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Polycyclic Aromatic Hydrocarbons–Aromatic DNA Adducts in Cord Blood and Behavior Scores in New York City Children

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Perera, Frederica P., Wang, Shuang, Vishnevetsky, Julia, Zhang, Bingzhi, Cole, Kathleen J., Tang, Deliang, Rauh, Virginia, Phillips, David H.·2011·Environmental Health Perspectives
DOI 10.1289/ehp.1002705
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Abstract

BACKGROUND: Airborne polycyclic aromatic hydrocarbons (PAH) are widespread urban pollutants that can bind to DNA to form PAH-DNA adducts. Prenatal PAH exposure measured by personal monitoring has been linked to cognitive deficits in childhood in a prospective study conducted by the Columbia Center for Children's Environmental Health. OBJECTIVES: We measured PAH-DNA and other bulky aromatic adducts in umbilical cord white blood cells using the 32P-postlabeling assay to determine the association between this molecular dosimeter and behavioral/attention problems in childhood. METHODS: Children born to nonsmoking African-American and Dominican women residing in New York City (NYC) were followed from in utero to 7-8 years of age. At two time points before 8 years of age (mean ages, 4.8 years and 7 years), child behavior was assessed using the Child Behavior Checklist (CBCL). To estimate and test the association between adducts and behavioral outcomes, both CBCL continuous raw scores and dichotomized T-scores were analyzed. RESULTS: Higher cord adducts were associated with higher symptom scores of Anxious/Depressed at 4.8 years and Attention Problems at 4.8 and 7 years, and with Diagnostic and Statistical Manual of Mental Disorders, 4th edition-oriented Anxiety Problems at 4.8 years. CONCLUSIONS: These results suggest that PAH exposure, measured by DNA adducts, may adversely affect child behavior, potentially affecting school performance.

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Metadata

Authors
Perera, F. P., Wang, S., Vishnevetsky, J., Zhang, B., Cole, K. J., Tang, D., Rauh, V., & Phillips, D. H.
Venue
Environmental Health Perspectives
Publisher
American Chemical Society (ACS)
Published
2011-08
Volume
119
Issue
8
Pages
1176-1181
ISSN
  • 0091-6765 (ISSN-L)
  • 1552-9924
DOI
10.1289/ehp.1002705
OpenAlex
W2068993609
Cited by
159
References
2
FWCI
9.43
Type
journal article
Language
en
Open access
gold
Licence
creativecommons.org/licenses/by/4.0/ (vor, 2453 d)

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Perera, F. P., Wang, S., Vishnevetsky, J., Zhang, B., Cole, K. J., Tang, D., Rauh, V., & Phillips, D. H. (2011). Polycyclic Aromatic Hydrocarbons–Aromatic DNA Adducts in Cord Blood and Behavior Scores in New York City Children. Environmental Health Perspectives. https://doi.org/10.1289/ehp.1002705

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