Induction of myelination in the central nervous system by electrical activity
Open accessAbstract
The oligodendrocyte is the myelin-forming cell in the central nervous system. Despite the close interaction between axons and oligodendrocytes, there is little evidence that neurons influence myelinogenesis. On the contrary, newly differentiated oligodendrocytes, which mature in culture in the total absence of neurons, synthesize the myelin-specific constituents of oligodendrocytes differentiated in vivo and even form myelin-like figures. Neuronal electrical activity may be required, however, for the appropriate formation of the myelin sheath. To investigate the role of electrical activity on myelin formation, we have used highly specific neurotoxins, which can either block (tetrodotoxin) or increase (alpha-scorpion toxin) the firing of neurons. We show that myelination can be inhibited by blocking the action potential of neighboring axons or enhanced by increasing their electrical activity, clearly linking neuronal electrical activity to myelinogenesis.
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Changes in the cellular organization of a brain region can result from molecular processes that follow neuronal activity.
“Although changes in the cellular organization of a specific brain region can result from the molecular processes after neuronal activity (65,68)”
From Neuroanatomic differences associated with stress susceptibility and resilience (2016) · cites this paper as [68]
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- Authors
- Demerens, C., Stankoff, B., Logak, M., Anglade, P., Allinquant, B., Couraud, F., Zalc, B., & Lubetzki, C.
- Affiliations
- Inserm (FR)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1996-09-03
- Volume
- 93
- Issue
- 18
- Pages
- 9887-9892
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC38524
- OpenAlex
- W2023693164
- Cited by
- 678
- References
- 40
- Citations by year
- 2026: 13 · 2025: 17 · 2024: 21 · 2023: 15 · 2022: 24 · 2021: 38 · 2020: 40 · 2019: 36 · 2018: 38 · 2017: 55 · 2016: 35 · 2015: 35 · 2014: 37 · 2013: 30 · 2012: 22
- FWCI
- 2.34
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- myelination, oligodendrocytes, neuronal electrical activity, action potential, tetrodotoxin, alpha-scorpion toxin, neurotoxins, central nervous system
- MeSH terms
- Action Potentials, Animals, Cells, Cultured, Central Nervous System, Electric Stimulation, Microscopy, Electron, Myelin Sheath, Optic Nerve, Potassium, Scorpion Venoms, Tetrodotoxin, Time Factors, Sodium Channels, Mice
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