The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
TRPC6 channels promote dendritic growth via the CaMKIV-CREB pathway
Abstract
The canonical transient receptor potential channels (TRPCs) are Ca2+-permeable nonselective cation channels with various physiological functions. Here, we report that TRPC6, a member of the TRPC family, promotes hippocampal neuron dendritic growth. The peak expression of TRPC6 in rat hippocampus was between postnatal day 7 and 14, a period known to be important for maximal dendritic growth. Overexpression of TRPC6 increased phosphorylation of Ca2+/calmodulin-dependent kinase IV (CaMKIV) and cAMP-response-element binding protein (CREB) and promoted dendritic growth in hippocampal cultures. Downregulation of TRPC6 by short hairpin RNA interference against TRPC6 suppressed phosphorylation of both CaMKIV and CREB and impaired dendritic growth. Expressing a dominant-negative form of CaMKIV or CREB blocked the TRPC6-induced dendritic growth. Furthermore, inhibition of Ca2+ influx suppressed the TRPC6 effect on dendritic growth. Finally, in TRPC6 transgenic mice, the phosphorylation of CaMKIV and CREB was enhanced and the dendritic growth was also increased. In conclusion, TRPC6 promoted dendritic growth via the CaMKIV-CREB pathway. Our results thus revealed a novel role of TRPC6 during the development of the central nervous system (CNS).
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Cites
TRP channels as cellular sensors
Clapham, D. E. (2003) · Nature · doi:10.1038/nature02196 · Cited by 2,779
Dendritic arbor development and synaptogenesis
Cline, H. T. (2001) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00182-3 · Cited by 499
Wnt signaling through Dishevelled, Rac and JNK regulates dendritic development
Rosso, S. B., Sussman, D., Wynshaw-Boris, A., & Salinas, P. C. (2005) · Nature Neuroscience · doi:10.1038/nn1374 · Cited by 485 · cited 1×
“Overexpression of TRPC6 increased phosphorylation of CaMKIV at Thr196, a site known to be critical for its kinase activity (Selbert et al., 1995), (1.592±0.323, n=3, P=0.042, normalized to total CaMKIV) (Fig.”
BackgroundInfluentialWayman, G. A., Impey, S., Marks, D., Saneyoshi, T., Grant, W. F., Derkach, V., & Soderling, T. R. (2006) · Neuron · doi:10.1016/j.neuron.2006.05.008 · Cited by 466
Activation of a TRPC3-Dependent Cation Current through the Neurotrophin BDNF
Li, H.-S., Xu, X.-Z. S., & Montell, C. (1999) · Neuron · doi:10.1016/s0896-6273(00)80838-7 · Cited by 345
Dendritic atrophy in children with down’s syndrome.
Becker, L. E., Armstrong, D. L., & Chan, F. (1986) · Annals of Neurology · doi:10.1002/ana.410200413 · Cited by 279
Cited by
Calmodulin-kinases: modulators of neuronal development and plasticity.
Wayman, G. A., Lee, Y.-S., Tokumitsu, H., Silva, A., & Soderling, T. R. (2008) · Neuron · doi:10.1016/j.neuron.2008.08.021 · Cited by 567
Transient receptor potential (TRP) channels: a clinical perspective
Kaneko, Y., & Szallasi, A. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12414 · Cited by 370
Modeling non-syndromic autism and the impact of TRPC6 disruption in human neurons
Griesi-Oliveira, K., Acab, A., Gupta, A. R., Sunaga, D. Y., Chailangkarn, T., Nicol, X., Nunez, Y., Walker, M. F., Murdoch, J. D., Sanders, S. J., et al. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.141 · Cited by 236
Yan, X., Liu, J., Ye, Z., Huang, J., He, F., Xiao, W., Hu, X., & Luo, Z. (2016) · PLOS ONE · doi:10.1371/journal.pone.0162784 · Cited by 167
Lin, Y., Chen, F., Zhang, J., Wang, T., Wei, X., Wu, J., Feng, Y., Dai, Z., & Wu, Q. (2013) · Journal of Molecular Neuroscience · doi:10.1007/s12031-013-9977-8 · Cited by 82
Metadata
- Authors
- Tai, Y., Feng, S., Ge, R., Du, W., Zhang, X., He, Z., & Wang, Y.
- Venue
- Journal of Cell Science
- Publisher
- The Company of Biologists
- Published
- 2008-07-15
- Volume
- 121
- Issue
- 14
- Pages
- 2301-2307
- ISSN
- 0021-9533 (ISSN-L)
- 1477-9137
- OpenAlex
- W2103371711
- Cited by
- 174
- References
- 6
- FWCI
- 4.11
- Type
- journal article
- Language
- en
- Open access
- closed
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- Tai, Y., Feng, S., Ge, R., Du, W., Zhang, X., He, Z., & Wang, Y. (2008). TRPC6 channels promote dendritic growth via the CaMKIV-CREB pathway. Journal of Cell Science. https://doi.org/10.1242/jcs.026906
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