Cited by 236Effects and risks of endocrine disrupting chemicalsEstrogen and related hormone effectsReproductive Biology and Fertility

The DOI matches its Crossref record; 79 of the 79 references it cites were found in a registry or an index.

Prenatal Exposure to Bisphenol A at Environmentally Relevant Doses Adversely Affects the Murine Female Reproductive Tract Later in Life

Open access

Newbold, Retha R., Jefferson, Wendy N., Padilla-Banks, Elizabeth·2009·Environmental Health Perspectives

DOI 10.1289/ehp.0800045PMC PMC2702400

Open this paper in CoChat — free account Open PDF

Abstract

Background: Exposure to endocrine-disrupting chemicals during critical developmental periods causes adverse consequences later in life; an example is prenatal exposure to the pharmaceutical diethylstilbestrol (DES). Bisphenol A (BPA), an environmental estrogen used in the synthesis of plastics, is of concern because its chemical structure resembles that of DES, and it is a “high-volume production” chemical with widespread human exposure. Objectives: In this study we investigated whether prenatal BPA causes long-term adverse effects in female reproductive tissues in an experimental animal model previously shown useful in studying effects of prenatal DES. Methods: Timed pregnant CD-1 mice were treated on days 9–16 of gestation with BPA (0.1, 1, 10, 100, or 1,000 μg/kg/day). After delivery, pups were held for 18 months; reproductive tissues were then evaluated. Results: Ovarian cysts were significantly increased in the 1-μg/kg BPA group; ovarian cyst-adenomas were seen in the other three BPA-treated groups but not in corn-oil controls. We observed increased progressive proliferative lesions of the oviduct after BPA treatment, similar to those described in response to DES. Further, although not statistically different from the controls, prominent mesonephric (Wolffian) remnants and squamous metaplasia of the uterus, as well as vaginal adenosis, were present in BPA-treated mice, similar to lesions reported following DES treatment. More severe pathologies observed in some BPA-treated animals included atypical hyperplasia and stromal polyps of the uterus; sarcoma of the uterine cervix; and mammary adenocarcinoma. We did not observe these lesions in controls. Conclusions: These data suggest that BPA causes long-term adverse reproductive and carcinogenic effects if exposure occurs during critical periods of differentiation.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1289/ehp.0800045

Cites

79 of 79 references verified0 citation errors · 0 not checkable

Statistics

Figure 1 Photomicrographs of representative examples of abnormalities (H&E-stained tissue sections) in mice prenatally treated with BPA. (A) Cystadenoma of the ovary (BPA-100) composed of anastomosing papillary fronds (arrow). (B) Adenomatous hyperplasia and CEH (arrow) in the uterus (BPA-1), characterized by hyperplastic endometrial glands and foci of cystic dilated glands lined by flattened epithelium; some secretory material is present in the lumen of some glands. (C) Higher magnification of (B) showing hyperplastic endometrial glands lined by cells with regularly shaped nuclei with little to no cellular pleomorphism or mitotic activity. (D) Atypical hyperplasia in the uterus (BPA-0.1) composed of foci of irregularly shaped glands with little intervening stroma (arrows). (E) Higher magnification of (D) shows “piling up” of cells (arrows) with hyperchromatic nuclei and many mitotic figures. (F) Endometrial polyps (P) extending into the uterine lumen (BPA-1).CC0 · PubMed Central

Figure 2 Photomicrographs of abnormalities in H&E-stained tissue sections from mice prenatally treated with BPA. (A) Endometrial stromal polyp (P) extending into the uterine lumen (BPA-10); note areas of CEH (arrow) with secretory material in glands. (B) Endometrial stromal sarcoma that has infiltrated into the uterine cervix (BPA-100). The lesion is composed of cells with pleomorphic nuclei with a moderate amount of mitotic activity; foci of inflammatory cells are indicated by the arrow. (C) Vaginal adenosis in tissue (BPA-1000) shows foci of “glandular structures” (G) lined by simple cuboidal to columnar epithelium. In one area, these “glands” were lined by squamous epithelium with keratinizing cells in the lumen (arrow); some of these glandular structures connected with the vaginal lumen (L), which is lined by stratified squamous epithelium. (D) Higher magnification of of vaginal adenosis in (C) showing glandular structures that connect to the squamous epithelium lining the vaginal lumen. (E) Mammary adenocarcinoma (BPA-1000) is a large solid tumor that has invaded the entire mammary structure and underlying muscle. (F) Higher magnification of (E) showing mammary adenocarcinoma composed of irregular shaped glands and pleomorphic cells with hyperchromatic nuclei.CC0 · PubMed Central

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Human exposure to bisphenol A (BPA)
Vandenberg, L. N., Hauser, R. B., Marcus, M., Olea, N., & Welshons, W. V. (2007) · Reproductive Toxicology · doi:10.1016/j.reprotox.2007.07.010 · Cited by 2,984
Exposure of the U.S. Population to Bisphenol A and 4- tertiary -Octylphenol: 2003–2004
Calafat, A. M., Ye, X., Wong, L.-Y., Reidy, J. A., & Needham, L. L. (2008) · Environmental Health Perspectives · doi:10.1289/ehp.10753 · Cited by 1,743
Estrogenicity of Resin-Based Composites and Sealants Used in Dentistry
Olea, N., Pulgar, R., Pérez, P., Olea‐Serrano, F., Rivas, A., Novillo-Fertrell, A., Pedraza, V., Soto, A. M., & Sonnenschein, C. (1996) · Environmental Health Perspectives · doi:10.1289/ehp.96104298 · Cited by 1,041
Xenoestrogens Released from Lacquer Coatings in Food Cans
Brotons, J. A., Olea‐Serrano, F., Villalobos, M., Pedraza, V., & Olea, N. (1995) · Environmental Health Perspectives · doi:10.1289/ehp.95103608 · Cited by 942
Fetal Origins of Obesity
Oken, E., & Gillman, M. W. (2003) · Obesity Research · doi:10.1038/oby.2003.69 · Cited by 929
In vitro molecular mechanisms of bisphenol A action.
Wetherill, Y. B., Akingbemi, B. T., Kanno, J., McLachlan, J. A., Nadal, A., Sonnenschein, C., Watson, C. S., Zoeller, R. T., & Belcher, S. M. (2007) · Reproductive Toxicology · doi:10.1016/j.reprotox.2007.05.010 · Cited by 920
Exposure to bisphenol A advances puberty
Howdeshell, K. L., Hotchkiss, A. K., Thayer, K. A., Vandenbergh, J. G., & vom Saal, F. S. (1999) · Nature · doi:10.1038/44517 · Cited by 820
Environmental Obesogens: Organotins and Endocrine Disruption via Nuclear Receptor Signaling
Grün, F., & Blumberg, B. (2006) · Endocrinology · doi:10.1210/en.2005-1129 · Cited by 812
Developmental Exposure to Estradiol and Bisphenol A Increases Susceptibility to Prostate Carcinogenesis and Epigenetically Regulates Phosphodiesterase Type 4 Variant 4
Ho, S.-M., Tang, W.-Y., Belmonte de Frausto, J., & Prins, G. S. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-0516 · Cited by 796
Prostate enlargement in mice due to fetal exposure to low doses of estradiol or diethylstilbestrol and opposite effects at high doses
Saal, F. S. V., Timms, B. G., Montano, M. M., Palanza, P., Thayer, K. A., Nagel, S. C., Dhar, M. D., Ganjam, V. K., Parmigiani, S., & Welshons, W. V. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.5.2056 · Cited by 701

Show all 79 references

Research works printed but not linked: 4

Bern, 1992, The Fragil Fetus
Davis, 1999, Ovary, Oviduct, Uterus, and Vagina.
NIH, 1999, DES Research Update: Current Knowledge, Future Directions
NTP, 2008, CEHR Brief on Bisphenol A

Sorted by citations

EDC-2: the endocrine society's second scientific statement on endocrine-disrupting chemicals
Gore, A. C., Chappell, V. A., Fenton, S. E., Flaws, J. A., Nadal, A., Prins, G. S., Toppari, J., & Zoeller, R. T. (2015) · Endocrine Reviews · doi:10.1210/er.2015-1010 · Cited by 2,407
Endocrine-Disrupting Chemicals and Public Health Protection: A Statement of Principles from The Endocrine Society
Zoeller, R. T., Brown, T. R., Doan, L. L., Gore, A. C., Skakkebæk, N. E., Soto, A. M., Woodruff, T. J., & Saal, F. S. V. (2012) · Endocrinology · doi:10.1210/en.2012-1422 · Cited by 1,185
Bisphenol A (BPA) in China: A review of sources, environmental levels, and potential human health impacts
Huang, Y., Wong, C. K. C., Zheng, J., Bouwman, H., Barra, R. O., Wahlström, B. A., Neretin, L. N., & Wong, M. H. (2011) · Environment International · doi:10.1016/j.envint.2011.04.010 · Cited by 1,148
Scientific Opinion on the risks to public health related to the presence of bisphenol A (BPA) in foodstuffs
EFSA Panel on Food Contact Materials, E. (2015) · EFSA Journal · doi:10.2903/j.efsa.2015.3978 · Cited by 1,075
Scientific Statement on the Diagnostic Criteria, Epidemiology, Pathophysiology, and Molecular Genetics of Polycystic Ovary Syndrome
Dumesic, D. A., Oberfield, S. E., Stener-Victorin, E., Marshall, J. C., Laven, J. S., & Legro, R. S. (2015) · Endocrine Reviews · doi:10.1210/er.2015-1018 · Cited by 1,020
Review of ‘emerging’ organic contaminants in biosolids and assessment of international research priorities for the agricultural use of biosolids
Clarke, B. O., & Smith, S. R. (2010) · Environment International · doi:10.1016/j.envint.2010.06.004 · Cited by 854
Prenatal environmental exposures, epigenetics, and disease
Perera, F. P., & Herbstman, J. B. (2011) · Reproductive Toxicology · doi:10.1016/j.reprotox.2010.12.055 · Cited by 666
Bisphenol A and Reproductive Health: Update of Experimental and Human Evidence, 2007–2013
Peretz, J., Vrooman, L., Ricke, W. A., Hunt, P. A., Ehrlich, S., Hauser, R., Padmanabhan, V., Taylor, H. S., Swan, S. H., VandeVoort, C. A., et al. (2014) · Environmental Health Perspectives · doi:10.1289/ehp.1307728 · Cited by 555
Acute Toxicity, Teratogenic, and Estrogenic Effects of Bisphenol A and Its Alternative Replacements Bisphenol S, Bisphenol F, and Bisphenol AF in Zebrafish Embryo-Larvae
Moreman, J., Lee, O., Trznadel, M., David, A., Kudoh, T., & Tyler, C. R. (2017) · Environmental Science & Technology · doi:10.1021/acs.est.7b03283 · Cited by 528
Bisphenol A: Food Exposure and Impact on Human Health
Almeida, S., Raposo, A., Almeida‐González, M., & Carrascosa, C. (2018) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12388 · Cited by 518
A review of the carcinogenic potential of bisphenol A
Seachrist, D. D., Bonk, K. W., Ho, S., Prins, G. S., Soto, A. M., & Keri, R. A. (2015) · Reproductive Toxicology · doi:10.1016/j.reprotox.2015.09.006 · Cited by 504
Structural and Mechanistic Insights into Bisphenols Action Provide Guidelines for Risk Assessment and Discovery of Bisphenol A Substitutes
Delfosse, V., Grimaldi, M., Pons, J.-L., Boulahtouf, A., le Maire, A., Cavailles, V., Labesse, G., Bourguet, W., & Balaguer, P. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1203574109 · Cited by 405
Endocrine Disruptors and Polycystic Ovary Syndrome (PCOS): Elevated Serum Levels of Bisphenol A in Women with PCOS
Kandaraki, E., Chatzigeorgiou, A., Livadas, S., Palioura, E., Economou, F., Koutsilieris, M., Palimeri, S., Panidis, D., & Diamanti‐Kandarakis, E. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-1658 · Cited by 402
Critical evaluation of key evidence on the human health hazards of exposure to bisphenol A
Hengstler, J. G., Foth, H., Gebel, T., Kramer, P.-J., Lilienblum, W., Schweinfurth, H., Völkel, W., Wollin, K., & Gundert‐Remy, U. (2011) · Critical Reviews in Toxicology · doi:10.3109/10408444.2011.558487 · Cited by 348
Effects of bisphenol A and its analogs on reproductive health: A mini review
Siracusa, J. S., Yin, L., Measel, E., Liang, S., & Yu, X. (2018) · Reproductive Toxicology · doi:10.1016/j.reprotox.2018.06.005 · Cited by 343
Transfer of bisphenol A across the human placenta
Balakrishnan, B., Henare, K., Thorstensen, E. B., Ponnampalam, A. P., & Mitchell, M. D. (2010) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2010.01.025 · Cited by 304
Peroxisome Proliferator-Activated Receptor γ Is a Target for Halogenated Analogs of Bisphenol A
Riu, A., Grimaldi, M., le Maire, A., Bey, G., Phillips, K. J., Boulahtouf, A., Perdu-Durand, E., Zalko, D., Bourguet, W., & Balaguer, P. (2011) · Environmental Health Perspectives · doi:10.1289/ehp.1003328 · Cited by 315
Exposure to endocrine disrupting compounds via the food chain: Is packaging a relevant source?
Muncke, J. (2009) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2009.05.006 · Cited by 313
Neuro-toxic and Reproductive Effects of BPA
Santoro, A., Chianese, R., Troisi, J., Richards, S. M., Nori, S. L., Fasano, S., Guida, M., Plunk, E. C., Viggiano, A., Pierantoni, R., et al. (2019) · Current Neuropharmacology · doi:10.2174/1570159x17666190726112101 · Cited by 288
Health risk of exposure to Bisphenol A (BPA).
Konieczna, A., Rutkowska, A. Z., & Rachoń, D. (2015) · PubMed · Cited by 283
Bisphenol A: an emerging threat to female fertility
Pivonello, C., Muscogiuri, G., Nardone, A., Garifalos, F., Provvisiero, D. P., Verde, N., de Angelis, C., Conforti, A., Piscopo, M., Auriemma, R. S., et al. (2020) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-019-0558-8 · Cited by 263
Evidence for bisphenol A-induced female infertility: a review (2007–2016)
Ziv‐Gal, A., & Flaws, J. A. (2016) · Fertility and Sterility · doi:10.1016/j.fertnstert.2016.06.027 · Cited by 247
Physical and Chemical Sensors on the Basis of Laser-Induced Graphene: Mechanisms, Applications, and Perspectives
Zhu, J., Huang, X. L., & Song, W. (2021) · ACS Nano · doi:10.1021/acsnano.1c05806 · Cited by 240
Low dose effects of bisphenol A
Vandenberg, L. N., Ehrlich, S. R., Belcher, S. M., Ben‐Jonathan, N., Dolinoy, D. C., Hugo, E. R., Hunt, P. A., Newbold, R. R., Rubin, B. S., Saili, K. S., et al. (2013) · Endocrine Disruptors · doi:10.4161/endo.26490 · Cited by 244
Self-citation
Human Excretion of Bisphenol A: Blood, Urine, and Sweat (BUS) Study
Genuis, S. J., Beesoon, S., Birkholz, D., & Lobo, R. A. (2011) · Journal of Environmental and Public Health · doi:10.1155/2012/185731 · Cited by 230
Female Reproductive Disorders, Diseases, and Costs of Exposure to Endocrine Disrupting Chemicals in the European Union
Hunt, P. A., Sathyanarayana, S., Fowler, P., & Trasande, L. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-2873 · Cited by 205
Estrogenic Endocrine-Disrupting Chemicals: Molecular Mechanisms of Actions on Putative Human Diseases
Yoon, K., Kwack, S. J., Kim, H. S., & Lee, B. (2014) · Journal of Toxicology and Environmental Health Part B · doi:10.1080/10937404.2014.882194 · Cited by 188
The Impact of Bisphenol A on Fertility, Reproductive System, and Development: A Review of the Literature
Matuszczak, E., Komarowska, M., Dębek, W., & Hermanowicz, A. (2019) · International Journal of Endocrinology · doi:10.1155/2019/4068717 · Cited by 188
Exposure to modern, widespread environmental endocrine disrupting chemicals and their effect on the reproductive potential of women: an overview of current epidemiological evidence
Karwacka, A., Zamkowska, D., Radwan, M., & Jurewicz, J. (2017) · Human Fertility · doi:10.1080/14647273.2017.1358828 · Cited by 187
Bisphenol A concentrations in human urine, human intakes across six continents, and annual trends of average intakes in adult and child populations worldwide: A thorough literature review
Huang, R.-P., Liu, Z., Yin, H., Dang, Z., Wu, P., Zhu, N., & Lin, Z. (2018) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2018.01.144 · Cited by 184
Low‐Dose Bisphenol A Exposure: A Seemingly Instigating Carcinogenic Effect on Breast Cancer
Wang, Z., Liu, H., & Liu, S. (2016) · Advanced Science · doi:10.1002/advs.201600248 · Cited by 189
Disruption of adult expression of sexually selected traits by developmental exposure to bisphenol A
Jašarević, E., Sieli, P. T., Twellman, E. E., Welsh, T. H., Schachtman, T. R., Roberts, R. M., Geary, D. C., & Rosenfeld, C. S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1107958108 · Cited by 183
A comprehensive review on the carcinogenic potential of bisphenol A: clues and evidence
Khan, N. G., Correia, J., Adiga, D., Satwadi, P. R., Dsouza, H. S., Chakrabarty, S., & Kabekkodu, S. P. (2021) · Environmental Science and Pollution Research · doi:10.1007/s11356-021-13071-w · Cited by 177
Synergistic activation of human pregnane X receptor by binary cocktails of pharmaceutical and environmental compounds
Delfosse, V., Dendelé, B., Huet, T., Grimaldi, M., Boulahtouf, A., Gerbal‐Chaloin, S., Beucher, B., Roecklin, D., Muller, C., Rahmani, R., et al. (2015) · Nature Communications · doi:10.1038/ncomms9089 · Cited by 170
Nonproliferative and Proliferative Lesions of the Rat and Mouse Female Reproductive System
Dixon, D., Alison, R., Bach, U. C., Colman, K., Foley, G. L., Harleman, J. H., Haworth, R., Herbert, R., Heuser, A., Long, G. G., et al. (2014) · Journal of Toxicologic Pathology · doi:10.1293/tox.27.1s · Cited by 169
DNA methylation: a mechanism linking environmental chemical exposures to risk of autism spectrum disorders?
Keil, K. P., & Lein, P. J. (2016) · Environmental Epigenetics · doi:10.1093/eep/dvv012 · Cited by 167
Endocrine disrupting chemical Bisphenol A and its potential effects on female health
Kawa, I. A., Masood, A., Fatima, Q., Mir, S. A., Jeelani, H., Manzoor, S., & Rashid, F. (2021) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2021.03.031 · Cited by 167
Epigenetic effects of endocrine-disrupting chemicals on female reproduction: An ovarian perspective
Zama, A. M., & Uzumcu, M. (2010) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2010.06.003 · Cited by 168
Microplastics and pollutants in biosolids have contaminated agricultural soils: An analytical study and a proposal to cease the use of biosolids in farmlands and utilise them in sustainable bricks
Mohajerani, A., & Karabatak, B. (2020) · Waste Management · doi:10.1016/j.wasman.2020.04.021 · Cited by 164
Environmental Estrogens Differentially Engage the Histone Methyltransferase EZH2 to Increase Risk of Uterine Tumorigenesis
Greathouse, K. L., Bredfeldt, T., Everitt, J. I., Lin, K., Berry, T., Kannan, K., Mittelstadt, M. L., Ho, S., & Walker, C. L. (2012) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-11-0605 · Cited by 161
Perinatal Exposure to Bisphenol-A and the Development of Metabolic Syndrome in CD-1 Mice
Ryan, K. K., Haller, A. M., Sorrell, J. E., Woods, S. C., Jandacek, R. J., & Seeley, R. J. (2010) · Endocrinology · doi:10.1210/en.2009-1218 · Cited by 163
Bisphenol A Increases Mammary Cancer Risk in Two Distinct Mouse Models of Breast Cancer
Lozada, K. W., & Keri, R. A. (2011) · Biology of Reproduction · doi:10.1095/biolreprod.110.090431 · Cited by 151
Characterization of Novel Ligands of ERα, Erβ, and PPARγ: The Case of Halogenated Bisphenol A and Their Conjugated Metabolites
Riu, A., le Maire, A., Grimaldi, M., Audebert, M., Hillenweck, A., Bourguet, W., Balaguer, P., & Zalko, D. (2011) · Toxicological Sciences · doi:10.1093/toxsci/kfr132 · Cited by 149
Laser induced graphene for biosensors
Wan, Z., Nguyen, N., Gao, Y., & Li, Q. (2020) · Sustainable materials and technologies · doi:10.1016/j.susmat.2020.e00205 · Cited by 151
Comparative study on ferrate oxidation of BPS and BPAF: Kinetics, reaction mechanism, and the improvement on their biodegradability
Yang, T., Wang, L., Liu, Y.-L., Huang, Z., He, H., Wang, X., Jiang, J., Gao, D., & Ma, J. (2018) · Water Research · doi:10.1016/j.watres.2018.10.018 · Cited by 136
Bisphenol A Exposure during Adulthood Causes Augmentation of Follicular Atresia and Luteal Regression by Decreasing 17β-Estradiol Synthesis via Downregulation of Aromatase in Rat Ovary
Lee, S. G., Kim, J. Y., Chung, J., Kim, Y. J., Park, J., Oh, S., Yoon, Y., Yoo, K. S., Yoo, Y. H., & Kim, J. (2013) · Environmental Health Perspectives · doi:10.1289/ehp.1205823 · Cited by 134
Pre-natal exposure of mice to bisphenol A elicits an endometriosis-like phenotype in female offspring
Signorile, P. G., Spugnini, E. P., Mita, L., Mellone, P., D’Avino, A., Bianco, M., Diano, N., Caputo, L., Rea, F., Viceconte, R., et al. (2010) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2010.03.030 · Cited by 136
Bisphenol A Sensors on Polyimide Fabricated by Laser Direct Writing for Onsite River Water Monitoring at Attomolar Concentration
Cheng, C., Wang, S., Wu, J. J., Yu, Y., Li, R., Eda, S., Chen, J., Feng, G., Lawrie, B. J., & Hu, A. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b03743 · Cited by 132
Bisphenol a and the female reproductive tract: an overview of recent laboratory evidence and epidemiological studies
Caserta, D., Segni, N. D., Mallozzi, M., Giovanale, V., Mantovani, A., Marci, R., & Moscarini, M. (2014) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-12-37 · Cited by 128
Human infertility: are endocrine disruptors to blame?
Marques-Pinto, A., & Carvalho, D. M. (2013) · Endocrine Connections · doi:10.1530/ec-13-0036 · Cited by 129
Bisphenol-A and Female Infertility: A Possible Role of Gene-Environment Interactions
Huo, X., Chen, D., He, Y., Zhu, W., Zhou, W., & Zhang, J. (2015) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph120911101 · Cited by 130
Preimplantation exposure to bisphenol A (BPA) affects embryo transport, preimplantation embryo development, and uterine receptivity in mice
Xiao, S., Diao, H., Smith, M. A., Song, X., & Ye, X. (2011) · Reproductive Toxicology · doi:10.1016/j.reprotox.2011.08.010 · Cited by 126
Effects of early prepubertal exposure to bisphenol A on the onset of puberty, ovarian weights, and estrous cycle in female mice
Nah, W. H., Park, M. J., & Gye, M. C. (2011) · Daehan saengsik uihak hoeji/Clinical and experimental reproductive medicine · doi:10.5653/cerm.2011.38.2.75 · Cited by 125
Effects of endocrine disruptors in the development of the female reproductive tract
Costa, E. M. F., Spritzer, P. M., Hohl, A., & Bachega, T. A. S. S. (2014) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/0004-2730000003031 · Cited by 125
The Impact of External Factors on the Epigenome:In Uteroand over Lifetime
Toraño, E. G., García, M. G., Fernández-Morera, J. L., García, P. N., & Fernández, A. F. (2016) · BioMed Research International · doi:10.1155/2016/2568635 · Cited by 130
Effect of bisphenol A on reproductive processes: A review of in vitro, in vivo and epidemiological studies
Tomza–Marciniak, A., Stępkowska, P., Kuba, J., & Pilarczyk, B. (2017) · Journal of Applied Toxicology · doi:10.1002/jat.3480 · Cited by 123
High Levels of Bisphenol A in Paper Currencies from Several Countries, and Implications for Dermal Exposure
Liao, C., & Kannan, K. (2011) · Environmental Science & Technology · doi:10.1021/es200977t · Cited by 122
Neonatal Exposure to Bisphenol A Alters Rat Uterine Implantation-Associated Gene Expression and Reduces the Number of Implantation Sites
Varayoud, J., Ramos, J. G., Bosquiazzo, V. L., Lower, M., Muñoz‐de‐Toro, M., & Luque, E. H. (2011) · Endocrinology · doi:10.1210/en.2009-1037 · Cited by 109
The Bisphenol A Experience: A Primer for the Analysis of Environmental Effects on Mammalian Reproduction1
Hunt, P. A., Susiarjo, M., Rubio, C., & Hassold, T. J. (2009) · Biology of Reproduction · doi:10.1095/biolreprod.109.077008 · Cited by 108
Embryologic origin of endometriosis: Analysis of 101 human female fetuses
Signorile, P. G., Baldi, F., Bussani, R., Viceconte, R., Bulzomi, P., D'Armiento, M., D’Avino, A., & Baldi, A. (2011) · Journal of Cellular Physiology · doi:10.1002/jcp.22888 · Cited by 109
Structural and Functional Profiling of Environmental Ligands for Estrogen Receptors
Delfosse, V., Grimaldi, M., Cavaillès, V., Balaguer, P., & Bourguet, W. (2014) · Environmental Health Perspectives · doi:10.1289/ehp.1408453 · Cited by 105
Normal and abnormal epithelial differentiation in the female reproductive tract
Kurita, T. (2011) · Differentiation · doi:10.1016/j.diff.2011.04.008 · Cited by 102
Endocrine Disruptor Chemicals and Children’s Health
Pietro, G. M. D., Forcucci, F., & Chiarelli, F. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032671 · Cited by 103
A systematic review of Bisphenol A “low dose” studies in the context of human exposure: A case for establishing standards for reporting “low-dose” effects of chemicals
Teeguarden, J., & Hanson-Drury, S. (2013) · Food and Chemical Toxicology · doi:10.1016/j.fct.2013.07.007 · Cited by 104
Prenatal and Perinatal Environmental Influences on the Human Fetal and Placental Epigenome
Hogg, K., Price, E. M., Hanna, C. W., & Robinson, W. P. (2012) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2012.141 · Cited by 92
Exposure to Microplastics during Early Developmental Stage: Review of Current Evidence
Amran, N. H., Zaid, S. S. M., Mokhtar, M. H., Manaf, L. A., & Othman, S. (2022) · Toxics · doi:10.3390/toxics10100597 · Cited by 94
New Insights in Pathogenesis of Endometriosis
Signorile, P. G., Viceconte, R., & Baldi, A. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.879015 · Cited by 88
LINE ‐1 hypomethylation in spermatozoa is associated with Bisphenol A exposure
Miao, M., Zhou, X., Li, Y., Zhang, O. G. H., Zhou, Z., Li, T., Yuan, W., Li, R., & Li, D. (2013) · Andrology · doi:10.1111/j.2047-2927.2013.00166.x · Cited by 91
Endocrine Disrupter Bisphenol A Increases In Situ Estrogen Production in the Mouse Urogenital Sinus
Arase, S., Ishii, K., Igarashi, K., Aisaki, K., Yoshio, Y., Matsushima, A., Shimohigashi, Y., Arima, K., Kanno, J., & Sugimura, Y. (2010) · Biology of Reproduction · doi:10.1095/biolreprod.110.087502 · Cited by 86
Bisphenol A, benzophenone-type ultraviolet filters, and phthalates in relation to uterine leiomyoma
Pollack, A. Z., Louis, G. M. B., Chen, Z., Sun, L., Trabert, B. L., Guo, Y., & Kannan, K. (2014) · Environmental Research · doi:10.1016/j.envres.2014.06.028 · Cited by 84
The detrimental effect of microplastics on critical periods of development in the neuroendocrine system
Solleiro-Villavicencio, H., de León, C. T. G., Río‐Araiza, V. H. D., & Morales‐Montor, J. (2020) · Birth Defects Research · doi:10.1002/bdr2.1776 · Cited by 84
Placental concentrations of bisphenol A and birth weight from births in the Southeastern U.S.
Troisi, J., Mikelson, C., Richards, S., Symes, S., Adair, D., Zullo, F., & Guida, M. (2014) · Placenta · doi:10.1016/j.placenta.2014.08.091 · Cited by 82
Polycystic Ovary Syndrome: Do Endocrine-Disrupting Chemicals Play a Role?
Sobolewski, M., & Barrett, E. S. (2014) · Seminars in Reproductive Medicine · doi:10.1055/s-0034-1371088 · Cited by 81
The development of cervical and vaginal adenosis as a result of diethylstilbestrol exposure in utero
Laronda, M. M., Unno, K., Butler, L. M., & Kurita, T. (2012) · Differentiation · doi:10.1016/j.diff.2012.05.004 · Cited by 74
Mixtures of xenoestrogens disrupt estradiol-induced non-genomic signaling and downstream functions in pituitary cells
Viñas, R., & Watson, C. S. (2013) · Environmental Health · doi:10.1186/1476-069x-12-26 · Cited by 74
Bisphenol S instead of bisphenol A: a story of reproductive disruption by regretable substitution - a review
Žalmanová, T., Hošková, K., Nevoral, J., Prokešová, Š., Zámostná, K., Kott, T., & Petr, J. (2016) · Czech Journal of Animal Science · doi:10.17221/81/2015-cjas · Cited by 74
Preferential epigenetic programming of estrogen response after in utero xenoestrogen (bisphenol‐A) exposure
Jorgensen, E. M., Alderman, M. H., & Taylor, H. S. (2016) · The FASEB Journal · doi:10.1096/fj.201500089r · Cited by 75
A green deep eutectic solvents microextraction coupled with acid-base induction for extraction of trace phenolic compounds in large volume water samples
Yang, D., Wang, Y., Peng, J., Xun, C., & Yang, Y. (2019) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2019.04.021 · Cited by 72
BPA and NP removal from municipal wastewater by tropical horizontal subsurface constructed wetlands
Toro-Vélez, A., Madera-Parra, C. A., Peña, M., Lee, W. Y., Bezares-Cruz, J. C., Walker, W. S., Cárdenas, H., Quesada‐Calderón, S., García, H. A., & Lens, P. N. L. (2015) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2015.09.154 · Cited by 69
A multi-generational study on low-dose BPA exposure in Wistar rats: Effects on maternal behavior, flavor intake and development
Boudalia, S., Bergès, R., Chabanet, C., Folia, M., Decocq, L., Pasquis, B., Abdennebi‐Najar, L., & Lavier, M.-C. C. (2013) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2013.11.002 · Cited by 69
Concerning influences of micro/nano plastics on female reproductive health: focusing on cellular and molecular pathways from animal models to human studies
Balali, H., Morabbi, A., & Karimian, M. (2024) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-024-01314-7 · Cited by 71
Endocrine disrupting chemicals promote the growth of ovarian cancer cells via the ER‐CXCL12‐CXCR4 signaling axis
Hall, J. M., & Korach, K. S. (2012) · Molecular Carcinogenesis · doi:10.1002/mc.21913 · Cited by 68
Perturbation of Nuclear Hormone Receptors by Endocrine Disrupting Chemicals: Mechanisms and Pathological Consequences of Exposure
Hall, J. M., & Greco, C. W. (2019) · Cells · doi:10.3390/cells9010013 · Cited by 66
First-Trimester Urinary Bisphenol A Concentration in Relation to Anogenital Distance, an Androgen-Sensitive Measure of Reproductive Development, in Infant Girls
Barrett, E. S., Sathyanarayana, S., Mbowe, O., Thurston, S. W., Redmon, J. B., Nguyen, R. H. N., & Swan, S. H. (2017) · Environmental Health Perspectives · doi:10.1289/ehp875 · Cited by 65
Mouse Oviduct Development
Stewart, C. A., & Behringer, R. R. (2012) · Results and problems in cell differentiation · doi:10.1007/978-3-642-30406-4_14 · Cited by 68
Bisphenol A exposure may increase the risk of development of atopic disorders in children
Wang, I., Chen, C., & Bornehag, C. (2015) · International Journal of Hygiene and Environmental Health · doi:10.1016/j.ijheh.2015.12.001 · Cited by 65
The interference effects of bisphenol A on the synthesis of steroid hormones in human ovarian granulosa cells
Shi, J., Liu, C., Chen, M., Yan, J., Wang, C., Zuo, Z., & He, C. (2020) · Environmental Toxicology · doi:10.1002/tox.23070 · Cited by 67
Effects of in utero exposure to Bisphenol A or diethylstilbestrol on the adult male reproductive system
LaRocca, J. L., Boyajian, A. J., Brown, C. W., Smith, S. D., & Hixon, M. L. (2011) · Birth Defects Research Part B Developmental and Reproductive Toxicology · doi:10.1002/bdrb.20336 · Cited by 64
Bisphenol A in supermarket receipts and its exposure to human in Shenzhen, China
Lu, S., Chang, W., Sojinu, S. O., & Ni, H. (2013) · Chemosphere · doi:10.1016/j.chemosphere.2013.01.096 · Cited by 64
Definition, classification and mechanism of action of endocrine disrupting chemicals
Wuttke, W., Jarry, H., & Seidlová‐Wuttke, D. (2010) · HORMONES · doi:10.1007/bf03401276 · Cited by 63
Bisphenol A and Metabolites in Meat and Meat Products: Occurrence, Toxicity, and Recent Development in Analytical Methods
Siddique, M. A. B., Harrison, S. M., Monahan, F. J., Cummins, E., & Brunton, N. P. (2021) · Foods · doi:10.3390/foods10040714 · Cited by 62
Perinatal bisphenol A exposures increase production of pro-inflammatory mediators in bone marrow-derived mast cells of adult mice
O’Brien, E., Dolinoy, D. C., & Mancuso, P. (2013) · Journal of Immunotoxicology · doi:10.3109/1547691x.2013.822036 · Cited by 62
Rapid estrogenic signaling activities of the modified (chlorinated, sulfonated, and glucuronidated) endocrine disruptor bisphenol A
Viñas, R., Goldblum, R. M., & Watson, C. S. (2013) · Endocrine Disruptors · doi:10.4161/endo.25411 · Cited by 60
Associations between maternal phenolic exposure and cord sex hormones in male newborns
Liu, C., Xu, X., Zhang, Y., Li, W., & Huo, X. (2016) · Human Reproduction · doi:10.1093/humrep/dev327 · Cited by 58
Bisphenol AP is anti-estrogenic and may cause adverse effects at low doses relevant to human exposure
Xiao, X., Li, J., Yu, T., Zhou, L., Fan, X., Xiao, H., Wang, Y., Yang, L., Lv, J., Jia, X., et al. (2018) · Environmental Pollution · doi:10.1016/j.envpol.2018.07.115 · Cited by 58
Administration of bisphenol A to dams during perinatal period modifies molecular and morphological reproductive parameters of the offspring
Mendoza-Rodríguez, C. A., García-Guzmán, M., Baranda-Ávila, N., Morimoto, S., Perrot‐Applanat, M., & Cerbón, M. A. (2010) · Reproductive Toxicology · doi:10.1016/j.reprotox.2010.10.013 · Cited by 57
Developmental low-dose exposure to bisphenol A induces chronic inflammation, bone marrow fibrosis and reduces bone stiffness in female rat offspring only
Lind, T., Lejonklou, M. H., Dunder, L., Kushnir, M. M., Öhman‐Mägi, C., Larsson, S., Melhus, H., & Lind, P. (2019) · Environmental Research · doi:10.1016/j.envres.2019.108584 · Cited by 56
Effects of bisphenol A on ovarian follicular development and female germline stem cells
Zhu, X., Tian, G. G., Yu, B., Yang, Y., & Wu, J. (2018) · Archives of Toxicology · doi:10.1007/s00204-018-2167-2 · Cited by 56
Egr1 is rapidly and transiently induced by estrogen and bisphenol A via activation of nuclear estrogen receptor-dependent ERK1/2 pathway in the uterus
Kim, H.-R., Kim, Y. S., Yoon, J. A., Lyu, S. W., Shin, H., Lim, H. J., Hong, S., Lee, D. R., & Song, H. (2014) · Reproductive Toxicology · doi:10.1016/j.reprotox.2014.10.010 · Cited by 52
From Sewage Sludge to the Soil—Transfer of Pharmaceuticals: A Review
Bolesta, W., Głodniok, M., & Styszko, K. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph191610246 · Cited by 51

Authors: Newbold, R. R., Jefferson, W. N., & Padilla-Banks, E.
Affiliations: National Institutes of Health (US)
Developmental Endocrinology and Endocrine Disruptor Section, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA
Corresponding author: Newbold, Retha R.
ORCID: Jefferson, Wendy N.
Venue: Environmental Health Perspectives
Publisher: American Chemical Society (ACS)
Published: 2009-01-15
Volume: 117
Issue: 6
Pages: 879-885
ISSN: 0091-6765 (ISSN-L)
1552-9924
DOI: 10.1289/ehp.0800045
PMC: PMC2702400
OpenAlex: W2080879610
Cited by: 236
References: 79
Citations by year: 2026: 4 · 2025: 7 · 2024: 8 · 2023: 11 · 2022: 12 · 2021: 17 · 2020: 12 · 2019: 14 · 2018: 15 · 2017: 17 · 2016: 19 · 2015: 19 · 2014: 16 · 2013: 13 · 2012: 13
FWCI: 12.31
Type: journal article
Language: en
Open access: gold
doi.org
Licence: public-domain
creativecommons.org/licenses/by/4.0/ (vor, 3270 d)
Locations: Environmental Health Perspectives (publishedVersion, public-domain)
PubMed Central (publishedVersion, public-domain)
PubMed (publishedVersion)
Funders: Wake Forest University
National Institutes of Health
National Institute of Environmental Health Sciences
Topics: Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
Keywords: bisphenol A, prenatal exposure, endocrine disruptors, female reproductive tract, ovarian cysts, vaginal adenosis, mammary adenocarcinoma, developmental toxicity, diethylstilbestrol
MeSH terms: Bisphenol A Compounds, Animals, Benzhydryl Compounds, Diethylstilbestrol, Female, Ovary, Phenols, Pregnancy, Prenatal Exposure Delayed Effects, Reproduction, Uterus, Water Pollutants, Chemical, Mice, Endocrine Disruptors

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Prenatal Exposure to Bisphenol A at Environmentally Relevant Doses Adversely Affects the Murine Female Reproductive Tract Later in Life

Abstract

Overview

Integrity signals

Figures

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks