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Cited by 40Effects and risks of endocrine disrupting chemicalsNeuroscience and Neuropharmacology ResearchGenetics and Neurodevelopmental Disorders

Bisphenol-A impairs synaptic formation and function by RGS4-mediated regulation of BDNF signaling in the cerebral cortex

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Hyun, Sung-Ae, Ko, Moon Yi, Jang, Sumi, Lee, Byoung-Seok, Rho, Jaerang, Kim, Kee K., Kim, Woo-Yang, Ka, Minhan·2022·Disease Models & Mechanisms
DOI 10.1242/dmm.049177PMC PMC9346518
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Abstract

Bisphenol-A (BPA) is a representative endocrine disruptor, widely used in a variety of products including plastics, medical equipment and receipts. Hence, most people are exposed to BPA via the skin, digestive system or inhalation in everyday life. Furthermore, BPA crosses the blood-brain barrier and is linked to multiple neurological dysfunctions found in neurodegenerative and neuropsychological disorders. However, the mechanisms underlying BPA-associated neurological dysfunctions remain poorly understood. Here, we report that BPA exposure alters synapse morphology and function in the cerebral cortex. Cortical pyramidal neurons treated with BPA showed reduced size and number of dendrites and spines. The density of excitatory synapses was also decreased by BPA treatment. More importantly, we found that BPA disrupted normal synaptic transmission and cognitive behavior. RGS4 and its downstream BDNF/NTRK2 pathway appeared to mediate the effect of BPA on synaptic and neurological function. Our findings provide molecular mechanistic insights into anatomical and physiological neurotoxic consequences related to a potent endocrine modifier.

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  • Bisphenols interfere with glutamate receptor-dependent processes, and disturbances in AMPA and NMDA receptor expression, phosphorylation, or membrane localization are particularly damaging because these receptors are essential for excitatory synaptic transmission and plasticity.

    “Bisphenols also interfere with glutamate receptor-dependent processes, and disturbances in AMPA and NMDA receptor expression, phosphorylation, or membrane localization are particularly damaging because these receptors are essential for excitatory synaptic transmission and plasticity (Hyun et al., 2022; Wang et al., 2021).”

    From Environmental endocrine disruptors at the synapse: mechanisms linking chemical exposure to cognitive and behavioral dysfunction (2026) · cites this paper as Hyun et al., 2022

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Cited by

Sorted by citations

Authors
Hyun, S.-A., Ko, M. Y., Jang, S., Lee, B.-S., Rho, J., Kim, K. K., Kim, W.-Y., & Ka, M.
Affiliations
  • Chungnam National University (KR)
  • Korea Institute of Toxicology (KR)
  • Kent State University (US)
Corresponding author
  • Kim, Woo-Yang
  • Ka, Minhan
ORCID
Venue
Disease Models & Mechanisms
Publisher
The Company of Biologists
Published
2022-07-01
Volume
15
Issue
7
ISSN
  • 1754-8403 (ISSN-L)
  • 1754-8411
DOI
10.1242/dmm.049177
PMC
PMC9346518
OpenAlex
W4283819437
Cited by
40
References
8
Citations by year
2026: 13 · 2025: 12 · 2024: 10 · 2023: 5
FWCI
2.65
Type
journal article
Language
en
Open access
Licence
Locations
  • Disease Models & Mechanisms (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Research Foundation of Korea (NRF-2019R1A2C1009006)
  • Korea Institute of Toxicology (1711133843)
Topics
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Keywords
bisphenol A, endocrine disruptors, neurotoxicity, synaptogenesis, synaptic transmission, RGS4, brain-derived neurotrophic factor, NTRK2, cerebral cortex, pyramidal neurons, dendritic spines, dendritic morphology, excitatory synapses, cognitive behavior, blood-brain barrier
MeSH terms
Cerebral Cortex, Humans, Pyramidal Cells, Brain-Derived Neurotrophic Factor, Dendritic Spines, Endocrine Disruptors

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