The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Unbiased Gene Expression Analysis Implicates the huntingtin Polyglutamine Tract in Extra-mitochondrial Energy Metabolism
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Energy deficiency in HD involves an extra-mitochondrial pathway, as suggested by studies in immortalized STHdhQ111/Q111 striatal cells.
“Studies in immortalized STHdhQ111/Q111 striatal cells suggest that energy deficiency in HD involves an extra-mitochondrial pathway [33].”
From Glucose transporter 3 is a rab11-dependent trafficking cargo and its transport to the cell surface is reduced in neurons of CAG140 Huntington’s disease mice (2014) · cites this paper as [33]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625
Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines
Panov, A. V., Gutekunst, C.-A., Leavitt, B. R., Hayden, M. R., Burke, J. R., Strittmatter, W. J., & Greenamyre, J. T. (2002) · Nature Neuroscience · doi:10.1038/nn884 · Cited by 1,030
Choo, Y. S. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh162 · Cited by 515 · cited 1×
“]. Huntingtin is detected throughout the cell, in the nucleus and in the cytoplasm, where it can associate with mitochondria [”
BackgroundEnergy metabolism defects in Huntington's disease and effects of coenzyme Q10
Koroshetz, W. J., Jenkins, B. G., Rosen, B. R., & Beal, M. F. (1997) · Annals of Neurology · doi:10.1002/ana.410410206 · Cited by 405
PGC-1α, a New Therapeutic Target in Huntington's Disease?
McGill, J. K., & Beal, M. F. (2006) · Cell · doi:10.1016/j.cell.2006.10.023 · Cited by 131
Flagged first, then by citations
Research works printed but not linked: 51
- The Huntington's Disease Collaborative Research Group, 1993, A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes., Cell, 72, 971, 10.1016/0092-8674(93)90585-E · DOI · Paper page
- 1985, Neuropathological classification of Huntington's disease., J Neuropathol Exp Neurol, 44, 559, 10.1097/00005072-198511000-00003 · DOI · Paper page
- 1997, 3-Nitropropionic acid animal model and Huntington's disease., Neurosci Biobehav Rev, 21, 289, 10.1016/S0149-7634(96)00027-9 · DOI
- 1982, Cerebral metabolism and atrophy in Huntington's disease determined by 18FDG and computed tomographic scan., Ann Neurol, 12, 425, 10.1002/ana.410120504 · DOI · Paper page
- 1987, Reduced cerebral glucose metabolism in asymptomatic subjects at risk for Huntington's disease., N Engl J Med, 316, 357, 10.1056/NEJM198702123160701 · DOI
- 1990, A comparison of neurological, metabolic, structural, and genetic evaluations in persons at risk for Huntington's disease., Ann Neurol, 28, 614, 10.1002/ana.410280503 · DOI
- 1993, Evidence for impairment of energy metabolism in vivo in Huntington's disease using localized 1H NMR spectroscopy., Neurology, 43, 2689, 10.1212/WNL.43.12.2689 · DOI
- 1998, 1H NMR spectroscopy studies of Huntington's disease: Correlations with CAG repeat numbers., Neurology, 50, 1357, 10.1212/WNL.50.5.1357 · DOI
- 2000, Abnormal in vivo skeletal muscle energy metabolism in Huntington's disease and dentatorubropallidoluysian atrophy., Ann Neurol, 48, 72, 10.1002/1531-8249(200007)48:1<72::AID-ANA11>3.0.CO;2-I · DOI
- 2005, Mitochondrial impairment in patients and asymptomatic mutation carriers of Huntington's disease., Mov Disord, 20, 674, 10.1002/mds.20373 · DOI
- 2005, HD CAG repeat implicates a dominant property of huntingtin in mitochondrial energy metabolism., Hum Mol Genet, 14, 2871, 10.1093/hmg/ddi319 · DOI
- 2006, Deletion of the triplet repeat encoding polyglutamine within the mouse Huntington's disease gene results in subtle behavioral/motor phenotypes in vivo and elevated levels of ATP with cellular senescence in vitro., Hum Mol Genet, 15, 607, 10.1093/hmg/ddi477 · DOI
- 2003, In vitro effects of polyglutamine tracts on Ca2+-dependent depolarization of rat and human mitochondria: relevance to Huntington's disease., Arch Biochem Biophys, 410, 1, 10.1016/S0003-9861(02)00585-4 · DOI
- 2000, Dominant phenotypes produced by the HD mutation in STHdh(Q111) striatal cells., Hum Mol Genet, 9, 2799, 10.1093/hmg/9.19.2799 · DOI
- 2006, Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration., Cell, 127, 59, 10.1016/j.cell.2006.09.015 · DOI · Paper page
- 2006, Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1alpha in Huntington's disease neurodegeneration., Cell Metab, 4, 349, 10.1016/j.cmet.2006.10.004 · DOI · Paper page
- 2005, Mitochondrial respiration and ATP production are significantly impaired in striatal cells expressing mutant huntingtin., J Biol Chem, 280, 30773, 10.1074/jbc.M504749200 · DOI
- 2003, Specific progressive cAMP reduction implicates energy deficit in presymptomatic Huntington's disease knock-in mice., Hum Mol Genet, 12, 497, 10.1093/hmg/ddg046 · DOI
- 2006, Cystamine and cysteamine prevent 3-NP-induced mitochondrial depolarization of Huntington's disease knock-in striatal cells., Eur J Neurosci, 23, 1701, 10.1111/j.1460-9568.2006.04686.x · DOI
- 2003, Influence of cytosolic and mitochondrial Ca2+, ATP, mitochondrial membrane potential, and calpain activity on the mechanism of neuron death induced by 3-nitropropionic acid., Neurochem Int, 43, 89, 10.1016/S0197-0186(02)00229-2 · DOI
- 2005, Discovering statistically significant pathways in expression profiling studies., Proc Natl Acad Sci U S A, 102, 13544, 10.1073/pnas.0506577102 · DOI
- 2002, Early transcriptional profiles in huntingtin-inducible striatal cells by microarray analyses., Hum Mol Genet, 11, 1953, 10.1093/hmg/11.17.1953 · DOI · Paper page
- 2004, Nitric oxide switches on glycolysis through the AMP protein kinase and 6-phosphofructo-2-kinase pathway., Nat Cell Biol, 6, 45, 10.1038/ncb1080 · DOI
- 2006, Systematic identification of human mitochondrial disease genes through integrative genomics., Nat Genet, 38, 576, 10.1038/ng1776 · DOI
- 2006, Regional and cellular gene expression changes in human Huntington's disease brain., Hum Mol Genet, 15, 965, 10.1093/hmg/ddl013 · DOI · Paper page
- 1997, Huntingtin is required for neurogenesis and is not impaired by the Huntington's disease CAG expansion., Nat Genet, 17, 404, 10.1038/ng1297-404 · DOI
- 2003, Wild-type huntingtin plays a role in brain development and neuronal survival., Mol Neurobiol, 28, 259, 10.1385/MN:28:3:259 · DOI
- 2006, Body weight is modulated by levels of full-length huntingtin., Hum Mol Genet, 15, 1513, 10.1093/hmg/ddl072 · DOI
- 2005, Inactivation of the Huntington's disease gene (Hdh) impairs anterior streak formation and early patterning of the mouse embryo., BMC Dev Biol, 5, 17, 10.1186/1471-213X-5-17 · DOI
- 1998, Mouse mutant embryos lacking huntingtin are rescued from lethality by wild-type extraembryonic tissues., Development, 125, 1529, 10.1242/dev.125.8.1529 · DOI
- 2000, Huntingtin: An iron-regulated protein essential for normal nuclear and perinuclear organelles., Hum Mol Genet, 9, 2789, 10.1093/hmg/9.19.2789 · DOI · Paper page
- 2003, Huntingtin: Alive and well and working in middle management., Sci STKE, 2003, pe48
- 2003, Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes., Nat Genet, 35, 76, 10.1038/ng1219 · DOI · Paper page
- 2004, NFY interacts with the promoter region of two genes involved in the rat peroxisomal fatty acid beta-oxidation: the multifunctional protein type 1 and the 3-ketoacyl-CoA B thiolase., Lipids Health Dis, 3, 4, 10.1186/1476-511X-3-4 · DOI
- 2006, Redox regulation in anabolic and catabolic processes., Curr Opin Clin Nutr Metab Care, 9, 190, 10.1097/01.mco.0000222098.98514.40 · DOI
- 2006, Activation of glutathione peroxidase via Nrf1 mediates genistein's protection against oxidative endothelial cell injury., Biochem Biophys Res Commun, 346, 851, 10.1016/j.bbrc.2006.05.197 · DOI
- 2002, Interaction of Huntington disease protein with transcriptional activator Sp1., Mol Cell Biol, 22, 1277, 10.1128/MCB.22.5.1277-1287.2002 · DOI
- 2005, In vitro analysis of huntingtin-mediated transcriptional repression reveals multiple transcription factor targets., Cell, 123, 1241, 10.1016/j.cell.2005.10.030 · DOI
- 2006, Decreased association of the transcription factor Sp1 with genes downregulated in Huntington's disease., Neurobiol Dis, 22, 233, 10.1016/j.nbd.2005.11.001 · DOI
- 2002, The predominantly HEAT-like motif structure of huntingtin and its association and coincident nuclear entry with dorsal, an NF-kB/Rel/dorsal family transcription factor., BMC Neurosci, 3, 15, 10.1186/1471-2202-3-15 · DOI
- 1992, Thioredoxin regulates the DNA binding activity of NF-kappa B by reduction of a disulphide bond involving cysteine 62., Nucleic Acids Res, 20, 3821, 10.1093/nar/20.15.3821 · DOI
- 2006, Buffering mitochondrial DNA variation., Nat Genet, 38, 1232, 10.1038/ng1106-1232 · DOI
- 2002, Bioenergetic adaptation of individual human diaphragmatic myofibers to severe COPD., J Appl Physiol, 92, 1205, 10.1152/japplphysiol.00116.2001 · DOI
- 2001, Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method., Methods, 25, 402, 10.1006/meth.2001.1262 · DOI · Paper page
- 2003, A comparison of normalization methods for high density oligonucleotide array data based on variance and bias., Bioinformatics, 19, 185, 10.1093/bioinformatics/19.2.185 · DOI
- 2003, Statistical significance for genomewide studies., Proc Natl Acad Sci U S A, 100, 9440, 10.1073/pnas.1530509100 · DOI · Paper page
- 2003, DAVID: Database for annotation, visualization, and integrated discovery., Genome Biol, 4, P3, 10.1186/gb-2003-4-5-p3 · DOI · Paper page
- 1998, Cluster analysis and display of genome-wide expression patterns., Proc Natl Acad Sci U S A, 95, 14863, 10.1073/pnas.95.25.14863 · DOI · Paper page
- 2001, Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection., Proc Natl Acad Sci U S A, 98, 31, 10.1073/pnas.98.1.31 · DOI · Paper page
- 2004, Bioconductor: open software development for computational biology and bioinformatics., Genome Biol, 5, R80, 10.1186/gb-2004-5-10-r80 · DOI
- 2005, The MAPPER database: A multi-genome catalog of putative transcription factor binding sites., Nucleic Acids Res, 33, D91
Cited by
Sorted by citations
Cannabidiol is a negative allosteric modulator of the cannabinoid CB 1 receptor
Laprairie, R. B., Bagher, A. M., Kelly, M. E. M., & Denovan‐Wright, E. M. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13250 · Cited by 1,039
Mitochondria and Huntington's Disease Pathogenesis: Insight from Genetic and Chemical Models
Browne, S. E. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1427.018 · Cited by 176
Ghose, J., Sinha, M., Das, E., Jana, N. R., & Bhattacharyya, N. P. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023837 · Cited by 98
McClory, H., Williams, D., Sapp, E., Gatune, L. W., Wang, P., DiFiglia, M., & Li, X. (2014) · Acta Neuropathologica Communications · doi:10.1186/s40478-014-0178-7 · Cited by 60
Metadata
- Authors
- Lee, J.-M., Ivanova, E. V., Seong, I. S., Cashorali, T., Kohane, I., Gusella, J. F., & MacDonald, M. E.
- Venue
- PLoS Genetics
- Publisher
- Public Library of Science (PLoS)
- Published
- 2007-08-17
- Volume
- 3
- Issue
- 8
- Pages
- e135
- ISSN
- 1553-7404
- PMC
- PMC1950164
- Cited by
- 71
- References
- 5
- Language
- en
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review