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Comparisons of Allergenic and Metazoan Parasite Proteins: Allergy the Price of Immunity

Tyagi, Nidhi, Farnell, Edward J, Fitzsimmons, Colin M, Ryan, Stephanie, Tukahebwa, Edridah, Maizels, Rick M, Dunne, David W, Thornton, Janet M, Furnham, Nicholas·2015·PLOS Computational Biology
DOI 10.1371/journal.pcbi.1004546PMC PMC4626114
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Fig 1 Flowchart depicting the workflow involved in the present analysis.
Fig 1 Flowchart depicting the workflow involved in the present analysis.CC BY · PubMed Central
Fig 2 The distribution of protein molecule entries (dark gray bars) listed in the Allergome database across different species (light gray bars) by taxonomic grouping (Bacteria, Fungi, Plants and Metazoan).
Fig 2 The distribution of protein molecule entries (dark gray bars) listed in the Allergome database across different species (light gray bars) by taxonomic grouping (Bacteria, Fungi, Plants and Metazoan).CC BY · PubMed Central
Fig 3 Distribution of allergenic molecules retrieved from Allergome database across Pfam domain families. Number of Pfam domain families with no allergenic members have also been represented. The Y-axis is scaled logarithmically (base 10), however true values are represented.
Fig 3 Distribution of allergenic molecules retrieved from Allergome database across Pfam domain families. Number of Pfam domain families with no allergenic members have also been represented. The Y-axis is scaled logarithmically (base 10), however true values are represented.CC BY · PubMed Central
Fig 4 Pfam domain families that are highly populated with allergenic protein sequences. Protein domain families considered for this analysis are highlighted in the box based on the families presented in the article co-authored by Fitzsimmons and Dunne [21].
Fig 4 Pfam domain families that are highly populated with allergenic protein sequences. Protein domain families considered for this analysis are highlighted in the box based on the families presented in the article co-authored by Fitzsimmons and Dunne [21].CC BY · PubMed Central
Fig 5 A. Sequence alignment of the epitopic region from Atlantic salmon (Salmo salar) allergenic parvalbumin-like 1 protein (UniProt accession: B5DH17) and predicted epitopic-like region from worm Schistosoma japonicum (UniProt accession: Q5C262). B. Superposition of the 3D structural model of salmon parvalbumin-like 1 protein (colored in green) and EF hand domain of the Schistosoma japonicum protein (in cyan). Epitope (allergen) and predicted epitopic-like regions (parasite protein) are depicted in the box.
Fig 5 A. Sequence alignment of the epitopic region from Atlantic salmon (Salmo salar) allergenic parvalbumin-like 1 protein (UniProt accession: B5DH17) and predicted epitopic-like region from worm Schistosoma japonicum (UniProt accession: Q5C262). B. Superposition of the 3D structural model of salmon parvalbumin-like 1 protein (colored in green) and EF hand domain of the Schistosoma japonicum protein (in cyan). Epitope (allergen) and predicted epitopic-like regions (parasite protein) are depicted in the box.CC BY · PubMed Central
Fig 6 A. Sequence alignment of the epitopic region from profilin protein (allergenic) from Betula pendula (European white birch) (UniProt accession: P25816) and predicted epitopic-like region from the worm Ascaris lumbricoides (UniProt accession: F1LGV9). B. Superposition of the 3D structure of plant allergenic protein (PDB accession: 1CQA) (colored in green) and the 3D structural model of profilin protein from the worm Ascaris lumbricoides (in cyan). Epitope (allergen) and predicted epitopic-like regions (parasite protein) are depicted in the box.
Fig 6 A. Sequence alignment of the epitopic region from profilin protein (allergenic) from Betula pendula (European white birch) (UniProt accession: P25816) and predicted epitopic-like region from the worm Ascaris lumbricoides (UniProt accession: F1LGV9). B. Superposition of the 3D structure of plant allergenic protein (PDB accession: 1CQA) (colored in green) and the 3D structural model of profilin protein from the worm Ascaris lumbricoides (in cyan). Epitope (allergen) and predicted epitopic-like regions (parasite protein) are depicted in the box.CC BY · PubMed Central
Fig 7 A. Superposition of the 3D structure of timothy grass Phl p 1 (PDB accession: 1N10) (in green) and the 3D structural model of mite protein (in cyan). Epitope (allergen) and predicted epitopic-like regions (parasite protein) are depicted in the box. B. Sequence alignment of the epitopic region from Phleum pratense ‘Phl p 1’, a major timothy grass pollen allergen (UniProt accession: P43213) and predicted epitopic-like region from Mite group 2 allergen ‘Pso o 2’ protein (UniProt accession: Q965E2) from Psoroptes ovis.
Fig 7 A. Superposition of the 3D structure of timothy grass Phl p 1 (PDB accession: 1N10) (in green) and the 3D structural model of mite protein (in cyan). Epitope (allergen) and predicted epitopic-like regions (parasite protein) are depicted in the box. B. Sequence alignment of the epitopic region from Phleum pratense ‘Phl p 1’, a major timothy grass pollen allergen (UniProt accession: P43213) and predicted epitopic-like region from Mite group 2 allergen ‘Pso o 2’ protein (UniProt accession: Q965E2) from Psoroptes ovis.CC BY · PubMed Central
Fig 8 Magnitudes of specific IgE, IgG4 and IgG1 responses to S. mansoni Bet v 1-like protein, SmBv1L, in a population of 222 individuals infected with S. mansoni, dotted lines indicate threshold of magnitude for a response. Data were normalized for expression on a log scale by the addition of constants so as to include zero values.
Fig 8 Magnitudes of specific IgE, IgG4 and IgG1 responses to S. mansoni Bet v 1-like protein, SmBv1L, in a population of 222 individuals infected with S. mansoni, dotted lines indicate threshold of magnitude for a response. Data were normalized for expression on a log scale by the addition of constants so as to include zero values.CC BY · PubMed Central
Fig 9 Venn diagram showing the distribution of Ab isotype responses to SmBv1L within IgG1, IgG4 and IgE responders in a population of 222 individuals endemically infected with S. mansoni.
Fig 9 Venn diagram showing the distribution of Ab isotype responses to SmBv1L within IgG1, IgG4 and IgE responders in a population of 222 individuals endemically infected with S. mansoni.CC BY · PubMed Central

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Authors
Tyagi, N., Farnell, E. J., Fitzsimmons, C. M., Ryan, S., Tukahebwa, E., Maizels, R. M., Dunne, D. W., Thornton, J. M., & Furnham, N.
Venue
PLOS Computational Biology
Publisher
Public Library of Science (PLoS)
Published
2015-10-29
Volume
11
Issue
10
Pages
e1004546
ISSN
1553-7358
DOI
10.1371/journal.pcbi.1004546
PMC
PMC4626114
Cited by
47
References
1
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (vor)

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Tyagi, N., Farnell, E. J., Fitzsimmons, C. M., Ryan, S., Tukahebwa, E., Maizels, R. M., Dunne, D. W., Thornton, J. M., & Furnham, N. (2015). Comparisons of Allergenic and Metazoan Parasite Proteins: Allergy the Price of Immunity. PLOS Computational Biology. https://doi.org/10.1371/journal.pcbi.1004546