Endocrine disruptors and childhood social impairment
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Prenatal exposure to endocrine disruptors has the potential to impact early brain development. Neurodevelopmental toxicity in utero may manifest as psychosocial deficits later in childhood. This study investigates prenatal exposure to two ubiquitous endocrine disruptors, the phthalate esters and bisphenol A (BPA), and social behavior in a sample of adolescent inner-city children. Third trimester urines of women enrolled in the Mount Sinai Children's Environmental Health Study between 1998 and 2002 (n=404) were analyzed for phthalate metabolites and BPA. Mother-child pairs were asked to return for a follow-up assessment when the child was between the ages of 7 and 9 years. At this visit, mothers completed the Social Responsiveness Scale (SRS) (n=137), a quantitative scale for measuring the severity of social impairment related to Autistic Spectrum Disorders (ASD) in the general population. In adjusted general linear models increasing log-transformed low molecular weight (LMW) phthalate metabolite concentrations were associated with greater social deficits (β=1.53, 95% CI 0.25-2.8). Among the subscales, LMWP were also associated with poorer Social Cognition (β=1.40, 95% CI 0.1-2.7); Social Communication (β=1.86, 95% CI 0.5-3.2); and Social Awareness (β=1.25, 95% CI 0.1-2.4), but not for Autistic Mannerisms or Social Motivation. No significant association with BPA was found (β=1.18, 95% CI -0.75, 3.11). Prenatal phthalate exposure was associated with childhood social impairment in a multiethnic urban population. Even mild degrees of impaired social functioning in otherwise healthy individuals can have very important adverse effects over a child's lifetime. These results extend our previous finding of atypical neonatal and early childhood behaviors in relation to prenatal phthalate exposure.
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Across three studies, several phthalate congeners appeared linked to higher autism risk.
“Several phthalate congeners, in contrast, appeared associated with increased autism across three different studies”
From Environmental Chemical Exposures and Autism Spectrum Disorders: A Review of the Epidemiological Evidence (2014) · cites this paper as [158]
Most phthalate studies lacked statistical precision for conclusive results.
“most lacked the statistical precision for conclusive results”
From Environmental Chemical Exposures and Autism Spectrum Disorders: A Review of the Epidemiological Evidence (2014) · cites this paper as [158]
BPA-autism associations from two studies were not consistent with a causal association.
“Associations between autism and BPA from two studies were not consistent with a causal association.”
From Environmental Chemical Exposures and Autism Spectrum Disorders: A Review of the Epidemiological Evidence (2014) · cites this paper as [158]
Phthalate results were not consistent across the three studies.
“although results were not consistent across these studies”
From Environmental Chemical Exposures and Autism Spectrum Disorders: A Review of the Epidemiological Evidence (2014) · cites this paper as [158]
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The role of phthalate esters in autism development: A systematic review
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Plasma phthalate and bisphenol a levels and oxidant-antioxidant status in autistic children
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Impact of Endocrine Disruptors on the Thyroid Hormone System
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- Authors
- Miodovnik, A., Engel, S. M., Zhu, C., Ye, X., Soorya, L. V., Silva, M. J., Calafat, A. M., & Wolff, M. S.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- Centers for Disease Control and Prevention (US)
- Corresponding author
- Miodovnik, Amir
- Venue
- NeuroToxicology
- Publisher
- Elsevier BV
- Published
- 2011-03
- Volume
- 32
- Issue
- 2
- Pages
- 261-267
- ISSN
- 0161-813X (ISSN-L)
- PMC
- PMC3057338
- OpenAlex
- W2094405673
- Cited by
- 423
- References
- 82
- Citations by year
- 2026: 11 · 2025: 14 · 2024: 29 · 2023: 22 · 2022: 26 · 2021: 47 · 2020: 32 · 2019: 32 · 2018: 26 · 2017: 33 · 2016: 29 · 2015: 37 · 2014: 32 · 2013: 22 · 2012: 19
- FWCI
- 12.73
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- NeuroToxicology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Centers for Disease Control and Prevention
- National Institute of Environmental Health Sciences (ES09584, P01ES009584)
- Agency for Toxic Substances and Disease Registry
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (T32HD049311)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Keywords
- endocrine disruptors, prenatal exposure, phthalate metabolites, bisphenol A, social dysfunction, autism spectrum disorder, developmental neurotoxicity, social cognition, social communication, Social Responsiveness Scale, adolescents, inner-city children, urinary biomarkers
- MeSH terms
- Adult, Child, Child Behavior Disorders, Child, Preschool, Female, Follow-Up Studies, Humans, Male, Pregnancy, Prenatal Exposure Delayed Effects, Prospective Studies, Cohort Studies, Endocrine Disruptors, Young Adult
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