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Molecular stop signs: regulation of cell-cycle arrest by C/EBP transcription factors

Johnson, Peter F.·2005·Journal of Cell Science

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Abstract

The CCAAT/enhancer-binding protein (C/EBP) family of transcription factors plays an important role in controlling cell proliferation and differentiation. C/EBPα is a particularly potent regulator of cell-cycle exit and is induced in terminally differentiating adipocytes and myeloid cells, where it also activates differentiation-specific genes. The growth-inhibiting activity of C/EBPα suppresses tumorigenesis in myeloid cells and possibly other tissues. In addition, recent work has identified C/EBPα as a component of the p53-regulated growth arrest response elicited by DNA damage in epidermal keratinocytes. Several studies have explored the mechanism by which C/EBPα blocks cell-cycle progression at the G1-S boundary, and several models have been proposed but no universally accepted mechanism has emerged. Controversial issues include whether C/EBPα acts through an `off-DNA' mechanism to inhibit cyclin-dependent kinases, and whether and how it functions with the RB-E2F system to repress transcription of S-phase genes. Other C/EBP-family members have also been implicated in positive and negative control of cell proliferation, and the mechanisms underlying their growth-regulatory activities are beginning to be elucidated.

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Self-citation
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See all 288

Authors: Johnson, P. F.
Venue: Journal of Cell Science
Publisher: The Company of Biologists
Published: 2005-06-15
Volume: 118
Issue: 12
Pages: 2545-2555
ISSN: 0021-9533 (ISSN-L)
1477-9137
DOI: 10.1242/jcs.02459
OpenAlex: W2040381793
Cited by: 288
References: 91
FWCI: 7.91
Type: journal article
Language: en
Open access: closed

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Molecular stop signs: regulation of cell-cycle arrest by C/EBP transcription factors

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