The M1 and M2 paradigm of macrophage activation: Time for reassessment

Martinez, Fernando O., Gordon, Siamon·2014·F1000Prime Reports

Cited by (137)

Items 101–137 of 137

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  4. Expression site of P2RY12 in residential microglial cells in astrocytomas correlates with M1 and M2 marker expression and tumor grade
    Zhu, Changbin, Kros, Johan M., van der Weiden, Marcel, Zheng, PingPin, Cheng, Caroline, Mustafa, Dana A. M. · 2017 · Acta Neuropathologica Communications
  5. The Cardiac Microenvironment Instructs Divergent Monocyte Fates and Functions in Myocarditis
    Hou, Xuezhou, Chen, Guobao, Bracamonte-Baran, William, Choi, Hee Sun, Diny, Nicola L., Sung, Jungeun, Hughes, David, Won, Taejoon, Wood, Megan Kay, Talor, Monica V. et al. · 2019 · Cell Reports
  6. The macrophage marker translocator protein (TSPO) is down-regulated on pro-inflammatory ‘M1’ human macrophages
    Narayan, Nehal, Mandhair, Harpreet, Smyth, Erica, Dakin, Stephanie Georgina, Kiriakidis, Serafim, Wells, Lisa, Owen, David, Sabokbar, Afsie, Taylor, Peter · 2017 · PLOS ONE
  7. Microglial Progranulin: Involvement in Alzheimer’s Disease and Neurodegenerative Diseases
    Mendsaikhan, Anarmaa, Tooyama, Ikuo, Walker, Douglas G. · 2019 · Cells
  8. Interleukin-13 immune gene therapy prevents CNS inflammation and demyelination via alternative activation of microglia and macrophages: Modulation of CNS Inflammation by Interkeukin-13
    Guglielmetti, Caroline, Le Blon, Debbie, Santermans, Eva, Salas-Perdomo, Angelica, Daans, Jasmijn, De Vocht, Nathalie, Shah, Disha, Hoornaert, Chloé, Praet, Jelle, Peerlings, Jurgen et al. · 2016 · Glia
  9. Hyperactivation of monocytes and macrophages in MCI patients contributes to the progression of Alzheimer's disease
    Munawara, Usma, Catanzaro, Michael, Xu, Weili, Tan, Crystal, Hirokawa, Katsuiku, Bosco, Nabil, Dumoulin, David, Khalil, Abdelouahed, Larbi, Anis, Lévesque, Simon et al. · 2021 · Immunity & Ageing
  10. Unraveling and Harnessing the Immune Response at the Cell–Biomaterial Interface for Tissue Engineering Purposes
    ten Brink, Tim, Damanik, Febriyani, Rotmans, Joris I., Moroni, Lorenzo · 2024 · Advanced Healthcare Materials
  11. Progressive striatonigral degeneration in a transgenic mouse model of multiple system atrophy: translational implications for interventional therapies
    Refolo, Violetta, Bez, Francesco, Polissidis, Alexia, Kuzdas-Wood, Daniela, Sturm, Edith, Kamaratou, Martina, Poewe, Werner, Stefanis, Leonidas, Angela Cenci, M., Romero-Ramos, Marina et al. · 2018 · Acta Neuropathologica Communications
  12. Microglia, Trem2, and Neurodegeneration
    Shi, Qian, Gutierrez, Raul A., Bhat, Manzoor A. · 2025 · The Neuroscientist
  13. Dynamic impact of brief electrical nerve stimulation on the neural immune axis—polarization of macrophages toward a pro‐repair phenotype in demyelinated peripheral nerve
    MLean, Nikki A., Verge, Valerie M. K. · 2016 · Glia
  14. The Role of Macrophages in Liver Fibrosis: New Therapeutic Opportunities
    Binatti, Eleonora, Gerussi, Alessio, Barisani, Donatella, Invernizzi, Pietro · 2022 · International Journal of Molecular Sciences
  15. Involvement of IGF-1 and Akt in M1/M2 activation state in bone marrow-derived macrophages
    Barrett, James P., Minogue, Aedín M., Falvey, Aidan, Lynch, Marina A. · 2015 · Experimental Cell Research
  16. Blocking siglec-10hi tumor-associated macrophages improves anti-tumor immunity and enhances immunotherapy for hepatocellular carcinoma
    Xiao, Nan, Zhu, Xiaodong, Li, Kangshuai, Chen, Yifan, Liu, Xuefeng, Xu, Bin, Lei, Ming, Xu, Jiejie, Sun, Hui-Chuan · 2021 · Experimental Hematology & Oncology
  17. LPS protects macrophages from AIF-independent parthanatos by downregulation of PARP1 expression, induction of SOD2 expression, and a metabolic shift to aerobic glycolysis
    Regdon, Zsolt, Robaszkiewicz, Agnieszka, Kovács, Katalin, Rygielska, Żaneta, Hegedűs, Csaba, Bodoor, Khaldon, Szabó, Éva, Virág, László · 2019 · Free Radical Biology and Medicine
  18. Improved Angiogenesis in Response to Localized Delivery of Macrophage-Recruiting Molecules
    Hsu, Chih-Wei, Poché, Ross A., Saik, Jennifer E., Ali, Saniya, Wang, Shang, Yosef, Nejla, Calderon, Gisele A., Scott, Larry, Vadakkan, Tegy J., Larina, Irina V. et al. · 2015 · PLOS ONE
  19. Macrophage subtype and cytokine expression characterization during the acute inflammatory phase of mouse bone fracture repair
    McCauley, James, Bitsaktsis, Constantine, Cottrell, Jessica · 2020 · Journal of Orthopaedic Research
  20. Bioengineered liver crosslinked with nano-graphene oxide enables efficient liver regeneration via MMP suppression and immunomodulation
    Kim, Da-Hyun, Kim, Min-Ji, Kwak, Seon-Yeong, Jeong, Jaemin, Choi, Dongho, Choi, Soon Won, Ryu, Jaechul, Kang, Kyung-Sun · 2023 · Nature Communications
  21. Dynamic Responses of Microglia in Animal Models of Multiple Sclerosis
    Plastini, Melanie J., Desu, Haritha L., Brambilla, Roberta · 2020 · Frontiers in Cellular Neuroscience
  22. Pirfenidone suppresses polarization to M2 phenotype macrophages and the fibrogenic activity of rat lung fibroblasts
    Toda, Michihito, Mizuguchi, Shinjiro, Minamiyama, Yukiko, Yamamoto-Oka, Hiroko, Aota, Takanori, Kubo, Shoji, Nishiyama, Noritoshi, Shibata, Toshihiko, Takemura, Shigekazu · 2018 · Journal of Clinical Biochemistry and Nutrition
  23. Lipid profiling of polarized human monocyte-derived macrophages
    Montenegro-Burke, J. Rafael, Sutton, Jessica A., Rogers, Lisa M., Milne, Ginger L., McLean, John A., Aronoff, David M. · 2016 · Prostaglandins & Other Lipid Mediators
  24. Immune response in bacterial and Candida sepsis
    Patricio, Patricia, Paiva, José Artur, Borrego, Luís Miguel · 2019 · European Journal of Microbiology and Immunology
  25. Nicotinamide: a vitamin able to shift macrophage differentiation toward macrophages with restricted inflammatory features
    Weiss, Ronald, Schilling, Erik, Grahnert, Anja, Kölling, Valeen, Dorow, Juliane, Ceglarek, Uta, Sack, Ulrich, Hauschildt, Sunna · 2015 · Innate Immunity
  26. Tissue-resident macrophages promote early dissemination of multiple myeloma via IL-6 and TNFα
    Akhmetzyanova, Ilseyar, Aaron, Tonya, Galbo, Phillip, Tikhonova, Anastasia, Dolgalev, Igor, Tanaka, Masato, Aifantis, Iannis, Zheng, Deyou, Zang, Xingxing, Fooksman, David · 2021 · Blood Advances
  27. Tumor-associated macrophages: Prognostic and therapeutic targets for cancer in humans and dogs
    Brady, Rachel V., Thamm, Douglas H. · 2023 · Frontiers in Immunology
  28. Models of immunogenicity in preclinical assessment of tissue engineered heart valves
    Ground, Marcus, Waqanivavalagi, Steve, Walker, Robert, Milsom, Paget, Cornish, Jillian · 2021 · Acta Biomaterialia
  29. HDACi delivery reprograms tumor-infiltrating myeloid cells to eliminate antigen-loss variants
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  30. Collagen morphology influences macrophage shape and marker expression in?vitro
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  31. Modulation of Monocyte-Driven Myositis in Alphavirus Infection Reveals a Role for CX <sub>3</sub> CR1 <sup>+</sup> Macrophages in Tissue Repair
    Zaid, Ali, Tharmarajah, Kothila, Mostafavi, Helen, Freitas, Joseph R., Sheng, Kuo-Ching, Foo, Suan-Sin, Chen, Weiqiang, Vider, Jelena, Liu, Xiang, West, Nicholas P. et al. · 2020 · mBio
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    Alan, Elif, Kerry, Zeliha, Sevin, Gulnur · 2023 · Fundamental &amp; Clinical Pharmacology
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    Dunne, Patrick W., Roberts, David L., Quinones, Marlon P., Velligan, Dawn I., Paredes, Madelaine, Walss-Bass, Consuelo · 2017 · Psychiatry Research
  34. Hierarchical cortical transcriptome disorganization in autism
    Lombardo, Michael V., Courchesne, Eric, Lewis, Nathan E., Pramparo, Tiziano · 2016
  35. Alcoholic Liver Disease Accelerates Early Hepatocellular Cancer in a Mouse Model
    Szabo, Gyongyi · 2018 · Advances in Experimental Medicine and Biology
  36. Targeting macrophages in liver fibrosis
    González del Barrio, Lydia, Ipsen, David H., Pfister, Dominik R., Hancz, Dora, Scott, Charlotte L. · 2026 · Frontiers in Immunology
  37. Mechanisms, efficacy, and future perspectives of cellular-based therapies for liver fibrosis/cirrhosis: focusing on mesenchymal stromal cells
    Pan, Xuan, Gao, Tianyun, Wang, Bin · 2025 · Cell &amp; Bioscience