Cited by 163Probiotics and Fermented FoodsGut microbiota and healthAdipokines, Inflammation, and Metabolic Diseases

The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.

Lactobacillus plantarum strain No. 14 reduces adipocyte size in mice fed high-fat diet

Takemura, Naoki, Okubo, Takuma, Sonoyama, Kei·2010·Experimental Biology and Medicine

DOI 10.1258/ebm.2010.009377

Open this paper in CoChat — free account

Abstract

Because gut microbiota has recently attracted much attention as an environmental factor involved in the development of obesity, probiotics may be useful in preventing and/or improving obesity and its related disorders. The present study aimed to investigate the effects of Lactobacillus plantarum strain No. 14 (LP14), a bacterial strain reported to decrease body fat percentage in healthy volunteers, on adipocyte size in mice. Female C57BL/6 mice were fed either normal- or high-fat diet and administered intragastrically with LP14 (1 x 10(8) colony-forming units/mouse) or vehicle daily for 11 weeks. High dietary fat intake increased body weight gain, white adipose tissue weight, mean adipocyte size and serum total cholesterol and leptin concentrations, and decreased serum adiponectin concentration. In mice fed the high-fat diet, LP14 administration significantly reduced the mean adipocyte size and tended to reduce the white adipose tissue weight and serum total cholesterol and leptin concentrations as compared with the vehicle-administered mice. All mice had undetectable serum levels of conjugated linoleic acids that reportedly exert antiobesity action. In a separate experiment, LP14 ingestion had no influence on serum triacylglycerol accumulation following olive oil administration in Triton WR1339-treated mice, suggesting that dietary fat absorption is unaffected by LP14. In conclusion, we propose that LP14 may exert a beneficial effect on the onset of diet-induced obesity by reducing the cell size of white adipose tissues, and it seems unlikely that previously reported mechanisms for other bacterial strains are involved in the action of LP14.

Integrity signals

Registry

Crossref · 10.1258/ebm.2010.009377

Cites

41 of 41 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

1 retracted

Loss-of-Function Mutation in Toll-Like Receptor 4 Prevents Diet-Induced Obesity and Insulin Resistance
Tsukumo, D. M. L., Carvalho-Filho, M. A., Carvalheira, J. B. C., Prada, P. O., Hirabara, S. M., Schenka, A. A., Araújo, E. P., Vassallo, J., Curi, R., Velloso, L. A., et al. (2007) · Diabetes · doi:10.2337/db06-1595 · Cited by 826
Retracted
An obesity-associated gut microbiome with increased capacity for energy harvest
Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444
Pathogen Recognition and Innate Immunity
Akira, S., Uematsu, S., & Takeuchi, O. (2006) · Cell · doi:10.1016/j.cell.2006.02.015 · Cited by 12,401
Human gut microbes associated with obesity
Ley, R. E., Turnbaugh, P. J., Klein, S., & Gordon, J. I. (2006) · Nature · doi:10.1038/4441022a · Cited by 8,785
AIN-93 Purified Diets for Laboratory Rodents: Final Report of the American Institute of Nutrition Ad Hoc Writing Committee on the Reformulation of the AIN-76A Rodent Diet
Reeves, P. G., Nielsen, F. H., & Fahey, G. C., Jr. (1993) · Journal of Nutrition · doi:10.1093/jn/123.11.1939 · Cited by 8,751
Metabolic Endotoxemia Initiates Obesity and Insulin Resistance
Cani, P. D., Amar, J., Iglesias, M. A., Poggi, M., Knauf, C., Bastelica, D., Neyrinck, A. M., Fava, F., Tuohy, K. M., Chabo, C., et al. (2007) · Diabetes · doi:10.2337/db06-1491 · Cited by 6,638
Brown Adipose Tissue: Function and Physiological Significance
CANNON, B., & NEDERGAARD, J. (2004) · Physiological Reviews · doi:10.1152/physrev.00015.2003 · Cited by 6,433
The gut microbiota as an environmental factor that regulates fat storage
Bäckhed, F., Ding, H., Wang, T., Hooper, L. V., Koh, G. Y., Nagy, A., Semenkovich, C. F., & Gordon, J. I. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407076101 · Cited by 6,245
Obesity alters gut microbial ecology
Ley, R. E., Bäckhed, F., Turnbaugh, P., Lozupone, C. A., Knight, R. D., & Gordon, J. I. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504978102 · Cited by 6,176
Probiotics in man and animals
AFRC, R. F. (1989) · Journal of Applied Bacteriology · doi:10.1111/j.1365-2672.1989.tb05105.x · Cited by 4,831
Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice
Cani, P. D., Bibiloni, R., Knauf, C., Waget, A., Neyrinck, A. M., Delzenne, N. M., & Burcelin, R. (2008) · Diabetes · doi:10.2337/db07-1403 · Cited by 4,819
Diet-Induced Obesity Is Linked to Marked but Reversible Alterations in the Mouse Distal Gut Microbiome
Turnbaugh, P. J., Bäckhed, F., Fulton, L., & Gordon, J. I. (2008) · Cell Host & Microbe · doi:10.1016/j.chom.2008.02.015 · Cited by 2,915
Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia
Cani, P. D., Neyrinck, A. M., Fava, F., Knauf, C., Burcelin, R., Tuohy, K. M., Gibson, G. R., & Delzenne, N. M. (2007) · Diabetologia · doi:10.1007/s00125-007-0791-0 · Cited by 1,770
Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41
Samuel, B. S., Shaito, A., Motoike, T., Rey, F. E., Backhed, F., Manchester, J. K., Hammer, R. E., Williams, S. C., Crowley, J., Yanagisawa, M., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808567105 · Cited by 1,564
Effect of conjugated linoleic acid on body composition in mice
Park, Y., Albright, K. J., Liu, W., Storkson, J. M., Cook, M. E., & Pariza, M. W. (1997) · Lipids · doi:10.1007/s11745-997-0109-x · Cited by 1,163
Methods for the determination of adipose cell size in man and animals
Hirsch, J., & Gallian, E. (1968) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)43151-7 · Cited by 894
Reciprocal Modulation of Toll-like Receptor-4 Signaling Pathways Involving MyD88 and Phosphatidylinositol 3-Kinase/AKT by Saturated and Polyunsaturated Fatty Acids
Lee, J. Y., Ye, J., Gao, Z., Youn, H. S., Lee, W. H., Zhao, L., Sizemore, N., & Hwang, D. H. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305213200 · Cited by 524
Probiotics and immunity
Borchers, A. T., Selmi, C. F., Meyers, F. J., Keen, C. L., & Gershwin, M. E. (2009) · Journal of Gastroenterology · doi:10.1007/s00535-008-2296-0 · Cited by 507
Adipose Tissue Macrophages, Low Grade Inflammation and Insulin Resistance in Human Obesity
Heilbronn, L. K., & Campbell, L. V. (2008) · Current Pharmaceutical Design · doi:10.2174/138161208784246153 · Cited by 496
Probiotics improve high fat diet-induced hepatic steatosis and insulin resistance by increasing hepatic NKT cells
Ma, X., Hua, J., & Li, Z. (2008) · Journal of Hepatology · doi:10.1016/j.jhep.2008.05.025 · Cited by 420
Human originated bacteria, Lactobacillus rhamnosus PL60, produce conjugated linoleic acid and show anti-obesity effects in diet-induced obese mice
Lee, H.-Y., Park, J.-H., Seok, S.-H., Baek, M.-W., Kim, D.-J., Lee, K.-E., Paek, K.-S., Lee, Y., & Park, J.-H. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2006.05.007 · Cited by 342
Tlr-4 deficiency selectively protects against obesity induced by diets high in saturated fat
Davis, J. E., Gabler, N. K., Walker‐Daniels, J., & Spurlock, M. E. (2008) · Obesity · doi:10.1038/oby.2008.210 · Cited by 334
Obesity and the Microbiota
Tilg, H., Moschen, A. R., & Kaser, A. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.03.030 · Cited by 233
Leptin secretion from adipose tissue in women. Relationship to plasma levels and gene expression.
Lönnqvist, F., Nordfors, L., Jansson, M., Thörne, A., Schalling, M., & Arner, P. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119422 · Cited by 232
Production of Free Conjugated Linoleic Acid by Lactobacillus acidophilus and Lactobacillus casei of Human Intestinal Origin
Alonso, L., Cuesta, E. P., & Gilliland, S. E. (2003) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(03)73781-3 · Cited by 229
Mechanisms of antidiabetogenic and body weight-lowering effects of estrogen in high-fat diet-fed mice
Bryzgalova, G., Lundholm, L., Portwood, N., Gustafsson, J.-Å., Khan, A., Efendić, S., & Dahlman‐Wright, K. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90248.2008 · Cited by 222
Fat Intake Affects Adiposity, Comorbidity Factors, and Energy Metabolism of Sprague‐Dawley Rats
Ghibaudi, L., Cook, J., Farley, C., van Heek, M., & Hwa, J. J. (2002) · Obesity Research · doi:10.1038/oby.2002.130 · Cited by 219
Antiobesity effect of trans-10,cis-12-conjugated linoleic acid-producing Lactobacillus plantarum PL62 on diet-induced obese mice
Lee, K., Paek, K., Lee, H. Y., Park, J. H., & Lee, Y. (2007) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2007.03336.x · Cited by 175
Probiotic Lactobacillus casei strain Shirota prevents indomethacin-induced small intestinal injury: involvement of lactic acid
Watanabe, T., Nishio, H., Tanigawa, T., Yamagami, H., Okazaki, H., Watanabe, K., Tominaga, K., Fujiwara, Y., Oshitani, N., Asahara, T., et al. (2009) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.90553.2008 · Cited by 160
Milk fermented byLactobacillus gasseriSBT2055 influences adipocyte size via inhibition of dietary fat absorption in Zucker rats
Hamad, E. M., Sato, M., Uzu, K., Yoshida, T., Higashi, S., Kawakami, H., Kadooka, Y., Matsuyama, H., El-Gawad, I. A. A., & Imaizumi, K. (2008) · British Journal Of Nutrition · doi:10.1017/s0007114508043808 · Cited by 135
Effects of milk fermented byLactobacillusgasseriSBT2055 on adipocyte size in rats
Sato, M., Uzu, K., Yoshida, T., Hamad, E. M., Kawakami, H., Matsuyama, H., El-Gawad, I. A. A., & Imaizumi, K. (2007) · British Journal Of Nutrition · doi:10.1017/s0007114507839006 · Cited by 130
Effects of obesity on the relationship of leptin mRNA expression and adipocyte size in anatomically distinct fat depots in mice
Guo, K., Halo, P., Leibel, R. L., & Zhang, Y. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00028.2004 · Cited by 114
Different forms of obesity as a function of diet composition
Dourmashkin, J. T., Chang, G.-Q., Gayles, E. C., Hill, J. O., Fried, S. K., Julien, C., & LEIBOWITZ, S. F. (2005) · International Journal of Obesity · doi:10.1038/sj.ijo.0803017 · Cited by 114
Aggregating Phenotype in Lactobacillus crispatus Determines Intestinal Colonization and TLR2 and TLR4 Modulation in Murine Colonic Mucosa
Voltan, S., Castagliuolo, I., Elli, M., Longo, S., Brun, P., D'Incà, R., Porzionato, A., Macchi, V., Palù, G., Sturniolo, G. C., et al. (2007) · Clinical and Vaccine Immunology · doi:10.1128/cvi.00079-07 · Cited by 96
High-fat diet-induced obesity is attenuated by probiotic strain Lactobacillus paracasei ST11 (NCC2461) in rats
Tanida, M., Shen, J., Maeda, K., Horii, Y., Yamano, T., Fukushima, Y., & Nagai, K. (2008) · Obesity Research & Clinical Practice · doi:10.1016/j.orcp.2008.04.003 · Cited by 93
Increased Energy Metabolism and Suppressed Body Fat Accumulation in Mice by a Low Concentration of Conjugated Linoleic Acid
Ohnuki, K., Haramizu, S., Ishihara, K., & Fushiki, T. (2001) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.65.2200 · Cited by 60
Clostridium butyricum TO-A Culture Supernatant Downregulates TLR4 in Human Colonic Epithelial Cells
Isono, A., Katsuno, T., Satô, T., Nakagawa, T., Kato, Y., Sato, N., Seo, G., Suzuki, Y., & Saitō, Y. (2007) · Digestive Diseases and Sciences · doi:10.1007/s10620-006-9593-3 · Cited by 52
Lactobacilli inhibit interleukin-8 production induced by Helicobacter pylori lipopolysaccharide-activated Toll-like receptor 4
Zhou, C., Ma, F.-Z., Deng, X., Yuan, H., & Ma, H. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.5090 · Cited by 49
Signal crosstalk between estrogen and peroxisome proliferator-activated receptor α on adiposity
Kim, B.-H., Won, Y. S., Kim, D.-Y., Kim, B., Kim, E., Yoon, M.-J., & Oh, G. T. (2009) · BMB Reports · doi:10.5483/bmbrep.2009.42.2.091 · Cited by 19
Inulin-Type Fructans Stimulated the Growth of Exogenously AdministeredLactobacillus plantarumNo. 14 in the Mouse Gastrointestinal Tract
Takemura, N., OZAWA, K., KIMURA, N., Watanabe, J., & Sonoyama, K. (2010) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.90794 · Cited by 16
Self-citation
Lactobacillus plantarum Strain No.14 Suppresses Human Allergic Reaction
Nagata, Y., Kamimura, Y., Saka, T., YOSHIDA, M., Saito, M., Kudo, H., Kunisaki, N., & Gomyô, T. (2008) · NIPPON SHOKUHIN KOGYO GAKKAISHI · doi:10.3136/nskkk.55.625 · Cited by 9

Sorted by citations

Minireview: Gut microbiota: The neglected endocrine organ
Clarke, G., Stilling, R. M., Kennedy, P. J., Stanton, C., Cryan, J. F., & Dinan, T. G. (2014) · Molecular Endocrinology · doi:10.1210/me.2014-1108 · Cited by 1,192
Effects of gut microbes on nutrient absorption and energy regulation
Krajmalnik‐Brown, R., Ilhan, Z., Kang, D., & DiBaise, J. K. (2012) · Nutrition in Clinical Practice · doi:10.1177/0884533611436116 · Cited by 852
Influence of a high-fat diet on gut microbiota, intestinal permeability and metabolic endotoxaemia
Moreira, A. P. B., Teixeira, T. F. S., Machado, A. B. F., Pelúzio, M. D. C. G., & Alfenas, R. D. C. G. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114512001213 · Cited by 675
Microbial endocrinology: the interplay between the microbiota and the endocrine system
Neuman, H., Debelius, J. W., Knight, R. D., & Koren, O. (2015) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuu010 · Cited by 624
Gut microbiota and metabolic syndrome
Festi, D., Schiumerini, R., Eusebi, L. H., Marasco, G., Taddia, M., & Colecchia, A. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i43.16079 · Cited by 534

See all 163

Authors: Takemura, N., Okubo, T., & Sonoyama, K.
Affiliations: Hokkaido University (JP)
Graduate School of Life Science
ORCID: Takemura, Naoki
Sonoyama, Kei
Venue: Experimental Biology and Medicine
Publisher: Frontiers Media SA
Published: 2010-07
Volume: 235
Issue: 7
Pages: 849-856
ISSN: 0071-3384 (ISSN-L)
1535-3702
1535-3699
DOI: 10.1258/ebm.2010.009377
OpenAlex: W1996596574
Cited by: 163
References: 41
Citations by year: 2026: 2 · 2025: 5 · 2024: 2 · 2023: 6 · 2022: 11 · 2021: 7 · 2020: 13 · 2019: 9 · 2018: 11 · 2017: 16 · 2016: 11 · 2015: 12 · 2014: 12 · 2013: 20 · 2012: 16
FWCI: 22.54
Type: journal article
Language: en
Open access: closed
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Experimental Biology and Medicine (publishedVersion)
PubMed (publishedVersion)
Funders: Hokkaido University
Topics: Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords: probiotics, adipocyte size, diet-induced obesity, high-fat diet, white adipose tissue, conjugated linoleic acid, leptin, adiponectin, serum cholesterol, gut microbiota, obesity prevention
MeSH terms: Adipose Tissue, Animals, Body Weight, Cholesterol, Dietary Fats, Female, Mice, Inbred C57BL, Obesity, Triglycerides, Weight Gain, Adipocytes, Leptin, Lactiplantibacillus plantarum, Mice, Adiponectin

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Lactobacillus plantarum strain No. 14 reduces adipocyte size in mice fed high-fat diet

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks