Metrnl: A secreted protein with new emerging functions

Adipokines in inflammation and metabolic disease

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Mechanisms of fatty acid-induced inhibition of glucose uptake.

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A draft map of the human proteome

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Forming functional fat: a growing understanding of adipocyte differentiation

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Adipose tissue browning and metabolic health

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Adipokines in health and disease

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Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis

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PPAR and human metabolic disease

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PPARγ in adipocyte differentiation and metabolism – Novel insights from genome‐wide studies

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White to Brown Fat Phenotypic Switch Induced by Genetic and Environmental Activation of a Hypothalamic-Adipocyte Axis

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Enhanced proportion of small adipose cells in insulin-resistant vs insulin-sensitive obese individuals implicates impaired adipogenesis

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Role of anti-inflammatory adipokines in obesity-related diseases

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Induction of autophagy contributes to the neuroprotection of nicotinamide phosphoribosyltransferase in cerebral ischemia

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Immunomodulatory effects of lactoferrin

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Perivascular adipose tissue-derived visfatin is a vascular smooth muscle cell growth factor: role of nicotinamide mononucleotide

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N-linked oligosaccharides as outfitters for glycoprotein folding, form and function

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Nicotinamide phosphoribosyltransferase protects against ischemic stroke through SIRT1‐dependent adenosine monophosphate–activated kinase pathway

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Adipokines – removing road blocks to obesity and diabetes therapy

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Brown adipose tissue and thermogenesis

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PPAR gamma and human metabolic disease

Chatterjee, K. (2006) · 8th European Congress of Endocrinology incorporating the British Endocrine Societies · Cited by 209 · see citing works

Adipocyte metrnl antagonizes insulin resistance through PPARγ signaling

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The role of perivascular adipose tissue in vascular smooth muscle cell growth

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Protein Tyrosine Phosphatases in Hypothalamic Insulin and Leptin Signaling

Zhang, Z., Dodd, G. T., & Tiganis, T. (2015) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2015.07.003 · Cited by 181 · see citing works

Control of Adipocyte Differentiation in Different Fat Depots; Implications for Pathophysiology or Therapy

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Long-Term Control of Bone Turnover in Paget's Disease With Zoledronic Acid and Risedronate

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The role of brown adipose tissue in human obesity

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METEORIN-LIKE is a cytokine associated with barrier tissues and alternatively activated macrophages

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ARRB1/β-arrestin-1 mediates neuroprotection through coordination of BECN1-dependent autophagy in cerebral ischemia

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Subcutaneous adipose cell size and distribution: Relationship to insulin resistance and body fat

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Meteorin: a secreted protein that regulates glial cell differentiation and promotes axonal extension

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Subfatin is a Novel Adipokine and Unlike Meteorin in Adipose and Brain Expression

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Regulation of white adipogenesis and its relation to ectopic fat accumulation and cardiovascular risk

Gustafson, B., & Smith, U. (2015) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2015.04.812 · Cited by 112 · see citing works

Lenti‐GDNF Gene Therapy Protects Against Alzheimer's Disease‐Like Neuropathology in 3xTg‐AD Mice and MC65 Cells

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Fighting Fat with Fat: The Expanding Field of Adipose Stem Cells

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Inflammation in subcutaneous adipose tissue: relationship to adipose cell size

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Involvement of Leptin Receptor Long Isoform (LepRb)-STAT3 Signaling Pathway in Brain Fat Mass- and Obesity-Associated (FTO) Downregulation during Energy Restriction

Wang, P., Yang, F., Du, H., Guan, Y., Xu, T., Xu, X., Su, D., & Miao, C. (2011) · Molecular Medicine · doi:10.2119/molmed.2010.000134 · Cited by 99 · see citing works

Loss of AMP-Activated Protein Kinase-α2 Impairs the Insulin-Sensitizing Effect of Calorie Restriction in Skeletal Muscle

Wang, P., Zhang, R.-Y., Song, J., Guan, Y., Xu, T., Du, H., Viollet, B., & Miao, C. (2012) · Diabetes · doi:10.2337/db11-1180 · Cited by 95 · see citing works

Regenerative Neurogenesis After Ischemic Stroke Promoted by Nicotinamide Phosphoribosyltransferase–Nicotinamide Adenine Dinucleotide Cascade

Zhao, Y., Guan, Y., Zhou, X., Li, G., Li, Z., Zhou, C., Wang, P., & Miao, C. (2015) · Stroke · doi:10.1161/strokeaha.115.009216 · Cited by 89 · see citing works

Cometin is a novel neurotrophic factor that promotes neurite outgrowth and neuroblast migration in vitro and supports survival of spiral ganglion neurons in vivo

Jørgensen, J. R., Fransson, A., Fjord‐Larsen, L., Thompson, L. H., Houchins, J. P., Andrade, N., Torp, M., Kalkkinen, N., Andersson, E., Lindvall, O., et al. (2011) · Experimental Neurology · doi:10.1016/j.expneurol.2011.09.027 · Cited by 87 · see citing works

NAMPT as a Therapeutic Target against Stroke

Wang, P., & Miao, C. (2015) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2015.08.012 · Cited by 86 · see citing works

Nicotinamide Phosphoribosyltransferase Is Required for the Calorie Restriction-Mediated Improvements in Oxidative Stress, Mitochondrial Biogenesis, and Metabolic Adaptation

Song, J., Ke, S.-F., Zhou, C.-C., Zhang, S.-L., Guan, Y.-F., Xu, T.-Y., Sheng, C., Wang, P., & Miao, C. (2013) · The Journals of Gerontology Series A · doi:10.1093/gerona/glt122 · Cited by 79 · see citing works

Intracellular NAMPT–NAD+–SIRT1 cascade improves post-ischaemic vascular repair by modulating Notch signalling in endothelial progenitors

Wang, P., Du, H., Zhou, C., Song, J., Liu, X., Cao, X., Mehta, J. L., Shi, Y., Su, D., & Miao, C. (2014) · Cardiovascular Research · doi:10.1093/cvr/cvu220 · Cited by 76 · see citing works

A fluorometric assay for high-throughput screening targeting nicotinamide phosphoribosyltransferase

Zhang, R.-Y., Ye, Q., Lv, X., Wang, P., Xu, T., Zhang, L., & Miao, C. (2011) · Analytical Biochemistry · doi:10.1016/j.ab.2010.12.035 · Cited by 72 · see citing works

Adipokines in inflammation, insulin resistance and cardiovascular disease

Li, Z., Wang, P., & Miao, C. (2011) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2011.05602.x · Cited by 69 · see citing works

Mild ring 17 syndrome shares common phenotypic features irrespective of the chromosomal breakpoints location

Surace, C., Piazzolla, S., Sirleto, P., Digilio, M., Roberti, M. C., Lombardo, A., D’Elia, G., Tomaiuolo, A. C., Petrocchi, S., Capolino, R., et al. (2009) · Clinical Genetics · doi:10.1111/j.1399-0004.2009.01203.x · Cited by 63 · see citing works

Extracellular Visfatin has Nicotinamide Phosphoribosyltransferase Enzymatic Activity and is Neuroprotective Against Ischemic Injury

Zhao, Y., Liu, X., Tian, W., Guan, Y., Wang, P., & Miao, C. (2014) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12273 · Cited by 62 · see citing works

Discovery and characterization of novel small-molecule inhibitors targeting nicotinamide phosphoribosyltransferase

Xu, T., Zhang, S.-L., Dong, G., Liu, X., Wang, X., Lv, X., Qian, Q., Zhang, R.-Y., Sheng, C., & Miao, C. (2015) · Scientific Reports · doi:10.1038/srep10043 · Cited by 60 · see citing works

The Therapeutic Potential of Brown Adipocytes in Humans

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Characterization of Meteorin—An Evolutionary Conserved Neurotrophic Factor

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Timing-Dependent Actions of NGF Required for Cell Differentiation

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The Expanding Universe of Neurotrophic Factors: Therapeutic Potential in Aging and Age-Associated Disorders

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Visfatin and Cardio–Cerebro–Vascular Disease

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Endothelial Nitric Oxide Synthase Protects Neurons against Ischemic Injury through Regulation of Brain‐Derived Neurotrophic Factor Expression

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The molecular skin pathology of familial primary localized cutaneous amyloidosis

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N europrotection by S ildenafil: N euronal N etworks P otentiation in A cute E xperimental S troke

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Eosinophils in Fat: Pink Is the New Brown

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Hepatocyte Growth Factor Promotes Long‐Term Survival and Axonal Regeneration of Retinal Ganglion Cells after Optic Nerve Injury: Comparison with CNTF and BDNF

Wong, W. K., Cheung, A. W. S., Yu, S., Sha, O., & Cho, E. Y. P. (2014) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12304 · Cited by 34 · see citing works

Intermittent cold exposure results in visceral adipose tissue “browning” in the plateau pika (Ochotona curzoniae)

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NAMPT and NAMPT-controlled NAD Metabolism in Vascular Repair

Wang, P., Li, W., Liu, J., & Miao, C. (2015) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000332 · Cited by 32 · see citing works

Discovery of Novel Inhibitors and Fluorescent Probe Targeting NAMPT

Wang, X., Xu, T., Liu, X., Zhang, S.-L., Wang, P., Li, Z., Guan, Y., Wang, S., Dong, G., Zhuo, S., et al. (2015) · Scientific Reports · doi:10.1038/srep12657 · Cited by 31 · see citing works

'Rejuvenation Factor' in Blood Turns Back the Clock in Old Mice

Kaiser, J. (2014) · Science · doi:10.1126/science.344.6184.570 · Cited by 30 · see citing works

Wogonin suppresses osteopontin expression in adipocytes by activating PPARα

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Latent process genes for cell differentiation are common decoders of neurite extension length

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Protein tyrosine phosphatase 1B inhibits adipocyte differentiation and mediates TNFα action in obesity

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Rapid identification of PAX2/5/8 direct downstream targets in the otic vesicle by combinatorial use of bioinformatics tools

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Lentiviral delivery of Meteorin protects striatal neurons against excitotoxicity and reverses motor deficits in the quinolinic acid rat model

Jørgensen, J. R., Emerich, D. F., Thanos, C. G., Thompson, L. H., Torp, M., Bintz, B. E., Fjord‐Larsen, L., Johansen, T. E., & Wahlberg, L. U. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2010.09.003 · Cited by 24 · see citing works

Nicotinamide Phosphoribosyltransferase Facilitates Post‐Stroke Angiogenesis

Wang, P., Guan, Y., Li, W., Lu, G., Liu, J., & Miao, C. (2015) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12388 · Cited by 23 · see citing works

The effect of inhibition of endoplasmic reticulum stress on lipolysis in white adipose tissue in a rat model of chronic kidney disease

Zhu, Y., Chen, Y., Li, C., Ding, X., Xu, G.-Y., Hu, L.-L., Hou, F. F., & Zhou, Q. (2014) · Acta Pharmacologica Sinica · doi:10.1038/aps.2013.177 · Cited by 16 · see citing works

Introduction

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Meteorin Regulates Mesendoderm Development by Enhancing Nodal Expression

Kim, Y., Moon, J.-S., Kwon, M.-C., Shin, J., Im, S., Kim, H.-A., Han, J., & Kong, Y. (2014) · PLoS ONE · doi:10.1371/journal.pone.0088811 · Cited by 14 · see citing works

Adiponectin downregulation is associated with volume overload-induced myocyte dysfunction in rats

Wang, L.-L., Miller, D. J., Wanders, D., Nanayakkara, G., Amin, R., Judd, R. L., Morrison, E. E., & Zhong, J. (2015) · Acta Pharmacologica Sinica · doi:10.1038/aps.2015.84 · Cited by 11 · see citing works

Chronic nicotine treatment enhances vascular smooth muscle relaxation in rats

Xu, T., Lan, X.-H., Guan, Y., Zhang, S.-L., Wang, X., & Miao, C. (2015) · Acta Pharmacologica Sinica · doi:10.1038/aps.2015.5 · Cited by 10 · see citing works

Macrophage functions in lean and obese adipose tissue

Thomas, D. D., & Apovian, C. M. (2017) · Metabolism · doi:10.1016/j.metabol.2017.04.005 · Cited by 318 · see citing works

The Role of Exercise in the Interplay between Myokines, Hepatokines, Osteokines, Adipokines, and Modulation of Inflammation for Energy Substrate Redistribution and Fat Mass Loss: A Review

Gonzalez-Gil, A. M., & Elizondo-Montemayor, L. (2020) · Nutrients · doi:10.3390/nu12061899 · Cited by 278 · see citing works

YTHDF2 inhibition potentiates radiotherapy antitumor efficacy

Wang, L., Dou, X., Chen, S., Yu, X., Huang, X., Zhang, L., Chen, Y., Wang, J., Yang, K., Bugno, J., et al. (2023) · Cancer Cell · doi:10.1016/j.ccell.2023.04.019 · Cited by 251 · see citing works

METRNL attenuates lipid-induced inflammation and insulin resistance via AMPK or PPARδ-dependent pathways in skeletal muscle of mice

Jung, T. W., Lee, S. H., Kim, H.-C., Bang, J. S., Abd El-Aty, A. M., Hacımüftüoğlu, A., Shin, Y. K., & Jeong, J. H. (2018) · Experimental & Molecular Medicine · doi:10.1038/s12276-018-0147-5 · Cited by 203 · see citing works

Metrnl ameliorates diabetic cardiomyopathy via inactivation of cGAS/STING signaling dependent on LKB1/AMPK/ULK1-mediated autophagy

Lu, Q.-B., Ding, Y., Liu, Y., Wang, Z.-C., Wu, Y., Niu, K.-M., Li, K., Zhang, J., & Sun, H. (2022) · Journal of Advanced Research · doi:10.1016/j.jare.2022.10.014 · Cited by 159 · see citing works

Role of Obesity, Mesenteric Adipose Tissue, and Adipokines in Inflammatory Bowel Diseases

Bilski, J., Mazur-Biały, A. I., Wójcik-Grzybek, D., Surmiak, M., Magierowski, M., Śliwowski, Z., Pajdo, R., Kwiecień, S., Danielak, A., Ptak‐Belowska, A., et al. (2019) · Biomolecules · doi:10.3390/biom9120780 · Cited by 137 · see citing works

Influence of Microbiota on Intestinal Immune System in Ulcerative Colitis and Its Intervention

Zhang, S.-L., Wang, S., & Miao, C. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01674 · Cited by 134 · see citing works

Meteorin-like/Meteorin-β Is a Novel Immunoregulatory Cytokine Associated with Inflammation

Ushach, I., Arrevillaga-Boni, G., Heller, G. N., Pone, E. J., Hernández-Ruíz, M., Catalan‐Dibene, J., Hevezi, P. A., & Zlotnik, A. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1800435 · Cited by 132 · see citing works

Myokines in skeletal muscle physiology and metabolism: Recent advances and future perspectives

Das, D. K., Graham, Z. A., & Cardozo, C. P. (2020) · Acta Physiologica · doi:10.1111/apha.13367 · Cited by 129 · see citing works

Meteorin-like/Metrnl, a novel secreted protein implicated in inflammation, immunology, and metabolism: A comprehensive review of preclinical and clinical studies

Li, Z., Gao, Z., Sun, T., Zhang, S., Yang, S., Zheng, M., & Shen, H. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1098570 · Cited by 97 · see citing works

Implications of circulating Meteorin-like (Metrnl) level in human subjects with type 2 diabetes

Chung, H. S., Hwang, S. Y., Choi, J. H., Lee, H. J., Kim, N. H., Yoo, H. J., Seo, J. A., Kim, S. G., Kim, N. H., Baik, S. H., et al. (2017) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2017.11.031 · Cited by 96 · see citing works

Association of low serum Meteorin like (Metrnl) concentrations with worsening of glucose tolerance, impaired endothelial function and atherosclerosis

El‐Ashmawy, H. M., Selim, F. O., Hosny, T., & Almassry, H. N. (2019) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2019.02.026 · Cited by 93 · see citing works

The myokine meteorin‐like (metrnl) improves glucose tolerance in both skeletal muscle cells and mice by targeting AMPKα2

Lee, J. O., Lee, H. J., Lee, Y. W., Han, J. A., Kang, M. J., Moon, J., Shin, M.-J., Lee, H. J., Chung, J. H., Lee, J., et al. (2020) · FEBS Journal · doi:10.1111/febs.15301 · Cited by 97 · see citing works

Lower serum levels of Meteorin-like/Subfatin in patients with coronary artery disease and type 2 diabetes mellitus are negatively associated with insulin resistance and inflammatory cytokines

Dadmanesh, M., Aghajani, H., Fadaei, R., & Ghorban, K. (2018) · PLOS ONE · doi:10.1371/journal.pone.0204180 · Cited by 89 · see citing works

The Role of Exercise, Diet, and Cytokines in Preventing Obesity and Improving Adipose Tissue

ATAKAN, M. M., Koşar, Ş. N., Güzel, Y., Tin, H. T., & Yan, X. (2021) · Nutrients · doi:10.3390/nu13051459 · Cited by 94 · see citing works

Involvement of the secreted protein Metrnl in human diseases

Miao, Z., Hu, W., Li, Z., & Miao, C. (2020) · Acta Pharmacologica Sinica · doi:10.1038/s41401-020-00529-9 · Cited by 84 · see citing works

Serum Metrnl is associated with the presence and severity of coronary artery disease

Liu, Z., Ji, H., Yao, M., Wang, L., Wang, Y., Zhou, P., Liu, Y., Zheng, X., He, H., Wang, L., et al. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13915 · Cited by 84 · see citing works

Increased Expression of Meteorin-Like Hormone in Type 2 Diabetes and Obesity and Its Association with Irisin

AlKhairi, I., Cherian, P., Abu-Farha, M., Madhoun, A. A., Nizam, R., Melhem, M., Jamal, M., Al-Sabah, S., Ali, H., Tuomilehto, J., et al. (2019) · Cells · doi:10.3390/cells8101283 · Cited by 82 · see citing works

Serum Meteorin-like protein levels decreased in patients newly diagnosed with type 2 diabetes

Lee, J. H., Kang, Y. E., Kim, J. M., Choung, S., Joung, K. H., Kim, H. J., & Ku, B. J. (2018) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2017.10.005 · Cited by 75 · see citing works

Aerobic Exercise Increases Meteorin-Like Protein in Muscle and Adipose Tissue of Chronic High-Fat Diet-Induced Obese Mice

Bae, J. Y. (2018) · BioMed Research International · doi:10.1155/2018/6283932 · Cited by 75 · see citing works

Serum Levels of Meteorin-Like (Metrnl) Are Increased in Patients with Newly Diagnosed Type 2 Diabetes Mellitus and Are Associated with Insulin Resistance

Wang, K., Li, F., Wang, C., Deng, Y., Cao, Z., Cui, Y., Xu, K., Ln, P., & Sun, Y. (2019) · Medical Science Monitor · doi:10.12659/msm.915331 · Cited by 71 · see citing works

The novel cytokine Metrnl/IL-41 is elevated in Psoriatic Arthritis synovium and inducible from both entheseal and synovial fibroblasts

Bridgewood, C., Russell, T., Weedon, H., Baboolal, T. G., Watad, ‬., Sharif, Κ., Cuthbert, R., Wittmann, M., Wechalekar, M. D., & McGonagle, D. (2019) · Clinical Immunology · doi:10.1016/j.clim.2019.108253 · Cited by 72 · see citing works

Metrnl regulates cognitive dysfunction and hippocampal BDNF levels in D-galactose-induced aging mice

Hong, C., Wang, Z., Zheng, S., Hu, W., Wang, S., Zhao, Y., & Miao, C. (2022) · Acta Pharmacologica Sinica · doi:10.1038/s41401-022-01009-y · Cited by 62 · see citing works

Epigenome-wide association study of DNA methylation in panic disorder

Shimada-Sugimoto, M., Otowa, T., Miyagawa, T., Umekage, T., Kawamura, Y., Bundo, M., Iwamoto, K., Tochigi, M., Kasai, K., Kaiya, H., et al. (2017) · Clinical Epigenetics · doi:10.1186/s13148-016-0307-1 · Cited by 61 · see citing works

METRNL decreases during adipogenesis and inhibits adipocyte differentiation leading to adipocyte hypertrophy in humans

Löffler, D., Landgraf, K., Rockstroh, D., Schwartze, J. T., Dunzendorfer, H., Kiess, W., & Körner, A. (2016) · International Journal of Obesity · doi:10.1038/ijo.2016.180 · Cited by 61 · see citing works

Myokines: Metabolic regulation in obesity and type 2 diabetes

Chen, Z.-T., Weng, Z.-X., Lin, J. D., & Meng, Z.-X. (2024) · Life Metabolism · doi:10.1093/lifemeta/loae006 · Cited by 58 · see citing works

Meteorin-like protein (METRNL)/IL-41 improves LPS-induced inflammatory responses via AMPK or PPARδ–mediated signaling pathways

Jung, T. W., Pyun, D. H., Kim, T. J., Lee, H. J., Park, E. S., El‐Aty, A. M. A., Hwang, E. J., Shin, Y. K., & Jeong, J. H. (2021) · Advances in Medical Sciences · doi:10.1016/j.advms.2021.01.007 · Cited by 57 · see citing works

Meteorin-like protein (Metrnl): A metabolic syndrome biomarker and an exercise mediator

Alizadeh, H. (2022) · Cytokine · doi:10.1016/j.cyto.2022.155952 · Cited by 57 · see citing works

Browning Epicardial Adipose Tissue: Friend or Foe?

Doukbi, E., Soghomonian, A., Sengenès, C., Ahmed, S., Ancel, P., Dutour, A., & Gaborit, B. (2022) · Cells · doi:10.3390/cells11060991 · Cited by 56 · see citing works

Aggravated ulcerative colitis caused by intestinal Metrnl deficiency is associated with reduced autophagy in epithelial cells

Zhang, S.-L., Li, Z., Wang, D., Xu, T., Fan, M.-B., Cheng, M., & Miao, C. (2020) · Acta Pharmacologica Sinica · doi:10.1038/s41401-019-0343-4 · Cited by 54 · see citing works

The Adipokine Metrnl Ameliorates Chronic Colitis in Il-10–/– Mice by Attenuating Mesenteric Adipose Tissue Lesions During Spontaneous Colitis

Zuo, L., Ge, S., Ge, Y., Li, J., Zhu, B., Zhang, Z., Jiang, C., Li, J., Wang, S., Liu, M., et al. (2019) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjz001 · Cited by 52 · see citing works

Metrnl deficiency decreases blood HDL cholesterol and increases blood triglyceride

Qi, Q., Hu, W., Zheng, S., Zhang, S.-L., Le, Y., Li, Z., & Miao, C. (2020) · Acta Pharmacologica Sinica · doi:10.1038/s41401-020-0368-8 · Cited by 51 · see citing works

Beyond mechanical loading: The metabolic contribution of obesity in osteoarthritis unveils novel therapeutic targets

Sobieh, B. H., EL-Mesallamy, H. O., & Kassem, D. H. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e15700 · Cited by 49 · see citing works

Endothelial METRNL determines circulating METRNL level and maintains endothelial function against atherosclerosis

Zheng, S., Li, Z., Song, J., Wang, P., Xu, J., Hu, W., Shi, Y., Qi, Q., Miao, Z., Guan, Y., et al. (2022) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2022.12.008 · Cited by 48 · see citing works

Interleukin 39: a new member of interleukin 12 family

Lu, Z., Xu, K., Wang, X., Li, Y., & Li, M. (2020) · Central European Journal of Immunology · doi:10.5114/ceji.2020.97911 · Cited by 45 · see citing works

Intestinal Metrnl released into the gut lumen acts as a local regulator for gut antimicrobial peptides

Li, Z., Fan, M.-B., Zhang, S.-L., Qu, Y., Zheng, S., Song, J., & Miao, C. (2016) · Acta Pharmacologica Sinica · doi:10.1038/aps.2016.70 · Cited by 44 · see citing works

Can novel adipokines, asprosin and meteorin-like, be biomarkers for malignant mesothelioma?

Kocaman, N., & Artaş, G. (2019) · Biotechnic & Histochemistry · doi:10.1080/10520295.2019.1656344 · Cited by 44 · see citing works

Serum Metrnl levels are decreased in subjects with overweight or obesity and are independently associated with adverse lipid profile

Ding, X., Chang, X., Wang, J., Bian, N., An, Y., Wang, G., & Liu, J. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.938341 · Cited by 43 · see citing works

Protective role of the novel cytokine Metrnl/ interleukin-41 in host immunity defense during sepsis by promoting macrophage recruitment and modulating Treg/Th17 immune cell balance

Chen, X., Chen, X., Yang, Y., Luo, N., Yang, J., Zhong, L., Guo, T., Yuan, Z., Wei, Q., & Wang, C. (2023) · Clinical Immunology · doi:10.1016/j.clim.2023.109690 · Cited by 45 · see citing works

Accelerating Wound Closure With Metrnl in Normal and Diabetic Mouse Skin

Song, L., Chang, X., Hu, L., Liu, L., Wang, G., Huang, Y., Xu, L., Jin, B., Song, J., Hu, L., et al. (2023) · Diabetes · doi:10.2337/db23-0173 · Cited by 42 · see citing works

Cellular and Molecular Regulation of Exercise—A Neuronal Perspective

Reddy, I., Yadav, Y., & Dey, C. S. (2022) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-022-01272-x · Cited by 41 · see citing works

Subfatin and asprosin, two new metabolic players of polycystic ovary syndrome

Deniz, R., Yavuzkır, Ş., Uğur, K., Üstebay, D. Ü., Baykuş, Y., Üstebay, S., & Aydın, S. (2020) · Journal of Obstetrics and Gynaecology · doi:10.1080/01443615.2020.1758926 · Cited by 39 · see citing works

Muscle-derived factors influencing bone metabolism

Gries, K. J., Zysik, V. S., Jobe, T. K., Griffin, N., Leeds, B. P., & Lowery, J. W. (2021) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2021.10.009 · Cited by 34 · see citing works

Serum levels of subfatin in patients with type 2 diabetes mellitus and its association with vascular adhesion molecules

Fadaei, R., Dadmanesh, M., Moradi, N., Ahmadi, R., Nahrkhalaji, A. S., Aghajani, H., & Ghorban, K. (2018) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2018.1538248 · Cited by 33 · see citing works

Meteorin-Like Protein (Metrnl) in Obesity, during Weight Loss and in Adipocyte Differentiation

Schmid, A., Karrasch, T., & Schäffler, A. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10194338 · Cited by 34 · see citing works

Metabolism-Related Adipokines and Metabolic Diseases: Their Role in Osteoarthritis

Zhang, Q., Zhao, Y. X., Li, L., Fan, Q., Huang, B., Du, H., Li, C., & Li, W. (2025) · Journal of Inflammation Research · doi:10.2147/jir.s499835 · Cited by 34 · see citing works

Is Metrnl an Adipokine İnvolved in the Anti-inflammatory Response to Acute Exacerbations of COPD?

Kerget, B., Afşin, D. E., Kerget, F., Aşkın, S., & Akgün, M. (2020) · Lung · doi:10.1007/s00408-020-00327-4 · Cited by 29 · see citing works

Discovery of Novel Insulin Sensitizers: Promising Approaches and Targets

Chen, Y., Ma, H., Dasheng, Z., Zhao, G., Wang, L., Fu, X., & Chen, W. (2017) · PPAR Research · doi:10.1155/2017/8360919 · Cited by 29 · see citing works

Meteorin-like protein elevation post-exercise improved vascular inflammation among coronary artery disease patients by downregulating NLRP3 inflammasome activity

Liu, J., Diao, L., Xia, W., Zeng, X., Li, W., Zou, J., Liu, T., Pang, X., & Wang, Y. (2023) · Aging · doi:10.18632/aging.205268 · Cited by 28 · see citing works

Potential emerging roles of the novel adipokines adipolin/CTRP12 and meteorin-like/METRNL in obesity-osteoarthritis interplay

Sobieh, B. H., Kassem, D. H., Zakaria, Z. M., & EL-Mesallamy, H. O. (2020) · Cytokine · doi:10.1016/j.cyto.2020.155368 · Cited by 29 · see citing works

Administration of metrnl delays the onset of diabetes in non-obese diabetic mice

Yao, Z., Lin, P., Wang, C., Wang, K., & Sun, Y. (2020) · Endocrine Journal · doi:10.1507/endocrj.ej20-0351 · Cited by 27 · see citing works

Meteorin-like protein overexpression ameliorates fulminant hepatitis in mice by inhibiting chemokine-dependent immune cell infiltration

Du, Y.-N., Teng, J., Zhou, T., Du, B.-Y., & Cai, W. (2023) · Acta Pharmacologica Sinica · doi:10.1038/s41401-022-01049-4 · Cited by 27 · see citing works

Maternal and umbilical cord blood subfatin and spexin levels in patients with gestational diabetes mellitus

Yavuzkır, Ş., Uğur, K., Deniz, R., Üstebay, D. Ü., Mirzaoglu, M., Yardım, M., Şahin, İ., Baykuş, Y., Karagöz, Z. K., & Aydın, S. (2020) · Peptides · doi:10.1016/j.peptides.2020.170277 · Cited by 27 · see citing works

Impact of Obesity on the Course of Management of Inflammatory Bowel Disease—A Review

Michalak, A., Kasztelan‐Szczerbińska, B., & Cichoż‐Lach, H. (2022) · Nutrients · doi:10.3390/nu14193983 · Cited by 26 · see citing works

IL-39 acts as a friend to pancreatic cancer

Manning, A. A., Zhao, L., Zhu, Z., Xiao, H., Redington, C. G., Ding, V. A., Stewart-Hester, T., Bai, Q., Dunlap, J., Wakefield, M. R., et al. (2018) · Medical Oncology · doi:10.1007/s12032-018-1236-y · Cited by 25 · see citing works

The Effects of Eight Weeks of Circuit Resistance Training on Serum METRNL Levels and Insulin Resistance in Individuals with Type 2 Diabetes

Tayebi, S. M., Golmohammadi, M., Eslami, R., Shakiba, N., & Costa, P. B. (2023) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-023-01225-1 · Cited by 23 · see citing works

Exercise in Diabetic Nephropathy: Protective Effects and Molecular Mechanism

Li, R.-Y., & Guo, L. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25073605 · Cited by 23 · see citing works

Metrnl as a secreted protein: Discovery and cardiovascular research

Miao, Z., Chen, J., Chen, C.-X., Zheng, S., Zhao, H., & Miao, C. (2024) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2024.108730 · Cited by 24 · see citing works

Effects of exercise training on type 2-diabetes: the role of Meteorinlike protein

Saeidi, A., Tayebi, S. M., Khosravi, A., Malekian, F., Khodamoradi, A., Sellami, M., Abderrahman, A. B., & Zouhal, H. (2019) · Health Promotion Perspectives · doi:10.15171/hpp.2019.12 · Cited by 23 · see citing works

Meteorin-like/Meteorin-β upregulates proinflammatory cytokines via NF-κB pathway in grass carp Ctenopharyngodon idella

Wang, J., Jia, Z., Dang, H., & Zou, J. (2021) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2021.104289 · Cited by 22 · see citing works

Elevated levels of Metrnl in rheumatoid arthritis: Association with disease activity

Zhang, S., Lei, Y., Sun, T., Gao, Z., Li, Z., & Shen, H. (2022) · Cytokine · doi:10.1016/j.cyto.2022.156026 · Cited by 22 · see citing works

Crystal structure-based comparison of two NAMPT inhibitors

Zhang, S.-L., Xu, T., Yang, Z., Han, S., Zhao, Q., & Miao, C. (2017) · Acta Pharmacologica Sinica · doi:10.1038/aps.2017.80 · Cited by 21 · see citing works

Low serum levels of meteorin-like/subfatin: an indicator of diabetes mellitus and insulin resistance?

Önalan, E., Cavlı, C., Doğan, Y., Etem, E. Ö., Gözel, N., Kavuran, İ. B., Yakar, B., & Dönder, E. (2020) · Endokrynologia Polska · doi:10.5603/ep.a2020.0038 · Cited by 20 · see citing works

Myokine-mediated exercise effects: the role of myokine meteorin-like hormone (Metrnl)

Alizadeh, H. (2021) · Growth Factors · doi:10.1080/08977194.2022.2032689 · Cited by 20 · see citing works

The response of meteorin-like hormone and interleukin-4 in overweight women during exercise in temperate, warm and cold water

Saghebjoo, M., Einaloo, A., Mogharnasi, M., & Ahmadabadi, F. (2018) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2018-0027 · Cited by 20 · see citing works

Meteorin-like Protein and Asprosin Levels in Children and Adolescents with Obesity and Their Relationship with Insulin Resistance and Metabolic Syndrome

Moradi, N., Fadaei, R., Roozbehkia, M., Nourbakhsh, M., Nourbakhsh, M., Razzaghy‐Azar, M., & Larijani, B. A. (2022) · Laboratory Medicine · doi:10.1093/labmed/lmac152 · Cited by 19 · see citing works

Meteorin-like (METRNL) attenuates hypertensive induced cardiac hypertrophy by inhibiting autophagy via activating BRCA2

Li, J., Hong, Y., Zhong, Y., Yang, S., Pei, L., Huang, Z., Long, H., Chen, X., Zhou, C., Zheng, G., et al. (2024) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2024.167113 · Cited by 17 · see citing works

A meta-analysis of the relationship between serums metrnl-like protein/subfatin and risk of type 2 diabetes mellitus and coronary artery disease

Ferns, G. A., Fekri, K., Abadi, M. S. S., Dehkordi, M. B., & Arjmand, M.-H. (2021) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2021.1899239 · Cited by 20 · see citing works

Increased serum IL-41 is associated with disease activity in rheumatoid arthritis

Gong, L., Zhou, Y., Shi, S., Ying, L., Li, Y. J., & Li, M. (2022) · Clinica Chimica Acta · doi:10.1016/j.cca.2022.11.021 · Cited by 17 · see citing works

Serum Metrnl Level is Correlated with Insulin Resistance, But Not with β-Cell Function in Type 2 Diabetics

Wang, C., Pan, Y., Song, J., Sun, Y. S., Li, H., Chen, L., & Hou, X. (2019) · Medical Science Monitor · doi:10.12659/msm.920222 · Cited by 17 · see citing works

Changes in the expression of meteorin‐like ( METRNL ), irisin ( FNDC5 ), and uncoupling proteins ( UCPs ) after bariatric surgery

Jamal, M. H., AlOtaibi, F., Dsouza, C. L., Al‐Sabah, S., Al‐Khaledi, G., Al-Ali, W., Ali, H., Cherian, P., Al‐Khairi, I., Devarajan, S., et al. (2022) · Obesity · doi:10.1002/oby.23473 · Cited by 16 · see citing works

Determination of the Disulfide Structure of Murine Meteorin, a Neurotrophic Factor, by LC–MS and Electron Transfer Dissociation-High-Energy Collisional Dissociation Analysis of Proteolytic Fragments

Wen, D., Xiao, Y., Vecchi, M. M., Gong, B. J., Dolníková, J., & Pepinsky, R. B. (2017) · Analytical Chemistry · doi:10.1021/acs.analchem.6b04600 · Cited by 16 · see citing works

Histone Deacetylases as Modulators of the Crosstalk Between Skeletal Muscle and Other Organs

Renzini, A., D’Onghia, M., Coletti, D., & Moresi, V. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.706003 · Cited by 15 · see citing works

Elevated meteorin-like protein from high-intensity interval training improves heart function via AMPK/HDAC4 pathway

Wang, Y., Yuan, J., Liu, H., Chen, J., Zou, J., Zeng, X., Du, L., Sun, X., Xia, Z., Geng, Q., et al. (2023) · Genes & Diseases · doi:10.1016/j.gendis.2023.101100 · Cited by 15 · see citing works

Serum Metrnl is Decreased in Metabolic Dysfunction-Associated Fatty Liver Disease: A Case-Control Study

Liu, M., Gao, X., Tian, Y., Li, H., Yin, Z., Han, L., & Zhang, L. (2024) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s447127 · Cited by 15 · see citing works

Asprosin and meteorin-like protein immunoreactivity in invasive ductal breast carcinoma stages

Akkuş, G., Koyutürk, L. C., Yılmaz, M., Hançer, S., Özercan, İ. H., & Kuloğlu, T. (2022) · Tissue and Cell · doi:10.1016/j.tice.2022.101855 · Cited by 15 · see citing works

The blooming intersection of subfatin and metabolic syndrome

Huang, S., Cao, L., Cheng, H., Li, D., Li, Y. W., & Wu, Z. (2021) · Reviews in Cardiovascular Medicine · doi:10.31083/j.rcm2203086 · Cited by 15 · see citing works

Changes Induced by Aging and Long-Term Exercise and/or DHA Supplementation in Muscle of Obese Female Mice

Martínez-Gayo, A., Félix‐Soriano, E., Sáinź, N., González‐Muniesa, P., & Moreno-Aliaga, M. J. (2022) · Nutrients · doi:10.3390/nu14204240 · Cited by 15 · see citing works

Chronic vascular pathogenesis results in the reduced serum Metrnl levels in ischemic stroke patients

Miao, Z., Wang, N., Hu, W., Zheng, S., Wang, D., Chang, F.-Q., Wang, Z., Tian, J., Dong, X., Wu, T., et al. (2024) · Acta Pharmacologica Sinica · doi:10.1038/s41401-023-01204-5 · Cited by 14 · see citing works

Myokines as potential mediators of changes in glucose homeostasis and muscle mass after bariatric surgery

Orioli, L., & Thissen, J. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1554617 · Cited by 13 · see citing works

Unveiling the Effects of Interval Resistance Training and Chlorella Vulgaris Supplementation on Meteorin-like Protein and Oxidative Stress in Obese Men

Delfan, M., Radkia, F., Juybari, R. A., Daneshyar, S., Willems, M. E., Saeidi, A., Hackney, A. C., Laher, I., & Zouhal, H. (2024) · Current Developments in Nutrition · doi:10.1016/j.cdnut.2024.104428 · Cited by 13 · see citing works

Protective effects of METRNL overexpression against pathological cardiac remodeling

Huang, C., Liao, Y., & Hong, J. (2024) · Gene · doi:10.1016/j.gene.2024.148171 · Cited by 12 · see citing works

The Function and Mechanism of Anti-Inflammatory Factor Metrnl Prevents the Progression of Inflammatory-Mediated Pathological Bone Osteolytic Diseases

Liu, N., Dong, J., Li, L., Zhou, D., & Liu, F. (2024) · Journal of Inflammation Research · doi:10.2147/jir.s455790 · Cited by 13 · see citing works

Meteorin-like protein (Metrnl): a key exerkine in exercise-mediated cardiovascular health

Alizadeh, H., Parsaeifar, A., & Mirzaei, R. M. (2025) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2025.2497272 · Cited by 12 · see citing works

Plasma interleukin-41 serves as a potential diagnostic biomarker for Kawasaki disease

Cai, X., Li, K., Li, M., Lu, Y., Wu, J., Qiu, H., & Li, Y. J. (2023) · Microvascular Research · doi:10.1016/j.mvr.2023.104478 · Cited by 11 · see citing works

Association of Meteorin-Like Hormone with insulin resistance and body composition in healthy Iranian adults

Alizadeh, H., & Alizadeh, A. (2020) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2020.05.031 · Cited by 11 · see citing works

Meteorin-like protein is associated with a higher risk profile and predicts a worse outcome in patients with STEMI

Ferrer‐Curriu, G., Rueda, F., Revuelta‐López, E., García‐García, C., Codina, P., Gálvez‐Montón, C., Roura, S., Aimo, A., Emdin, M., Planavila, A., et al. (2023) · Revista Española de Cardiología (English Edition) · doi:10.1016/j.rec.2023.03.015 · Cited by 11 · see citing works

Human Amniotic Epithelial Cells as a Tool to Investigate the Effects of Cyanidin 3-O-Glucoside on Cell Differentiation

Takahashi, S., Ferdousi, F., Zheng, Y., Oda, T., & Isoda, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073768 · Cited by 10 · see citing works

scRNA-Seq of Cultured Human Amniotic Fluid from Fetuses with Spina Bifida Reveals the Origin and Heterogeneity of the Cellular Content

Dasargyri, A., Rodríguez, D. G., Rehrauer, H., Ernst Reichmann, A., Biedermann, T., & Moehrlen, U. (2023) · Cells · doi:10.3390/cells12121577 · Cited by 10 · see citing works

Effects of meteorin-like hormone on endocrine function of hypothalamo-hypophysial system and peripheral uncoupling proteins in rats

Şekerci, G., Erden, Y., & Tekin, S. (2022) · Molecular Biology Reports · doi:10.1007/s11033-022-07374-5 · Cited by 10 · see citing works

Role of the AMP-Activated Protein Kinase in the Pathogenesis of Polycystic Ovary Syndrome

Jalil, A. T., Zair, M. A., Hanthal, Z. R., Naser, S. J., Aslandook, T., Abosaooda, M., & Fadhil, A. A. (2023) · Indian Journal of Clinical Biochemistry · doi:10.1007/s12291-023-01139-y · Cited by 9 · see citing works

Upregulation of Metrnl improves diabetic kidney disease by inhibiting the TGF-β1/Smads signaling pathway: A potential therapeutic target

Lu, L., Huang, S., Lin, X., Liu, X., Xu, X., Li, C., & Chen, P. (2024) · PLoS ONE · doi:10.1371/journal.pone.0309338 · Cited by 9 · see citing works

The Meteorin-like cytokine is upregulated in grass carp after infection with Aeromonas hydrophila

Jia, Z., Feng, J., Yuan, G., Xiao, H., Dang, H., Zhang, Y., Chen, K., Zou, J., & Wang, J. (2023) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2023.104632 · Cited by 9 · see citing works

De novo structure prediction of meteorin and meteorin-like protein for identification of domains, functional receptor binding regions, and their high-risk missense variants

Shankar, S. S., Banarjee, R., Jathar, S. M., Rajesh, S., Ramasamy, S., & Kulkarni, M. J. (2023) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2023.2220804 · Cited by 10 · see citing works

Homotherapy for heteropathy: Interleukin‐41 and its biological functions

Shi, R., He, M., Peng, Y., & Xu, X. (2024) · Immunology · doi:10.1111/imm.13791 · Cited by 10 · see citing works

Oleoylethanolamide mitigates cardiometabolic disruption secondary to obesity induced by high-fat diet in mice

Comella, F., Aragón‐Herrera, A., Pirozzi, C., Feijóo‐Bandín, S., Lama, A., Opallo, N., Melini, S., Piano, F. D., Gualillo, O., Meli, R., et al. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.123226 · Cited by 9 · see citing works

The hMetrnl-PLGA-PEG-PLGA Hydrogel Facilitates Skin Wound Healing Through Dual Regulation on eNOS Activity and Stability

Zhao, H., Jiang, J.-B., Chen, Y., & Miao, C. (2025) · Pharmaceuticals · doi:10.3390/ph18081180 · Cited by 8 · see citing works

Changes in body composition, muscle function, and muscle insulin sensitivity induced by obesity and bariatric surgery: Implications for sarcopenic obesity

Orioli, L., Thissen, J.-P. M., & Loumaye, A. (2025) · Clinical Nutrition · doi:10.1016/j.clnu.2025.106547 · Cited by 8 · see citing works

Transcriptional Control of Subcutaneous Adipose Tissue by the Transcription Factor CTCF Modulates Heterogeneity in Fat Distribution in Women

Erdős, E., Sandor, K. D., Young, C. L., Halász, L., Smith, S. R., Osborne, T. F., & Divoux, A. (2023) · Cells · doi:10.3390/cells13010086 · Cited by 8 · see citing works

Correlation of serum Meteorin-like (Metrnl) level with type 2 diabetic peripheral neuropathy

Yao, C., Zhang, H., Wang, L., & Li, J. (2024) · BMC Endocrine Disorders · doi:10.1186/s12902-024-01616-2 · Cited by 8 · see citing works

Involvement of the secreted protein Metrnl in human diseases

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