Inflammatory theory of depression
Open accessAbstract
Brain diseases are one of the most socially and economically burdening diseases in Europe. Among all brain diseases, more than 60% of social and economic costs are generated by mental disorders (mainly depressive disorders and anxiety disorders). Recurrent depressive disorders have been a significant civilizational problem in recent times. Among the biological and psychological theories explaining the causes of depression, the hypothesis involving an active inflammatory process taking place in a human organism is becoming increasingly important. The following are considered inflammation markers: inflammatory enzymes (e.g., manganese superoxide dismutase (MnSOD), myeloperoxidase (MPO), inducible nitric oxide synthase), proinflammatory and anti-inflammatory cytokines, and the phenomenon of oxidative stress. Through the kynurenine pathway, these factors lead to a deficit in serotonin and melatonin, which is considered one of the main reasons of depression. We can consider depression to be a chronic cold of the organism, which develops in response to the action of greater or smaller everyday stressors. This paper presents results of recent studies regarding this matter.
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Recent evidence suggests a possible role of immune dysregulation in the etiopathogenesis of depression.
“Furthermore, recent evidence suggested a possible role of immune dysregulation in the etiopathogenesis of depression [13,14,15,16].”
From C-Reactive protein as a biomarker for major depressive disorder? (2022) · cites this paper as [13]
According to the World Health Organization, stress-induced chronic diseases are the leading cause of death in developed countries.
“According to the World Health Organization, stress-induced chronic diseases are the leading cause of death in developed countries [1,2,3].”
From Comprehensive review of chronic stress pathways and the efficacy of behavioral stress reduction programs (BSRPs) in managing diseases. (2024) · cites this paper as [1]
Patients with somatic symptom disorder who underwent BSRP showed significant reductions in depression, anxiety, stress, and physical symptoms compared to controls.
“Similarly, patients with somatic symptom disorder (SSD) who underwent BSRP showed significant reductions in depression, anxiety, stress, and physical symptoms, compared to controls [1,70,71].”
From Comprehensive review of chronic stress pathways and the efficacy of behavioral stress reduction programs (BSRPs) in managing diseases. (2024) · cites this paper as [1]
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- Authors
- Gałecki, P., & Talarowska, M.
- Affiliations
- Medical University of Lodz (PL)
- Venue
- Psychiatria Polska
- Published
- 2018-06-30
- Volume
- 52
- Issue
- 3
- Pages
- 437-447
- ISSN
- 0033-2674 (ISSN-L)
- 2391-5854
- OpenAlex
- W2810602662
- Cited by
- 192
- References
- 46
- Citations by year
- 2026: 14 · 2025: 23 · 2024: 31 · 2023: 43 · 2022: 25 · 2021: 30 · 2020: 14 · 2019: 12
- FWCI
- 4.43
- Type
- journal article
- Language
- pl
- Open access
- diamond
- doi.org
- Licence
- Locations
- Psychiatria Polska (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- depression, neuroinflammation, inflammatory markers, oxidative stress, cytokines, manganese superoxide dismutase, myeloperoxidase, inducible nitric oxide synthase, kynurenine pathway, serotonin, melatonin, chronic stress, recurrent depression
- MeSH terms
- Depressive Disorder, Humans, Inflammation, Stress, Psychological, Cytokines
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