Cited by 4,388Circular RNAs in diseasesRNA Research and SplicingCancer-related molecular mechanisms research

The DOI matches its Crossref record; 40 of the 41 references it cites were found in a registry or an index.

Circular RNAs are abundant, conserved, and associated with ALU repeats

Open access

Jeck, William R., Sorrentino, Jessica A., Wang, Kai, Slevin, Michael K., Burd, Christin E., Liu, Jinze, Marzluff, William F., Sharpless, Norman E.·2013·RNA

DOI 10.1261/rna.035667.112PMC PMC3543092

Open this paper in CoChat — free account Open PDF

Abstract

Circular RNAs composed of exonic sequence have been described in a small number of genes. Thought to result from splicing errors, circular RNA species possess no known function. To delineate the universe of endogenous circular RNAs, we performed high-throughput sequencing (RNA-seq) of libraries prepared from ribosome-depleted RNA with or without digestion with the RNA exonuclease, RNase R. We identified >25,000 distinct RNA species in human fibroblasts that contained non-colinear exons (a "backsplice") and were reproducibly enriched by exonuclease degradation of linear RNA. These RNAs were validated as circular RNA (ecircRNA), rather than linear RNA, and were more stable than associated linear mRNAs in vivo. In some cases, the abundance of circular molecules exceeded that of associated linear mRNA by >10-fold. By conservative estimate, we identified ecircRNAs from 14.4% of actively transcribed genes in human fibroblasts. Application of this method to murine testis RNA identified 69 ecircRNAs in precisely orthologous locations to human circular RNAs. Of note, paralogous kinases HIPK2 and HIPK3 produce abundant ecircRNA from their second exon in both humans and mice. Though HIPK3 circular RNAs contain an AUG translation start, it and other ecircRNAs were not bound to ribosomes. Circular RNAs could be degraded by siRNAs and, therefore, may act as competing endogenous RNAs. Bioinformatic analysis revealed shared features of circularized exons, including long bordering introns that contained complementary ALU repeats. These data show that ecircRNAs are abundant, stable, conserved and nonrandom products of RNA splicing that could be involved in control of gene expression.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1261/rna.035667.112

Cites

40 of 40 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction
Chomczynski, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1006/abio.1987.9999 · Cited by 65,515
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
Huang, D. W., Sherman, B. T., & Lempicki, R. A. (2009) · Nature Protocols · doi:10.1038/nprot.2008.211 · Cited by 35,890
BEDTools: a flexible suite of utilities for comparing genomic features
Quinlan, A. R., & Hall, I. M. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq033 · Cited by 27,437
Integrative genomics viewer
Robinson, J. T., Thorvaldsdóttir, H., Winckler, W., Guttman, M., Lander, E. S., Getz, G., & Mesirov, J. P. (2011) · Nature Biotechnology · doi:10.1038/nbt.1754 · Cited by 15,390
Non-coding RNAs in human disease
Esteller, M. (2011) · Nature Reviews Genetics · doi:10.1038/nrg3074 · Cited by 4,825
Argonaute2 is the catalytic engine of mammalian RNAi
Liu, J., Carmell, M. A., Rivas, F. V., Marsden, C. G., Thomson, J. M., Song, J.-J., Hammond, S. M., Joshua-Tor, L., & Hannon, G. J. (2004) · Science · doi:10.1126/science.1102513 · Cited by 2,796
Self-citation
A coding-independent function of gene and pseudogene mRNAs regulates tumour biology
Poliseno, L., Salmena, L., Zhang, J., Carver, B. S., Haveman, W. J., & Pandolfi, P. P. (2010) · Nature · doi:10.1038/nature09144 · Cited by 2,364
Circular RNAs Are the Predominant Transcript Isoform from Hundreds of Human Genes in Diverse Cell Types
Salzman, J., Gawad, C., Wang, P. L., Lacayo, N., & Brown, P. O. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030733 · Cited by 2,239
MicroRNA sponges: competitive inhibitors of small RNAs in mammalian cells
Ebert, M. S., Neilson, J. R., & Sharp, P. A. (2007) · Nature Methods · doi:10.1038/nmeth1079 · Cited by 2,108
Target mimicry provides a new mechanism for regulation of microRNA activity
Franco‐Zorrilla, J. M., Valli, A. A., Todesco, M., Mateos, I., Puga, M. I., Rubio‐Somoza, I., Leyva, A., Weigel, D., Garcı́a, J. A., & Paz‐Ares, J. (2007) · Nature Genetics · doi:10.1038/ng2079 · Cited by 2,101

Show all 41 references

Research works printed but not linked: 2

10.1093/emboj/21.12.2936 · DOI
10.1016/0003-2697(87)90021-2 · DOI

Sorted by citations

Items 901–1,000 of 1,005

A circular RNA from APC inhibits the proliferation of diffuse large B-cell lymphoma by inactivating Wnt/β-catenin signaling via interacting with TET1 and miR-888
Hu, Y., Zhao, Y., Shi, C., Ren, P., Wei, B., Guo, Y., & Ma, J. (2019) · Aging · doi:10.18632/aging.102122 · Cited by 64
Novel role of circRSU1 in the progression of osteoarthritis by adjusting oxidative stress
Yang, Y., Shen, P., Teng, Y., Ma, J., Chen, Z., Zhu, J., Gong, Z., Shen, S., & Fang, X. (2020) · Theranostics · doi:10.7150/thno.53307 · Cited by 66
Quantifying circular RNA expression from RNA-seq data using model-based framework
Li, M., Xie, X., Zhou, J., Sheng, M., Yin, X., Ko, E.-A., Zhou, T., & Gu, W. (2017) · Bioinformatics · doi:10.1093/bioinformatics/btx129 · Cited by 64
The potential roles of circRNAs in osteoarthritis: a coming journey to find a treasure
Li, H., Zhong, L., Xu, X., Lin, N., & Lu, H.-D. (2018) · Bioscience Reports · doi:10.1042/bsr20180542 · Cited by 66
Upregulation of circular RNA circ_0001721 predicts unfavorable prognosis in osteosarcoma and facilitates cell progression via sponging miR-569 and miR-599
Li, L., Guo, L., Yin, G., Yu, G., Zhao, Y., & Pan, Y. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.10.072 · Cited by 63
Computational approaches for circular RNA analysis
Jakobi, T., & Dieterich, C. (2019) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1528 · Cited by 64
Circ-SLC7A5, a potential prognostic circulating biomarker for detection of ESCC
Wang, Q., Liu, H., Liu, Z., Yang, L., Zhou, J. P., Cao, X., & Sun, H. (2019) · Cancer Genetics · doi:10.1016/j.cancergen.2019.11.001 · Cited by 63
Epigenetic Regulation of Alternative Splicing: How LncRNAs Tailor the Message
Pisignano, G., & Ladomery, M. (2021) · Non-Coding RNA · doi:10.3390/ncrna7010021 · Cited by 65
Long Non-Coding RNAs in Cardiovascular Diseases: Potential Function as Biomarkers and Therapeutic Targets of Exercise Training
Correia, C. C. M., Rodrigues, L. F., Pelozin, B. R. D. A., de Oliveira, E. M., & Fernandes, T. M. (2021) · Non-Coding RNA · doi:10.3390/ncrna7040065 · Cited by 64
CircRNA: a rising star in plant biology
Zhang, P., & Dai, M. (2022) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2022.05.004 · Cited by 63
Is an observed non-co-linear RNA product spliced intrans, incisor justin vitro?
Yu, C., Liu, H.-J., Hung, L.-Y., Kuo, H., & Chuang, T. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku643 · Cited by 61
Noncoding RNA s as therapeutic targets in atherosclerosis with diabetes mellitus
Tang, N., Jiang, S., Yang, Y., Liu, S., Ponnusamy, M., Xin, H., & Yu, T. (2018) · Cardiovascular Therapeutics · doi:10.1111/1755-5922.12436 · Cited by 63
Noncoding RNAs in Cardiac Hypertrophy
Li, Y., Liang, Y., Zhu, Y., Zhang, Y., & Bei, Y. (2018) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-018-9797-x · Cited by 63
Exosomal circLPAR1 Promoted Osteogenic Differentiation of Homotypic Dental Pulp Stem Cells by Competitively Binding to hsa‐miR‐31
Xie, L., Guan, Z., Zhang, M., Lyu, S., Thuaksuban, N., Kamolmattayakul, S., & Nuntanaranont, T. (2020) · BioMed Research International · doi:10.1155/2020/6319395 · Cited by 60
Differentially Expressed Circular RNAs in Peripheral Blood Mononuclear Cells of Patients with Parkinson's Disease
Ravanidis, S., Bougea, A., Karampatsi, D., Papagiannakis, N., Maniati, M., Stefanis, L., & Doxakis, E. (2021) · Movement Disorders · doi:10.1002/mds.28467 · Cited by 63
From genotype to phenotype in human atherosclerosis - recent findings
Holdt, L. M., & Teupser, D. (2013) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e3283654e7c · Cited by 62
Fusion of multiple heterogeneous networks for predicting circRNA-disease associations
Deng, L., Zhang, W., Shi, Y., & Tang, Y. (2019) · Scientific Reports · doi:10.1038/s41598-019-45954-x · Cited by 62
Oxaliplatin-Induced DHX9 Phosphorylation Promotes Oncogenic Circular RNA CCDC66 Expression and Development of Chemoresistance
Lin, Y., Yu, Y.-S., Lin, H.-H., & Hsiao, K. (2020) · Cancers · doi:10.3390/cancers12030697 · Cited by 62
Identification of Circular RNA hsa_Circ_0003391 in Peripheral Blood Is Potentially Associated With Alzheimer's Disease
Liu, L., Chen, X., Chen, Y., & Zhang, K. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.601965 · Cited by 61
Sensitive, reliable and robust circRNA detection from RNA-seq with CirComPara2
Gaffo, E., Buratin, A., Molin, A. D., & Bortoluzzi, S. (2021) · Briefings in Bioinformatics · doi:10.1093/bib/bbab418 · Cited by 62
Circular RNA: a new star in neurological diseases
Li, T., Jia, Y., Wang, Q., Shao, X.-Q., & Lv, R. (2016) · International Journal of Neuroscience · doi:10.1080/00207454.2016.1236382 · Cited by 63
Circular RNA profile indicates circular RNA VRK1 is negatively related with breast cancer stem cells
Yan, N., Xu, H., Zhang, J., Xu, L., Zhang, Y., Zhang, L., Xu, Y., & Zhang, F. (2017) · Oncotarget · doi:10.18632/oncotarget.21183 · Cited by 61
Targeting circular RNA-ZRANB1 for therapeutic intervention in retinal neurodegeneration
Wang, J., Shan, K. Y., Liu, B.-H., Liu, C., Zhou, R., Li, X., Dong, R., Zhang, S., Zhang, S.-H., Wu, J., et al. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0597-7 · Cited by 62
The nuclear export of circular RNAs is primarily defined by their length
Li, Z., Kearse, M. G., & Huang, C. (2018) · RNA Biology · doi:10.1080/15476286.2018.1557498 · Cited by 63
Genome-Wide Profiling of Circular RNAs in the Rapidly Growing Shoots of Moso Bamboo (Phyllostachys edulis)
Wang, Y., Gao, Y., Zhang, H., Wang, H., Liu, X., Xu, X., Zhang, Z., Kohnen, M. V., Hu, K., Wang, H., et al. (2019) · Plant and Cell Physiology · doi:10.1093/pcp/pcz043 · Cited by 61
CircRNAs: A new perspective of biomarkers in the nervous system
Ma, Y., Liu, Y., & Jiang, Z. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110251 · Cited by 61
Discriminating cirRNAs from other lncRNAs using a hierarchical extreme learning machine (H-ELM) algorithm with feature selection
Chen, L., Zhang, Y., Huang, G., Pan, X., Wang, S., Huang, T., & Cai, Y. (2017) · Molecular Genetics and Genomics · doi:10.1007/s00438-017-1372-7 · Cited by 62
Circular RNA: New Regulatory Molecules
Belousova, E. A., Филипенко, М. Л., & Кушлинский, Н. Е. (2018) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-018-4084-z · Cited by 61
Prospect of Circular RNA in Hepatocellular Carcinoma: A Novel Potential Biomarker and Therapeutic Target
Yao, R., Zou, H., & Liao, W. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00332 · Cited by 61
RETRACTED ARTICLE: Circular RNA ITCH suppressed prostate cancer progression by increasing HOXB13 expression via spongy miR-17-5p
Wang, X., Wang, R., Wu, Z., & Bai, P. (2019) · Cancer Cell International · doi:10.1186/s12935-019-0994-8 · Cited by 62
Retracted
Profiling of circular RNA N6‐methyladenosine in moso bamboo (Phyllostachys edulis) using nanopore‐based direct RNA sequencing
Wang, Y., Wang, H., Xi, F., Wang, H., Han, X., Wei, W., Zhang, H., Zhang, Q., Zheng, Y., Zhu, Q., et al. (2020) · Journal of Integrative Plant Biology · doi:10.1111/jipb.13002 · Cited by 62
The Role of Circular RNAs in Therapy Resistance of Patients With Solid Tumors
Papatsirou, M., Artemaki, P. I., Scorilas, A., & Kontos, C. K. (2020) · Personalized Medicine · doi:10.2217/pme-2020-0103 · Cited by 62
Epigenetic regulation of cellular functions in wound healing
Pastar, I., Marjanović, J., Stone, R. C., Chen, V., Burgess, J. L., Mervis, J. S., & Tomic‐Canic, M. (2021) · Experimental Dermatology · doi:10.1111/exd.14325 · Cited by 63
The functional roles, cross-talk and clinical implications of m6A modification and circRNA in hepatocellular carcinoma
Qin, S., Mao, Y., Xue, C., Xiao, J., Qin, Y., & Zhao, L. (2021) · International Journal of Biological Sciences · doi:10.7150/ijbs.62767 · Cited by 61
Circular RNAs: New layer of complexity evading breast cancer heterogeneity
Dawoud, A., Zakaria, Z. I., Rashwan, H. H., Braoudaki, M., & Youness, R. A. (2022) · Non-coding RNA Research · doi:10.1016/j.ncrna.2022.09.011 · Cited by 61
Circular RNAs: Emerging roles and new insights in human cancers
He, Z., & Zhu, Q. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115217 · Cited by 61
Highly efficient cellular expression of circular mRNA enables prolonged protein expression
Unti, M. J., & Jaffrey, S. R. (2023) · Cell chemical biology · doi:10.1016/j.chembiol.2023.09.015 · Cited by 63
Characterization of Circular RNAs
Zhang, Y., Yang, L. C., & Chen, L. (2015) · Methods in molecular biology · doi:10.1007/978-1-4939-3378-5_17 · Cited by 61
Circular RNAs: Coding or noncoding?
Schneider, T. P., & Bindereif, A. (2017) · Cell Research · doi:10.1038/cr.2017.70 · Cited by 60
Circ-HIPK3 Strengthens the Effects of Adrenaline in Heart Failure by MiR-17-3p - ADCY6 Axis
Deng, Y., Wang, J., Xie, G., Zeng, X., & Li, H. (2019) · International Journal of Biological Sciences · doi:10.7150/ijbs.36149 · Cited by 65
Silencing of circular RNA HIPK2 in neural stem cells enhances functional recovery following ischaemic stroke
Wang, G., Han, B., Shen, L., Wu, S., Yang, L., Liao, J., Wu, F., Li, M., Leng, S., Zang, F., et al. (2020) · EBioMedicine · doi:10.1016/j.ebiom.2020.102660 · Cited by 61
CircGRIA1 shows an age-related increase in male macaque brain and regulates synaptic plasticity and synaptogenesis
Xu, K., Zhang, Y., Xiong, W., Zhang, Z., Wang, Z., Lv, L., Liu, C., Hu, Z., Zheng, Y., Lü, L., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17435-7 · Cited by 62
Emerging important roles of circRNAs in human cancer and other diseases
Huang, Y., Zhang, C., Xiong, J., & Ren, H. (2020) · Genes & Diseases · doi:10.1016/j.gendis.2020.07.012 · Cited by 62
The role of Alu elements in the cis-regulation of RNA processing
Daniel, C., Behm, M., & Öhman, M. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-1990-3 · Cited by 62
Genome-Wide Analysis of Circular RNAs Mediated ceRNA Regulation in Porcine Embryonic Muscle Development
Hong, L., Gu, T., He, Y., Zhou, C., Hu, Q., Wang, X., Zheng, E., Huang, S., Xu, Z., Yang, J., et al. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00289 · Cited by 61
Circular RNAs: The Brain Transcriptome Comes Full Circle
Gokoolparsadh, A., Loy, C. T., Halliday, G. M., & Voineagu, I. (2020) · Trends in Neurosciences · doi:10.1016/j.tins.2020.07.007 · Cited by 61
The Role of Epigenetics in Congenital Heart Disease
Lim, T. B., Foo, S. Y. R., & Chen, C. K. (2021) · Genes · doi:10.3390/genes12030390 · Cited by 62
Circular RNAs in acute myeloid leukemia
Singh, V., Uddin, M. H., Zonder, J. A., Azmi, A. S., & Balasubramanian, S. K. (2021) · Molecular Cancer · doi:10.1186/s12943-021-01446-z · Cited by 63
Biogenesis, Functions, Interactions, and Resources of Non-Coding RNAs in Plants
Chao, H., Hu, Y., Zhao, L., Xin, S., Ni, Q., Zhang, P., & Chen, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073695 · Cited by 58
Extracellular Vesicle‐Associated RNA as a Carrier of Epigenetic Information
Liegro, C. M. D., Schiera, G., & Liegro, I. D. (2017) · Genes · doi:10.3390/genes8100240 · Cited by 64
Changes in circular RNA expression patterns during human foetal brain development
Chen, B. J., Huang, S., & Janitz, M. (2018) · Genomics · doi:10.1016/j.ygeno.2018.04.015 · Cited by 60
Circular RNA expression and function in the brain
Sekar, S., & Liang, W. S. (2019) · Non-coding RNA Research · doi:10.1016/j.ncrna.2019.01.001 · Cited by 64
Circular RNA circ_0000284 plays an oncogenic role in the progression of non-small cell lung cancer through the miR-377-3p-mediated PD-L1 promotion
Li, L., Zhang, Q., & Lian, K. (2020) · Cancer Cell International · doi:10.1186/s12935-020-01310-y · Cited by 60
RNA structures in alternative splicing and back‐splicing
Xu, B., Meng, Y., & Jin, Y. (2020) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1626 · Cited by 63
Role of Transposable Elements in Gene Regulation in the Human Genome
Ali, A., Han, K., & Liang, P. (2021) · Life · doi:10.3390/life11020118 · Cited by 76
Circular RNAs as Potential Theranostics in the Cardiovascular System
Bei, Y., Yang, T., Wang, L., Holvoet, P., Das, S., Sluijter, J. P. G., Monteiro, M. C., Liu, Y., Zhou, Q., & Xiao, J. (2018) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2018.09.022 · Cited by 60
RETRACTED ARTICLE: A regulatory circuit of circ-MTO1/miR-17/QKI-5 inhibits the proliferation of lung adenocarcinoma
Zhang, B., Chen, M., Jiang, N., Shi, K., & Qian, R. (2019) · Cancer Biology & Therapy · doi:10.1080/15384047.2019.1598762 · Cited by 59
Retracted
Inhibition of SARS-CoV-2 coronavirus proliferation by designer antisense-circRNAs
Pfafenrot, C., Schneider, T. P., Müller, C., Hung, L.-H., Schreiner, S., Ziebuhr, J., & Bindereif, A. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab1096 · Cited by 59
The roles of glycolysis in osteosarcoma
Feng, Z., Ou, Y., & Hao, L. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.950886 · Cited by 60
Retrozymes are a unique family of non-autonomous retrotransposons with hammerhead ribozymes that propagate in plants through circular RNAs
Cervera, A., Urbina, D., & de la Peña, M. (2016) · Genome biology · doi:10.1186/s13059-016-1002-4 · Cited by 59
Deep Circular RNA Sequencing Provides Insights into the Mechanism Underlying Grass Carp Reovirus Infection
He, L., Zhang, A., Xiong, L., Li, Y., Huang, R., Liao, L., Zhu, Z., & Wang, A. Y. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18091977 · Cited by 59
Deciphering the roles of lncRNAs in breast development and disease
Richard, J. L. C., & Eichhorn, P. J. A. (2018) · Oncotarget · doi:10.18632/oncotarget.24591 · Cited by 62
Detection and profiling of circular RNAs in uninfected and maize Iranian mosaic virus-infected maize
Ghorbani, A., Izadpanah, K., Peters, J. R., Dietzgen, R. G., & Mitter, N. (2018) · Plant Science · doi:10.1016/j.plantsci.2018.06.016 · Cited by 59
Long non-coding RNAs in vascular biology and disease
Jaé, N., Heumüller, A. W., Fouani, Y., & Dimmeler, S. (2019) · Vascular Pharmacology · doi:10.1016/j.vph.2018.03.003 · Cited by 62
Methods for analysis of circular RNAs
Pandey, P. R., Munk, R. B., Kundu, G., De, S., Abdelmohsen, K., & Gorospe, M. (2019) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1566 · Cited by 61
TGF-β- and lipopolysaccharide-induced upregulation of circular RNA PWWP2A promotes hepatic fibrosis via sponging miR-203 and miR-223
Liu, W., Feng, R., Li, X., Li, D., & Zhai, W. (2019) · Aging · doi:10.18632/aging.102405 · Cited by 59
CircAST: Full-Length Assembly and Quantification of Alternatively Spliced Isoforms in Circular RNAs
Wu, J., Li, Y., Wang, C., Cui, Y., Xu, T., Wang, C., Wang, X., Sha, J., Jiang, B., Wang, K., et al. (2019) · Genomics Proteomics & Bioinformatics · doi:10.1016/j.gpb.2019.03.004 · Cited by 59
Self-citation
Noncoding RNAs versus Protein Biomarkers in Cardiovascular Disease
Schulte, C., Barwari, T., Joshi, A., Zeller, T., & Mayr, M. (2020) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2020.02.001 · Cited by 59
CircRNAs: a new target for the diagnosis and treatment of digestive system neoplasms
Li, J., Xu, Q., Huang, Z., Mao, N., Lin, Z., Cheng, L., Sun, B., & Wang, G. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03495-0 · Cited by 59
An antisense circular RNA circSCRIB enhances cancer progression by suppressing parental gene splicing and translation
Ma, J., Du, W. W., Zeng, K., Wu, N., Fang, L., Lyu, J., Yee, A., & Yang, B. B. (2021) · Molecular Therapy · doi:10.1016/j.ymthe.2021.08.002 · Cited by 59
Crosstalk in competing endogenous RNA network reveals the complex molecular mechanism underlying lung cancer
Jin, X., Guan, Y., Sheng, H., & Liu, Y. (2017) · Oncotarget · doi:10.18632/oncotarget.20441 · Cited by 58
A potential risk factor of essential hypertension in case-control study: Circular RNA hsa_circ_0037911
Bao, X., Zheng, S., Mao, S., Gu, T., Liu, S., Sun, J., & Zhang, L. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.03.059 · Cited by 58
Circular RNA-Associated Competing Endogenous RNA Network and Prognostic Nomogram for Patients With Colorectal Cancer
Song, W., & Fu, T. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.01181 · Cited by 58
Understanding aberrant RNA splicing to facilitate cancer diagnosis and therapy
Dong, X., & Chen, R. (2019) · Oncogene · doi:10.1038/s41388-019-1138-2 · Cited by 57
Circ_0088194 Promotes the Invasion and Migration of Rheumatoid Arthritis Fibroblast-Like Synoviocytes via the miR-766-3p/MMP2 Axis
Cai, Y., Liang, R., Xiao, S., Huang, Q., Zhu, D., Shi, G., Ouyang, Q., & Yang, M. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.628654 · Cited by 57
circCHST15 is a novel prognostic biomarker that promotes clear cell renal cell carcinoma cell proliferation and metastasis through the miR-125a-5p/EIF4EBP1 axis
Gui, C., Liao, B., Luo, C., Chen, Y., Tan, L., Tang, Y., Li, J., Hou, Y., Song, H., Lin, H., et al. (2021) · Molecular Cancer · doi:10.1186/s12943-021-01449-w · Cited by 56
Advances of Epigenetic Biomarkers and Epigenome Editing for Early Diagnosis in Breast Cancer
Sarvari, P., Sarvari, P., Ramírez‐Díaz, I., Mahjoubi, F., & Rubio, K. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23179521 · Cited by 68
Immunopeptidomics-based identification of naturally presented non-canonical circRNA-derived peptides
Ferreira, H. J., Stevenson, B. J., Pak, H., Yu, F., Oliveira, J., Huber, F., Taillandier-Coindard, M., Michaux, J., Altimiras, E. R., Kraemer, A. I., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-46408-3 · Cited by 61
Novel insights into circular RNAs in clinical application of carcinomas
Rong, D., Tang, W., Li, Z., Zhou, J., Shi, J., Wang, H., & Cao, H. (2017) · OncoTargets and Therapy · doi:10.2147/ott.s134403 · Cited by 58
Characterization of conserved circular RNA in polyploid Gossypium species and their ancestors
Zhao, T., Wang, L., Li, S., Xu, M., Guan, X., & Zhou, B. (2017) · FEBS Letters · doi:10.1002/1873-3468.12868 · Cited by 58
Circular RNA expression profiles of mouse ovaries during postnatal development and the function of circular RNA epidermal growth factor receptor in granulosa cells
Jia, W., Xu, B., & Wu, J. (2018) · Metabolism · doi:10.1016/j.metabol.2018.04.002 · Cited by 58
Circular RNA hsa_circ_0001178 facilitates the invasion and metastasis of colorectal cancer through upregulating ZEB1 via sponging multiple miRNAs
Ren, C., Zhang, Z., Wang, S., Zhu, W., Zheng, P., & Wang, W. (2019) · Biological Chemistry · doi:10.1515/hsz-2019-0350 · Cited by 59
Expression of circZNF609 is Down-Regulated in Colorectal Cancer Tissue and Promotes Apoptosis in Colorectal Cancer Cells by Upregulating p53
Zhang, X., Zhao, Y., Kong, P., Han, M., & Li, B. (2019) · Medical Science Monitor · doi:10.12659/msm.915926 · Cited by 58
Circular RNAs in digestive system cancer: potential biomarkers and therapeutic targets.
Sheng, J., Liu, L., Wang, M.-R., & Li, P. (2018) · Europe PMC (PubMed Central) · Cited by 57
Circular RNAs: A New Piece in the Colorectal Cancer Puzzle
Artemaki, P. I., Scorilas, A., & Kontos, C. K. (2020) · Cancers · doi:10.3390/cancers12092464 · Cited by 57
Circular RNAs: Functions and Clinical Significance in Cardiovascular Disease
Zhang, L., Zhang, Y., Wang, Y., Zhao, Y., Ding, H., & Li, P. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.584051 · Cited by 58
HNRNPM controls circRNA biogenesis and splicing fidelity to sustain cancer cell fitness
Ho, J., Tullio, F. D., Schwarz, M. C., Low, D. H. P., Incarnato, D., Gay, F. P. H., Tabaglio, T., Zhang, J., Wollmann, H., Chen, L., et al. (2021) · eLife · doi:10.7554/elife.59654 · Cited by 60
N6-Methyladenosine Modification Opens a New Chapter in Circular RNA Biology
Wu, J., Guo, X., Wen, Y., Huang, S.-Q., Yuan, X., Tang, L., & Sun, H. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.709299 · Cited by 55
Mechanisms Regulating Abnormal Circular RNA Biogenesis in Cancer
Huang, Y., & Zhu, Q. (2021) · Cancers · doi:10.3390/cancers13164185 · Cited by 57
Circular RNA circSNX6 promotes sunitinib resistance in renal cell carcinoma through the miR-1184/GPCPD1/ lysophosphatidic acid axis
Huang, K., Pan, Y., Shu, G., Yao, H., Liu, X., Zhou, M., Wei, J., Chen, Z., Lu, J. K., Feng, Z., et al. (2021) · Cancer Letters · doi:10.1016/j.canlet.2021.10.003 · Cited by 58
Exosomes derived from myeloid-derived suppressor cells facilitate castration-resistant prostate cancer progression via S100A9/circMID1/miR-506-3p/MID1
Gao, F., Xu, Q., Tang, Z., Zhang, N., Huang, Y., Li, Z., Dai, Y., Yu, Q., & Zhu, J. (2022) · Journal of Translational Medicine · doi:10.1186/s12967-022-03494-5 · Cited by 57
Noncoding RNAs: Master Regulator of Fibroblast to Myofibroblast Transition in Fibrosis
Zhang, H., Zhou, Y., Wen, D., & Wang, J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021801 · Cited by 56
LncRNA, a new component of expanding RNA-protein regulatory network important for animal sperm development
Zhang, C., Gao, L., & Xu, E. Y. (2016) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2016.06.013 · Cited by 58
Construction and analysis of circular RNA molecular regulatory networks in liver cancer
Ren, S., Xin, Z., Xu, Y., Xu, J., & Wang, G. (2017) · Cell Cycle · doi:10.1080/15384101.2017.1346754 · Cited by 57
Comprehensive analysis of circular RNAs in pathological states: biogenesis, cellular regulation, and therapeutic relevance
Braicu, C., Zimta, A.-A., Gulei, D., Olariu, A., & Berindan‐Neagoe, I. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03016-5 · Cited by 57
Identification of Altered Circular RNA Expression in Serum Exosomes from Patients with Papillary Thyroid Carcinoma by High-Throughput Sequencing
Yang, C., wei, Y., Yu, L., & Xiao, Y. (2019) · Medical Science Monitor · doi:10.12659/msm.915658 · Cited by 57
The circ_0021977/miR‐10b‐5p/P21 and P53 regulatory axis suppresses proliferation, migration, and invasion in colorectal cancer
Chen, L., Jiang, W., Hui, B., Rong, D., Fu, K., Dong, C., Tang, W., & Cao, H. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.29135 · Cited by 57
Protein-Related Circular RNAs in Human Pathologies
Wawrzyniak, O., Zarębska, Ż., Kuczyński, K., Gotz‐Więckowska, A., & Rolle, K. (2020) · Cells · doi:10.3390/cells9081841 · Cited by 58
Downregulation of hsa_circ_0007534 restricts the proliferation and invasion of cervical cancer through regulating miR-498/BMI-1 signaling
Rong, X., Gao, W., Yang, X., & Guo, J. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.116785 · Cited by 56
Preferential production of RNA rings by T4 RNA ligase 2 without any splint through rational design of precursor strand
Chen, H., Cheng, K., Liu, X., An, R., Komiyama, M., & Liang, X. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkaa181 · Cited by 58

Authors: Jeck, W. R., Sorrentino, J. A., Wang, K., Slevin, M. K., Burd, C. E., Liu, J., Marzluff, W. F., & Sharpless, N. E.
Affiliations: University of North Carolina at Chapel Hill (US)
University of Kentucky (US)
ORCID: Jeck, William R.
Sorrentino, Jessica A.
Slevin, Michael K.
Burd, Christin E.
Liu, Jinze
Marzluff, William F.
Sharpless, Norman E.
Venue: RNA
Publisher: Cold Spring Harbor Laboratory
Published: 2012-12-18
Volume: 19
Issue: 2
Pages: 141-157
ISSN: 1355-8382 (ISSN-L)
1469-9001
DOI: 10.1261/rna.035667.112
PMC: PMC3543092
OpenAlex: W2147806662
Cited by: 4,388
References: 41
Citations by year: 2026: 165 · 2025: 251 · 2024: 369 · 2023: 409 · 2022: 566 · 2021: 655 · 2020: 612 · 2019: 467 · 2018: 369 · 2017: 227 · 2016: 121 · 2015: 92 · 2014: 47 · 2013: 31 · 2012: 1
FWCI: 22.00
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: RNA (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
HighWire Press Open Archive (submittedVersion)
UNC Libraries
Funders: Glenn Foundation for Medical Research
National Institutes of Health (5r01ag024379-15)
National Institute on Aging (AG024379, AG041567, R01-AG024379, F30AG041567)
National Human Genome Research Institute (R01HG006272)
National Institute of General Medical Sciences (F32GM087059, T32GM007092)
National Institute of Environmental Health Sciences (T32ES007126)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Circular RNAs in diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
Keywords: circular RNA, back-splicing, Alu elements, RNase R, human fibroblasts, mouse testis, HIPK2, HIPK3, competing endogenous RNA, RNA stability, gene expression regulation
MeSH terms: RNA, Circular, Animals, Base Sequence, Cells, Cultured, Exons, Exoribonucleases, Gene Expression Regulation, Humans, Male, Molecular Sequence Data, Phosphotransferases, RNA, RNA Splicing, Conserved Sequence, Sequence Analysis, RNA, Evolution, Molecular, Computational Biology, Trans-Splicing, Alu Elements, RNA Stability, RNA, Small Interfering, Mice, High-Throughput Nucleotide Sequencing, Nucleotide Motifs

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Circular RNAs are abundant, conserved, and associated with ALU repeats

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks