Antiobesity effect of trans-10,cis-12-conjugated linoleic acid-producing Lactobacillus plantarum PL62 on diet-induced obese mice
Abstract
AIMS: To observe the antiobesity activity of trans-10,cis-12-conjugated linoleic acid (CLA)-producing lactobacillus in mice. METHODS AND RESULTS: Lactobacillus plantarum PL62, which can grow in the presence of linoleic acid, was selected and studied. The culture supernatant of Lact. plantarum PL62 contained trans-10,cis-12-conjugated linoleic acid (6.4 microg ml(-1)), and the crude enzyme prepared from washed cells produced trans-10,cis-12 CLA (1395 microg mg(-1) protein). Lact. plantarum PL62 reduced the weights of epididymal, inguinal, mesenteric, and perirenal white adipose tissues and significantly reduced the blood levels of total glucose and body weights of mice (P<0.01). CONCLUSIONS: trans-10,cis-12-CLA-producing Lact. plantarum PL62 can exert the same antiobesity activity as trans-10,cis-12-CLA in mice. SIGNIFICANCE AND IMPACT OF THE STUDY: trans-10,cis-12-CLA-producing Lactobacillus can be a replacement for CLA for obesity treatment via the continuous production of trans-10,cis-12-CLA. The results provide a novel opportunity to develop foods with antiobesity activity.
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L. rhamnosus can generate and isomerize cLA and exert anti-obesity effects in diet-induced obese mice in a cLA-dependent manner.
“to generate and isomerize cLA and exert anti-obesity effects in diet-induced obese mice in a cLA-dependent manner[279,403,415,416]”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [415]
Cites
Nucleic acid techniques in bacterial systematics
Stackebrandt, E., & Goodfellow, M. (1991) · Wiley eBooks · Cited by 9,494 · see citing works
Lane, D. (1991) · Medical Entomology and Zoology · Cited by 7,944 · see citing works
Effect of conjugated linoleic acid on body composition in mice
Park, Y., Albright, K. J., Liu, W., Storkson, J. M., Cook, M. E., & Pariza, M. W. (1997) · Lipids · doi:10.1007/s11745-997-0109-x · Cited by 1,163 · see citing works
Conjugated linoleic acid and atherosclerosis in rabbits
Lee, K. N., Kritchevsky, D., & Parizaa, M. W. (1994) · Atherosclerosis · doi:10.1016/0021-9150(94)90034-5 · Cited by 998 · see citing works
Self-citationPark, Y., Storkson, J. M., Albright, K. J., Liu, W., & Pariza, M. W. (1999) · Lipids · doi:10.1007/s11745-999-0358-8 · Cited by 815 · see citing works
Intermediates and Products of the Biohydrogenation of Linoleic Acid by Butyrivibrio fibrisolvens
Kepler, C. R., Hirons, K. P., McNeill, J. J., & Tove, S. B. (1966) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)96781-5 · Cited by 693 · see citing works
A Phylogenetic Analysis of the Genus Nocardia with 16S rRNA Gene Sequences
Chun, J., & Goodfellow, M. (1995) · International Journal of Systematic Bacteriology · doi:10.1099/00207713-45-2-240 · Cited by 690 · see citing works
Ha, Y. L., STORKSON, J. M., & Pariza, M. W. (1990) · PubMed · Cited by 669 · see citing works
COOK, M. E., MILLER, C. C., Park, Y., & Pariza, M. W. (1993) · Poultry Science · doi:10.3382/ps.0721301 · Cited by 477 · see citing works
Perspective on the safety and effectiveness of conjugated linoleic acid
Pariza, M. W. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.6.1132s · Cited by 351 · see citing works
Song, Y., Kato, N., Liu, C.-X., Matsumiya, Y., Kato, H., & Watanabe, K. (2000) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2000.tb09155.x · Cited by 314 · see citing works
Conjugated linoleic acid supplementation for 1 y reduces body fat mass in healthy overweight humans
Gaullier, J., Halse, J., Høye, K., Kristiansen, K., Fagertun, H., Vik, H., & Gudmundsen, O. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.6.1118 · Cited by 292 · see citing works
Alonso, L., Cuesta, E. P., & Gilliland, S. E. (2003) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(03)73781-3 · Cited by 229 · see citing works
Kim, Y. J., Liu, R. H., Rychlik, J. L., & Russell, J. B. (2002) · Journal of Applied Microbiology · doi:10.1046/j.1365-2672.2002.01610.x · Cited by 208 · see citing works
Ogawa, J., Matsumura, K., Kishino, S., Omura, Y., & Shimizu, S. (2001) · Applied and Environmental Microbiology · doi:10.1128/aem.67.3.1246-1252.2001 · Cited by 202 · see citing works
Conjugated linoleic acid production from linoleic acid by lactic acid bacteria
Kishino, S., Ogawa, J., Omura, Y., Matsumura, K., & Shimizu, S. (2002) · Journal of the American Oil Chemists Society · doi:10.1007/s11746-002-0451-4 · Cited by 194 · see citing works
trans-10,cis-12 CLA inhibits differentiation of 3T3-L1 adipocytes and decreases PPARγ expression
Kang, K., Liu, W., ALBRIGHT, K. J., Park, Y., & Pariza, M. W. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)00413-3 · Cited by 170 · see citing works
Jiang, J. Q., Wolk, A., & Vessby, B. O. (1999) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/70.1.21 · Cited by 154 · see citing works
House, R. L., Cassady, J. P., Eisen, E. J., McIntosh, M. K., & Odle, J. (2005) · Obesity Reviews · doi:10.1111/j.1467-789x.2005.00198.x · Cited by 124 · see citing works
Metabolic effects of conjugated linoleic acid in humans: the Swedish experience
Risérus, U., Smedman, A., Basu, S., & Vessby, B. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.6.1146s · Cited by 87 · see citing works
Kishino, S., Ogawa, J., Ando, A., Omura, Y., & Shimizu, S. (2002) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.66.2283 · Cited by 77 · see citing works
Supplemental Products Used for Weight Loss
Lenz, T. L., & Hamilton, W. R. (2004) · Journal of the American Pharmacists Association · doi:10.1331/154434504322713246 · Cited by 73 · see citing works
Lee, S. O., Kim, C. S., Cho, S. K., et al. (2003) · Biotechnology Letters · doi:10.1023/a:1024084203052 · Cited by 56 · see citing works
Isomer-specific regulation of differentiating pig preadipocytes by conjugated linoleic acids1
Brandebourg, T. D., & Hu, C. Y. (2005) · Journal of Animal Science · doi:10.2527/2005.8392096x · Cited by 52 · see citing works
Lin, T. Y., Lin, C. W., & Wang, Y. J. (2002) · Journal of Food Science · doi:10.1111/j.1365-2621.2002.tb10312.x · Cited by 48 · see citing works
Effect of conjugated FA on feed intake, body composition, and liver FA in mice
Chardigny, J., Hasselwander, O., Genty, M., Kraemer, K., Ptock, A., & Sébédio, J. L. (2003) · Lipids · doi:10.1007/s11745-003-1142-5 · Cited by 44 · see citing works
Mizunoya, W., Haramizu, S., Shibakusa, T., Okabe, Y., & Fushiki, T. (2005) · Lipids · doi:10.1007/s11745-005-1381-5 · Cited by 41 · see citing works
Anti-Metrazol® Efficacy of Combinations of Meparfynol and Anticonvulsant Drugs
Brodie, D. A., Tye, A., & Nelson, J. W. (1955) · Journal of the American Pharmaceutical Association (Scientific ed ) · doi:10.1002/jps.3030440122 · Cited by 26 · see citing works
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Minireview: Gut microbiota: The neglected endocrine organ
Clarke, G., Stilling, R. M., Kennedy, P. J., Stanton, C., Cryan, J. F., & Dinan, T. G. (2014) · Molecular Endocrinology · doi:10.1210/me.2014-1108 · Cited by 1,192 · see citing works
Genes and Molecules of Lactobacilli Supporting Probiotic Action
Lebeer, S., Vanderleyden, J., & De Keersmaecker, S. C. J. (2008) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00017-08 · Cited by 1,013 · see citing works
Effects of gut microbes on nutrient absorption and energy regulation
Krajmalnik‐Brown, R., Ilhan, Z., Kang, D., & DiBaise, J. K. (2012) · Nutrition in Clinical Practice · doi:10.1177/0884533611436116 · Cited by 852 · see citing works
Gut microbiota and metabolic syndrome
Festi, D., Schiumerini, R., Eusebi, L. H., Marasco, G., Taddia, M., & Colecchia, A. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i43.16079 · Cited by 534 · see citing works
den Hartigh, L. (2019) · Nutrients · doi:10.3390/nu11020370 · Cited by 371 · see citing works
Linares, D. M., Gómez, C., Renes, E., Fresno, J. M., Tornadijo, M. E., Ross, R. P., & Stanton, C. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.00846 · Cited by 335 · see citing works
Park, D.-Y., Ahn, Y.-T., Park, S.-H., Huh, C.-S., Yoo, S.-R., Yu, R., Sung, M.-K., McGregor, R. A., & Choi, M.-S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059470 · Cited by 317 · see citing works
O'Shea, E. F., Cotter, P. D., Stanton, C., Ross, R. P., & Hill, C. (2012) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2011.05.025 · Cited by 305 · see citing works
International Society of Sports Nutrition Position Stand: Probiotics
Jäger, R., Mohr, A. E., Carpenter, K. C., Kerksick, C. M., Purpura, M., Moussa, A., Townsend, J. R., Lamprecht, M., West, N. P., Black, K., et al. (2019) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-019-0329-0 · Cited by 277 · see citing works
Anti-Obesity Effect of Lactobacillus gasseri BNR17 in High-Sucrose Diet-Induced Obese Mice
Kang, J.-H., Yun, S.-I., Park, M.-H., Park, J.-H., Jeong, S.-Y., & Park, H.-O. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054617 · Cited by 230 · see citing works
Self-citationKoch, C. D., Gladwin, M. T., Freeman, B. A., Lundberg, J. O., Weitzberg, E., & Morris, A. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.12.015 · Cited by 186 · see citing works
The influence of the human microbiome and probiotics on cardiovascular health
Ettinger, G., MacDonald, K., Reid, G., & Burton, J. P. (2014) · Gut Microbes · doi:10.4161/19490976.2014.983775 · Cited by 180 · see citing works
Probiotics: interaction with gut microbiome and antiobesity potential.
Arora, T., Singh, S., & Sharma, R. K. (2013) · Nutrition · doi:10.1016/j.nut.2012.07.017 · Cited by 176 · see citing works
<i>Lactobacillus plantarum</i> strain No. 14 reduces adipocyte size in mice fed high-fat diet
Takemura, N., Okubo, T., & Sonoyama, K. (2010) · Experimental Biology and Medicine · doi:10.1258/ebm.2010.009377 · Cited by 163 · see citing works
Jung, S.-P., Lee, K.-M., Kang, J.-H., Yun, S.-I., Park, H.-O., Moon, Y., & Kim, J.-Y. (2013) · Korean Journal of Family Medicine · doi:10.4082/kjfm.2013.34.2.80 · Cited by 140 · see citing works
Self-citationKang, J.-H., Yun, S.-I., & Park, H.-O. (2010) · The Journal of Microbiology · doi:10.1007/s12275-010-0363-8 · Cited by 135 · see citing works
Jacouton, E., Mach, N., Cadiou, J., Lapaque, N., Clément, K., Doré, J., van Hylckama Vlieg, J. E. T., Smokvina, T., & Blottière, H. M. (2015) · PLOS ONE · doi:10.1371/journal.pone.0138880 · Cited by 32 · see citing works
Unveiling The Therapeutic Potential of Probiotics: A Review
Tukaram, K. S., Sopanrao, S. R., & Kacharu, L. O. (2025) · Journal of Future Foods · doi:10.1016/j.jfutfo.2025.09.011 · Cited by 19 · see citing works
Kim, D. H., Choi, M.-R., Hong, J. E., Lee, J.-Y., Lee, S. I., Jung, S. H., & Kim, E. J. (2014) · Journal of the Korean Society of Food Science and Nutrition · doi:10.3746/jkfn.2014.43.10.1484 · Cited by 5 · see citing works
- Authors
- Lee, K., Paek, K., Lee, H. Y., Park, J. H., & Lee, Y.
- Affiliations
- Seoul Women's University (KR)
- Soongsil University (KR)
- Seoul National University (KR)
- Corresponding author
- Lee, K.
- Venue
- Journal of Applied Microbiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-10
- Volume
- 103
- Issue
- 4
- Pages
- 1140-1146
- ISSN
- 1364-5072 (ISSN-L)
- 1365-2672
- OpenAlex
- W2155921937
- Cited by
- 175
- References
- 28
- Citations by year
- 2025: 5 · 2024: 5 · 2023: 5 · 2022: 10 · 2021: 6 · 2020: 10 · 2019: 6 · 2018: 5 · 2017: 14 · 2016: 18 · 2015: 16 · 2014: 16 · 2013: 19 · 2012: 10
- FWCI
- 10.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Applied Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Seoul National University Open Repository (Seoul National University) (submittedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- trans-10, cis-12 conjugated linoleic acid, anti-obesity, diet-induced obesity, white adipose tissue, linoleic acid, probiotics, obesity treatment, functional foods
- MeSH terms
- Animals, Energy Intake, Chromatography, Gas, Dietary Fats, Eating, Feces, Glycerol, Lipids, Male, Mice, Inbred C57BL, Obesity, Organ Size, Weight Gain, Probiotics, Leptin, Linoleic Acids, Conjugated, Lactobacillus plantarum, Lactiplantibacillus plantarum, Mice
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