Serum Levels of Meteorin-Like (Metrnl) Are Increased in Patients with Newly Diagnosed Type 2 Diabetes Mellitus and Are Associated with Insulin Resistance
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BACKGROUND Meteorin-like (Metrnl) is a novel adipomyokine that may improve glucose tolerance and affect insulin resistance. This study aimed to investigate the association between serum levels of Metrnl with blood glucose status and to its association with insulin resistance. MATERIAL AND METHODS The study included 160 subjects with normal glucose tolerance (NGT) (n=40), impaired fasting glucose (IFG) (n=40), impaired glucose tolerance (IGT) (n=40), and newly diagnosed type 2 diabetes mellitus (T2DM) (n=40). An enzyme-linked immunosorbent assay (ELISA) was used to measure the serum levels of Metrnl. Partial correlation analysis was used to analyze the relationship between serum levels of Metrnl and metabolic parameters. Multiple logistic regression analysis was performed to identify the association between serum levels of Metrnl with the risk of diabetes. RESULTS Serum levels of Metrnl was highest in patients with T2DM and significantly increased in patients with prediabetes compared with individuals with NGT. After adjusting for age, gender, and body mass index (BMI), serum Metrnl level was significantly correlated with lipid profile, glucose profile, and insulin resistance. Multiple logistic regression analysis showed that Metrnl significantly increased the risk of T2DM (OR=1.727; P=0.008) before adjusting for the homeostatic model assessment of insulin resistance (HOMA-IR). When further adjusted for HOMA-IR, Metrnl was no longer associated with an increased OR for T2DM (OR=1.491; P=0.066), while the HOMA-IR significantly increased the risk of T2DM (OR=1.935; P=0.008). CONCLUSIONS Serum levels of Metrnl were significantly increased in patients with T2DM and may increase the risk of T2DM independent of insulin resistance.
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Individuals with type 2 diabetes or obesity may present with either elevated or reduced concentrations of Metrnl.
“Research indicates that individuals with type 2 diabetes or obesity may present with either elevated [69,70] or reduced concentrations of this myokine [71].”
From Exercise-Induced Myokines in Obesity-Related Metabolic Disorders and Cardiovascular Protection: A Narrative Review (2026) · cites this paper as [69]
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“Research indicates that individuals with type 2 diabetes or obesity may present with either elevated [69,70] or reduced concentrations of this myokine [71].”
- Authors
- Wang, K., Li, F., Wang, C., Deng, Y., Cao, Z., Cui, Y., Xu, K., Ln, P., & Sun, Y.
- Affiliations
- Shandong University (CN)
- Qilu Hospital of Shandong University (CN)
- Department of Endocrinology, Shouguang Peoples’ Hospital, Shouguang, Shandong, China (mainland)
- Department of Endocrinology, The First Peoples’ Hospital of Pingyuan County, Pingyuan, Shandong, China (mainland)
- Corresponding author
- Sun, Yu
- Venue
- Medical Science Monitor
- Published
- 2019-03-31
- Volume
- 25
- Pages
- 2337-2343
- ISSN
- 1234-1010 (ISSN-L)
- 1643-3750
- PMC
- PMC6454984
- OpenAlex
- W2929166201
- Cited by
- 71
- References
- 28
- Citations by year
- 2026: 9 · 2025: 9 · 2024: 11 · 2023: 16 · 2022: 8 · 2021: 5 · 2020: 12 · 2019: 1
- FWCI
- 4.95
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- Medical Science Monitor (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- Shandong University (2014WS0148, 2014QLKY21)
- National Natural Science Foundation of China (2014QLKY21, 2014WS0148, 81873650, 2018JC15, 81700739)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- meteorin-like, Metrnl, type 2 diabetes, insulin resistance, prediabetes, impaired glucose tolerance, impaired fasting glucose, adipokines, HOMA-IR, diabetes risk, serum biomarkers, lipid profile
- MeSH terms
- Adult, Blood Glucose, China, Diabetes Mellitus, Type 2, Female, Glucose, Glucose Tolerance Test, Humans, Insulin, Insulin Resistance, Male, Middle Aged, Prediabetic State, Body Mass Index, Glucose Intolerance, Adipokines
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