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Cited by 130Exercise and Physiological ResponsesCardiovascular and exercise physiologyCardiovascular Effects of Exercise

Ultra-Endurance Exercise and Oxidative Damage: Implications for Cardiovascular Health

Knez, Wade L, Coombes, Jeff S, Jenkins, David G·2006·Sports Medicine
DOI 10.2165/00007256-200636050-00005
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Abstract

At least 30 minutes of moderate-intensity physical activity accumulated on most, preferably all days is considered the minimum level necessary to reduce the risk of developing cardiovascular disease. Despite an unclear explanation, some epidemiological data paradoxically suggest that a very high volume of exercise is associated with a decrease in cardiovascular health. Although ultra-endurance exercise training has been shown to increase antioxidant defences (and therefore confer a protective effect against oxidative stress), an increase in oxidative stress may contribute to the development of atherosclerosis via oxidative modification of low-density lipoprotein (LDL). Research has also shown that ultra-endurance exercise is associated with acute cardiac dysfunction and injury, and these may also be related to an increase in free radical production. Longitudinal studies are needed to assess whether antioxidant defences are adequate to prevent LDL oxidation that may occur as a result of increased free radical production during very high volumes of exercise. In addition, this work will assist in understanding the accrued effect of repeated ultra-endurance exercise-induced myocardial damage.

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  • At the extreme end of the exercise continuum, very prolonged and/or intensive bouts of exercise result in substantial oxidative stress.

    “At the extreme end of the exercise continuum, very prolonged and/or intensive bouts of exercise result in substantial oxidative stress (Knez et al. 2006).”

    From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as Knez et al. 2006

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Authors
Knez, W. L., Coombes, J. S., & Jenkins, D. G.
Affiliations
The University of Queensland (AU)
Corresponding author
Knez, Wade L
ORCID
Venue
Sports Medicine
Publisher
Springer Science and Business Media LLC
Published
2006
Volume
36
Issue
5
Pages
429-441
ISSN
0112-1642 (ISSN-L)
DOI
10.2165/00007256-200636050-00005
OpenAlex
W2157959523
Cited by
130
References
105
Citations by year
2026: 2 · 2025: 2 · 2024: 9 · 2023: 7 · 2022: 3 · 2021: 9 · 2020: 3 · 2019: 3 · 2018: 8 · 2017: 10 · 2016: 4 · 2015: 3 · 2014: 13 · 2013: 10 · 2012: 6
FWCI
1.04
Type
journal article
Language
en
Open access
closed
Locations
  • Sports Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Effects of Exercise
Keywords
ultra-endurance exercise, oxidative stress, antioxidant defense, free radicals, LDL oxidation, atherosclerosis, exercise-induced myocardial injury, cardiovascular risk, exercise volume
MeSH terms
Antioxidants, Cardiovascular System, Energy Metabolism, Physical Exertion, Humans, Cholesterol, LDL, Physical Endurance, Physical Fitness, Queensland, Exercise, Oxidative Stress

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