Autism Spectrum Disorder: Interaction of Air Pollution with the MET Receptor Tyrosine Kinase Gene
Open accessAbstract
BACKGROUND: Independent studies report association of autism spectrum disorder with air pollution exposure and a functional promoter variant (rs1858830) in the MET receptor tyrosine kinase (MET) gene. Toxicological data find altered brain Met expression in mice after prenatal exposure to a model air pollutant. Our objective was to investigate whether air pollution exposure and MET rs1858830 genotype interact to alter the risk of autism spectrum disorder. METHODS: We studied 252 cases of autism spectrum disorder and 156 typically developing controls from the Childhood Autism Risk from Genetics and the Environment Study. Air pollution exposure was assigned for local traffic-related sources and regional sources (particulate matter, nitrogen dioxide, and ozone). MET genotype was determined by direct resequencing. RESULTS: Subjects with both MET rs1858830 CC genotype and high air pollutant exposures were at increased risk of autism spectrum disorder compared with subjects who had both the CG/GG genotypes and lower air pollutant exposures. There was evidence of multiplicative interaction between NO2 and MET CC genotype (P= 0.03). CONCLUSIONS: MET rs1858830 CC genotype and air pollutant exposure may interact to increase the risk of autism spectrum disorder.
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One study found an interaction between traffic-related air pollution and a functional MET gene variant for autism risk.
“a study demonstrating interaction between traffic-related air pollutants and a functional variant of the Met receptor tyrosine kinase (MET) gene with regard to autism risk,163”
From Environmental Chemical Exposures and Autism Spectrum Disorders: A Review of the Epidemiological Evidence (2014) · cites this paper as [163]
The MET 'C' allele and exposure to high levels of air pollution during prenatal development act synergistically to increase risk of ASD.
“the MET ‘C’ allele and exposure to high levels of air pollution during prenatal development act synergistically to increase risk of this disorder45.”
From Immune mediators in the brain and peripheral tissues in autism spectrum disorder (2015) · cites this paper as [45]
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Cites
Traffic-Related Air Pollution, Particulate Matter, and Autism
Volk, H. E., Lurmann, F., Penfold, B., Hertz-Picciotto, I., & McConnell, R. (2013) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.266 · Cited by 638 · see citing works
Self-citationHertz‐Picciotto, I., Croen, L., Hansen, R. L., Jones, C. R., de Water, J. V., & Pessah, I. N. (2006) · Environmental Health Perspectives · doi:10.1289/ehp.8483 · Cited by 420 · see citing works
Self-citationPrenatal Airborne Polycyclic Aromatic Hydrocarbon Exposure and Child IQ at Age 5 Years
Perera, F. P., Li, Z., Whyatt, R., Hoepner, L., Wang, S., Camann, D., & Rauh, V. (2009) · Pediatrics · doi:10.1542/peds.2008-3506 · Cited by 420 · see citing works
A genetic variant that disrupts <i>MET</i> transcription is associated with autism
Campbell, D. B., Sutcliffe, J. S., Ebert, P. J., Militerni, R., Bravaccio, C., Trillo, S., Elia, M., Schneider, C., Melmed, R., Sacco, R., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605296103 · Cited by 401 · see citing works
Self-citationResidential Proximity to Freeways and Autism in the CHARGE Study
Volk, H. E., Hertz-Picciotto, I., Delwiche, L., Lurmann, F., & McConnell, R. (2011) · Environmental Health Perspectives · doi:10.1289/ehp.1002835 · Cited by 347 · see citing works
Self-citationPrenatal vitamins, one-carbon metabolism gene variants, and risk for autism
Schmidt, R. J., Hansen, R. L., Hartiala, J., Allayee, H., Schmidt, L. C., Tancredi, D. J., Tassone, F., & Hertz-Picciotto, I. (2011) · Epidemiology · doi:10.1097/ede.0b013e31821d0e30 · Cited by 308 · see citing works
Self-citationA review of the development and application of the CALINE3 and 4 models
Benson, P. E. (1992) · Atmospheric Environment Part B Urban Atmosphere · doi:10.1016/0957-1272(92)90013-i · Cited by 234 · see citing works
Disruption of cerebral cortex MET signaling in autism spectrum disorder
Campbell, D. B., D'Oronzio, R., Garbett, K., Ebert, P. J., Mirnics, K., Levitt, P., & Persico, A. M. (2007) · Annals of Neurology · doi:10.1002/ana.21180 · Cited by 193 · see citing works
Self-citationPerera, F. P., Wang, S., Vishnevetsky, J., Zhang, B., Cole, K. J., Tang, D. L., Rauh, V., & Phillips, D. H. (2011) · Environmental Health Perspectives · doi:10.1289/ehp.1002705 · Cited by 159 · see citing works
Campbell, D. B., Li, C., Sutcliffe, J. S., Persico, A. M., & Levitt, P. (2008) · Autism Research · doi:10.1002/aur.27 · Cited by 154 · see citing works
Self-citationSheng, L., Ding, X., Ferguson, M., McCallister, M., Rhoades, R., Maguire, M., Ramesh, A., Aschner, M., Campbell, D., Levitt, P., et al. (2010) · Toxicological Sciences · doi:10.1093/toxsci/kfq304 · Cited by 63 · see citing works
Self-citationHeuer, L., Braunschweig, D., Ashwood, P., Van de Water, J., & Campbell, D. B. (2011) · Translational Psychiatry · doi:10.1038/tp.2011.48 · Cited by 62 · see citing works
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Immune mediators in the brain and peripheral tissues in autism spectrum disorder
Estes, M. L., & McAllister, A. K. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3978 · Cited by 514 · see citing works
The contribution of environmental exposure to the etiology of autism spectrum disorder
Bölte, S., Girdler, S., & Marschik, P. B. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2988-4 · Cited by 509 · see citing works
Is there a link between air pollution and mental disorders?
Buoli, M., Grassi, S., Caldiroli, A., Carnevali, G. S., Mucci, F., Iodice, S., Cantone, L., Pergoli, L., & Bollati, V. (2018) · Environment International · doi:10.1016/j.envint.2018.05.044 · Cited by 370 · see citing works
Mandy, W., & Lai, M. (2016) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12501 · Cited by 283 · see citing works
Kalkbrenner, A. E., Schmidt, R. J., & Penlesky, A. C. (2014) · Current Problems in Pediatric and Adolescent Health Care · doi:10.1016/j.cppeds.2014.06.001 · Cited by 268 · see citing works
A Systematic Review and Meta-Analysis of Multiple Airborne Pollutants and Autism Spectrum Disorder
Lam, J., Sutton, P., Kalkbrenner, A., Windham, G., Halladay, A., Koustas, E., Lawler, C., Davidson, L., Daniels, N., Newschaffer, C., et al. (2016) · PLOS ONE · doi:10.1371/journal.pone.0161851 · Cited by 247 · see citing works
“One of the included studies reported an elevated risk of ASD only in those with a mutation in the MET tyrosine kinase receptor and those in the highest exposure level category [53].”
InfluentialAutism spectrum disorder in sub‐saharan africa: A comprehensive scoping review
Franz, L., Chambers, N., von Isenburg, M., & de Vries, P. J. (2017) · Autism Research · doi:10.1002/aur.1766 · Cited by 189 · see citing works
Maternal Intake of Supplemental Iron and Risk of Autism Spectrum Disorder
Schmidt, R. J., Tancredi, D. J., Krakowiak, P., Hansen, R. L., & Ozonoff, S. (2014) · American Journal of Epidemiology · doi:10.1093/aje/kwu208 · Cited by 184 · see citing works
Flores-Pajot, M.-C., Ofner, M., Do, M. T., Lavigne, E., & Villeneuve, P. J. (2016) · Environmental Research · doi:10.1016/j.envres.2016.07.030 · Cited by 157 · see citing works
Beversdorf, D. Q., & MISSOURI AUTISM SUMMIT CONSORTIUM* (2016) · Journal of Developmental & Behavioral Pediatrics · doi:10.1097/dbp.0000000000000351 · Cited by 74 · see citing works
Zerbo, O., Traglia, M., Yoshida, C., Heuer, L. S., Ashwood, P., Delorenze, G. N., Hansen, R. L., Kharrazi, M., Van de Water, J., Yolken, R. H., et al. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.46 · Cited by 67 · see citing works
Revisiting the Prevalence of Autism Spectrum Disorder among Omani Children: A multicentre study
Al-Mamari, W., Idris, A. B., Dakak, S., Al-Shekaili, M., Al-Harthi, Z., Alnaamani, A. M., Alhinai, F. I., Jalees, S., Hatmi, M. A., El-Naggari, M. A., et al. (2019) · Sultan Qaboos University Medical Journal · doi:10.18295/squmj.2019.19.04.005 · Cited by 67 · see citing works
Nutritional management of (some) autism: a case for gluten- and casein-free diets?
Whiteley, P. (2015) · Proceedings of The Nutrition Society · doi:10.1017/s0029665114001475 · Cited by 52 · see citing works
The association between air pollutants and autism spectrum disorders
Yang, C., Zhao, W., Deng, K., Zhou, V., Zhou, X., & Hou, Y. (2017) · Environmental Science and Pollution Research · doi:10.1007/s11356-017-8928-2 · Cited by 32 · see citing works
- Authors
- Volk, H. E., Kerin, T., Lurmann, F., Hertz-Picciotto, I., McConnell, R., & Campbell, D. B.
- Affiliations
- University of Southern California (US)
- Sonoma Technology (United States) (US)
- Corresponding author
- Volk, Heather E.
- Venue
- Epidemiology
- Published
- 2014-01
- Volume
- 25
- Issue
- 1
- Pages
- 44-47
- ISSN
- 1044-3983 (ISSN-L)
- PMC
- PMC4019012
- OpenAlex
- W1991422316
- Cited by
- 163
- References
- 12
- Citations by year
- 2026: 6 · 2025: 4 · 2024: 16 · 2023: 7 · 2022: 9 · 2021: 13 · 2020: 12 · 2019: 12 · 2018: 14 · 2017: 18 · 2016: 25 · 2015: 13 · 2014: 14
- FWCI
- 9.47
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Epidemiology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institute of Mental Health (R01MH100172)
- National Institute of Environmental Health Sciences (ES011627, R21ES019002, P01ES011627, ES016535, ES019002, L40 ES020599, ES015359, ES013578, R01ES015359, ES007048, P01ES011269, R01ES016535, ES11269, P30ES007048)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Health, Environment, Cognitive Aging
- Keywords
- autism spectrum disorder, air pollution exposure, MET gene, promoter polymorphism, gene-environment interaction, nitrogen dioxide, particulate matter, ozone, traffic-related pollution, prenatal exposure, genetic susceptibility
- MeSH terms
- Air Pollution, Vehicle Emissions, Child Development Disorders, Pervasive, Child, Preschool, Environmental Exposure, Female, Genotype, Humans, Male, Nitrogen Dioxide, Ozone, Risk Factors, Logistic Models, Case-Control Studies, Proto-Oncogene Proteins c-met, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Particulate Matter, Gene-Environment Interaction
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