crossref record.
The formation of mesodermal tissues in the mouse embryo during gastrulation and early organogenesis
Abstract
Orthotopic grafts of [3H]thymidine-labelled cells have been used to demonstrate differences in the normal fate of tissue located adjacent to and in different regions of the primitive streak of 8th day mouse embryos developing in vitro. The posterior streak produces predominantly extraembryonic mesoderm, while the middle portion gives rise to lateral mesoderm and the anterior region generates mostly paraxial mesoderm, gut and notochord. Embryonic ectoderm adjacent to the anterior part of the streak contributes mainly to paraxial mesoderm and neurectoderm. This pattern of colonization is similar to the fate map constructed in primitive-streak-stage chick embryos. Similar grafts between early-somite-stage (9th day) embryos have established that the older primitive streak continues to generate embryonic mesoderm and endoderm, but ceases to make a substantial contribution to extraembryonic mesoderm. Orthotopic grafts and specific labelling of ectodermal cells with wheat germ agglutinin conjugated to colloidal gold (WGA-Au) have been used to analyse the recruitment of cells into the paraxial mesoderm of 8th and 9th day embryos. The continuous addition of primitive-streak-derived cells to the paraxial mesoderm is confirmed and the distribution of labelled cells along the craniocaudal sequence of somites is consistent with some cell mixing occurring within the presomitic mesoderm.
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Citations
Cited by
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Galceran, J., Farinas, I., Depew, M. J., Clevers, H., & Grosschedl, R. (1999) · Genes & Development · doi:10.1101/gad.13.6.709 · Cited by 462
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Kwon, G. S., Viotti, M., & Hadjantonakis, A.-K. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.07.017 · Cited by 402
Morphogenesis of the murine node and notochordal plate
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A single-embryo, single-cell time-resolved model for mouse gastrulation
Mittnenzweig, M., Mayshar, Y., Cheng, S., Ben-Yair, R., Hadas, R., Rais, Y., Chomsky, E., Reines, N., Uzonyi, A., Lumerman, L., et al. (2021) · Cell · doi:10.1016/j.cell.2021.04.004 · Cited by 214
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Self-citationCellular dynamics in the early mouse embryo: from axis formation to gastrulation
Nowotschin, S., & Hadjantonakis, A.-K. (2010) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2010.05.008 · Cited by 79
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Cheung, K.-K., Mok, S. C., Rezaie, P., & Chan, W. Y. (2008) · BMC Developmental Biology · doi:10.1186/1471-213x-8-76 · Cited by 23
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Metadata
- Authors
- Tam, P. P. L., & Beddington, R. S. P.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1987-01-01
- Volume
- 99
- Issue
- 1
- Pages
- 109-126
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2405685946
- Cited by
- 386
- References
- 0
- FWCI
- 2.77
- Type
- journal article
- Language
- en
- Open access
- closed
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