Cited by 4,388Circular RNAs in diseasesRNA Research and SplicingCancer-related molecular mechanisms research

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Circular RNAs are abundant, conserved, and associated with ALU repeats

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Jeck, William R., Sorrentino, Jessica A., Wang, Kai, Slevin, Michael K., Burd, Christin E., Liu, Jinze, Marzluff, William F., Sharpless, Norman E.·2013·RNA

DOI 10.1261/rna.035667.112PMC PMC3543092

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Abstract

Circular RNAs composed of exonic sequence have been described in a small number of genes. Thought to result from splicing errors, circular RNA species possess no known function. To delineate the universe of endogenous circular RNAs, we performed high-throughput sequencing (RNA-seq) of libraries prepared from ribosome-depleted RNA with or without digestion with the RNA exonuclease, RNase R. We identified >25,000 distinct RNA species in human fibroblasts that contained non-colinear exons (a "backsplice") and were reproducibly enriched by exonuclease degradation of linear RNA. These RNAs were validated as circular RNA (ecircRNA), rather than linear RNA, and were more stable than associated linear mRNAs in vivo. In some cases, the abundance of circular molecules exceeded that of associated linear mRNA by >10-fold. By conservative estimate, we identified ecircRNAs from 14.4% of actively transcribed genes in human fibroblasts. Application of this method to murine testis RNA identified 69 ecircRNAs in precisely orthologous locations to human circular RNAs. Of note, paralogous kinases HIPK2 and HIPK3 produce abundant ecircRNA from their second exon in both humans and mice. Though HIPK3 circular RNAs contain an AUG translation start, it and other ecircRNAs were not bound to ribosomes. Circular RNAs could be degraded by siRNAs and, therefore, may act as competing endogenous RNAs. Bioinformatic analysis revealed shared features of circularized exons, including long bordering introns that contained complementary ALU repeats. These data show that ecircRNAs are abundant, stable, conserved and nonrandom products of RNA splicing that could be involved in control of gene expression.

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Chomczynski, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1006/abio.1987.9999 · Cited by 65,515
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
Huang, D. W., Sherman, B. T., & Lempicki, R. A. (2009) · Nature Protocols · doi:10.1038/nprot.2008.211 · Cited by 35,890
BEDTools: a flexible suite of utilities for comparing genomic features
Quinlan, A. R., & Hall, I. M. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq033 · Cited by 27,437
Integrative genomics viewer
Robinson, J. T., Thorvaldsdóttir, H., Winckler, W., Guttman, M., Lander, E. S., Getz, G., & Mesirov, J. P. (2011) · Nature Biotechnology · doi:10.1038/nbt.1754 · Cited by 15,390
Non-coding RNAs in human disease
Esteller, M. (2011) · Nature Reviews Genetics · doi:10.1038/nrg3074 · Cited by 4,825
Argonaute2 is the catalytic engine of mammalian RNAi
Liu, J., Carmell, M. A., Rivas, F. V., Marsden, C. G., Thomson, J. M., Song, J.-J., Hammond, S. M., Joshua-Tor, L., & Hannon, G. J. (2004) · Science · doi:10.1126/science.1102513 · Cited by 2,796
Self-citation
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Poliseno, L., Salmena, L., Zhang, J., Carver, B. S., Haveman, W. J., & Pandolfi, P. P. (2010) · Nature · doi:10.1038/nature09144 · Cited by 2,364
Circular RNAs Are the Predominant Transcript Isoform from Hundreds of Human Genes in Diverse Cell Types
Salzman, J., Gawad, C., Wang, P. L., Lacayo, N., & Brown, P. O. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030733 · Cited by 2,239
MicroRNA sponges: competitive inhibitors of small RNAs in mammalian cells
Ebert, M. S., Neilson, J. R., & Sharp, P. A. (2007) · Nature Methods · doi:10.1038/nmeth1079 · Cited by 2,108
Target mimicry provides a new mechanism for regulation of microRNA activity
Franco‐Zorrilla, J. M., Valli, A. A., Todesco, M., Mateos, I., Puga, M. I., Rubio‐Somoza, I., Leyva, A., Weigel, D., Garcı́a, J. A., & Paz‐Ares, J. (2007) · Nature Genetics · doi:10.1038/ng2079 · Cited by 2,101

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Wu, J., Jiang, Z., Chen, C., Hu, Q., Fu, Z., Chen, J., Wang, Z., Wang, Q., Li, A., Marks, J. R., et al. (2018) · Cancer Letters · doi:10.1016/j.canlet.2018.05.033 · Cited by 167
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Zhang, Y., Nguyen, T. M., Zhang, X.-O., Wang, L., Phan, T., Clohessy, J. G., & Pandolfi, P. P. (2021) · Genome biology · doi:10.1186/s13059-021-02263-9 · Cited by 166
Amplification of spatially isolated adenosine pathway by tumor–macrophage interaction induces anti-PD1 resistance in hepatocellular carcinoma
Lu, J., Zhang, P., Huang, X., Guo, X.-J., Gao, C., Zeng, H., Zheng, Y.-M., Wang, S., Cai, J., Sun, Q., et al. (2021) · Journal of Hematology & Oncology · doi:10.1186/s13045-021-01207-x · Cited by 168
High-throughput data integration of RNA–miRNA–circRNA reveals novel insights into mechanisms of benzo[a]pyrene-induced carcinogenicity
Caiment, F., Gaj, S., Claessen, S. M. H., & Kleinjans, J. C. S. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv115 · Cited by 164
Circular RNAs and gastrointestinal cancers: Epigenetic regulators with a prognostic and therapeutic role
Naeli, P., Pourhanifeh, M. H., Karimzadeh, M. R., Shabaninejad, Z., Movahedpour, A., Tarrahimofrad, H., Mirzaei, H. R., Bafrani, H. H., Savardashtaki, A., Mirzaei, H., et al. (2019) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2019.102854 · Cited by 165
Genome-wide identification and characterization of circular RNAs by high throughput sequencing in soybean
Zhao, W., Cheng, Y., Zhang, C., You, Q., Shen, X., Guo, W., & Jiao, Y. (2017) · Scientific Reports · doi:10.1038/s41598-017-05922-9 · Cited by 162
Emerging function and potential diagnostic value of circular RNAs in cancer
Cui, X., Wang, J., Guo, Z., Li, M., Li, M., Liu, S., Liu, H., Li, W., Yin, X., Tao, J., et al. (2018) · Molecular Cancer · doi:10.1186/s12943-018-0877-y · Cited by 164
CircRNA-protein complexes: IMP3 protein component defines subfamily of circRNPs
Schneider, T. P., Hung, L.-H., Schreiner, S., Starke, S., Eckhof, H., Roßbach, O., Reich, S., Medenbach, J., & Bindereif, A. (2016) · Scientific Reports · doi:10.1038/srep31313 · Cited by 161
Circular RNAs and their associations with breast cancer subtypes
Nair, A., Niu, N., Tang, X., Thompson, K. J., Wang, L., Kocher, J., Subramanian, S., & Kalari, K. R. (2016) · Oncotarget · doi:10.18632/oncotarget.13134 · Cited by 159
Potential clinical utility of liquid biopsies in ovarian cancer
Zhu, J. W., Charkhchi, P., & Akbari, M. R. (2022) · Molecular Cancer · doi:10.1186/s12943-022-01588-8 · Cited by 166
Screening Circular RNA Related to Chemotherapeutic Resistance in Breast Cancer
Gao, D., Zhang, X., Liu, B., Meng, D., Fang, K., Guo, Z., & Li, L. (2017) · Epigenomics · doi:10.2217/epi-2017-0055 · Cited by 161
Intragenic antagonistic roles of protein and circRNA in tumorigenesis
Guarnerio, J., Zhang, Y., Cheloni, G., Panella, R., Katon, J. M., Simpson, M., Matsumoto, A., Papa, A., Loretelli, C., Petri, A., et al. (2019) · Cell Research · doi:10.1038/s41422-019-0192-1 · Cited by 161
isoCirc catalogs full-length circular RNA isoforms in human transcriptomes
Xin, R., Gao, Y. P., Gao, Y., Wang, R., Kadash-Edmondson, K. E., Liu, B., Wang, Y., Lin, L., & Xing, Y. (2021) · Nature Communications · doi:10.1038/s41467-020-20459-8 · Cited by 169
The RNA Atlas expands the catalog of human non-coding RNAs
Lorenzi, L., Chiu, H.-S., Avila Cobos, F., Gross, S., Volders, P.-J., Cannoodt, R., Nuytens, J., Vanderheyden, K., Anckaert, J., Lefever, S., et al. (2021) · Nature Biotechnology · doi:10.1038/s41587-021-00936-1 · Cited by 163
Circular RNAs and complex diseases: from experimental results to computational models
Wang, C.-C., Han, C., Zhao, Q., & Chen, X. (2021) · Briefings in Bioinformatics · doi:10.1093/bib/bbab286 · Cited by 161
RETRACTED: circFGFR4 Promotes Differentiation of Myoblasts via Binding miR-107 to Relieve Its Inhibition of Wnt3a
Li, H., Wei, X., Yang, J., Dong, D., Hao, D., Huang, Y., Lan, X., Plath, M. W., Lei, C., Ma, Y., et al. (2018) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2018.02.012 · Cited by 158
Retracted
Circular RNA expression alterations are involved in OGD/R-induced neuron injury
Lin, S.-P., Ye, S., Long, Y., Fan, Y., Mao, H., Chen, M., & Ma, Q.-J. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.01.183 · Cited by 157
A psychiatric disease-related circular RNA controls synaptic gene expression and cognition
Zimmerman, A. J., Hafez, A. K., Amoah, S. K., Rodriguez, B. A., Dell’Orco, M., Lozano, E., Hartley, B. J., Alural, B., Lalonde, J., Chander, P. N., et al. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0653-4 · Cited by 153
Discovery of Replicating Circular RNAs by RNA-Seq and Computational Algorithms
Zhang, Z., Qi, S., Tang, N., Zhang, X., Chen, S., Zhu, P., Ma, L., Cheng, J., Xu, Y., Lu, M., et al. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004553 · Cited by 160
Inducible RasGEF1B circular RNA is a positive regulator of ICAM-1 in the TLR4/LPS pathway
Ng, W. L., Marinov, G. K., Liau, E. S., Lam, Y. L., Lim, Y., & Ea, C.-K. (2016) · RNA Biology · doi:10.1080/15476286.2016.1207036 · Cited by 156
Circular RNA Expression Profile of Pancreatic Ductal Adenocarcinoma Revealed by Microarray
Li, H., Hao, X., Wang, H., Liu, Z., He, Y., Pu, M., Zhang, H., Yu, H., Duan, J., & Qu, S. (2016) · Cellular Physiology and Biochemistry · doi:10.1159/000453186 · Cited by 155
CircRNAs: a regulator of cellular stress
Fischer, J. W., & Leung, A. K. L. (2017) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2016.1276882 · Cited by 156
Emerging role of non-coding RNA in oral cancer
Momen‐Heravi, F., & Bala, S. (2017) · Cellular Signalling · doi:10.1016/j.cellsig.2017.10.009 · Cited by 153
circKDM4C suppresses tumor progression and attenuates doxorubicin resistance by regulating miR-548p/PBLD axis in breast cancer
Liang, Y., Song, X., Li, Y., Su, P., Han, D., Ma, T., Guo, R., Chen, B., Zhao, W., Sang, Y., et al. (2019) · Oncogene · doi:10.1038/s41388-019-0926-z · Cited by 155
When Long Noncoding Becomes Protein Coding
Hartford, C. C. R., & Lal, A. (2020) · Molecular and Cellular Biology · doi:10.1128/mcb.00528-19 · Cited by 160
Emerging roles and context of circular RNAs
Panda, A. C., Grammatikakis, I., Munk, R. B., Gorospe, M., & Abdelmohsen, K. (2016) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1386 · Cited by 154
Circular RNA Expression Profiles Alter Significantly in Mouse Brain After Transient Focal Ischemia
Mehta, S. L., Pandi, G., & Vemuganti, R. (2017) · Stroke · doi:10.1161/strokeaha.117.017469 · Cited by 157

Authors: Jeck, W. R., Sorrentino, J. A., Wang, K., Slevin, M. K., Burd, C. E., Liu, J., Marzluff, W. F., & Sharpless, N. E.
Affiliations: University of North Carolina at Chapel Hill (US)
University of Kentucky (US)
ORCID: Jeck, William R.
Sorrentino, Jessica A.
Slevin, Michael K.
Burd, Christin E.
Liu, Jinze
Marzluff, William F.
Sharpless, Norman E.
Venue: RNA
Publisher: Cold Spring Harbor Laboratory
Published: 2012-12-18
Volume: 19
Issue: 2
Pages: 141-157
ISSN: 1355-8382 (ISSN-L)
1469-9001
DOI: 10.1261/rna.035667.112
PMC: PMC3543092
OpenAlex: W2147806662
Cited by: 4,388
References: 41
Citations by year: 2026: 165 · 2025: 251 · 2024: 369 · 2023: 409 · 2022: 566 · 2021: 655 · 2020: 612 · 2019: 467 · 2018: 369 · 2017: 227 · 2016: 121 · 2015: 92 · 2014: 47 · 2013: 31 · 2012: 1
FWCI: 22.00
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: RNA (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
HighWire Press Open Archive (submittedVersion)
UNC Libraries
Funders: Glenn Foundation for Medical Research
National Institutes of Health (5r01ag024379-15)
National Institute on Aging (AG024379, AG041567, R01-AG024379, F30AG041567)
National Human Genome Research Institute (R01HG006272)
National Institute of General Medical Sciences (F32GM087059, T32GM007092)
National Institute of Environmental Health Sciences (T32ES007126)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Circular RNAs in diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
Keywords: circular RNA, back-splicing, Alu elements, RNase R, human fibroblasts, mouse testis, HIPK2, HIPK3, competing endogenous RNA, RNA stability, gene expression regulation
MeSH terms: RNA, Circular, Animals, Base Sequence, Cells, Cultured, Exons, Exoribonucleases, Gene Expression Regulation, Humans, Male, Molecular Sequence Data, Phosphotransferases, RNA, RNA Splicing, Conserved Sequence, Sequence Analysis, RNA, Evolution, Molecular, Computational Biology, Trans-Splicing, Alu Elements, RNA Stability, RNA, Small Interfering, Mice, High-Throughput Nucleotide Sequencing, Nucleotide Motifs

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Circular RNAs are abundant, conserved, and associated with ALU repeats

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