Characteristics of Circadian Gene Expressions in Mice White Adipose Tissue and 3T3-L1 Adipocytes
Open accessAbstract
Most, if not all, of physiological and behavioral processes exhibit circadian rhythms. Recently, molecular clocks similar to those operating in the suprachiasmatic nucleus (SCN) neurons have been found in several peripheral tissues. Among peripheral tissues, several recent studies have revealed that white adipose tissues secrete a number of biologically active molecules such as leptin, resistin, adiponectin, etc. Importantly, the levels of these cytokine-like molecules are associated with development of lifestyle-related diseases such as diabetic mellitus, cardiovascular diseases, and obesity. In this study, we attempted to characterize circadian gene expression in adipose tissue. Here, we show that the expression of several clock genes exhibits daily oscillation in mice white adipocytes. Circadian expression of adipocytes-related genes such as peroxisome proliferator-activated receptor (PPAR) γ2 was also observed. Interestingly, expression pattern of some clock genes in adipocytes is distinct from that in stromal-vascular fractions containing preadipocytes. In addition to these in vivo studies, we demonstrated that serum- or dexamethasone-shock induced the cyclic gene expression of clock genes in cultured adipocytes. Consequently, we are led to conclude that adipocytes contain the machineries necessary for circadian oscillation similar to that found in SCN. We then examined that whether the pharmacological effects of PPARγ2 ligand depend on the time of administration. Consist with its receptor levels, the pharmacological effects of PPARγ ligand administered during a dark period were more efficient than those during a light period in mice. These results suggest that chronotherapy targeted for adipocyte functions could be effective in improving of the symptoms of hyperlipidemia and other related diseases.
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Eating regularly was particularly inversely associated with waist circumference (OR 0•64 (95 % CI 0•47; 0•88)) and directly related to HDL-cholesterol (OR 0•63 (95 % CI 0•45, 0•91)) and circulating γ-glutamyl transferase concentrations (OR 0•54 (95 % CI 0•35, 0•84)).
“Eating regularly was particularly inversely associated with waist circumference (OR 0•64 (95 % CI 0•47; 0•88)) and directly related to HDL-cholesterol (OR 0•63 (95 % CI 0•45, 0•91)) and circulating γ-glutamyl transferase concentrations (OR 0•54 (95 % CI 0•35, 0•84)), believed to be a marker of oxidative stress (34) .”
From Meal irregularity and cardiometabolic consequences: results from observational and intervention studies (2016) · cites this paper as [34]
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- Authors
- Aoyagi, T., Shimba, S., & Tezuka, M.
- Affiliations
- Nihon University (JP)
- ORCID
- Shimba, Shigeki
- Venue
- Journal of Health Science
- Publisher
- Pharmaceutical Society of Japan
- Published
- 2005
- Volume
- 51
- Issue
- 1
- Pages
- 21-32
- ISSN
- 0013-273X (ISSN-L)
- 1344-9702
- 1347-5207
- OpenAlex
- W2140117724
- Cited by
- 37
- References
- 52
- Citations by year
- 2026: 1 · 2022: 3 · 2020: 1 · 2019: 2 · 2016: 2 · 2015: 3 · 2014: 1 · 2013: 1 · 2012: 5
- FWCI
- 1.09
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Eisei kagaku (publishedVersion)
- Funders
- Nihon University
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- circadian rhythm, clock genes, white adipose tissue, adipocytes, 3T3-L1 adipocytes, PPARγ2, circadian gene expression, stromal vascular fraction, preadipocytes, dexamethasone, chronotherapy, hyperlipidemia
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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