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Cited by 358

The DOI matches its Crossref record; 77 of the 77 references it cites were found in a registry or an index.

Functional Convergence of Neurons Generated in the Developing and Adult Hippocampus

Open access
Laplagne, Diego A, Espósito, M. Soledad, Piatti, Verónica C, Morgenstern, Nicolás A, Zhao, Chunmei, van Praag, Henriette, Gage, Fred H, Schinder, Alejandro F·2006·PLoS Biology
DOI 10.1371/journal.pbio.0040409
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Abstract

The dentate gyrus of the hippocampus contains neural progenitor cells (NPCs) that generate neurons throughout life. Developing neurons of the adult hippocampus have been described in depth. However, little is known about their functional properties as they become fully mature dentate granule cells (DGCs). To compare mature DGCs generated during development and adulthood, NPCs were labeled at both time points using retroviruses expressing different fluorescent proteins. Sequential electrophysiological recordings from neighboring neurons of different ages were carried out to quantitatively study their major synaptic inputs: excitatory projections from the entorhinal cortex and inhibitory afferents from local interneurons. Our results show that DGCs generated in the developing and adult hippocampus display a remarkably similar afferent connectivity with regard to both glutamate and GABA, the major neurotransmitters. We also demonstrate that adult-born neurons can fire action potentials in response to an excitatory drive, exhibiting a firing behavior comparable to that of neurons generated during development. We propose that neurons born in the developing and adult hippocampus constitute a functionally homogeneous neuronal population. These observations are critical to understanding the role of adult neurogenesis in hippocampal function.

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Metadata

Authors
Laplagne, D. A., Espósito, M. S., Piatti, V. C., Morgenstern, N. A., Zhao, C., van Praag, H., Gage, F. H., & Schinder, A. F.
Venue
PLoS Biology
Publisher
Public Library of Science (PLoS)
Published
2006-11-21
Volume
4
Issue
12
Pages
e409
ISSN
  • 1544-9173 (ISSN-L)
  • 1545-7885
DOI
10.1371/journal.pbio.0040409
OpenAlex
W2018743597
Cited by
358
References
77
FWCI
5.55
Type
journal article
Language
en
Open access
gold

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