p53 Functions through Stress- and Promoter-Specific Recruitment of Transcription Initiation Components before and after DNA Damage

Live or let die: the cell's response to p53

Vousden, K. H., & Lü, X. (2002) · Nature reviews. Cancer · doi:10.1038/nrc864 · Cited by 3,177 · see citing works

The RNA Polymerase II Core Promoter

Smale, S. T., & Kadonaga, J. T. (2003) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.72.121801.161520 · Cited by 1,138 · see citing works

Different phosphorylated forms of RNA polymerase II and associated mRNA processing factors during transcriptionPreprint

Komarnitsky, P. B., Cho, E., & Buratowski, S. (2000) · Genes & Development · doi:10.1101/gad.824700 · Cited by 1,098 · see citing works

Histone deacetylase inhibitor selectively induces p21 ^WAF1 expression and gene-associated histone acetylation

Richon, V. M., Sandhoff, T. W., Rifkind, R. A., & Marks, P. A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.180316197 · Cited by 1,090 · see citing works

p63 and p73 are required for p53-dependent apoptosis in response to DNA damage

Flores, E. R., Tsai, K. Y., Crowley, D. G., Sengupta, S., Yang, A., McKeon, F., & Jacks, T. (2002) · Nature · doi:10.1038/416560a · Cited by 801 · see citing works

The RNA polymerase II molecule at the 5′ end of the uninduced hsp70 gene of D. melanogaster is transcriptionally engaged

Rougvie, A. E., & Lis, J. T. (1988) · Cell · doi:10.1016/s0092-8674(88)91087-2 · Cited by 680 · see citing works

ASPP Proteins Specifically Stimulate the Apoptotic Function of p53

Samuels-Lev, Y., O'Connor, D. J., Bergamaschi, D., Trigiante, G., Hsieh, J.-K., Zhong, S., Campargue, I., Naumovski, L., Crook, T., & Lu, X. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00367-7 · Cited by 664 · see citing works

The RNA polymerase II core promoter: a key component in the regulation of gene expressionPreprint

Butler, J. E. F., & Kadonaga, J. T. (2002) · Genes & Development · doi:10.1101/gad.1026202 · Cited by 651 · see citing works

Analysis of p53-regulated gene expression patterns using oligonucleotide arraysPreprint

Zhao, R., Gish, K., Murphy, M. E., Yin, Y., Notterman, D. A., Hoffman, W. H., Tom, E., Mack, D. H., & Levine, A. J. (2000) · Genes & Development · doi:10.1101/gad.14.8.981 · Cited by 631 · see citing works

Signaling to p53

Prives, C. (1998) · Cell · doi:10.1016/s0092-8674(00)81774-2 · Cited by 623 · see citing works

Regulation of p53 function and stability by phosphorylation.

Ashcroft, M., Kubbutat, M. H. G., & Vousden, K. H. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.3.1751 · Cited by 452 · see citing works

Transcriptional Regulation by p53 through Intrinsic DNA/Chromatin Binding and Site-Directed Cofactor Recruitment

Espinosa, J. M., & Emerson, B. M. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00283-0 · Cited by 440 · see citing works

Opposing effects of Ctk1 kinase and Fcp1 phosphatase at Ser 2 of the RNA polymerase II C-terminal domainPreprint

Cho, E., Kobor, M. S., Kim, M. K., Greenblatt, J., & Buratowski, S. (2001) · Genes & Development · doi:10.1101/gad.935901 · Cited by 428 · see citing works

The evolution of diverse biological responses to DNA damage: insights from yeast and p53

Wahl, G. M., & Carr, A. M. (2001) · Nature Cell Biology · doi:10.1038/ncb1201-e277 · Cited by 376 · see citing works

Chromatin immunoprecipitation analysis fails to support the latency model for regulation of p53 DNA binding activity in vivo

Kaeser, M., & Iggo, R. (2001) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.012283399 · Cited by 346 · see citing works

TAFs revisited: more data reveal new twists and confirm old ideas

Albright, S. R., & Tjian, R. (2000) · Gene · doi:10.1016/s0378-1119(99)00495-3 · Cited by 322 · see citing works

A DNA Damage–Induced p53 Serine 392 Kinase Complex Contains CK2, hSpt16, and SSRP1

Keller, D. M., Zeng, X., Wang, Y., Zhang, Q. H., Kapoor, M., Shu, H., Goodman, R. H., Lozano, G., Zhao, Y., & Lu, H. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00176-9 · Cited by 297 · see citing works

The block to transcriptional elongation within the human c-myc gene is determined in the promoter-proximal region.Preprint

Krumm, A., Meulia, T., Brunvand, M. W., & Groudine, M. T. (1992) · Genes & Development · doi:10.1101/gad.6.11.2201 · Cited by 263 · see citing works

Transcriptional elongation by RNA polymerase II is stimulated by transactivators

Yankulov, K., Blau, J., Purton, T. J., Roberts, S., & Bentley, D. L. (1994) · Cell · doi:10.1016/0092-8674(94)90058-2 · Cited by 243 · see citing works

Kinetics of p53 Binding to Promoter Sites In Vivo

Szak, S. T., Mays, D. J., & Pietenpol, J. A. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.10.3375-3386.2001 · Cited by 178 · see citing works

Functional interactions between p53 and the TFIIH complex are affected by tumour‐associated mutations.

Léveillard, T., Anděra, L., Bissonnette, N., Schaeffer, L., Bracco, L. P., Egly, J., & Wasylyk, B. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00506.x · Cited by 173 · see citing works

p21/p53, Cellular Growth Control and Genomic Integrity

El‐Deiry, W. S. (1998) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-71941-7_6 · Cited by 172 · see citing works

TAFII250

Wassarman, D. A., & Sauer, F. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.16.2895 · Cited by 107 · see citing works

SURVEY AND SUMMARY: Spatial organization of RNA polymerase II transcription in the nucleus

Szentirmay, M. N. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.10.2019 · Cited by 39 · see citing works

Cellular senescence: when bad things happen to good cells

Campisi, J., & d'Adda di Fagagna, F. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2233 · Cited by 4,441 · see citing works

Putting p53 in context

Kastenhuber, E. R., & Lowe, S. W. (2017) · Cell · doi:10.1016/j.cell.2017.08.028 · Cited by 1,906 · see citing works

c-Myc Regulates Transcriptional Pause Release

Rahl, P. B., Lin, C. Y., Seila, A. C., Flynn, R. A., McCuine, S., Burge, C. B., Sharp, P. A., & Young, R. A. (2010) · Cell · doi:10.1016/j.cell.2010.03.030 · Cited by 1,279 · see citing works

The multiple mechanisms that regulate p53 activity and cell fate

Hafner, A., Bulyk, M. L., Jambhekar, A., & Lahav, G. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0110-x · Cited by 1,129 · see citing works

Census and evaluation of p53 target genes

Fischer, M. (2017) · Oncogene · doi:10.1038/onc.2016.502 · Cited by 971 · see citing works

Transcriptional Regulation by P53

Beckerman, R., & Prives, C. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a000935 · Cited by 569 · see citing works

The expanding universe of p53 targets

Menendez, D., Inga, A., & Resnick, M. A. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2730 · Cited by 568 · see citing works

H3K4me3 Interactions with TAF3 Regulate Preinitiation Complex Assembly and Selective Gene Activation

Lauberth, S. M., Nakayama, T., Wu, X., Ferris, A. L., Tang, Z., Hughes, S. H., & Roeder, R. G. (2013) · Cell · doi:10.1016/j.cell.2013.01.052 · Cited by 473 · see citing works

The p53 response to DNA damage

Meek, D. W. (2004) · DNA Repair · doi:10.1016/j.dnarep.2004.03.027 · Cited by 329 · see citing works

Cooperative regulation of p53 by modulation of ternary complex formation with CBP/p300 and HDM2

Ferreon, J. C., Lee, C. W., Arai, M., Martinez-Yamout, M. A., Dyson, H. J., & Wright, P. E. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811023106 · Cited by 210 · see citing works

Diverse stresses dramatically alter genome-wide p53 binding and transactivation landscape in human cancer cells

Menendez, D., Nguyen, T.-A., Freudenberg, J. M., Mathew, V. J., Anderson, C. W., Jothi, R., & Resnick, M. A. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt504 · Cited by 154 · see citing works

E2F7, a novel target, is up-regulated by p53 and mediates DNA damage-dependent transcriptional repression

Carvajal, L. A., Hamard, P.-J., Tonnessen, C., & Manfredi, J. J. (2012) · Genes & Development · doi:10.1101/gad.184911.111 · Cited by 151 · see citing works

Another fork in the road—life or death decisions by the tumour suppressor p53

Carvajal, L. A., & Manfredi, J. J. (2013) · The EMBO Reports · doi:10.1038/embor.2013.25 · Cited by 149 · see citing works

The Toll-like receptor gene family is integrated into human DNA damage and p53 networks

Menendez, D., Shatz, M., Azzam, K., Garantziotis, S., Fessler, M. B., & Resnick, M. A. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1001360 · Cited by 148 · see citing works

Pharmacological inhibition of the transcription factor PU.1 in leukemia

Antony-Debré, I., Paul, A., Leite, J., Mitchell, K., Kim, H. M., Carvajal, L. A., Todorova, T. I., Huang, K., Kumar, A., Farahat, A. A., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci92504 · Cited by 120 · see citing works

Noncanonical DNA Motifs as Transactivation Targets by Wild Type and Mutant p53

Jordan, J. J., Menendez, D., Inga, A., Nourredine, M., Bell, D., & Resnick, M. A. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000104 · Cited by 103 · see citing works

A distinct p53 target gene set predicts for response to the selective p53–HDM2 inhibitor NVP-CGM097

Jeay, S., Gaulis, S., Ferretti, S., Bitter, H., Ito, M., Valat, T., Murakami, M., Ruetz, S., Guthy, D. A., Rynn, C., et al. (2015) · eLife · doi:10.7554/elife.06498 · Cited by 85 · see citing works

Characterization of the p53 Cistrome – DNA Binding Cooperativity Dissects p53's Tumor Suppressor Functions

Schlereth, K., Heyl, C., Krampitz, A.-M., Mernberger, M., Finkernagel, F., Scharfe, M., Jarek, M., Leich, E., Rosenwald, A., & Stiewe, T. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003726 · Cited by 87 · see citing works

Regulation of the p53 transcriptional response by structurally diverse core promoters

Morachis, J. M., Murawsky, C. M., & Emerson, B. M. (2010) · Genes & Development · doi:10.1101/gad.1856710 · Cited by 86 · see citing works

USP7 enforces heterochromatinization of p53 target promoters by protecting SUV39H1 from MDM2-mediated degradation.

Mungamuri, S. K., Qiao, R. F., Yao, S., Manfredi, J. J., Gu, W., & Aaronson, S. A. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.02.049 · Cited by 54 · see citing works

Fine-tuning p53 activity through C-terminal modification significantly contributes to HSC homeostasis and mouse radiosensitivity

Wang, Y. V., Leblanc, M., Fox, N., Mao, J.-H., Tinkum, K. L., Krummel, K., Engle, D., Piwnica-Worms, D., Piwnica-Worms, H., Balmain, A., et al. (2011) · Genes & Development · doi:10.1101/gad.2024411 · Cited by 53 · see citing works

A Spectrum of Mechanisms for the Assembly of the RNA Polymerase II Transcription Preinitiation Complex

George, C. P., Lira, L. M., Wampler, S. L., & Kadonaga, J. T. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.2.1049 · Cited by 14 · see citing works

Author Index for Volume 244, Numbers 1-3

(1994) · Journal of Molecular Biology · doi:10.1006/jmbi.1994.1734

Kinetic and mechanistic analysis of the RNA polymerase II transcription reaction at the human interleukin-2 promoter

Ferguson, H. A., Kugel, J. F., & Goodrich, J. A. (2001) · Journal of Molecular Biology · doi:10.1006/jmbi.2000.5215 · Cited by 25 · see citing works

RNA polymerase II transcriptional machinery

Hampsey, M. (2000) · doi:10.1093/oso/9780199637737.003.0006

Recruitment of TBP or TFIIB to a Promoter Proximal Position Leads to Stimulation of RNA Polymerase II Transcription without Activator Proteins bothin Vivoandin Vitro

Huh, J. R., Park, J. M., Kim, M., et al. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0280 · Cited by 12 · see citing works