Improvement of Obesity and Glucose Tolerance by Acetate in Type 2 Diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) Rats
Abstract
Acetate has been found to have an inhibitory effect on the activity of carbohydrate-responsive element-binding protein (ChREBP) in cultured hepatocytes, this being a transcription factor that regulates several genes required for the conversion of glucose to fatty acids in the liver. The aim of this study was to investigate whether an oral administration of acetate would contribute to reducing lypogenic genes and protecting against obesity. We orally injected 5.2 mg/kg BW of acetate to obesity-linked type 2 diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats. The treatment with acetate showed a marked reduction in lipid accumulation in the adipose tissue, protection against accumulation of fat in the liver, and improved glucose tolerance. An analysis by Northern blotting revealed that the transcripts of several lipogenic genes in the liver of OLETF rats were decreased by the acetate treatment. On the basis of those results, it was indicated that acetate was a potential compound to improve obesity and obesity-linked type 2 diabetes.
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Acetic acid downregulates the expression of lipogenic genes through the activation of AMPK, subsequently inducing diminution of fatty acid synthase and Acetyl-CoA carboxylase levels.
“It has been shown that the acetic acid downregulates the expression of lipogenic genes through the activation of AMPK, subsequently inducing diminution of fatty acid synthase and Acetyl-CoA carboxylase levels [95,96].”
From Fruits Vinegar: Quality Characteristics, Phytochemistry, and Functionality (2021) · cites this paper as [96]
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- Authors
- YAMASHITA, H., FUJISAWA, K., ITO, E., IDEI, S., KAWAGUCHI, N., KIMOTO, M., HIEMORI, M., & TSUJI, H.
- Affiliations
- Okayama Prefectural University (JP)
- Venue
- Bioscience, Biotechnology, and Biochemistry
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-05-23
- Volume
- 71
- Issue
- 5
- Pages
- 1236-1243
- ISSN
- 0916-8451 (ISSN-L)
- 1347-6947
- OpenAlex
- W2031776562
- Cited by
- 297
- References
- 30
- Citations by year
- 2026: 8 · 2025: 17 · 2024: 35 · 2023: 22 · 2022: 21 · 2021: 30 · 2020: 44 · 2019: 13 · 2018: 23 · 2017: 11 · 2016: 22 · 2015: 16 · 2014: 12 · 2013: 6 · 2012: 3
- FWCI
- 1.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Bioscience Biotechnology and Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Otsuka Pharmaceutical
- Japan Society for the Promotion of Science
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Keywords
- acetate, obesity, glucose tolerance, type 2 diabetes, OLETF rats, ChREBP, lipogenic genes, hepatic lipid accumulation, oral administration, hepatocytes
- MeSH terms
- Acetates, Animals, Blood Glucose, Body Weight, Cholesterol, Diabetes Mellitus, Type 2, Glucose Tolerance Test, Insulin, Lipids, Male, Models, Biological, Obesity, Random Allocation, RNA, Messenger, Time Factors, Triglycerides, Rats, Inbred OLETF, Leptin, Rats
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