Human originated bacteria, Lactobacillus rhamnosus PL60, produce conjugated linoleic acid and show anti-obesity effects in diet-induced obese mice
Abstract
Many previous studies have reported that conjugated linoleic acid could be produced by starter culture bacteria, but the effects of the bacteria were not investigated. Moreover, there was no evidence of the conjugated linoleic acid-producing bacteria having potential health or nutritional effects related to conjugated linoleic acid, including reducing body fat. Here, we investigated the anti-obesity effect of Lactobacillus rhamnosus PL60, a human originated bacterium that produces t10, c12-conjugated linoleic acid, on diet-induced obese mice. After 8 weeks of feeding, L. rhamnosus PL60 reduced body weight without reducing energy intake, and caused a significant, specific reduction of white adipose tissue (epididymal and perirenal). Although the size of epididymal adipocytes was not reduced by L. rhamnosus PL60, apoptotic signals and UCP-2 mRNA levels increased in adipose tissue. Liver steatosis, a well known side effect of CLA, was not observed by L. rhamnosus PL60 treatment; on the contrary it seemed to be normalized. Results showed that the amount of conjugated linoleic acid produced by Lactobacillus rhamnosus PL60 was enough to produce an anti-obesity effect.
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Different bacteria produce different ratios of CLA isomers.
“Different bacteria produce different ratios of CLA isomers [25, 26]”
From Dietary lipids, gut microbiota and lipid metabolism (2019) · cites this paper as [26]
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- Authors
- Lee, H.-Y., Park, J.-H., Seok, S.-H., Baek, M.-W., Kim, D.-J., Lee, K.-E., Paek, K.-S., Lee, Y., & Park, J.-H.
- Affiliations
- Seoul National University (KR)
- Seoul Women's University (KR)
- Corresponding author
- Park, Jae-Hak
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
- Publisher
- Elsevier BV
- Published
- 2006-07
- Volume
- 1761
- Issue
- 7
- Pages
- 736-744
- ISSN
- 1388-1981 (ISSN-L)
- OpenAlex
- W2159567888
- Cited by
- 342
- References
- 2
- Citations by year
- 2025: 7 · 2024: 13 · 2023: 17 · 2022: 16 · 2021: 24 · 2020: 17 · 2019: 21 · 2018: 18 · 2017: 25 · 2016: 25 · 2015: 27 · 2014: 33 · 2013: 30 · 2012: 18
- FWCI
- 9.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids (publishedVersion)
- PubMed (publishedVersion)
- Seoul National University Open Repository (Seoul National University) (submittedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- conjugated linoleic acid, anti-obesity, diet-induced obesity, white adipose tissue, adipocyte apoptosis, UCP2, hepatic steatosis, weight loss, probiotics
- MeSH terms
- Animals, Biological Therapy, Body Weight, Energy Intake, Diet, Humans, Mice, Obese, Obesity, Probiotics, Linoleic Acids, Conjugated, Mice, Lacticaseibacillus rhamnosus
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