The DOI matches its Crossref record; 72 of the 72 references it cites were found in a registry or an index.
Neuregulin and BDNF Induce a Switch to NMDA Receptor-Dependent Myelination by Oligodendrocytes
Open accessAbstract
Myelination is essential for rapid impulse conduction in the CNS, but what determines whether an individual axon becomes myelinated remains unknown. Here we show, using a myelinating coculture system, that there are two distinct modes of myelination, one that is independent of neuronal activity and glutamate release and another that depends on neuronal action potentials releasing glutamate to activate NMDA receptors on oligodendrocyte lineage cells. Neuregulin switches oligodendrocytes from the activity-independent to the activity-dependent mode of myelination by increasing NMDA receptor currents in oligodendrocyte lineage cells 6-fold. With neuregulin present myelination is accelerated and increased, and NMDA receptor block reduces myelination to far below its level without neuregulin. Thus, a neuregulin-controlled switch enhances the myelination of active axons. In vivo, we demonstrate that remyelination after white matter damage is NMDA receptor-dependent. These data resolve controversies over the signalling regulating myelination and suggest novel roles for neuregulin in schizophrenia and in remyelination after white matter damage.
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Cites
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Neuregulin 1 and Susceptibility to Schizophrenia
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Myelination and support of axonal integrity by glia
Nave, K.-A. (2010) · Nature · doi:10.1038/nature09614 · Cited by 1,062
CREB Is a Regulatory Target for the Protein Kinase Akt/PKB
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Axonal Neuregulin-1 Regulates Myelin Sheath Thickness
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A critical period for social experience-dependent oligodendrocyte maturation and myelination
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NMDA receptors are expressed in oligodendrocytes and activated in ischaemia
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Cited by
Integrative single-cell analysis of transcriptional and epigenetic states in the human adult brain
Lake, B. B., Chen, S., Sos, B. C., Fan, J., Kaeser, G. E., Yung, Y. C., Duong, T. E., Gao, D., Chun, J., Kharchenko, P. V., et al. (2018) · Nature Biotechnology · doi:10.1038/nbt.4038 · Cited by 983
Myelination of the Nervous System: Mechanisms and Functions
Nave, K.-A., & Werner, H. B. (2014) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100913-013101 · Cited by 983
A new mechanism of nervous system plasticity: activity-dependent myelination
Fields, R. D. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn4023 · Cited by 794
Regenerating CNS myelin — from mechanisms to experimental medicines
Franklin, R. J. M., & ffrench-Constant, C. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.136 · Cited by 647
Self-citationNeuregulin-ERBB Signaling in the Nervous System and Neuropsychiatric Diseases
Mei, L., & Nave, K.-A. (2014) · Neuron · doi:10.1016/j.neuron.2014.06.007 · Cited by 592
Metadata
- Authors
- Lundgaard, I., Luzhynskaya, A., Stockley, J. H., Wang, Z., Evans, K. A., Swire, M., Volbracht, K., Gautier, H. O. B., Franklin, R. J. M., ffrench-Constant, C., Attwell, D., & Káradóttir, R. T.
- Venue
- PLoS Biology
- Publisher
- Public Library of Science (PLoS)
- Published
- 2013-12-31
- Volume
- 11
- Issue
- 12
- Pages
- e1001743
- ISSN
- 1544-9173 (ISSN-L)
- 1545-7885
- OpenAlex
- W2140916089
- Cited by
- 339
- References
- 72
- FWCI
- 8.33
- Type
- journal article
- Language
- en
- Open access
- gold
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- CoChat. (2026). Citation check: Neuregulin and BDNF Induce a Switch to NMDA Receptor-Dependent Myelination by Oligodendrocytes. https://app.cochat.ai/papers/10.1371/journal.pbio.1001743
- The paper
- Lundgaard, I., Luzhynskaya, A., Stockley, J. H., Wang, Z., Evans, K. A., Swire, M., Volbracht, K., Gautier, H. O. B., Franklin, R. J. M., ffrench-Constant, C., Attwell, D., & Káradóttir, R. T. (2013). Neuregulin and BDNF Induce a Switch to NMDA Receptor-Dependent Myelination by Oligodendrocytes. PLoS Biology. https://doi.org/10.1371/journal.pbio.1001743
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
