Cited by 192Tryptophan and brain disordersStress Responses and CortisolTreatment of Major Depression

Inflammatory theory of depression

Open access
Gałecki, Piotr, Talarowska, Monika·2018·Psychiatria Polska

Abstract

Brain diseases are one of the most socially and economically burdening diseases in Europe. Among all brain diseases, more than 60% of social and economic costs are generated by mental disorders (mainly depressive disorders and anxiety disorders). Recurrent depressive disorders have been a significant civilizational problem in recent times. Among the biological and psychological theories explaining the causes of depression, the hypothesis involving an active inflammatory process taking place in a human organism is becoming increasingly important. The following are considered inflammation markers: inflammatory enzymes (e.g., manganese superoxide dismutase (MnSOD), myeloperoxidase (MPO), inducible nitric oxide synthase), proinflammatory and anti-inflammatory cytokines, and the phenomenon of oxidative stress. Through the kynurenine pathway, these factors lead to a deficit in serotonin and melatonin, which is considered one of the main reasons of depression. We can consider depression to be a chronic cold of the organism, which develops in response to the action of greater or smaller everyday stressors. This paper presents results of recent studies regarding this matter.

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Crossref · 10.12740/pp/76863

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Authors
Gałecki, P., & Talarowska, M.
Affiliations
Medical University of Lodz (PL)
Venue
Psychiatria Polska
Published
2018-06-30
Volume
52
Issue
3
Pages
437-447
ISSN
  • 0033-2674 (ISSN-L)
  • 2391-5854
OpenAlex
W2810602662
Cited by
192
References
46
Citations by year
2026: 14 · 2025: 23 · 2024: 31 · 2023: 43 · 2022: 25 · 2021: 30 · 2020: 14 · 2019: 12
FWCI
4.43
Type
journal article
Language
pl
Open access
Locations
  • Psychiatria Polska (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Keywords
depression, neuroinflammation, inflammatory markers, oxidative stress, cytokines, manganese superoxide dismutase, myeloperoxidase, inducible nitric oxide synthase, kynurenine pathway, serotonin, melatonin, chronic stress, recurrent depression
MeSH terms
Depressive Disorder, Humans, Inflammation, Stress, Psychological, Cytokines

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