The DOI matches its Crossref record; 77 of the 77 references it cites were found in a registry or an index.
Functional Convergence of Neurons Generated in the Developing and Adult Hippocampus
Open accessAbstract
The dentate gyrus of the hippocampus contains neural progenitor cells (NPCs) that generate neurons throughout life. Developing neurons of the adult hippocampus have been described in depth. However, little is known about their functional properties as they become fully mature dentate granule cells (DGCs). To compare mature DGCs generated during development and adulthood, NPCs were labeled at both time points using retroviruses expressing different fluorescent proteins. Sequential electrophysiological recordings from neighboring neurons of different ages were carried out to quantitatively study their major synaptic inputs: excitatory projections from the entorhinal cortex and inhibitory afferents from local interneurons. Our results show that DGCs generated in the developing and adult hippocampus display a remarkably similar afferent connectivity with regard to both glutamate and GABA, the major neurotransmitters. We also demonstrate that adult-born neurons can fire action potentials in response to an excitatory drive, exhibiting a firing behavior comparable to that of neurons generated during development. We propose that neurons born in the developing and adult hippocampus constitute a functionally homogeneous neuronal population. These observations are critical to understanding the role of adult neurogenesis in hippocampal function.
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Cites
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Down-Regulation of Na+/K+ATPase Activity by Human Parvovirus B19 Capsid Protein VP1
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Regulation of the Voltage Gated K+ Channel Kv1.3 by Recombinant Human Klotho Protein
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Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants
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Interneurons of the hippocampus
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Functional neurogenesis in the adult hippocampus
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Self-citationHomeostatic plasticity in the developing nervous system
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Excitatory actions of gaba during development: the nature of the nurture
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A monomeric red fluorescent protein
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Cited by
Mechanisms and Functional Implications of Adult Neurogenesis
Zhao, C., Deng, W., & Gage, F. H. (2008) · Cell · doi:10.1016/j.cell.2008.01.033 · Cited by 3,007
Self-citationAdult Neurogenesis in the Hippocampus: From Stem Cells to Behavior
Gonçalves, J. T., Schafer, S. T., & Gage, F. H. (2016) · Cell · doi:10.1016/j.cell.2016.10.021 · Cited by 1,122
Self-citationNeurogenesis in the adult hippocampus
Kempermann, G., Song, H., & Gage, F. H. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a018812 · Cited by 1,072
Self-citationA Critical Period for Enhanced Synaptic Plasticity in Newly Generated Neurons of the Adult Brain
Ge, S., Yang, C.-H., Hsu, K.-S., Ming, G.-L., & Song, H. (2007) · Neuron · doi:10.1016/j.neuron.2007.05.002 · Cited by 927
Hippocampal Neurogenesis Regulates Forgetting During Adulthood and Infancy
Akers, K. G., Martinez-Canabal, A., Restivo, L., Yiu, A. P., De Cristofaro, A., Hsiang, H.-L. (., Wheeler, A. L., Guskjolen, A., Niibori, Y., Shoji, H., et al. (2014) · Science · doi:10.1126/science.1248903 · Cited by 761
Metadata
- Authors
- Laplagne, D. A., Espósito, M. S., Piatti, V. C., Morgenstern, N. A., Zhao, C., van Praag, H., Gage, F. H., & Schinder, A. F.
- Venue
- PLoS Biology
- Publisher
- Public Library of Science (PLoS)
- Published
- 2006-11-21
- Volume
- 4
- Issue
- 12
- Pages
- e409
- ISSN
- 1544-9173 (ISSN-L)
- 1545-7885
- OpenAlex
- W2018743597
- Cited by
- 358
- References
- 77
- FWCI
- 5.55
- Type
- journal article
- Language
- en
- Open access
- gold
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- Laplagne, D. A., Espósito, M. S., Piatti, V. C., Morgenstern, N. A., Zhao, C., van Praag, H., Gage, F. H., & Schinder, A. F. (2006). Functional Convergence of Neurons Generated in the Developing and Adult Hippocampus. PLoS Biology. https://doi.org/10.1371/journal.pbio.0040409
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