Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 170

The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.

Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution

Open access
Lindgren, Cecilia M., Heid, Iris M., Randall, Joshua C., Lamina, Claudia, Steinthorsdottir, Valgerdur, Qi, Lu, Speliotes, Elizabeth K., Thorleifsson, Gudmar, Willer, Cristen J., Herrera, Blanca M., Jackson, Anne U., Lim, Noha, Scheet, Paul, Soranzo, Nicole, Amin, Najaf, Aulchenko, Yurii S., Chambers, John C., Drong, Alexander, Luan, Jian'an, Lyon, Helen N., Rivadeneira, Fernando, Sanna, Serena, Timpson, Nicholas J., Zillikens, M. Carola, Zhao, Jing Hua, Almgren, Peter, Bandinelli, Stefania, Bennett, Amanda J., Bergman, Richard N., Bonnycastle, Lori L., Bumpstead, Suzannah J., Chanock, Stephen J., Cherkas, Lynn, Chines, Peter, Coin, Lachlan, Cooper, Cyrus, Crawford, Gabriel, Doering, Angela, Dominiczak, Anna, Doney, Alex S. F., Ebrahim, Shah, Elliott, Paul, Erdos, Michael R., Estrada, Karol, Ferrucci, Luigi, Fischer, Guido, Forouhi, Nita G., Gieger, Christian, Grallert, Harald, Groves, Christopher J., Grundy, Scott, Guiducci, Candace, Hadley, David, Hamsten, Anders, Havulinna, Aki S., Hofman, Albert, Holle, Rolf, Holloway, John W., Illig, Thomas, Isomaa, Bo, Jacobs, Leonie C., Jameson, Karen, Jousilahti, Pekka, Karpe, Fredrik, Kuusisto, Johanna, Laitinen, Jaana, Lathrop, G. Mark, Lawlor, Debbie A., Mangino, Massimo, McArdle, Wendy L., Meitinger, Thomas, Morken, Mario A., Morris, Andrew P., Munroe, Patricia, Narisu, Narisu, Nordström, Anna, Nordström, Peter, Oostra, Ben A., Palmer, Colin N. A., Payne, Felicity, Peden, John F., Prokopenko, Inga, Renström, Frida, Ruokonen, Aimo, Salomaa, Veikko, Sandhu, Manjinder S., Scott, Laura J., Scuteri, Angelo, Silander, Kaisa, Song, Kijoung, Yuan, Xin, Stringham, Heather M., Swift, Amy J., Tuomi, Tiinamaija, Uda, Manuela, Vollenweider, Peter, Waeber, Gerard, Wallace, Chris, Walters, G. Bragi, Weedon, Michael N., The Wellcome Trust Case Control Consortium, Witteman, Jacqueline C. M., Zhang, Cuilin, Zhang, Weihua, Caulfield, Mark J., Collins, Francis S., Davey Smith, George, Day, Ian N. M., Franks, Paul W., Hattersley, Andrew T., Hu, Frank B., Jarvelin, Marjo-Riitta, Kong, Augustine, Kooner, Jaspal S., Laakso, Markku, Lakatta, Edward, Mooser, Vincent, Morris, Andrew D., Peltonen, Leena, Samani, Nilesh J., Spector, Timothy D., Strachan, David P., Tanaka, Toshiko, Tuomilehto, Jaakko, Uitterlinden, André G., van Duijn, Cornelia M., Wareham, Nicholas J., Watkins for the PROCARDIS consortia, Hugh, Waterworth, Dawn M., Boehnke, Michael, Deloukas, Panos, Groop, Leif, Hunter, David J., Thorsteinsdottir, Unnur, Schlessinger, David, Wichmann, H.-Erich, Frayling, Timothy M., Abecasis, Gonçalo R., Hirschhorn, Joel N., Loos, Ruth J. F., Stefansson, Kari, Mohlke, Karen L., Barroso, Inês, McCarthy for the GIANT consortium, Mark I.·2009·PLoS Genetics
DOI 10.1371/journal.pgen.1000508
Open this paper in CoChat — free account

Abstract

To identify genetic loci influencing central obesity and fat distribution, we performed a meta-analysis of 16 genome-wide association studies (GWAS, N = 38,580) informative for adult waist circumference (WC) and waist-hip ratio (WHR). We selected 26 SNPs for follow-up, for which the evidence of association with measures of central adiposity (WC and/or WHR) was strong and disproportionate to that for overall adiposity or height. Follow-up studies in a maximum of 70,689 individuals identified two loci strongly associated with measures of central adiposity; these map near TFAP2B (WC, P = 1.9x10(-11)) and MSRA (WC, P = 8.9x10(-9)). A third locus, near LYPLAL1, was associated with WHR in women only (P = 2.6x10(-8)). The variants near TFAP2B appear to influence central adiposity through an effect on overall obesity/fat-mass, whereas LYPLAL1 displays a strong female-only association with fat distribution. By focusing on anthropometric measures of central obesity and fat distribution, we have identified three loci implicated in the regulation of human adiposity.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1371/journal.pgen.1000508

Cites

10 of 10 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 10 references

Cited by

See all 170

Metadata

Authors
Lindgren, C. M., Heid, I. M., Randall, J. C., Lamina, C., Steinthorsdottir, V., Qi, L., Speliotes, E. K., Thorleifsson, G., Willer, C. J., Herrera, B. M., Jackson, A. U., Lim, N., Scheet, P., Soranzo, N., Amin, N., Aulchenko, Y. S., Chambers, J. C., Drong, A., Luan, J., Lyon, H. N., Rivadeneira, F., Sanna, S., Timpson, N. J., Zillikens, M. C., Zhao, J. H., Almgren, P., Bandinelli, S., Bennett, A. J., Bergman, R. N., Bonnycastle, L. L., Bumpstead, S. J., Chanock, S. J., Cherkas, L., Chines, P., Coin, L., Cooper, C., Crawford, G., Doering, A., Dominiczak, A., Doney, A. S. F., Ebrahim, S., Elliott, P., Erdos, M. R., Estrada, K., Ferrucci, L., Fischer, G., Forouhi, N. G., Gieger, C., Grallert, H., Groves, C. J., Grundy, S., Guiducci, C., Hadley, D., Hamsten, A., Havulinna, A. S., Hofman, A., Holle, R., Holloway, J. W., Illig, T., Isomaa, B., Jacobs, L. C., Jameson, K., Jousilahti, P., Karpe, F., Kuusisto, J., Laitinen, J., Lathrop, G. M., Lawlor, D. A., Mangino, M., McArdle, W. L., Meitinger, T., Morken, M. A., Morris, A. P., Munroe, P., Narisu, N., Nordström, A., Nordström, P., Oostra, B. A., Palmer, C. N. A., Payne, F., Peden, J. F., Prokopenko, I., Renström, F., Ruokonen, A., Salomaa, V., Sandhu, M. S., Scott, L. J., Scuteri, A., Silander, K., Song, K., Yuan, X., Stringham, H. M., Swift, A. J., Tuomi, T., Uda, M., Vollenweider, P., Waeber, G., Wallace, C., Walters, G. B., Weedon, M. N., The Wellcome Trust Case Control Consortium, Witteman, J. C. M., Zhang, C., Zhang, W., Caulfield, M. J., Collins, F. S., Davey Smith, G., Day, I. N. M., Franks, P. W., Hattersley, A. T., Hu, F. B., Jarvelin, M.-R., Kong, A., Kooner, J. S., Laakso, M., Lakatta, E., Mooser, V., Morris, A. D., Peltonen, L., Samani, N. J., Spector, T. D., Strachan, D. P., Tanaka, T., Tuomilehto, J., Uitterlinden, A. G., van Duijn, C. M., Wareham, N. J., Watkins for the PROCARDIS consortia, H., Waterworth, D. M., Boehnke, M., Deloukas, P., Groop, L., Hunter, D. J., Thorsteinsdottir, U., Schlessinger, D., Wichmann, H.-E., Frayling, T. M., Abecasis, G. R., Hirschhorn, J. N., Loos, R. J. F., Stefansson, K., Mohlke, K. L., Barroso, I., & McCarthy for the GIANT consortium, M. I.
Venue
PLoS Genetics
Publisher
Public Library of Science (PLoS)
Published
2009-06-26
Volume
5
Issue
6
Pages
e1000508
ISSN
  • 1553-7390 (ISSN-L)
  • 1553-7404
DOI
10.1371/journal.pgen.1000508
OpenAlex
W1572982878
Cited by
170
References
10
FWCI
12.12
Type
journal article
Language
en
Open access
gold

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution. https://app.cochat.ai/papers/10.1371/journal.pgen.1000508
The paper
Lindgren, C. M., Heid, I. M., Randall, J. C., Lamina, C., Steinthorsdottir, V., Qi, L., Speliotes, E. K., Thorleifsson, G., Willer, C. J., Herrera, B. M., Jackson, A. U., Lim, N., Scheet, P., Soranzo, N., Amin, N., Aulchenko, Y. S., Chambers, J. C., Drong, A., Luan, J., . . . McCarthy for the GIANT consortium, M. I. (2009). Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution. PLoS Genetics. https://doi.org/10.1371/journal.pgen.1000508

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.