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Cited by 339

The DOI matches its Crossref record; 72 of the 72 references it cites were found in a registry or an index.

Neuregulin and BDNF Induce a Switch to NMDA Receptor-Dependent Myelination by Oligodendrocytes

Open access
Lundgaard, Iben, Luzhynskaya, Aryna, Stockley, John H., Wang, Zhen, Evans, Kimberley A., Swire, Matthew, Volbracht, Katrin, Gautier, Hélène O. B., Franklin, Robin J. M., ffrench-Constant, Charles, Attwell, David, Káradóttir, Ragnhildur T.·2013·PLoS Biology
DOI 10.1371/journal.pbio.1001743
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Abstract

Myelination is essential for rapid impulse conduction in the CNS, but what determines whether an individual axon becomes myelinated remains unknown. Here we show, using a myelinating coculture system, that there are two distinct modes of myelination, one that is independent of neuronal activity and glutamate release and another that depends on neuronal action potentials releasing glutamate to activate NMDA receptors on oligodendrocyte lineage cells. Neuregulin switches oligodendrocytes from the activity-independent to the activity-dependent mode of myelination by increasing NMDA receptor currents in oligodendrocyte lineage cells 6-fold. With neuregulin present myelination is accelerated and increased, and NMDA receptor block reduces myelination to far below its level without neuregulin. Thus, a neuregulin-controlled switch enhances the myelination of active axons. In vivo, we demonstrate that remyelination after white matter damage is NMDA receptor-dependent. These data resolve controversies over the signalling regulating myelination and suggest novel roles for neuregulin in schizophrenia and in remyelination after white matter damage.

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Crossref · 10.1371/journal.pbio.1001743

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Metadata

Authors
Lundgaard, I., Luzhynskaya, A., Stockley, J. H., Wang, Z., Evans, K. A., Swire, M., Volbracht, K., Gautier, H. O. B., Franklin, R. J. M., ffrench-Constant, C., Attwell, D., & Káradóttir, R. T.
Venue
PLoS Biology
Publisher
Public Library of Science (PLoS)
Published
2013-12-31
Volume
11
Issue
12
Pages
e1001743
ISSN
  • 1544-9173 (ISSN-L)
  • 1545-7885
DOI
10.1371/journal.pbio.1001743
OpenAlex
W2140916089
Cited by
339
References
72
FWCI
8.33
Type
journal article
Language
en
Open access
gold

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