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Bacteriocin production: a relatively unharnessed probiotic trait?
Open accessAbstract
Probiotics are "live microorganisms which, when consumed in adequate amounts, confer a health benefit to the host". A number of attributes are highly sought after among these microorganisms, including immunomodulation, epithelial barrier maintenance, competitive exclusion, production of short-chain fatty acids, and bile salt metabolism. Bacteriocin production is also generally regarded as a probiotic trait, but it can be argued that, in contrast to other traits, it is often considered a feature that is desirable, rather than a key probiotic trait. As such, the true potential of these antimicrobials has yet to be realised.
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“Several in vitro and in vivo studies have shown that bacteriocins produced by LAB can exert a protective effect on the gastrointestinal tract by excluding pathogens and promoting the colonization of the gut [245].”
From Lactic Acid Bacteria in Raw-Milk Cheeses: From Starter Cultures to Probiotic Functions (2022) · cites this paper as [245]
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Metadata
- Authors
- Hegarty, J. W., Guinane, C. M., Ross, R. P., Hill, C., & Cotter, P. D.
- Affiliations
- Teagasc - The Irish Agriculture and Food Development Authority (IE)
- University College Cork (IE)
- Corresponding author
- Cotter, Paul D.
- Venue
- F1000Research
- Publisher
- F1000 Research Ltd
- Published
- 2016-10-27
- Volume
- 5
- Pages
- 2587
- ISSN
- 2046-1402 (ISSN-L)
- PMC
- PMC5089130
- OpenAlex
- W2543921200
- Cited by
- 141
- References
- 75
- Citations by year
- 2026: 6 · 2025: 12 · 2024: 9 · 2023: 18 · 2022: 20 · 2021: 20 · 2020: 21 · 2019: 15 · 2018: 14 · 2017: 6
- FWCI
- 1.33
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- F1000Research (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- T-Stór (Teagasc) (submittedVersion, cc-by-nc-sa)
- Funders
- Science Foundation Ireland (11/P1/1137)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- bacteriocin production, probiotics, antimicrobial peptides, competitive exclusion, immunomodulation, bile salt metabolism, short-chain fatty acids
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