Cited by 297Peroxisome Proliferator-Activated ReceptorsLipid metabolism and biosynthesisNatural Antidiabetic Agents Studies

Improvement of Obesity and Glucose Tolerance by Acetate in Type 2 Diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) Rats

YAMASHITA, Hiromi, FUJISAWA, Katsuhiko, ITO, Erina, IDEI, Seika, KAWAGUCHI, Nobuyo, KIMOTO, Masumi, HIEMORI, Miki, TSUJI, Hideaki·2007·Bioscience, Biotechnology, and Biochemistry

Abstract

Acetate has been found to have an inhibitory effect on the activity of carbohydrate-responsive element-binding protein (ChREBP) in cultured hepatocytes, this being a transcription factor that regulates several genes required for the conversion of glucose to fatty acids in the liver. The aim of this study was to investigate whether an oral administration of acetate would contribute to reducing lypogenic genes and protecting against obesity. We orally injected 5.2 mg/kg BW of acetate to obesity-linked type 2 diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats. The treatment with acetate showed a marked reduction in lipid accumulation in the adipose tissue, protection against accumulation of fat in the liver, and improved glucose tolerance. An analysis by Northern blotting revealed that the transcripts of several lipogenic genes in the liver of OLETF rats were decreased by the acetate treatment. On the basis of those results, it was indicated that acetate was a potential compound to improve obesity and obesity-linked type 2 diabetes.

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Crossref · 10.1271/bbb.60668

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  • Acetic acid downregulates the expression of lipogenic genes through the activation of AMPK, subsequently inducing diminution of fatty acid synthase and Acetyl-CoA carboxylase levels.

    “It has been shown that the acetic acid downregulates the expression of lipogenic genes through the activation of AMPK, subsequently inducing diminution of fatty acid synthase and Acetyl-CoA carboxylase levels [95,96].”

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Authors
YAMASHITA, H., FUJISAWA, K., ITO, E., IDEI, S., KAWAGUCHI, N., KIMOTO, M., HIEMORI, M., & TSUJI, H.
Affiliations
Okayama Prefectural University (JP)
Venue
Bioscience, Biotechnology, and Biochemistry
Published
2007-05-23
Volume
71
Issue
5
Pages
1236-1243
ISSN
  • 0916-8451 (ISSN-L)
  • 1347-6947
OpenAlex
W2031776562
Cited by
297
References
30
Citations by year
2026: 8 · 2025: 17 · 2024: 35 · 2023: 22 · 2022: 21 · 2021: 30 · 2020: 44 · 2019: 13 · 2018: 23 · 2017: 11 · 2016: 22 · 2015: 16 · 2014: 12 · 2013: 6 · 2012: 3
FWCI
1.32
Type
journal article
Language
en
Open access
closed
Locations
  • Bioscience Biotechnology and Biochemistry (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Otsuka Pharmaceutical
  • Japan Society for the Promotion of Science
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
Keywords
acetate, obesity, glucose tolerance, type 2 diabetes, OLETF rats, ChREBP, lipogenic genes, hepatic lipid accumulation, oral administration, hepatocytes
MeSH terms
Acetates, Animals, Blood Glucose, Body Weight, Cholesterol, Diabetes Mellitus, Type 2, Glucose Tolerance Test, Insulin, Lipids, Male, Models, Biological, Obesity, Random Allocation, RNA, Messenger, Time Factors, Triglycerides, Rats, Inbred OLETF, Leptin, Rats

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