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Exploiting synthetic lethality to target BRCA1/2-deficient tumors: where we stand

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Overexpression of Flap Endonuclease 1 Correlates with Enhanced Proliferation and Poor Prognosis of Non–Small-Cell Lung Cancer

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Synthetic Lethality and Cancer – Penetrance as the Major Barrier

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PROTACs: Current and Future Potential as a Precision Medicine Strategy to Combat Cancer

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Cellularly active N-hydroxyurea FEN1 inhibitors block substrate entry to the active site

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Overexpression screens identify conserved dosage chromosome instability genes in yeast and human cancer

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Inferring synthetic lethal interactions from mutual exclusivity of genetic events in cancer

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Evolving Therapeutic Strategies to Exploit Chromosome Instability in Cancer

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Discovery of Myricetin as a Potent Inhibitor of Human Flap Endonuclease 1, Which Potentially Can Be Used as Sensitizing Agent against HT-29 Human Colon Cancer Cells

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DNA damage repair in breast cancer and its therapeutic implications

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Integrating genetic and protein–protein interaction networks maps a functional wiring diagram of a cell

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Synthetic Lethal Targeting of Superoxide Dismutase 1 Selectively Kills RAD54B-Deficient Colorectal Cancer Cells

Sajesh, B. V., Bailey, M. L., Lichtensztejn, Z., Hieter, P., & McManus, K. J. (2013) · Genetics · doi:10.1534/genetics.113.156836 · Cited by 49 · see citing works

Small molecule inhibitors uncover synthetic genetic interactions of human flap endonuclease 1 (FEN1) with DNA damage response genes

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Flap endonuclease overexpression drives genome instability and DNA damage hypersensitivity in a PCNA-dependent manner

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Detection of Cancer Marker Flap Endonuclease 1 Using One-Pot Transcription-Powered Clustered Regularly Interspaced Short Palindromic Repeat/Cas12a Signal Expansion

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Beyond Kinases: Targeting Replication Stress Proteins in Cancer Therapy

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Synthetic Lethal Vulnerabilities of Cancer

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Saccharomyces cerevisiaeGenetics Predicts Candidate Therapeutic Genetic Interactions at the Mammalian Replication Fork

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Fragment- and structure-based drug discovery for developing therapeutic agents targeting the DNA Damage Response

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Identification of human flap endonuclease 1 (FEN1) inhibitors using a machine learning based consensus virtual screening

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Synthetic Genetic Targeting of Genome Instability in Cancer

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Building high-resolution synthetic lethal networks: a ‘Google map’ of the cancer cell

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Endonuclease FEN1 Coregulates ERα Activity and Provides a Novel Drug Interface in Tamoxifen-Resistant Breast Cancer

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Mitotic Accumulation of Dimethylated Lysine 79 of Histone H3 Is Important for Maintaining Genome Integrity During Mitosis in Human Cells

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The synthetic lethal killing of RAD54B-deficient colorectal cancer cells by PARP1 inhibition is enhanced with SOD1 inhibition

McAndrew, E. N., Lepage, C. C., & McManus, K. J. (2016) · Oncotarget · doi:10.18632/oncotarget.13654 · Cited by 31 · see citing works

Targeting the Genome‐Stability Hub Ctf4 by Stapled‐Peptide Design

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Cancer TARGETases: DSB repair as a pharmacological target

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A Novel Multiplexed, Image-Based Approach to Detect Phenotypes That Underlie Chromosome Instability in Human Cells

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Synthetic Lethal Networks for Precision Oncology: Promises and Pitfalls

Shen, J. P., & Ideker, T. (2018) · Journal of Molecular Biology · doi:10.1016/j.jmb.2018.06.026 · Cited by 27 · see citing works

Mdivi-1 and mitochondrial fission: recent insights from fungal pathogens

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Crosstalk of promoter and terminator during RNA polymerase II transcription cycle

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Nucleases in homologous recombination as targets for cancer therapy

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Synthetic lethality in cancer drug discovery: challenges and opportunities

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Association of functional FEN1 genetic variants and haplotypes and breast cancer risk

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DNA Repair Endonucleases: Physiological Roles and Potential as Drug Targets

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The natural anticancer agent cantharidin alters GPI-anchored protein sorting by targeting Cdc1-mediated remodeling in endoplasmic reticulum

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Positioning the 5′-flap junction in the active site controls the rate of flap endonuclease-1–catalyzed DNA cleavage

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Cross-Species Complementation of Nonessential Yeast Genes Establishes Platforms for Testing Inhibitors of Human Proteins

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Small Molecule Inhibitors Targeting Key Proteins in the DNA Damage Response for Cancer Therapy

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Inhibition of AKT Sensitizes Cancer Cells to Antineoplastic Drugs by Downregulating Flap Endonuclease 1

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Global genetic interaction network of a human cell maps conserved principles and informs functional interpretation of gene co-essentiality profiles

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Application of the concept synthetic lethality toward anticancer therapy: A promise fulfilled?

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Genetic interaction networks mediate individual statin drug response in Saccharomyces cerevisiae

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Theranostic Interpolation of Genomic Instability in Breast Cancer

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Synthetic Cytotoxicity: Digenic Interactions with TEL1/ATM Mutations Reveal Sensitivity to Low Doses of Camptothecin

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Synthetic lethal targeting of RNF20 through PARP1 silencing and inhibition

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FEN1 inhibitor SC13 promotes CAR‐T cells infiltration into solid tumours through cGAS–STING signalling pathway

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Dynamics of replication proteins during lagging strand synthesis: A crossroads for genomic instability and cancer

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Regional conformational flexibility couples substrate specificity and scissile phosphate diester selectivity in human flap endonuclease 1

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FEN1gene variants confer reduced risk of breast cancer in chinese women: A case-control study

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Implementing fluorescence enhancement, quenching, and FRET for investigating flap endonuclease 1 enzymatic reaction at the single-molecule level

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Human artificial chromosome (HAC) for measuring chromosome instability (CIN) and identification of genes required for proper chromosome transmission

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FEN1 knockdown improves trastuzumab sensitivity in human epidermal growth factor 2-positive breast cancer cells

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A computational approach inspired by simulated annealing to study the stability of protein interaction networks in cancer and neurological disorders

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FEN1 inhibitor synergizes with low-dose camptothecin to induce increased cell killing via the mitochondria mediated apoptotic pathway

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The prognostic significance of Flap Endonuclease 1 (FEN1) in breast ductal carcinoma in situ

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Selective Targeting of Cancer Cells using Personalized Nanomedicine

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Mechanism of Homologous Recombination

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Discovery of new inhibitors of nuclease MRE11

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Modeling DNA trapping of anticancer therapeutic targets using missense mutations identifies dominant synthetic lethal interactions

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Navigating yeast genome maintenance with functional genomics

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Revealing Functional Crosstalk between Distinct Bioprocesses through Reciprocal Functional Tests of Genetically Interacting Genes

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Exploring Candidate Human Synthetic Lethal Interactions Through siRNA and Quantitative Imaging-Based Approaches

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Targeting the Genome‐Stability Hub Ctf4 by Stapled‐Peptide Design

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Cell plasticity and genomic instability in cancer evolution

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Employing Cross-Species Approaches to Construct Humanized Genetic Interaction Networks

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Synthetic Genetic Approaches in Colorectal Cancer: Exploiting and Targeting Genome Instability

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Development and implementation of precision therapies targeting base-excision DNA repair in BRCA1-associated tumors

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A redução de DDB2 está relacionada ao pior prognóstico de sobrevida dos pacientes com glioma e a maior agressividade de células U138MG

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Identification of synthetic cytotoxic interactions to improve the efficacy of DNA damaging therapeutic agents

Moshgabadi, N. (2014) · cIRcle (University of British Columbia) · doi:10.14288/1.0166852

Meeting report – 9th IRIC International Symposium on Molecular Targets in Cancer Genomics

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Profile of Philip Hieter

Gabrielsen, P. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1616437113

The Molecular Pathology of Serous Endometrial Cancer

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Base unpairing at the flap junction controls the rate of FEN1‐catalyzed cleavage of DNA during replication and repair

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Fluorescence-Based Detection of FEN1 Nuclease Activity and Screening of Small-Molecule Inhibitors

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A dual mode one-pot assay detecting FEN1 activity through magnetic separation-based cascade exponential amplification strategy

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BindingDB Entry 50023107: Discovery of new inhibitors of nuclease MRE11.

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BindingDB Entry 7477: Cellularly active N-hydroxyurea FEN1 inhibitors block substrate entry to the active site.

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Evolutionarily conserved synthetic lethal interaction networks reveal targets for anticancer therapeutic development

van Pel, D. M. (2012) · cIRcle (University of British Columbia)

FEN1 endonuclease as a therapeutic target for human cancers with defects in homologous recombination

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Saccharomyces cerevisiaeGenetics Predicts Candidate Therapeutic Genetic Interactions at the Mammalian Replication Fork

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Specific synthetic lethal killing of RAD54B-deficient human colorectal cancer cells by FEN1 silencing

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Abstract IA7: Chromosome instability and synthetic lethality in yeast and cancer

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