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Cited by 625

The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

Perfluorinated Chemicals and Fetal Growth: A Study within the Danish National Birth Cohort

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Fei, Chunyuan, McLaughlin, Joseph K., Tarone, Robert E., Olsen, Jørn·2007·Environmental Health Perspectives
DOI 10.1289/ehp.10506
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Abstract

BACKGROUND: Perfluorooctanesulfonate (PFOS) and perfluorooctanoate (PFOA) are man-made, persistent organic pollutants widely spread throughout the environment and human populations. They have been found to interfere with fetal growth in some animal models, but whether a similar effect is seen in humans is uncertain. OBJECTIVES: We investigated the association between plasma levels of PFOS and PFOA in pregnant women and their infants' birth weight and length of gestation. METHODS: We randomly selected 1,400 women and their infants from the Danish National Birth Cohort among those who completed all four computer-assisted telephone interviews, provided the first blood samples between gestational weeks 4 and 14, and who gave birth to a single live-born child without congenital malformation. PFOS and PFOA were measured by high performance liquid chromatography-tandem mass spectrometer. RESULTS: PFOS and PFOA levels in maternal plasma were on average 35.3 and 5.6 ng/mL, respectively. Only PFOA levels were inversely associated with birth weight (adjusted beta = -10.63 g; 95% confidence interval, -20.79 to -0.47 g). Neither maternal PFOS nor PFOA levels were consistently associated with the risk for preterm birth or low birth weight. We observed no adverse effects for maternal PFOS or PFOA levels on small for gestational age. CONCLUSION: Our nationwide cohort data suggest an inverse association between maternal plasma PFOA levels and birth weight. Because of widespread exposure to these chemicals, our findings may be of potential public health concern.

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Research works printed but not linked: 36

  1. Albertsen, 2004, Alcohol consumption during pregnancy and the risk of preterm delivery, Am J Epidemiol, 159, 155, 10.1093/aje/kwh034 · DOI
  2. Apelberg, 2007, Determinants of fetal exposure to polyfluoroalkyl compounds in Baltimore, Maryland, Environ Sci Technol, 41, 3891, 10.1021/es0700911 · DOI
  3. Apelberg, 2007, Cord serum concentrations of perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) in relation to weight and size at birth, Environ Health Perspect, 115, 1670, 10.1289/ehp.10334 · DOI · Paper page
  4. Betts, 2007, Perfluoroalkyl acids: what is the evidence telling us?, Environ Sci Technol, 115, A250
  5. Butenhoff, 2004, Characterization of risk for general population exposure to perfluorooctanoate, Regul Toxicol Pharmacol, 39, 363, 10.1016/j.yrtph.2004.03.003 · DOI
  6. Butenhoff, 2004, The reproductive toxicology of ammonium perfluorooctanoate (APFO) in the rat, Toxicology, 196, 95, 10.1016/j.tox.2003.11.005 · DOI · Paper page
  7. Butenhoff, 2006, The applicability of biomonitoring data for perfluorooctanesulfonate to the environmental public health continuum, Environ Health Perspect, 114, 1776, 10.1289/ehp.9060 · DOI
  8. Calafat, 2007, Serum concentrations of 11 polyfluoroalkyl compounds in the u.s. population: data from the national health and nutrition examination survey (NHANES), Environ Sci Technol, 41, 2237, 10.1021/es062686m · DOI · Paper page
  9. Case, 2001, Rat and rabbit oral developmental toxicology studies with two perfluorinated compounds, Int J Toxicol, 20, 101, 10.1177/109158180102000207 · DOI
  10. Ehresman, 2007, Comparison of human whole blood, plasma, and serum matrices for the determination of perfluorooctane-sulfonate (PFOS), perfluorooctanoate (PFOA), and other fluorochemicals, Environ Res, 103, 176, 10.1016/j.envres.2006.06.008 · DOI · Paper page
  11. Emmett, 2006, Community exposure to perfluorooctanoate: relationships between serum concentrations and exposure sources, J Occup Environ Med, 48, 759, 10.1097/01.jom.0000232486.07658.74 · DOI · Paper page
  12. Emmett, 2006, Community exposure to perfluorooctanoate: relationships between serum levels and certain health parameters, J Occup Environ Med, 48, 771, 10.1097/01.jom.0000233380.13087.37 · DOI
  13. Frederiksen, 2001, Physiologic changes in pregnancy and their effect on drug disposition, Semin Perinatol, 25, 120, 10.1053/sper.2001.24565 · DOI
  14. Glucksman, 2006, Developmental Origins of Health and Disease, 10.1017/CBO9780511544699 · DOI · Paper page
  15. Grasty, 2003, Prenatal window of susceptibility to perfluorooctane sulfonate-induced neonatal mortality in the Sprague-Dawley rat, Birth Defects Res B Dev Reprod Toxicol, 68, 465, 10.1002/bdrb.10046 · DOI
  16. Grice, 2007, Self-Reported medical conditions in perfluorooctanesulfonyl fluoride manufacturing workers, J Occup Environ Med, 49, 722, 10.1097/JOM.0b013e3180582043 · DOI
  17. Henderson, 2007, Perfluorooctanoic acid and perfluorononanoic acid in fetal and neonatal mice following in utero exposure to 8-2 fluorotelomer alcohol, Toxicol Sci, 95, 452, 10.1093/toxsci/kfl162 · DOI
  18. Hinderliter, 2005, Perfluorooctanoate: placental and lactational transport pharmacokinetics in rats, Toxicology, 211, 139, 10.1016/j.tox.2005.03.010 · DOI
  19. Inoue, 2004, Perfluorooctane sulfonate (PFOS) and related perfluorinated compounds in human maternal and cord blood samples: assessment of PFOS exposure in a susceptible population during pregnancy, Environ Health Perspect, 112, 1204, 10.1289/ehp.6864 · DOI · Paper page
  20. Jin, 2004, Status of perfluorochemicals in adult serum and umbilical blood in Shenyang [in Chinese], Wei Sheng Yan Jiu, 33, 481
  21. Karrman, 2007, Exposure of perfluorinated chemicals through lactation: levels of matched human milk and serum and a temporal trend, 1996–2004, in Sweden, Environ Health Perspect, 115, 226, 10.1289/ehp.9491 · DOI · Paper page
  22. Karrman, 2006, Levels of 12 perfluorinated chemicals in pooled Australian serum collected 2002–2003 in relation to age, gender and region, Environ Sci Technol, 40, 3742, 10.1021/es060301u · DOI
  23. Lau, 2004, The developmental toxicity of perfluoroalkyl acids and their derivatives, Toxicol Appl Pharmacol, 198, 231, 10.1016/j.taap.2003.11.031 · DOI · Paper page
  24. Lau, 2006, Effects of perfluorooctanoic acid exposure during pregnancy in the mouse, Toxicol Sci, 90, 510, 10.1093/toxsci/kfj105 · DOI · Paper page
  25. Luebker, 2005, Two-generation reproduction and cross-foster studies of perfluorooctanesulfonate (PFOS) in rats, Toxicology, 215, 126, 10.1016/j.tox.2005.07.018 · DOI · Paper page
  26. Luebker, 2005, Neonatal mortality from in utero exposure to perfluorooctanesulfonate (PFOS) in Sprague-Dawley rats: doseresponse, pharmacokinetics, and clinical chemistry, Toxicology, 215, 149, 10.1016/j.tox.2005.07.019 · DOI · Paper page
  27. Martin, 2003, Bioconcentration and tissue distribution of perfluorinated acids in rainbow trout (Oncorhynchus mykiss), Environ Toxicol Chem, 22, 196, 10.1002/etc.5620220126 · DOI · Paper page
  28. Midasch, 2007, Transplacental exposure of neonates to perfluorooctane-sulfonate and perfluorooctanoate: a pilot study, Int Arch Occup Environ Health, 80, 643, 10.1007/s00420-006-0165-9 · DOI · Paper page
  29. Olsen, 2003, Epidemiologic assessment of worker serum perfluorooctanesulfonate (PFOS) and perfluorooctanoate (PFOA) concentrations and medical surveillance examinations, J Occup Environ Med, 45, 260, 10.1097/01.jom.0000052958.59271.10 · DOI · Paper page
  30. Olsen, 1998, An epidemiologic investigation of reproductive hormones in men with occupational exposure to perfluorooctanoic acid, J Occup Environ Med, 40, 614, 10.1097/00043764-199807000-00006 · DOI
  31. Olsen, 2001, The Danish National Birth Cohort—its background, structure and aim, Scand J Public Health, 29, 300, 10.1177/14034948010290040201 · DOI · Paper page
  32. So, 2006, Health risks in infants associated with exposure to perfluorinated compounds in human breast milk from Zhoushan, China, Environ Sci Technol, 40, 2924, 10.1021/es060031f · DOI · Paper page
  33. Swanson, 1983, Reduced serum zinc concentration during pregnancy, Obstet Gynecol, 62, 313, 10.1097/00006250-198309000-00010 · DOI
  34. Tittlemier, 2004, Presence of anionic organic compounds in serum collected from northern Canadian populations, Organohalogen Compounds, 66, 4009
  35. Wolf, 2007, Developmental toxicity of perfluorooctanoic acid in the CD-1 mouse after cross-foster and restricted gestational exposures, Toxicol Sci, 95, 462, 10.1093/toxsci/kfl159 · DOI
  36. Yeung, 2006, Perfluorooctanesulfonate and related fluoro-chemicals in human blood samples from China, Environ Sci Technol, 40, 715, 10.1021/es052067y · DOI · Paper page

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Metadata

Authors
Fei, C., McLaughlin, J. K., Tarone, R. E., & Olsen, J.
Venue
Environmental Health Perspectives
Publisher
American Chemical Society (ACS)
Published
2007-11
Volume
115
Issue
11
Pages
1677-1682
ISSN
  • 0091-6765 (ISSN-L)
  • 1552-9924
DOI
10.1289/ehp.10506
OpenAlex
W2111464473
Cited by
625
References
5
FWCI
27.73
Type
journal article
Language
en
Open access
gold
Licence
creativecommons.org/licenses/by/4.0/ (vor, 3788 d)

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CoChat. (2026). Citation check: Perfluorinated Chemicals and Fetal Growth: A Study within the Danish National Birth Cohort. https://app.cochat.ai/papers/10.1289/ehp.10506
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Fei, C., McLaughlin, J. K., Tarone, R. E., & Olsen, J. (2007). Perfluorinated Chemicals and Fetal Growth: A Study within the Danish National Birth Cohort. Environmental Health Perspectives. https://doi.org/10.1289/ehp.10506

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