The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Adaptive Variation in Beach Mice Produced by Two Interacting Pigmentation Genes
Open accessAbstract
Little is known about the genetic basis of ecologically important morphological variation such as the diverse color patterns of mammals. Here we identify genetic changes contributing to an adaptive difference in color pattern between two subspecies of oldfield mice (Peromyscus polionotus). One mainland subspecies has a cryptic dark brown dorsal coat, while a younger beach-dwelling subspecies has a lighter coat produced by natural selection for camouflage on pale coastal sand dunes. Using genome-wide linkage mapping, we identified three chromosomal regions (two of major and one of minor effect) associated with differences in pigmentation traits. Two candidate genes, the melanocortin-1 receptor (Mc1r) and its antagonist, the Agouti signaling protein (Agouti), map to independent regions that together are responsible for most of the difference in pigmentation between subspecies. A derived mutation in the coding region of Mc1r, rather than change in its expression level, contributes to light pigmentation. Conversely, beach mice have a derived increase in Agouti mRNA expression but no changes in protein sequence. These two genes also interact epistatically: the phenotypic effects of Mc1r are visible only in genetic backgrounds containing the derived Agouti allele. These results demonstrate that cryptic coloration can be based largely on a few interacting genes of major effect.
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Cites
Widespread parallel evolution in sticklebacks by repeated fixation of Ectodysplasin alleles.
Colosimo, P. F., Hosemann, K. E., Balabhadra, S., Villarreal, G., Dickson, M., Grimwood, J., Schmutz, J., Myers, R. M., Schluter, D., & Kingsley, D. M. (2005) · Science · doi:10.1126/science.1107239 · Cited by 1,448
A Mathematical Theory of Natural and Artificial Selection, Part V: Selection and Mutation
Haldane, J. B. S. (1927) · Mathematical Proceedings of the Cambridge Philosophical Society · doi:10.1017/s0305004100015644 · Cited by 1,326
Evolution at Two Levels: On Genes and Form
Carroll, S. B. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030245 · Cited by 882
Genetic analysis of cavefish reveals molecular convergence in the evolution of albinism
Protas, M. E., Hersey, C., Kochanek, D., Zhou, Y., Wilkens, H., Jeffery, W. R., Zon, L. I., Borowsky, R., & Tabin, C. J. (2006) · Nature Genetics · doi:10.1038/ng1700 · Cited by 543
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Evo-Devo and an Expanding Evolutionary Synthesis: A Genetic Theory of Morphological Evolution
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The strength and genetic basis of reproductive isolating barriers in flowering plants
Lowry, D. B., Modliszewski, J. L., Wright, K. M., Wu, C. A., & Willis, J. H. (2008) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2008.0064 · Cited by 496
Miller, C. T., Beleza, S., Pollen, A. A., Schluter, D., Kittles, R. A., Shriver, M. D., & Kingsley, D. M. (2007) · Cell · doi:10.1016/j.cell.2007.10.055 · Cited by 388
The Developmental Role of Agouti in Color Pattern Evolution
Manceau, M., Domingues, V. S., Mallarino, R., & Hoekstra, H. E. (2011) · Science · doi:10.1126/science.1200684 · Cited by 233
Self-citationGenetic adaptation associated with genome-doubling in autotetraploid Arabidopsis arenosa
Hollister, J. D., Arnold, B. J., Svedin, E., Xue, K. S., Dilkes, B. P., & Bomblies, K. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1003093 · Cited by 182
The probability of parallel genetic evolution from standing genetic variation
MacPherson, A., & Nuismer, S. L. (2017) · Journal of Evolutionary Biology · doi:10.1111/jeb.13006 · Cited by 79
Overview on the Role of Advance Genomics in Conservation Biology of Endangered Species
Khan, S., Nabi, G., Ullah, M. W., Yousaf, M., Manan, S., Siddique, R., & Hou, H. (2016) · International Journal of Genomics · doi:10.1155/2016/3460416 · Cited by 63
Evolutionary History, Selective Sweeps, and Deleterious Variation in the Dog
Freedman, A. H., Lohmueller, K. E., & Wayne, R. K. (2016) · Annual Review of Ecology, Evolution, and Systematics · doi:10.1146/annurev-ecolsys-121415-032155 · Cited by 50
Metadata
- Authors
- Steiner, C. C., Weber, J. N., & Hoekstra, H. E.
- Venue
- PLoS Biology
- Publisher
- Public Library of Science (PLoS)
- Published
- 2007-08-14
- Volume
- 5
- Issue
- 9
- Pages
- e219
- ISSN
- 1544-9173 (ISSN-L)
- 1545-7885
- OpenAlex
- W2157240032
- Cited by
- 337
- References
- 4
- FWCI
- 10.54
- Type
- journal article
- Language
- en
- Open access
- gold
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