Cited by 120RNA Research and SplicingRNA regulation and diseaseAmyotrophic Lateral Sclerosis Research

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Autoregulation of Fox protein expression to produce dominant negative splicing factors

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Damianov, Andrey, Black, Douglas L.·2010·RNA

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Abstract

The Fox proteins are a family of regulators that control the alternative splicing of many exons in neurons, muscle, and other tissues. Each of the three mammalian paralogs, Fox-1 ( A2BP1 ), Fox-2 ( RBM9 ), and Fox-3 ( HRNBP3 ), produces proteins with a single RNA-binding domain (RRM) flanked by N- and C-terminal domains that are highly diversified through the use of alternative promoters and alternative splicing patterns. These genes also express protein isoforms lacking the second half of the RRM (FoxΔRRM), due to the skipping of a highly conserved 93-nt exon. Fox binding elements overlap the splice sites of these exons in Fox-1 and Fox-2, and the Fox proteins themselves inhibit exon inclusion. Unlike other cases of splicing autoregulation by RNA-binding proteins, skipping the RRM exon creates an in-frame deletion in the mRNA to produce a stable protein. These FoxΔRRM isoforms expressed from cDNA exhibit highly reduced binding to RNA in vivo. However, we show that they can act as repressors of Fox-dependent splicing, presumably by competing with full-length Fox isoforms for interaction with other splicing factors. Interestingly, the Drosophila Fox homolog contains a nearly identical exon in its RRM domain that also has flanking Fox-binding sites. Thus, rather than autoregulation of splicing controlling the abundance of the regulator, the Fox proteins use a highly conserved mechanism of splicing autoregulation to control production of a dominant negative isoform.

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Authors: Damianov, A., & Black, D. L.
Affiliations: Howard Hughes Medical Institute (US)
ORCID: Damianov, Andrey
Black, Douglas L.
Venue: RNA
Publisher: Cold Spring Harbor Laboratory
Published: 2009-12-30
Volume: 16
Issue: 2
Pages: 405-416
ISSN: 1355-8382 (ISSN-L)
1469-9001
DOI: 10.1261/rna.1838210
PMC: PMC2811669
OpenAlex: W2158982822
Cited by: 120
References: 54
Citations by year: 2026: 3 · 2025: 5 · 2024: 7 · 2023: 7 · 2022: 9 · 2021: 3 · 2020: 3 · 2019: 2 · 2018: 4 · 2017: 15 · 2016: 10 · 2015: 5 · 2014: 8 · 2013: 13 · 2012: 10
FWCI: 3.33
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: other-oa
Locations: RNA (publishedVersion, other-oa)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
HighWire Press Open Archive (submittedVersion)
Funders: Howard Hughes Medical Institute
National Institutes of Health (RO1 GM49662)
National Institute of General Medical Sciences (R01GM049662)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
Health Sciences › Medicine › Clinical Neurology › Amyotrophic Lateral Sclerosis Research
Keywords: alternative splicing, RRM domain, exon skipping, RNA-binding proteins, splicing repressor, alternative promoters, protein isoforms
MeSH terms: RNA Splicing Factors, Amino Acid Sequence, Animals, Base Sequence, Cell Line, Female, Homeostasis, Humans, Male, Molecular Sequence Data, Gene Expression, RNA-Binding Proteins, Sequence Homology, Amino Acid, Alternative Splicing, DNA Primers, Mice

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Autoregulation of Fox protein expression to produce dominant negative splicing factors

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