Adipocyte metrnl antagonizes insulin resistance through PPARγ signaling

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

Bligh, E. G., & Dyer, W. J. (1959) · Canadian Journal of Biochemistry and Physiology · doi:10.1139/o59-099 · Cited by 54,751 · see citing works

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

Bligh, E. G., & Dyer, W. J. (1959) · Canadian Journal of Biochemistry and Physiology · doi:10.1139/y59-099 · Cited by 23,189 · see citing works

Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance

Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518 · see citing works

Adipokines in inflammation and metabolic disease

Ouchi, N., Parker, J. L., Lugus, J. J., & Walsh, K. (2011) · Nature Reviews Immunology · doi:10.1038/nri2921 · Cited by 4,625 · see citing works

Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes.

Guilherme, A., Virbasius, J. V., Puri, V., & Czech, M. P. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2391 · Cited by 2,292 · see citing works

Fat and Beyond: The Diverse Biology of PPARγ

Tontonoz, P., & Spiegelman, B. M. (2008) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.77.061307.091829 · Cited by 2,085 · see citing works

PPARγ signaling and metabolism: the good, the bad and the future

Ahmadian, M., Suh, J. M., Hah, N., Liddle, C., Atkins, A. R., Downes, M., & Evans, R. M. (2013) · Nature Medicine · doi:10.1038/nm.3159 · Cited by 2,016 · see citing works

Are oxidative stress-activated signaling pathways mediators of insulin resistance and β-cell dysfunction?

Evans, J. L., Goldfine, I. D., Maddux, B. A., & Grodsky, G. M. (2003) · Diabetes · doi:10.2337/diabetes.52.1.1 · Cited by 1,482 · see citing works

Forming functional fat: a growing understanding of adipocyte differentiation

Cristancho, A. G., & Lazar, M. A. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3198 · Cited by 1,382 · see citing works

Obesity-associated improvements in metabolic profile through expansion of adipose tissue

Kim, J.-Y., van de Wall, E., Laplante, M., Azzara, A., Trujillo, M. E., Hofmann, S. M., Schraw, T., Durand, J. L., Li, H., Li, G., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31021 · Cited by 1,310 · see citing works

Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment

Naveiras, O., Nardi, V., Wenzel, P. L., Hauschka, P. V., Fahey, F., & Daley, G. Q. (2009) · Nature · doi:10.1038/nature08099 · Cited by 1,129 · see citing works

Disordered lipid metabolism and the pathogenesis of insulin resistance.

Savage, D. B., Petersen, K. F., & Shulman, G. I. (2007) · Physiological Reviews · doi:10.1152/physrev.00024.2006 · Cited by 1,107 · see citing works

Metabolic Dysregulation and Adipose Tissue Fibrosis: Role of Collagen VI

Khan, T., Muise, E. S., Iyengar, P., Wang, Z. V., Chandalia, M., Abate, N., Zhang, B. B., Bonaldo, P., Chua, S., & Scherer, P. E. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01300-08 · Cited by 1,053 · see citing works

Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis

Rao, R. R., Long, J. Z., White, J. P., Svensson, K. J., Lou, J., Lokurkar, I., Jedrychowski, M. P., Ruas, J. L., Wrann, C. D., Lo, J. C., et al. (2014) · Cell · doi:10.1016/j.cell.2014.03.065 · Cited by 973 · see citing works

Lipoprotein lipase: from gene to obesity

Wang, H., & Eckel, R. H. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90920.2008 · Cited by 862 · see citing works

A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity

Okada-Iwabu, M., Yamauchi, T., Iwabu, M., Honma, T., Hamagami, K.-I., Matsuda, K., Yamaguchi, M., Tanabe, H., Kimura-Someya, T., Shirouzu, M., et al. (2013) · Nature · doi:10.1038/nature12656 · Cited by 757 · see citing works

Adipose tissue as a buffer for daily lipid flux

Frayn, K. (2002) · Diabetologia · doi:10.1007/s00125-002-0873-y · Cited by 752 · see citing works

Beneficial Effects of Subcutaneous Fat Transplantation on Metabolism

Tran, T. T., Yamamoto, Y., Gesta, S., & Kahn, C. R. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.04.004 · Cited by 705 · see citing works

Lack of macrophage fatty-acid–binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis

Makowski, L., Boord, J. B., Maeda, K., Babaev, V. R., Uysal, K. T., Morgan, M. A., Parker, R. A., Suttles, J., Fazio, S., Hotamışlıgil, G. S., et al. (2001) · Nature Medicine · doi:10.1038/89076 · Cited by 687 · see citing works

The Origins and Drivers of Insulin Resistance

Johnson, A. M. F., & Olefsky, J. M. (2013) · Cell · doi:10.1016/j.cell.2013.01.041 · Cited by 639 · see citing works

Mechanism of Insulin Resistance in A-ZIP/F-1 Fatless Mice

Kim, J. K., Gavrilova, O., Chen, Y., Reitman, M. L., & Shulman, G. I. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.12.8456 · Cited by 443 · see citing works

Dynamics of human adipose lipid turnover in health and metabolic disease

Arner, P., Bernard, S., Salehpour, M., Possnert, G., Liebl, J., Steier, P., Buchholz, B. A., Eriksson, M., Arner, E., Hauner, H., et al. (2011) · Nature · doi:10.1038/nature10426 · Cited by 401 · see citing works

The Health Risk of Obesity—Better Metrics Imperative

Ahima, R. S., & Lazar, M. A. (2013) · Science · doi:10.1126/science.1241244 · Cited by 384 · see citing works

Induction of autophagy contributes to the neuroprotection of nicotinamide phosphoribosyltransferase in cerebral ischemia

Wang, P., Guan, Y., Du, H., Zhai, Q., Su, D., & Miao, C. (2012) · Autophagy · doi:10.4161/auto.8.1.18274 · Cited by 319 · see citing works

It's Not How Fat You Are, It's What You Do with It That Counts

Virtue, S., & Vidal‐Puig, A. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060237 · Cited by 309 · see citing works

Perivascular adipose tissue-derived visfatin is a vascular smooth muscle cell growth factor: role of nicotinamide mononucleotide

Wang, P., Xu, T., Guan, Y., Su, D., Fan, G., & Miao, C. (2008) · Cardiovascular Research · doi:10.1093/cvr/cvn288 · Cited by 304 · see citing works

Nicotinamide phosphoribosyltransferase protects against ischemic stroke through SIRT1‐dependent adenosine monophosphate–activated kinase pathway

Wang, P., Xu, T., Guan, Y., Tian, W., Viollet, B., Rui, Y., Zhai, Q., Su, D., & Miao, C. (2011) · Annals of Neurology · doi:10.1002/ana.22236 · Cited by 288 · see citing works

Adipocyte NCoR Knockout Decreases PPARγ Phosphorylation and Enhances PPARγ Activity and Insulin Sensitivity

Li, P., Fan, W., Xu, J., Lu, M. M., Yamamoto, H., Auwerx, J. H., Sears, D. D., Talukdar, S., Oh, D., Chen, A., et al. (2011) · Cell · doi:10.1016/j.cell.2011.09.050 · Cited by 264 · see citing works

PPARγ activation in adipocytes is sufficient for systemic insulin sensitization

Sugii, S., Olson, P., Sears, D. D., Saberi, M., Atkins, A. R., Barish, G. D., Hong, S.-H., Castro, G. L., Yin, Y.-Q., Nelson, M. C., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0912487106 · Cited by 255 · see citing works

Hyperinsulinemic-euglycemic Clamps in Conscious, Unrestrained Mice

Ayala, J. E., Bracy, D. P., Malabanan, C. M., James, F. D., Ansari, T., Fueger, P. T., McGuinness, O. P., & Wasserman, D. H. (2011) · Journal of Visualized Experiments · doi:10.3791/3188 · Cited by 157 · see citing works

METEORIN-LIKE is a cytokine associated with barrier tissues and alternatively activated macrophages

Ushach, I., Burkhardt, A. M., Martinez, C., Hevezi, P. A., Gerber, P. A., Buhren, B. A., Schrumpf, H., Valle‐Rios, R., Vazquez, M. I., Homey, B., et al. (2014) · Clinical Immunology · doi:10.1016/j.clim.2014.11.006 · Cited by 155 · see citing works

Suppression of PPAR-γ attenuates insulin-stimulated glucose uptake by affecting both GLUT1 and GLUT4 in 3T3-L1 adipocytes

Liao, W., Nguyen, M. T., Yoshizaki, T., Favelyukis, S., Patsouris, D., Imamura, T., Verma, I. M., & Olefsky, J. M. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00695.2006 · Cited by 142 · see citing works

Subfatin is a Novel Adipokine and Unlike Meteorin in Adipose and Brain Expression

Li, Z., Zheng, S., Wang, P., Xu, T., Guan, Y., Zhang, Y., & Miao, C. (2014) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12219 · Cited by 131 · see citing works

Ectopic recombination in the central and peripheral nervous system by aP2/FABP4‐Cre mice: Implications for metabolism research

Martens, K., Bottelbergs, A., & Baes, M. I. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.01.061 · Cited by 100 · see citing works

Loss of AMP-Activated Protein Kinase-α2 Impairs the Insulin-Sensitizing Effect of Calorie Restriction in Skeletal Muscle

Wang, P., Zhang, R.-Y., Song, J., Guan, Y., Xu, T., Du, H., Viollet, B., & Miao, C. (2012) · Diabetes · doi:10.2337/db11-1180 · Cited by 95 · see citing works

Cometin is a novel neurotrophic factor that promotes neurite outgrowth and neuroblast migration in vitro and supports survival of spiral ganglion neurons in vivo

Jørgensen, J. R., Fransson, A., Fjord‐Larsen, L., Thompson, L. H., Houchins, J. P., Andrade, N., Torp, M., Kalkkinen, N., Andersson, E., Lindvall, O., et al. (2011) · Experimental Neurology · doi:10.1016/j.expneurol.2011.09.027 · Cited by 87 · see citing works

Leptin Deficiency Unmasks the Deleterious Effects of Impaired Peroxisome Proliferator–Activated Receptor γ Function (P465L PPARγ) in Mice

Gray, S. L., Nora, E. D., Grosse, J., Manieri, M., Stoeger, T., Medina‐Gómez, G., Burling, K., Wattler, S., Russ, A., Yeo, G. S. H., et al. (2006) · Diabetes · doi:10.2337/db06-0389 · Cited by 85 · see citing works

Hyperinsulinemic-euglycemic Clamps in Conscious, Unrestrained Mice

Ayala, J. E., Bracy, D. P., Malabanan, C. M., James, F. D., Ansari, T., Fueger, P. T., McGuinness, O. P., & Wasserman, D. H. (2011) · Journal of Visualized Experiments · doi:10.3791/3188-v · Cited by 56 · see citing works

Protein tyrosine phosphatase 1B inhibits adipocyte differentiation and mediates TNFα action in obesity

Song, D., Chen, Y., Li, Z., Guan, Y., Zou, D., & Miao, C. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.05.006 · Cited by 25 · see citing works

Introduction

Miao, C. (2011) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2011.05598.x · Cited by 15 · see citing works

Natural products for the treatment of type 2 diabetes mellitus: Pharmacology and mechanisms

Xu, L., Li, Y., Dai, Y., & Peng, J. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.01.015 · Cited by 452 · see citing works

Autophagy in ischemic stroke

Wang, P., Shao, B., Deng, Z., Chen, S., Yue, Z., & Miao, C. (2018) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2018.01.001 · Cited by 396 · see citing works

Macrophage functions in lean and obese adipose tissue

Thomas, D. D., & Apovian, C. M. (2017) · Metabolism · doi:10.1016/j.metabol.2017.04.005 · Cited by 318 · see citing works

The Role of Exercise in the Interplay between Myokines, Hepatokines, Osteokines, Adipokines, and Modulation of Inflammation for Energy Substrate Redistribution and Fat Mass Loss: A Review

Gonzalez-Gil, A. M., & Elizondo-Montemayor, L. (2020) · Nutrients · doi:10.3390/nu12061899 · Cited by 278 · see citing works

Meteorin-like protein attenuates doxorubicin-induced cardiotoxicity via activating cAMP/PKA/SIRT1 pathway

Hu, C., Zhang, X., Song, P. K., Yuan, Y., Kong, C., Wu, H., Xu, S., Ma, Z., & Tang, Q. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101747 · Cited by 243 · see citing works

The role of exercise-induced myokines in regulating metabolism

Huh, J. Y. (2018) · Archives of Pharmacal Research · doi:10.1007/s12272-017-0994-y · Cited by 242 · see citing works

Adipose tissue: an endocrine organ playing a role in metabolic regulation

Booth, A. D., Magnuson, A. M., Fouts, J. K., & Foster, M. T. (2016) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2015-0073 · Cited by 215 · see citing works

METRNL attenuates lipid-induced inflammation and insulin resistance via AMPK or PPARδ-dependent pathways in skeletal muscle of mice

Jung, T. W., Lee, S. H., Kim, H.-C., Bang, J. S., Abd El-Aty, A. M., Hacımüftüoğlu, A., Shin, Y. K., & Jeong, J. H. (2018) · Experimental & Molecular Medicine · doi:10.1038/s12276-018-0147-5 · Cited by 203 · see citing works

Flavonoids and type 2 diabetes: Evidence of efficacy in clinical and animal studies and delivery strategies to enhance their therapeutic efficacy

Hussain, T., Tan, B., Murtaza, G., Liu, G., Rahu, N., Kalhoro, M. S., Kalhoro, D. H., Adebowale, T. O., Mazhar, M. U., Rehman, Z. U., et al. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104629 · Cited by 202 · see citing works

Metrnl: A secreted protein with new emerging functions

Zheng, S.-L., Li, Z.-Y., Song, J., Liu, J.-M., & Miao, C.-Y. (2016) · Acta Pharmacologica Sinica · doi:10.1038/aps.2016.9 · Cited by 190 · see citing works

Crosstalk between adipokines and myokines in fat browning

Rodrı́guez, A., Becerril, S., Ezquerro, S., Méndez-Giménez, L., & Frühbeck, G. (2016) · Acta Physiologica · doi:10.1111/apha.12686 · Cited by 192 · see citing works

Hormonal changes in PCOS

Yang, J., & Chen, C. (2024) · Journal of Endocrinology · doi:10.1530/joe-23-0342 · Cited by 175 · see citing works

Exercise induced meteorin-like protects chondrocytes against inflammation and pyroptosis in osteoarthritis by inhibiting PI3K/Akt/NF-κB and NLRP3/caspase-1/GSDMD signaling

Liu, J., Jia, S., Yang, Y., Piao, L., Wang, Z., Jin, Z., & Bai, L. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.114118 · Cited by 176 · see citing works

Myokines mediate the cross talk between skeletal muscle and other organs

Chen, W., Wang, L., You, W., & Shan, T. (2021) · Journal of Cellular Physiology · doi:10.1002/jcp.30033 · Cited by 162 · see citing works

Brown and Beige Adipose Tissues in Health and Disease

Rui, L. (2017) · Comprehensive physiology · doi:10.1002/cphy.c170001 · Cited by 178 · see citing works

Metrnl ameliorates diabetic cardiomyopathy via inactivation of cGAS/STING signaling dependent on LKB1/AMPK/ULK1-mediated autophagy

Lu, Q.-B., Ding, Y., Liu, Y., Wang, Z.-C., Wu, Y., Niu, K.-M., Li, K., Zhang, J., & Sun, H. (2022) · Journal of Advanced Research · doi:10.1016/j.jare.2022.10.014 · Cited by 159 · see citing works

The antidepressant-like effects of pioglitazone in a chronic mild stress mouse model are associated with PPARγ-mediated alteration of microglial activation phenotypes

Zhao, Q., Wu, X., Yan, S., Xie, X., Fan, Y., Zhang, J., Peng, C. Y., & You, Z. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0728-y · Cited by 142 · see citing works

Influence of Microbiota on Intestinal Immune System in Ulcerative Colitis and Its Intervention

Zhang, S.-L., Wang, S., & Miao, C. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01674 · Cited by 134 · see citing works

Meteorin-like/Meteorin-β Is a Novel Immunoregulatory Cytokine Associated with Inflammation

Ushach, I., Arrevillaga-Boni, G., Heller, G. N., Pone, E. J., Hernández-Ruíz, M., Catalan‐Dibene, J., Hevezi, P. A., & Zlotnik, A. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1800435 · Cited by 132 · see citing works

Identification of strong candidate genes for backfat and intramuscular fatty acid composition in three crosses based on the Iberian pig

Crespo‐Piazuelo, D., Criado‐Mesas, L., Revilla, M., Castelló, A., Noguera, J. L., Fernández, A. I., Ballester, M., & Folch, J. M. (2020) · Scientific Reports · doi:10.1038/s41598-020-70894-2 · Cited by 95 · see citing works

Meteorin-like/Metrnl, a novel secreted protein implicated in inflammation, immunology, and metabolism: A comprehensive review of preclinical and clinical studies

Li, Z., Gao, Z., Sun, T., Zhang, S., Yang, S., Zheng, M., & Shen, H. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1098570 · Cited by 97 · see citing works

Implications of circulating Meteorin-like (Metrnl) level in human subjects with type 2 diabetes

Chung, H. S., Hwang, S. Y., Choi, J. H., Lee, H. J., Kim, N. H., Yoo, H. J., Seo, J. A., Kim, S. G., Kim, N. H., Baik, S. H., et al. (2017) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2017.11.031 · Cited by 96 · see citing works

Exercise Inhibits NLRP3 Inflammasome Activation in Obese Mice via the Anti-Inflammatory Effect of Meteorin-like

Javaid, H. M. A., Sahar, N.-E., Zhuge, D., & Huh, J. Y. (2021) · Cells · doi:10.3390/cells10123480 · Cited by 96 · see citing works

Association of low serum Meteorin like (Metrnl) concentrations with worsening of glucose tolerance, impaired endothelial function and atherosclerosis

El‐Ashmawy, H. M., Selim, F. O., Hosny, T., & Almassry, H. N. (2019) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2019.02.026 · Cited by 93 · see citing works

Diabetes Mellitus and Associated Vascular Disease: Pathogenesis, Complications, and Evolving Treatments

Islam, K. N., Islam, R. K., Nguyen, I. D., Malik, H., Pirzadah, H., Shrestha, B., Lentz, I. B., Shekoohi, S., & Kaye, A. D. (2025) · Advances in Therapy · doi:10.1007/s12325-025-03185-9 · Cited by 103 · see citing works

The myokine meteorin‐like (metrnl) improves glucose tolerance in both skeletal muscle cells and mice by targeting AMPKα2

Lee, J. O., Lee, H. J., Lee, Y. W., Han, J. A., Kang, M. J., Moon, J., Shin, M.-J., Lee, H. J., Chung, J. H., Lee, J., et al. (2020) · FEBS Journal · doi:10.1111/febs.15301 · Cited by 97 · see citing works

Lower serum levels of Meteorin-like/Subfatin in patients with coronary artery disease and type 2 diabetes mellitus are negatively associated with insulin resistance and inflammatory cytokines

Dadmanesh, M., Aghajani, H., Fadaei, R., & Ghorban, K. (2018) · PLOS ONE · doi:10.1371/journal.pone.0204180 · Cited by 89 · see citing works

The Role of Exercise, Diet, and Cytokines in Preventing Obesity and Improving Adipose Tissue

ATAKAN, M. M., Koşar, Ş. N., Güzel, Y., Tin, H. T., & Yan, X. (2021) · Nutrients · doi:10.3390/nu13051459 · Cited by 94 · see citing works

Involvement of the secreted protein Metrnl in human diseases

Miao, Z., Hu, W., Li, Z., & Miao, C. (2020) · Acta Pharmacologica Sinica · doi:10.1038/s41401-020-00529-9 · Cited by 84 · see citing works

Novel targets for potential therapeutic use in Diabetes mellitus

Dhankhar, S., Chauhan, S., Mehta, D. K., Nitika, Saini, K., Saini, M., Das, R., Gupta, S., & Gautam, V. (2023) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-023-00983-5 · Cited by 86 · see citing works

Serum Metrnl is associated with the presence and severity of coronary artery disease

Liu, Z., Ji, H., Yao, M., Wang, L., Wang, Y., Zhou, P., Liu, Y., Zheng, X., He, H., Wang, L., et al. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13915 · Cited by 84 · see citing works

Cerebral organoids transplantation improves neurological motor function in rat brain injury

Wang, Z., Wang, S., Xu, T., Hong, C., Cheng, M., Zhu, P., Lin, J., Su, D., & Miao, C. (2020) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13286 · Cited by 82 · see citing works

Meteorin-like/Meteorin-β protects heart against cardiac dysfunction

Rupérez, C., Ferrer‐Curriu, G., Cervera-Barea, A., Florit, L., Guitart‐Mampel, M., Garrabou, G., Zamora, M., Crispi, F., Fernández‐Solà, J., Lupón, J., et al. (2021) · The Journal of Experimental Medicine · doi:10.1084/jem.20201206 · Cited by 79 · see citing works

Serum Meteorin-like protein levels decreased in patients newly diagnosed with type 2 diabetes

Lee, J. H., Kang, Y. E., Kim, J. M., Choung, S., Joung, K. H., Kim, H. J., & Ku, B. J. (2018) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2017.10.005 · Cited by 75 · see citing works

Aerobic Exercise Increases Meteorin-Like Protein in Muscle and Adipose Tissue of Chronic High-Fat Diet-Induced Obese Mice

Bae, J. Y. (2018) · BioMed Research International · doi:10.1155/2018/6283932 · Cited by 75 · see citing works

Serum Levels of Meteorin-Like (Metrnl) Are Increased in Patients with Newly Diagnosed Type 2 Diabetes Mellitus and Are Associated with Insulin Resistance

Wang, K., Li, F., Wang, C., Deng, Y., Cao, Z., Cui, Y., Xu, K., Ln, P., & Sun, Y. (2019) · Medical Science Monitor · doi:10.12659/msm.915331 · Cited by 71 · see citing works

The novel cytokine Metrnl/IL-41 is elevated in Psoriatic Arthritis synovium and inducible from both entheseal and synovial fibroblasts

Bridgewood, C., Russell, T., Weedon, H., Baboolal, T. G., Watad, ‬., Sharif, Κ., Cuthbert, R., Wittmann, M., Wechalekar, M. D., & McGonagle, D. (2019) · Clinical Immunology · doi:10.1016/j.clim.2019.108253 · Cited by 72 · see citing works

Novel Adipokine, FAM19A5, Inhibits Neointima Formation After Injury Through Sphingosine-1-Phosphate Receptor 2

Wang, Y., Chen, D., Zhang, Y., Wang, P., Zheng, C., Zhang, S., Yu, B., Zhang, L., Zhao, G., Ma, B., et al. (2018) · Circulation · doi:10.1161/circulationaha.117.032398 · Cited by 68 · see citing works

Meteorin-β/Meteorin like/IL-41 attenuates airway inflammation in house dust mite-induced allergic asthma

Gao, X., Leung, T. F., Wong, G., Ko, W. H., Cai, M., He, E. J., Chu, I. M., Tsang, M. S., Chan, B. C.-L., Ling, J., et al. (2021) · Cellular and Molecular Immunology · doi:10.1038/s41423-021-00803-8 · Cited by 66 · see citing works

Brown/Beige adipose tissues and the emerging role of their secretory factors in improving metabolic health: The batokines

Ahmad, B., Vohra, M. S., Saleemi, M. A., Serpell, C. J., Fong, I. L., & Wong, E. H. (2021) · Biochimie · doi:10.1016/j.biochi.2021.01.015 · Cited by 64 · see citing works

Metrnl regulates cognitive dysfunction and hippocampal BDNF levels in D-galactose-induced aging mice

Hong, C., Wang, Z., Zheng, S., Hu, W., Wang, S., Zhao, Y., & Miao, C. (2022) · Acta Pharmacologica Sinica · doi:10.1038/s41401-022-01009-y · Cited by 62 · see citing works

METRNL decreases during adipogenesis and inhibits adipocyte differentiation leading to adipocyte hypertrophy in humans

Löffler, D., Landgraf, K., Rockstroh, D., Schwartze, J. T., Dunzendorfer, H., Kiess, W., & Körner, A. (2016) · International Journal of Obesity · doi:10.1038/ijo.2016.180 · Cited by 61 · see citing works

Myokines: Metabolic regulation in obesity and type 2 diabetes

Chen, Z.-T., Weng, Z.-X., Lin, J. D., & Meng, Z.-X. (2024) · Life Metabolism · doi:10.1093/lifemeta/loae006 · Cited by 58 · see citing works

Meteorin-like protein (METRNL)/IL-41 improves LPS-induced inflammatory responses via AMPK or PPARδ–mediated signaling pathways

Jung, T. W., Pyun, D. H., Kim, T. J., Lee, H. J., Park, E. S., El‐Aty, A. M. A., Hwang, E. J., Shin, Y. K., & Jeong, J. H. (2021) · Advances in Medical Sciences · doi:10.1016/j.advms.2021.01.007 · Cited by 57 · see citing works

Meteorin-like protein (Metrnl): A metabolic syndrome biomarker and an exercise mediator

Alizadeh, H. (2022) · Cytokine · doi:10.1016/j.cyto.2022.155952 · Cited by 57 · see citing works

Aggravated ulcerative colitis caused by intestinal Metrnl deficiency is associated with reduced autophagy in epithelial cells

Zhang, S.-L., Li, Z., Wang, D., Xu, T., Fan, M.-B., Cheng, M., & Miao, C. (2020) · Acta Pharmacologica Sinica · doi:10.1038/s41401-019-0343-4 · Cited by 54 · see citing works

Opposite changes in meteorin-like and oncostatin m levels are associated with metabolic improvements after bariatric surgery

Pellitero, S., Piquer‐Garcia, I., Ferrer‐Curriu, G., Puig, R., Martínez, E., Moreno, P., Tarascó, J., Balibrea, J. M., Lerín, C., Puig‐Domingo, M., et al. (2017) · International Journal of Obesity · doi:10.1038/ijo.2017.268 · Cited by 52 · see citing works

The Adipokine Metrnl Ameliorates Chronic Colitis in Il-10–/– Mice by Attenuating Mesenteric Adipose Tissue Lesions During Spontaneous Colitis

Zuo, L., Ge, S., Ge, Y., Li, J., Zhu, B., Zhang, Z., Jiang, C., Li, J., Wang, S., Liu, M., et al. (2019) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjz001 · Cited by 52 · see citing works

Metrnl deficiency decreases blood HDL cholesterol and increases blood triglyceride

Qi, Q., Hu, W., Zheng, S., Zhang, S.-L., Le, Y., Li, Z., & Miao, C. (2020) · Acta Pharmacologica Sinica · doi:10.1038/s41401-020-0368-8 · Cited by 51 · see citing works

Inverse relationship between serum Metrnl levels and visceral fat obesity (VFO) in patients with type 2 diabetes

Du, Y., Ye, X., Lu, A., Zhao, D., Liu, J., Cheng, J., & Yang, T. (2020) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2020.108068 · Cited by 49 · see citing works

Beyond mechanical loading: The metabolic contribution of obesity in osteoarthritis unveils novel therapeutic targets

Sobieh, B. H., EL-Mesallamy, H. O., & Kassem, D. H. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e15700 · Cited by 49 · see citing works

Endothelial METRNL determines circulating METRNL level and maintains endothelial function against atherosclerosis

Zheng, S., Li, Z., Song, J., Wang, P., Xu, J., Hu, W., Shi, Y., Qi, Q., Miao, Z., Guan, Y., et al. (2022) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2022.12.008 · Cited by 48 · see citing works

The cytokine Meteorin-like inhibits anti-tumor CD8+ T cell responses by disrupting mitochondrial function

Jackson, C. M., Pant, A., Dinalankara, W., Choi, J. H., Jain, A., Nitta, R. T., Yazigi, E., Saleh, L., Zhao, L., Nirschl, T. R., et al. (2024) · Immunity · doi:10.1016/j.immuni.2024.07.003 · Cited by 48 · see citing works

Effect of resveratrol on adipokines and myokines involved in fat browning: Perspectives in healthy weight against obesity

Kim, O. Y., Chung, J. Y., & Song, J. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104411 · Cited by 47 · see citing works

Circulating levels of Meteorin-like protein in polycystic ovary syndrome: A case-control study

Fouani, F. Z., Fadaei, R., Moradi, N., Zandieh, Z., Ansaripour, S., Yekaninejad, M. S., Vatannejad, A., & Mahmoudi, M. (2020) · PLoS ONE · doi:10.1371/journal.pone.0231943 · Cited by 50 · see citing works

Sarcopenia and cachexia: molecular mechanisms and therapeutic interventions

Wang, T., Zhou, D., & Hong, Z. (2025) · MedComm · doi:10.1002/mco2.70030 · Cited by 46 · see citing works

Intestinal Metrnl released into the gut lumen acts as a local regulator for gut antimicrobial peptides

Li, Z., Fan, M.-B., Zhang, S.-L., Qu, Y., Zheng, S., Song, J., & Miao, C. (2016) · Acta Pharmacologica Sinica · doi:10.1038/aps.2016.70 · Cited by 44 · see citing works

Epigenome-wide skeletal muscle DNA methylation profiles at the background of distinct metabolic types and ryanodine receptor variation in pigs

Ponsuksili, S., Trakooljul, N., Sajjanar, B., Hadlich, F., Muráni, E., & Wimmers, K. (2019) · BMC Genomics · doi:10.1186/s12864-019-5880-1 · Cited by 44 · see citing works

Serum Metrnl levels are decreased in subjects with overweight or obesity and are independently associated with adverse lipid profile

Ding, X., Chang, X., Wang, J., Bian, N., An, Y., Wang, G., & Liu, J. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.938341 · Cited by 43 · see citing works

Hyperglycemia affects global 5-methylcytosine and 5-hydroxymethylcytosine in blood genomic DNA through upregulation of SIRT6 and TETs

Yuan, E., Yang, Y., Cheng, L. Z., Deng, X., Chen, S., Zhou, X. H., & Liu, S. (2019) · Clinical Epigenetics · doi:10.1186/s13148-019-0660-y · Cited by 41 · see citing works

Characterization of the serum levels of Meteorin-like in patients with inflammatory bowel disease and its association with inflammatory cytokines

Gholamrezayi, A., Mohamadinarab, M., Rahbarinejad, P., Fallah, S., Barez, S. R., Setayesh, L., Moradi, N., Fadaei, R., Chamani, E., & Tavakoli, T. (2020) · Lipids in Health and Disease · doi:10.1186/s12944-020-01404-6 · Cited by 41 · see citing works

P7C3‐A20 alleviates fatty liver by shaping gut microbiota and inducing FGF21/FGF1, via the AMP‐activated protein kinase/CREB regulated transcription coactivator 2 pathway

Hua, X., Sun, D., Zhang, W., Fu, J., Tong, J., Sun, S., Zeng, F., Ouyang, S., Zhang, G., Wang, S., et al. (2020) · British Journal of Pharmacology · doi:10.1111/bph.15008 · Cited by 40 · see citing works

Polycystic ovary syndrome and recurrent pregnancy loss, a review of literature

Wartena, R., & Matjila, M. J. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1183060 · Cited by 40 · see citing works

Subfatin and asprosin, two new metabolic players of polycystic ovary syndrome

Deniz, R., Yavuzkır, Ş., Uğur, K., Üstebay, D. Ü., Baykuş, Y., Üstebay, S., & Aydın, S. (2020) · Journal of Obstetrics and Gynaecology · doi:10.1080/01443615.2020.1758926 · Cited by 39 · see citing works

Serum Meteorin‐like is associated with weight loss in the elderly patients with chronic heart failure

Cai, J., Wang, Q., Li, J., Xu, F., Bu, Y., Wang, M., Lü, X., & Gao, W. Q. (2021) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12865 · Cited by 38 · see citing works

Energy metabolism and frailty: The potential role of exercise-induced myokines – A narrative review

Barros, D. G. M., Marques, E. A., Magalhães, J., & Carvalho, J. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101780 · Cited by 36 · see citing works

Metrnl deficiency retards skin wound healing in mice by inhibiting AKT/eNOS signaling and angiogenesis

Xu, T., Qing, S.-L., Zhao, J.-X., Song, J., Miao, Z., Li, J., Yang, F.-Y., Zhao, H., Zheng, S., Li, Z., et al. (2023) · Acta Pharmacologica Sinica · doi:10.1038/s41401-023-01090-x · Cited by 35 · see citing works

Serum levels of subfatin in patients with type 2 diabetes mellitus and its association with vascular adhesion molecules

Fadaei, R., Dadmanesh, M., Moradi, N., Ahmadi, R., Nahrkhalaji, A. S., Aghajani, H., & Ghorban, K. (2018) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2018.1538248 · Cited by 33 · see citing works

Effects of electrical stimulation‐induced resistance exercise training on white and brown adipose tissues and plasma meteorin‐like concentration in rats

Amano, Y., Nonaka, Y., Takeda, R., Kano, Y., & Hoshino, D. (2020) · Physiological Reports · doi:10.14814/phy2.14540 · Cited by 33 · see citing works

Chlorogenic Acid Functions as a Novel Agonist of PPAR γ 2 during the Differentiation of Mouse 3T3-L1 Preadipocytes

Peng, S., Pang, Y.-L., Zhu, Q., Kang, J., Liu, M., & Wang, Z. (2018) · BioMed Research International · doi:10.1155/2018/8594767 · Cited by 33 · see citing works

Bioactive Agent Discovery from the Natural Compounds for the Treatment of Type 2 Diabetes Rat Model

Yang, S.-C., Hsu, C., Chou, W.-L., Fang, J., & Chuang, S.-Y. (2020) · Molecules · doi:10.3390/molecules25235713 · Cited by 32 · see citing works

Meteorin-Like Protein (Metrnl) in Obesity, during Weight Loss and in Adipocyte Differentiation

Schmid, A., Karrasch, T., & Schäffler, A. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10194338 · Cited by 34 · see citing works

Metrnl: a promising biomarker and therapeutic target for cardiovascular and metabolic diseases

Dong, W.-S., Hu, C., Hu, M., Gao, Y.-P., Hu, Y.-X., Li, K., Ye, Y.-J., & Zhang, X. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01767-8 · Cited by 27 · see citing works

Transcriptome-Based Analysis Reveals Therapeutic Effects of Resveratrol on Endometriosis in aRat Model

Wang, C., Chen, Z., Zhao, X., Lin, C., Hong, S., Lou, Y., Shi, X., Zhao, M., Yang, X., Guan, M., et al. (2021) · Drug Design Development and Therapy · doi:10.2147/dddt.s323790 · Cited by 31 · see citing works

Type I collagen inhibits adipogenic differentiation via YAP activation in vitro

Liu, X., Long, X., Gao, Y., Liu, W., Hayashi, T., Mizuno, K., Hattori, S., Fujisaki, H., Ogura, T., Onodera, S., et al. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.29100 · Cited by 30 · see citing works

The role of Meteorin‐like in skeletal development and bone fracture healing

Rong, H., Balu, A. R., Molitoris, K. H., White, J. P., Robling, A. G., Ayturk, U. M., & Baht, G. S. (2022) · Journal of Orthopaedic Research® · doi:10.1002/jor.25286 · Cited by 29 · see citing works

Discovery of Novel Insulin Sensitizers: Promising Approaches and Targets

Chen, Y., Ma, H., Dasheng, Z., Zhao, G., Wang, L., Fu, X., & Chen, W. (2017) · PPAR Research · doi:10.1155/2017/8360919 · Cited by 29 · see citing works

Potential emerging roles of the novel adipokines adipolin/CTRP12 and meteorin-like/METRNL in obesity-osteoarthritis interplay

Sobieh, B. H., Kassem, D. H., Zakaria, Z. M., & EL-Mesallamy, H. O. (2020) · Cytokine · doi:10.1016/j.cyto.2020.155368 · Cited by 29 · see citing works

Sarcopenic obesity and osteoporosis: Research progress and hot spots

Fan, S., Cai, Y., Wei, Y., Yang, J., Gao, J., & Yang, Y. (2024) · Experimental Gerontology · doi:10.1016/j.exger.2024.112544 · Cited by 27 · see citing works

Administration of metrnl delays the onset of diabetes in non-obese diabetic mice

Yao, Z., Lin, P., Wang, C., Wang, K., & Sun, Y. (2020) · Endocrine Journal · doi:10.1507/endocrj.ej20-0351 · Cited by 27 · see citing works

Maternal and umbilical cord blood subfatin and spexin levels in patients with gestational diabetes mellitus

Yavuzkır, Ş., Uğur, K., Deniz, R., Üstebay, D. Ü., Mirzaoglu, M., Yardım, M., Şahin, İ., Baykuş, Y., Karagöz, Z. K., & Aydın, S. (2020) · Peptides · doi:10.1016/j.peptides.2020.170277 · Cited by 27 · see citing works

IL-39 acts as a friend to pancreatic cancer

Manning, A. A., Zhao, L., Zhu, Z., Xiao, H., Redington, C. G., Ding, V. A., Stewart-Hester, T., Bai, Q., Dunlap, J., Wakefield, M. R., et al. (2018) · Medical Oncology · doi:10.1007/s12032-018-1236-y · Cited by 25 · see citing works

CXCL13 is a differentiation- and hypoxia-induced adipocytokine that exacerbates the inflammatory phenotype of adipocytes through PHLPP1 induction

Kusuyama, J., Bandow, K., Ohnishi, T., Amir, M. S., Shima, K., Semba, I., & Matsuguchi, T. (2019) · Biochemical Journal · doi:10.1042/bcj20190709 · Cited by 25 · see citing works

Meteorin-like alleviates hepatic steatosis by regulating hepatic triglyceride secretion and fatty acid oxidation

Song, L., Huang, Y., Liu, L., Chang, X., Hu, L., Wang, G., Xu, L., Zhang, T., Wang, Y., Xiao, Y., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115246 · Cited by 24 · see citing works

The Effects of Eight Weeks of Circuit Resistance Training on Serum METRNL Levels and Insulin Resistance in Individuals with Type 2 Diabetes

Tayebi, S. M., Golmohammadi, M., Eslami, R., Shakiba, N., & Costa, P. B. (2023) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-023-01225-1 · Cited by 23 · see citing works

Metrnl as a secreted protein: Discovery and cardiovascular research

Miao, Z., Chen, J., Chen, C.-X., Zheng, S., Zhao, H., & Miao, C. (2024) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2024.108730 · Cited by 24 · see citing works

Effects of exercise training on type 2-diabetes: the role of Meteorinlike protein

Saeidi, A., Tayebi, S. M., Khosravi, A., Malekian, F., Khodamoradi, A., Sellami, M., Abderrahman, A. B., & Zouhal, H. (2019) · Health Promotion Perspectives · doi:10.15171/hpp.2019.12 · Cited by 23 · see citing works

Elevated levels of Metrnl in rheumatoid arthritis: Association with disease activity

Zhang, S., Lei, Y., Sun, T., Gao, Z., Li, Z., & Shen, H. (2022) · Cytokine · doi:10.1016/j.cyto.2022.156026 · Cited by 22 · see citing works

The role of adipokines in osteoporosis management: a mini review

Patil, J. D., & Fredericks, S. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1336543 · Cited by 23 · see citing works

Brown and Beige Adipose Tissues in Health and Disease

Rui, L. (2017) · Comprehensive physiology · doi:10.1002/j.2040-4603.2017.tb00784.x · Cited by 21 · see citing works

Crystal structure-based comparison of two NAMPT inhibitors

Zhang, S.-L., Xu, T., Yang, Z., Han, S., Zhao, Q., & Miao, C. (2017) · Acta Pharmacologica Sinica · doi:10.1038/aps.2017.80 · Cited by 21 · see citing works

EoTHINophils: Eosinophils as key players in adipose tissue homeostasis

Vohralik, E. J., Psaila, A. M., Knights, A. J., & Quinlan, K. G. R. (2020) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.13304 · Cited by 20 · see citing works

Low serum levels of meteorin-like/subfatin: an indicator of diabetes mellitus and insulin resistance?

Önalan, E., Cavlı, C., Doğan, Y., Etem, E. Ö., Gözel, N., Kavuran, İ. B., Yakar, B., & Dönder, E. (2020) · Endokrynologia Polska · doi:10.5603/ep.a2020.0038 · Cited by 20 · see citing works

Myokine-mediated exercise effects: the role of myokine meteorin-like hormone (Metrnl)

Alizadeh, H. (2021) · Growth Factors · doi:10.1080/08977194.2022.2032689 · Cited by 20 · see citing works

The effect of diclofenac sodium intoxication on the cardiovascular system in rats

Dolanbay, T., Makav, M., Gül, H. F., & KARAKURT, E. (2020) · The American Journal of Emergency Medicine · doi:10.1016/j.ajem.2020.11.022 · Cited by 19 · see citing works

The Potential Roles of Myokines in Adipose Tissue Metabolism with Exercise and Cold Exposure

Jiang, S., Bae, J. H., Wang, Y., & Song, W. J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911523 · Cited by 20 · see citing works

Meteorin-like Protein and Asprosin Levels in Children and Adolescents with Obesity and Their Relationship with Insulin Resistance and Metabolic Syndrome

Moradi, N., Fadaei, R., Roozbehkia, M., Nourbakhsh, M., Nourbakhsh, M., Razzaghy‐Azar, M., & Larijani, B. A. (2022) · Laboratory Medicine · doi:10.1093/labmed/lmac152 · Cited by 19 · see citing works

A meta-analysis of the relationship between serums metrnl-like protein/subfatin and risk of type 2 diabetes mellitus and coronary artery disease

Ferns, G. A., Fekri, K., Abadi, M. S. S., Dehkordi, M. B., & Arjmand, M.-H. (2021) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2021.1899239 · Cited by 20 · see citing works

Serum Metrnl Level is Correlated with Insulin Resistance, But Not with β-Cell Function in Type 2 Diabetics

Wang, C., Pan, Y., Song, J., Sun, Y. S., Li, H., Chen, L., & Hou, X. (2019) · Medical Science Monitor · doi:10.12659/msm.920222 · Cited by 17 · see citing works

Diabetes mellitus: Complications, emerging therapeutic targets, and evolving treatment approaches

Mohd, S., Kumar, L. L., Harish, V., Kumar, R., Chaudhary, A., & Sharma, V. (2025) · Obesity Medicine · doi:10.1016/j.obmed.2025.100652 · Cited by 15 · see citing works

Metrnl: a novel secreted protein against insulin resistance

Miao, C. (2018) · Proceedings for Annual Meeting of The Japanese Pharmacological Society · doi:10.1254/jpssuppl.wcp2018.0_po1-2-70 · Cited by 1 · see citing works

Insulin resistance in adipocytes: Novel insights into the pathophysiology of metabolic syndrome

Kerr, A. G., Andersson, D. P., Rydén, M., & Arner, P. (2023) · Clinical Nutrition · doi:10.1016/j.clnu.2023.12.012 · Cited by 16 · see citing works

METRNL decreases during adipogenesis and inhibits adipocyte differentiation leading to adipocyte hypertrophy in humans

Löffler, D., Landgraf, K., Rockstroh, D., Schwartze, J. T., Dunzendorfer, H., Kiess, W., & Körner, A. (2016) · International Journal of Obesity · doi:10.1038/ijo.2016.180 · Cited by 61 · see citing works

Membrane metallo-endopeptidase (Neprilysin) regulates inflammatory response and insulin signaling in white preadipocytes

Ramirez, A. K., Dankel, S. N., Cai, W., Sakaguchi, M., Kasif, S., & Kahn, C. R. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.01.006 · Cited by 25 · see citing works

A hypothesis for insulin resistance in primary human adipocytes involving MRTF-A and suppression of PPARγ

Hansson, B., Schumacher, S., Fryklund, C., Morén, B., Björkqvist, M., Swärd, K., & Stenkula, K. G. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.08.105 · Cited by 5 · see citing works