Therapeutic opportunities within the DNA damage response
Open accessAbstract
The DNA damage response (DDR) is essential for maintaining the genomic integrity of the cell, and its disruption is one of the hallmarks of cancer. Classically, defects in the DDR have been exploited therapeutically in the treatment of cancer with radiation therapies or genotoxic chemotherapies. More recently, protein components of the DDR systems have been identified as promising avenues for targeted cancer therapeutics. Here, we present an in-depth analysis of the function, role in cancer and therapeutic potential of 450 expert-curated human DDR genes. We discuss the DDR drugs that have been approved by the US Food and Drug Administration (FDA) or that are under clinical investigation. We examine large-scale genomic and expression data for 15 cancers to identify deregulated components of the DDR, and we apply systematic computational analysis to identify DDR proteins that are amenable to modulation by small molecules, highlighting potential novel therapeutic targets.
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No biallelic inactivation was found in 52 additional HR pathway genes that could explain the HR-defective signatures.
“We found no evidence of biallelic inactivation of 52 additional genes involved in the HR pathway [12] that could account for the HR defective signatures”
From Whole-genome sequencing reveals clinically relevant insights into the aetiology of familial breast cancers (2019) · cites this paper as [12]
No biallelic inactivation of 52 HR-related genes was found in case FBC060681.
“No evidence of biallelic inactivation in 52 HR-related genes [12] were identified in this case”
From Whole-genome sequencing reveals clinically relevant insights into the aetiology of familial breast cancers (2019) · cites this paper as [12]
Cites
Gene Ontology: tool for the unification of biology
Ashburner, M., Ball, C. A., Blake, J. A., Botstein, D., Butler, H., Cherry, J. M., Davis, A. P., Dolinski, K., Dwight, S. S., Eppig, J. T., et al. (2000) · Nature Genetics · doi:10.1038/75556 · Cited by 43,206 · see citing works
PD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer
Hartkopf, A. D., Taran, F., Wallwiener, M., Walter, C. B., Krämer, B., Grischke, E., & Brucker, S. Y. (2016) · Breast Care · doi:10.1159/000453569 · Cited by 30,989 · see citing works
Nishimura, R., Osako, T., Nishiyama, Y., Tashima, R., Nakano, M., Fujisue, M., Toyozumi, Y., & Arima, N. (2013) · Oncology · doi:10.1159/000353099 · Cited by 13,239 · see citing works
Comprehensive molecular portraits of human breast tumours
The Cancer Genome Atlas Network (2012) · Nature · doi:10.1038/nature11412 · Cited by 12,129 · see citing works
Gephi: An Open Source Software for Exploring and Manipulating Networks
Bastian, M., Heymann, S., & Jacomy, M. (2009) · Proceedings of the International AAAI Conference on Web and Social Media · doi:10.1609/icwsm.v3i1.13937 · Cited by 11,675 · see citing works
Signatures of mutational processes in human cancer
Initiative, A. P. C. G., Alexandrov, L. B., ICGC Breast Cancer Consortium, ICGC MMML-Seq Consortium, PedBrain, I., Nik-Zainal, S., Wedge, D. C., Aparicio, S. A. J. R., Behjati, S., Biankin, A. V., et al. (2013) · Nature · doi:10.1038/nature12477 · Cited by 9,660 · see citing works
The cancer genome atlas pan-cancer analysis project
The Cancer Genome Atlas Research Network, Weinstein, J. N., Collisson, E. A., Mills, G. B., Shaw, K. R. M., Ozenberger, B. A., Ellrott, K., Shmulevich, I., Sander, C., & Stuart, J. M. (2013) · Nature Genetics · doi:10.1038/ng.2764 · Cited by 9,092 · see citing works
Comprehensive molecular characterization of human colon and rectal cancer
The Cancer Genome Atlas Network (2012) · Nature · doi:10.1038/nature11252 · Cited by 8,499 · see citing works
Integrated genomic analyses of ovarian carcinoma
Perou, C. M. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/hvp3-wg08 · Cited by 7,927 · see citing works
Vogelstein, B., Papadopoulos, N., Velculescu, V. E., Zhou, S., Diaz, L. A., & Kinzler, K. W. (2013) · Science · doi:10.1126/science.1235122 · Cited by 7,863 · see citing works
Comprehensive genomic characterization defines human glioblastoma genes and core pathways
The Cancer Genome Atlas Research Network (2008) · Nature · doi:10.1038/nature07385 · Cited by 7,735 · see citing works
Vogelstein, B., Lane, D., & Levine, A. J. (2000) · Nature · doi:10.1038/35042675 · Cited by 6,607 · see citing works
An Integrated Genomic Analysis of Human Glioblastoma Multiforme
Parsons, D. W., Jones, S., Zhang, X., Lin, J. C.-H., Leary, R. J., Angenendt, P., Mankoo, P., Carter, H., Siu, I.-M., Gallia, G. L., et al. (2008) · Science · doi:10.1126/science.1164382 · Cited by 5,857 · see citing works
Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia
The Cancer Genome Atlas Research Network (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1301689 · Cited by 5,078 · see citing works
Cytoscape 2.8: new features for data integration and network visualization
Smoot, M. E., Ono, K., Ruscheinski, J., Wang, P., & Ideker, T. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq675 · Cited by 4,770 · see citing works
STRING v9.1: protein-protein interaction networks, with increased coverage and integration
Franceschini, A., Szklarczyk, D., Frankild, S., Kuhn, M., Simonovic, M., Roth, A., Lin, J., Minguez, P., Bork, P., von Mering, C., et al. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks1094 · Cited by 4,398 · see citing works
ChEMBL: a large-scale bioactivity database for drug discovery
Gaulton, A., Bellis, L. J., Bento, A. P., Chambers, J., Davies, M., Hersey, A., Light, Y., McGlinchey, S., Michalovich, D., Al-Lazikani, B., et al. (2012) · Nucleic Acids Research · doi:10.1093/nar/gkr777 · Cited by 4,382 · see citing works
Self-citationComprehensive genomic characterization of squamous cell lung cancers
The Cancer Genome Atlas Research Network (2012) · Nature · doi:10.1038/nature11404 · Cited by 3,994 · see citing works
Drug-like properties and the causes of poor solubility and poor permeability
Lipinski, C. A. (2000) · Journal of Pharmacological and Toxicological Methods · doi:10.1016/s1056-8719(00)00107-6 · Cited by 3,776 · see citing works
How many drug targets are there?
Overington, J. P., Al-Lazikani, B., & Hopkins, A. L. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd2199 · Cited by 3,505 · see citing works
Self-citationComprehensive molecular characterization of clear cell renal cell carcinoma
The Cancer Genome Atlas Research Network (2013) · Nature · doi:10.1038/nature12222 · Cited by 3,485 · see citing works
A census of human cancer genes
Futreal, P. A., Coin, L., Marshall, M., Down, T., Hubbard, T., Wooster, R., Rahman, N., & Stratton, M. R. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1299 · Cited by 3,184 · see citing works
Data, information, knowledge and principle: back to metabolism in KEGG
Kanehisa, M. I., Goto, S., Sato, Y., Kawashima, M., Furumichi, M., & Tanabe, M. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt1076 · Cited by 3,103 · see citing works
Patterns of somatic mutation in human cancer genomes
Greenman, C. D., Stephens, P., Smith, R., Dalgliesh, G. L., Hunter, C., Bignell, G. R., Davies, H. R., Teague, J. W., Butler, A. P., Stevens, C., et al. (2007) · Nature · doi:10.1038/nature05610 · Cited by 3,062 · see citing works
Comprehensive molecular characterization of urothelial bladder carcinoma
Perou, C. M. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/za09-dk57 · Cited by 2,992 · see citing works
Molecular mechanisms of cisplatin resistance
Galluzzi, L., Senovilla, L., Vitale, I., Michels, J., Martins, I., Kepp, O., Castedo, M., & Kroemer, G. (2012) · Oncogene · doi:10.1038/onc.2011.384 · Cited by 2,760 · see citing works
COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer
Forbes, S. A., Bindal, N., Bamford, S., Cole, C., Kok, C. Y., Beare, D., Jia, M., Shepherd, R., Leung, K., Menzies, A., et al. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkq929 · Cited by 2,278 · see citing works
The causes and consequences of genetic heterogeneity in cancer evolution
Burrell, R. A., McGranahan, N., Bartek, J., & Swanton, C. (2013) · Nature · doi:10.1038/nature12625 · Cited by 2,262 · see citing works
Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints
Bartkova, J., Rezaei, N., Liontos, M., Karakaidos, P., Kletsas, D., Issaeva, N., Vassiliou, L.-V. F., Kolettas, E., Niforou, K., Zoumpourlis, V. C., et al. (2006) · Nature · doi:10.1038/nature05268 · Cited by 1,986 · see citing works
An Oncogene-Induced DNA Damage Model for Cancer Development
Halazonetis, T. D., Gorgoulis, V. G., & Bartek, J. (2008) · Science · doi:10.1126/science.1140735 · Cited by 1,851 · see citing works
The DNA damage response and cancer therapy
Lord, C. J., & Ashworth, A. (2012) · Nature · doi:10.1038/nature10760 · Cited by 1,843 · see citing works
Reactome: a database of reactions, pathways and biological processes
Croft, D., O'Kelly, G., Wu, G., Haw, R., Gillespie, M., Matthews, L., Caudy, M., Garapati, P., Gopinath, G., Jassal, B., et al. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkq1018 · Cited by 1,751 · see citing works
The DNA Damage Response: Ten Years After
Harper, J. W., & Elledge, S. J. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.11.015 · Cited by 1,705 · see citing works
DNA repair pathways as targets for cancer therapy
Helleday, T., Petermann, E., Lundin, C., Hodgson, B., & Sharma, R. A. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2342 · Cited by 1,666 · see citing works
Hornbeck, P. V., Kornhauser, J. M., Tkachev, S., Zhang, B., Skrzypek, E., Murray, B. W., Latham, V. M., & Sullivan, M. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr1122 · Cited by 1,636 · see citing works
The Concept of Synthetic Lethality in the Context of Anticancer Therapy
Kaelin, W. G. (2005) · Nature reviews. Cancer · doi:10.1038/nrc1691 · Cited by 1,369 · see citing works
Biallelic Inactivation of <i>BRCA2</i> in Fanconi Anemia
Howlett, N. G., Taniguchi, T., Olson, S., Cox, B., Waisfisz, Q., de Die-Smulders, C., Persky, N., Grompe, M., Joenje, H., Pals, G., et al. (2002) · Science · doi:10.1126/science.1073834 · Cited by 1,149 · see citing works
Tobacco smoke carcinogens, DNA damage and p53 mutations in smoking-associated cancers
Pfeifer, G. P., Denissenko, M. F., Olivier, M., Tretyakova, N. Y., Hecht, S. S., & Hainaut, P. L. (2002) · Oncogene · doi:10.1038/sj.onc.1205803 · Cited by 1,114 · see citing works
DNA repair dysregulation from cancer driver to therapeutic target
Curtin, N. J. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3399 · Cited by 1,051 · see citing works
The BioGRID interaction database: 2013 update
Chatr‐aryamontri, A., Breitkreutz, B., Heinicke, S., Boucher, L., Winter, A. G., Stark, C., Nixon, J., Ramage, L., Kolas, N. K., O’Donnell, L., et al. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks1158 · Cited by 1,010 · see citing works
EUKARYOTIC TRANSLESION SYNTHESIS DNA POLYMERASES: Specificity of Structure and Function
Prakash, S., Johnson, R. E., & Prakash, L. (2005) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.74.082803.133250 · Cited by 999 · see citing works
Temozolomide: Mechanisms of Action, Repair and Resistance
Zhang, J., Stevens, M. F. G., & Bradshaw, T. D. (2011) · Current Molecular Pharmacology · doi:10.2174/1874467211205010102 · Cited by 887 · see citing works
Cytoscape 2.8: new features for data integration and network
Smoot, E., Ono, K., Ruscheinski, J., Wang, P., & Ideker, T. E. (2011) · Cited by 791 · see citing works
Genetic instability and darwinian selection in tumours
Cahill, D. P., Kinzler, K. W., Vogelstein, B., & Christoph Lengauer, C. (1999) · Trends in Cell Biology · doi:10.1016/s0962-8924(99)01661-x · Cited by 747 · see citing works
Drugging the p53 pathway: understanding the route to clinical efficacy
Khoo, K. H., Verma, C. S., & Lane, D. P. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4236 · Cited by 723 · see citing works
The effects of deregulated DNA damage signalling on cancer chemotherapy response and resistance
Bouwman, P., & Jonkers, J. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3342 · Cited by 615 · see citing works
Regulation of DNA Damage Responses by Ubiquitin and SUMO
Jackson, S. P., & Durocher, D. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.01.017 · Cited by 601 · see citing works
The BOADICEA model of genetic susceptibility to breast and ovarian cancers: updates and extensions
Antoniou, A. C., Cunningham, A. P., Peto, J., Evans, D. G., Lalloo, F. I., Narod, S. A., Risch, H. A., Eyfjord, J. E., Hopper, J. L., Southey, M. C., et al. (2008) · British Journal of Cancer · doi:10.1038/sj.bjc.6604305 · Cited by 525 · see citing works
Mutational signatures: the patterns of somatic mutations hidden in cancer genomes
Alexandrov, L. B., & Stratton, M. R. (2014) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2013.11.014 · Cited by 488 · see citing works
Synthetic Lethality and Cancer Therapy: Lessons Learned from the Development of PARP Inhibitors
Lord, C. J., Tutt, A. N. J., & Ashworth, A. (2014) · Annual Review of Medicine · doi:10.1146/annurev-med-050913-022545 · Cited by 476 · see citing works
Replication and protection of telomeres
Verdun, R. E., & Karlseder, J. (2007) · Nature · doi:10.1038/nature05976 · Cited by 463 · see citing works
MEN and SIN: what's the difference?
Bardin, A. J., & Amon, A. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35099020 · Cited by 344 · see citing works
Secondary mutations in BRCA2 associated with clinical resistance to a PARP inhibitor
Barber, L. J., Sandhu, S. K., Chen, L., Campbell, J., Kozarewa, I., Fenwick, K., Assiotis, I., Rodrigues, D. N., Reis-Filho, J. S., Moreno, V., et al. (2012) · The Journal of Pathology · doi:10.1002/path.4140 · Cited by 337 · see citing works
A synthetic lethal siRNA screen identifying genes mediating sensitivity to a PARP inhibitor
Turner, N. C., Lord, C. J., Iorns, E. J., Brough, R., Swift, S., Elliott, R. J. R., Rayter, S., Tutt, A. N. J., & Ashworth, A. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.61 · Cited by 322 · see citing works
NPM1/B23: A Multifunctional Chaperone in Ribosome Biogenesis and Chromatin Remodeling
Lindström, M. S. (2011) · Biochemistry Research International · doi:10.1155/2011/195209 · Cited by 308 · see citing works
Factors underlying sensitivity of cancers to small-molecule kinase inhibitors
Janne, P. A., Gray, N. S., & Settleman, J. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2871 · Cited by 303 · see citing works
Integrated analysis of germline and somatic variants in ovarian cancer
Kanchi, K., Johnson, K. J., Lu, C., McLellan, M. D., Leiserson, M. D. M., Wendl, M. C., Zhang, Q., Koboldt, D. C., Xie, M., Kandoth, C., et al. (2014) · Nature Communications · doi:10.1038/ncomms4156 · Cited by 294 · see citing works
Tankyrase-targeted therapeutics: expanding opportunities in the PARP family
Riffell, J. L., Lord, C. J., & Ashworth, A. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3868 · Cited by 290 · see citing works
A selective USP1–UAF1 inhibitor links deubiquitination to DNA damage responses
Liang, Q., Dexheimer, T. S., Zhang, P., Rosenthal, A. S., Villamil, M. A., You, C., Zhang, Q., Chen, J., Ott, C. A., Sun, H., et al. (2014) · Nature Chemical Biology · doi:10.1038/nchembio.1455 · Cited by 264 · see citing works
Bancroft, E. K., Page, E. C., Castro, E., Lilja, H. G., Vickers, A. J., Sjoberg, D. D., Assel, M. J., Foster, C. S., Mitchell, G., Drew, K., et al. (2014) · European Urology · doi:10.1016/j.eururo.2014.01.003 · Cited by 253 · see citing works
Identification of Molecular Pathway Aberrations in Uterine Serous Carcinoma by Genome-wide Analyses
Kuhn, E., Wu, R., Guan, B., Wu, G., Zhang, J., Wang, Y., Song, L., Yuan, X., Wei, L., Roden, R. B. S., et al. (2012) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djs345 · Cited by 249 · see citing works
Collins, F. S., & Barker, A. D. (2007) · Scientific American · doi:10.1038/scientificamerican0307-50 · Cited by 231 · see citing works
Nakazawa, Y., Sasaki, K., Mitsutake, N., Matsuse, M., Shimada, M., Nardò, T., Takahashi, Y., Ohyama, K., Ito, K., Mishima, H., et al. (2012) · Nature Genetics · doi:10.1038/ng.2229 · Cited by 213 · see citing works
Martin, S. A., McCabe, N., Mullarkey, M. J., Cummins, R., Burgess, D. J., Nakabeppu, Y., Oka, S., Kay, E. W., Lord, C. J., & Ashworth, A. (2010) · Cancer Cell · doi:10.1016/j.ccr.2009.12.046 · Cited by 201 · see citing works
USP7 inhibitor P22077 inhibits neuroblastoma growth via inducing p53-mediated apoptosis.
Fan, Y.-H., Cheng, J., Vasudevan, S. A., Dou, J., Zhang, H., Patel, R. H., Ma, I. T., Rojas, Y., Zhao, Y., Yu, Y., et al. (2013) · Cell Death & Disease · doi:10.1038/cddis.2013.400 · Cited by 199 · see citing works
DNA repair: From molecular mechanism to human disease
Friedberg, E. C., Aguilera, A., Gellert, M. F., Hanawalt, P. C., Hays, J. B., Lehmann, A. R., Lindahl, T. L., Lowndes, N. F., Sarasin, A. R., & Wood, R. D. (2006) · DNA repair · doi:10.1016/j.dnarep.2006.05.005 · Cited by 193 · see citing works
Structural basis for recruitment of BRCA2 by PALB2
Oliver, A. W., Swift, S., Lord, C. J., Ashworth, A., & Pearl, L. H. (2009) · EMBO Reports · doi:10.1038/embor.2009.126 · Cited by 181 · see citing works
Self-citationFauman, E. B., Rai, B. K., & Huang, E. S. (2011) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2011.05.020 · Cited by 178 · see citing works
Collins, F. S., & Barker, A. D. (2007) · PubMed · Cited by 176 · see citing works
A Small Molecule Inhibitor of the BLM Helicase Modulates Chromosome Stability in Human Cells
Nguyen, G. H., Dexheimer, T. S., Rosenthal, A. S., Chu, W. K., Singh, D. K., Mosedale, G., Bachrati, C. Z., Schultz, L., Sakurai, M., Savitsky, P. A., et al. (2013) · Chemistry & Biology · doi:10.1016/j.chembiol.2012.10.016 · Cited by 169 · see citing works
Non-homologous DNA end joining.
Pastwa, E., & Błasiak, J. (2003) · Acta Biochimica Polonica · doi:10.18388/abp.2003_3622 · Cited by 163 · see citing works
Systematic characterization of deubiquitylating enzymes for roles in maintaining genome integrity
Nishi, R., Wijnhoven, P. W. G., le Sage, C., Tjeertes, J., Galanty, Y., Forment, J. V., Clague, M. J., Urbé, S., & Jackson, S. P. (2014) · Nature Cell Biology · doi:10.1038/ncb3028 · Cited by 148 · see citing works
canSAR: an updated cancer research and drug discovery knowledgebase
Tym, J. E., Mitsopoulos, C., Coker, E. A., Razaz, P., Schierz, A. C., Antolín, A. A., & Al‐Lazikani, B. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv1030 · Cited by 135 · see citing works
Self-citationObjective assessment of cancer genes for drug discovery
Patel, M. N., Halling‐Brown, M., Tym, J. E., Workman, P., & Al‐Lazikani, B. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3913 · Cited by 130 · see citing works
Self-citationIntegrated genomic analyses of ovarian carcinoma
The Cancer Genome Atlas Research Network (2011) · Nature · doi:10.1038/nature10166 · Cited by 129 · see citing works
Smc5/6: a link between DNA repair and unidirectional replication?
Murray, J. M., & Carr, A. M. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2309 · Cited by 113 · see citing works
Larrea, A. A., Lujan, S. A., & Kunkel, T. A. (2010) · Cell · doi:10.1016/j.cell.2010.05.002 · Cited by 106 · see citing works
Screening for E3-Ubiquitin ligase inhibitors: challenges and opportunities
Landré, V., Rotblat, B., Melino, S., Bernassola, F., & Melino, G. (2014) · Oncotarget · doi:10.18632/oncotarget.2431 · Cited by 105 · see citing works
Searching for synthetic lethality in cancer
Brough, R., Frankum, J. R., Costa-Cabral, S., Lord, C. J., & Ashworth, A. (2011) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2010.10.009 · Cited by 104 · see citing works
Franchitto, A., Pichierri, P., Piergentili, R., Crescenzi, M., Bignami, M., & Palitti, F. (2003) · Oncogene · doi:10.1038/sj.onc.1206254 · Cited by 102 · see citing works
Familial pancreatic cancer: genetic advancesPreprint
Rustgi, A. K. (2014) · Genes & Development · doi:10.1101/gad.228452.113 · Cited by 101 · see citing works
Chromosome Segregation in Budding Yeast: Sister Chromatid Cohesion and Related Mechanisms
Marston, A. L. (2014) · Genetics · doi:10.1534/genetics.112.145144 · Cited by 95 · see citing works
Deubiquitylating Enzymes and DNA Damage Response Pathways
Jacq, X., Kemp, M. I., Martin, N. M. B., & Jackson, S. P. (2013) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-013-9635-3 · Cited by 90 · see citing works
van Pel, D. M., Barrett, I. J., Shimizu, Y., Sajesh, B. V., Guppy, B. J., Pfeifer, T., McManus, K. J., & Hieter, P. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003254 · Cited by 89 · see citing works
Buisson, R., Joshi, N., Pauty, J., Maity, R., Zhao, W., Coulombe, Y., Sung, P., & Masson, J. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.01.009 · Cited by 88 · see citing works
Polo-like kinase 1 as target for cancer therapy
Weiß, L., & Efferth, T. (2012) · Experimental Hematology and Oncology · doi:10.1186/2162-3619-1-38 · Cited by 84 · see citing works
canSAR: updated cancer research and drug discovery knowledgebase
Bulusu, K. C., Tym, J. E., Coker, E. A., Schierz, A. C., & Al‐Lazikani, B. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt1182 · Cited by 74 · see citing works
Self-citationEker, A. P. M., Quayle, C., Chaves, I., & van der Horst, G. T. J. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-8735-0 · Cited by 72 · see citing works
Liu, L. V., Bell, C. B., Wong, S. D., Wilson, S. A., Kwak, Y., Chow, M. S., Zhao, J. Y., Hodgson, K. O., Hedman, B., & Solomon, E. I. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016323107 · Cited by 72 · see citing works
Aurora kinases in head and neck cancer
Mehra, R., Serebriiskii, I. G., Burtness, B. A., Astsaturov, I. A., & Golemis, E. A. (2013) · The Lancet Oncology · doi:10.1016/s1470-2045(13)70128-1 · Cited by 72 · see citing works
Nikolaev, S. I., Sotiriou, S. K., Pateras, I. S., Santoni, F. A., Sougioultzis, S., Edgren, H., Almusa, H., Robyr, D., Guipponi, M., Saarela, J., et al. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-3869 · Cited by 69 · see citing works
Brough, R., Bajrami, I., Vatcheva, R., Natrajan, R., Reis-Filho, J. S., Lord, C. J., & Ashworth, A. (2012) · The EMBO Journal · doi:10.1038/emboj.2011.490 · Cited by 68 · see citing works
Cancer chromosomes going to POT1
Chang, S. S. (2013) · Nature Genetics · doi:10.1038/ng.2617 · Cited by 64 · see citing works
Targeting an Achilles’ heel of cancer with a WRN helicase inhibitor
Aggarwal, M., Banerjee, T., Sommers, J. A., & Brosh, R. M. (2013) · Cell Cycle · doi:10.4161/cc.26320 · Cited by 62 · see citing works
DNA ligases as therapeutic targets.
Tomkinson, A. E., Howes, T. R. L., & Wiest, N. E. (2013) · PubMed · Cited by 60 · see citing works
Workman, P., Al‐Lazikani, B., & Clarke, P. A. (2013) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2013.06.004 · Cited by 58 · see citing works
Self-citationDNA End-Processing Enzyme Polynucleotide Kinase As a Potential Target in the Treatment of Cancer
Allinson, S. L. (2010) · Future Oncology · doi:10.2217/fon.10.40 · Cited by 56 · see citing works
Deubiquitinating Enzymes as Therapeutic Targets in Cancer
Lim, K., & Baek, K. (2013) · Current Pharmaceutical Design · doi:10.2174/1381612811319220013 · Cited by 54 · see citing works
Complementary non-radioactive assays for investigation of human flap endonuclease 1 activity
Dorjsuren, D. G., Kim, D., Maloney, D. J., Wilson, D. M., & Simeonov, A. M. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq1082 · Cited by 54 · see citing works
MoKCa database—mutations of kinases in cancer
Richardson, C. J., Gao, Q., Mitsopoulous, C., Zvelebil, M., Pearl, L. H., & Pearl, F. M. G. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn832 · Cited by 51 · see citing works
Self-citationInvestigations of homologous recombination pathways and their regulation.
Daley, J. M., Kwon, Y., Niu, H., & Sung, P. (2013) · Europe PMC (PubMed Central) · Cited by 46 · see citing works
The RSC and INO80 Chromatin-Remodeling Complexes in DNA Double-Strand Break Repair
Chambers, A. L., & Downs, J. A. (2012) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-387665-2.00009-2 · Cited by 45 · see citing works
Analysis of the gene coding for the BRCA2‐Interacting protein PALB2 in hereditary prostate cancer
Tischkowitz, M. D., Sabbaghian, N., Ray, A. M., Lange, E. M., Foulkes, W. D., & Cooney, K. A. (2008) · The Prostate · doi:10.1002/pros.20729 · Cited by 41 · see citing works
van Pel, D. M., Stirling, P. C., Minaker, S. W., Sipahimalani, P., & Hieter, P. (2013) · G3 Genes Genomes Genetics · doi:10.1534/g3.112.004754 · Cited by 37 · see citing works
Amino Acid Asp181 of 5′-Flap Endonuclease 1 Is a Useful Target for Chemotherapeutic Development
Panda, H., Jaiswal, A. S., Corsino, P. E., Armas, M. L., Law, B. K., & Narayan, S. (2009) · Biochemistry · doi:10.1021/bi9010754 · Cited by 36 · see citing works
Fanconi anemia: a signal transduction and DNA repair pathway.
Kupfer, G. M. (2013) · Europe PMC (PubMed Central) · Cited by 33 · see citing works
Building high-resolution synthetic lethal networks: a ‘Google map’ of the cancer cell
Paul, J., Templeton, S. D., Baharani, A., Freywald, A., & Vizeacoumar, F. J. (2014) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2014.09.009 · Cited by 32 · see citing works
Mereniuk, T. R., Gendy, M. A. M. E., Mendes‐Pereira, A. M., Lord, C. J., Ghosh, S., Foley, E., Ashworth, A., & Weinfeld, M. (2013) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-12-1093 · Cited by 30 · see citing works
Molecular Mechanism of Base Excision Repair of Uracil-containing DNA in Yeast Cell-free Extracts
Wang, Z., Wu, X., & Friedberg, E. C. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.38.24064 · Cited by 29 · see citing works
McWhirter, C. L., Tonge, M. E., Plant, H., Hardern, I. M., Nissink, J. W. M., & Durant, S. T. (2013) · SLAS DISCOVERY · doi:10.1177/1087057113476551 · Cited by 25 · see citing works
Deriving a Mutation Index of Carcinogenicity Using Protein Structure and Protein Interfaces
Espinosa, O., Mitsopoulos, K., Hakas, J., Pearl, F. M. G., & Zvelebil, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0084598 · Cited by 22 · see citing works
Self-citationRecessive cancer genes engage in negative genetic interactions with their functional paralogs.
D'Antonio, M., Guerra, R., Cereda, M., Marchesi, S., Montani, F., Nicassio, F., Fiore, P. D., & Ciccarelli, F. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.11.033 · Cited by 17 · see citing works
DNA Repair: Nucleotide excision–repair in the test tube
Jaspers, N. G. J., & Hoeijmakers, J. H. J. (1995) · Current Biology · doi:10.1016/s0960-9822(95)00137-0 · Cited by 5 · see citing works
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Pan-cancer analysis of whole genomes
The ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium, Aaltonen, L. A., Abascal, F., Abeshouse, A., Aburatani, H., Adams, D. J., Agrawal, N., Ahn, K. S., Ahn, S.-M., Aikata, H., et al. (2020) · Nature · doi:10.1038/s41586-020-1969-6 · Cited by 3,064 · see citing works
Targeting the DNA Damage Response in Cancer
O’Connor, M. J. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.10.040 · Cited by 1,551 · see citing works
Matthews, H. K., Bertoli, C., & de Bruin, R. A. M. (2022) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-021-00404-3 · Cited by 1,506 · see citing works
Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas
Knijnenburg, T., Wang, L., Zimmermann, M. T., Chambwe, N., Gao, G. F., Cherniack, A. D., Fan, H., Shen, H., Way, G. P., Greene, C. S., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.03.076 · Cited by 1,126 · see citing works
Huang, R., & Zhou, P. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00648-7 · Cited by 948 · see citing works
Revisiting the hallmarks of cancer.
Fouad, Y. A., & Aanei, C. M. (2017) · Europe PMC (PubMed Central) · Cited by 873 · see citing works
DNA repair, genome stability and cancer: a historical perspective
Jeggo, P. A., Pearl, L. H., & Carr, A. M. (2015) · Nature reviews. Cancer · doi:10.1038/nrc.2015.4 · Cited by 764 · see citing works
Self-citationCAG Repeat Not Polyglutamine Length Determines Timing of Huntington’s Disease Onset
Lee, J., Correia, K., Loupe, J. M., Kim, K., Barker, D., Hong, E. P., Chao, M. J., Long, J. D., Lucente, D. E., Vonsattel, J. P., et al. (2019) · Cell · doi:10.1016/j.cell.2019.06.036 · Cited by 532 · see citing works
Overcoming cancer therapeutic bottleneck by drug repurposing
Zhang, Z., Zhou, L., Xie, N., Nice, E. C., Zhang, T., Cui, Y., & Huang, C. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00213-8 · Cited by 521 · see citing works
Melatonin, a Full Service Anti-Cancer Agent: Inhibition of Initiation, Progression and Metastasis
Reiter, R. J., Rosales‐Corral, S., Tan, D., Acuña-Castroviejo, D., Qin, L., Yang, S., & Xu, K. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18040843 · Cited by 446 · see citing works
Genetic Insights Into Biological Mechanisms Governing Human Ovarian Ageing
Ruth, K. S., Day, F. R., Hussain, J., Martínez-Marchal, A., Aiken, C., Azad, A., Thompson, D. J., Knoblochová, L., Abe, H., Tarry‐Adkins, J. L., et al. (2021) · Nature · doi:10.1038/s41586-021-03779-7 · Cited by 436 · see citing works
Secrier, M., Li, X., de Silva, N., Eldridge, M., Contino, G., Bornschein, J., MacRae, S., Grehan, N., O’Donovan, M., Miremadi, A., et al. (2016) · Nature Genetics · doi:10.1038/ng.3659 · Cited by 397 · see citing works
DNA Repair Pathways in Cancer Therapy and Resistance
Li, L.-Y., Guan, Y.-D., Chen, X.-S., Yang, J.-M., & Cheng, Y. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.629266 · Cited by 383 · see citing works
“Numerous studies have indicated that certain cancers are associated with the defect or mutation in the proteins of nuclear or mitochondrial DNA repair pathways (Pearl et al., 2015; Cerrato et al., 2016).”
BackgroundLifestyle and dietary environmental factors in colorectal cancer susceptibility
Murphy, N., Moreno, V. R., Hughes, D. J., Vodicka, L., Vodička, P., Aglago, E. K., Gunter, M. J., & Jenab, M. (2019) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2019.06.005 · Cited by 320 · see citing works
Tumour treating fields therapy for glioblastoma: current advances and future directions
Rominiyi, O., Vanderlinden, A., Clenton, S. J., Bridgewater, C. H., Al-Tamimi, Y., & Collis, S. J. (2020) · British Journal of Cancer · doi:10.1038/s41416-020-01136-5 · Cited by 319 · see citing works
Paganetti, H., Blakely, E. A., Cárabe, A., Carlson, D. J., Das, I. J., Dong, L., Grosshans, D. R., Held, K. D., Mohan, R., Moiseenko, V., et al. (2019) · Medical Physics · doi:10.1002/mp.13390 · Cited by 318 · see citing works
Moss, D. J. H., Pardiñas, A. F., Langbehn, D., Lo, K., Leavitt, B. R., Roos, R., Durr, A., Mead, S., Coleman, A., Santos, R. D., et al. (2017) · The Lancet Neurology · doi:10.1016/s1474-4422(17)30161-8 · Cited by 312 · see citing works
Targeted Therapies for Triple-Negative Breast Cancer: Combating a Stubborn Disease
Kalimutho, M., Parsons, K., Mittal, D., López, J. A., Srihari, S., & Khanna, K. K. (2015) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2015.08.009 · Cited by 289 · see citing works
Genetic etiology of oral cancer
Ali, J., Sabiha, B., Jan, H., Haider, S. A., Khan, A. A., & Ali, S. (2017) · Oral Oncology · doi:10.1016/j.oraloncology.2017.05.004 · Cited by 264 · see citing works
Homologous recombination deficiency and ovarian cancer
Ledermann, J. A., Drew, Y., & Kristeleit, R. S. (2016) · European Journal of Cancer · doi:10.1016/j.ejca.2016.03.005 · Cited by 258 · see citing works
MRE11-RAD50-NBS1 complex alterations and DNA damage response: implications for cancer treatment
Bian, L., Meng, Y., Zhang, M., & Li, D. (2019) · Molecular Cancer · doi:10.1186/s12943-019-1100-5 · Cited by 253 · see citing works
Distinct Classes of Complex Structural Variation Uncovered across Thousands of Cancer Genome Graphs
Hadi, K., Yao, X., Behr, J. M., Deshpande, A. S., Xanthopoulakis, C., Tian, H., Kudman, S., Rosiene, J. A., Darmofal, M., DeRose, J., et al. (2020) · Cell · doi:10.1016/j.cell.2020.08.006 · Cited by 249 · see citing works
Wang, Y.-Q., Wang, P., Wang, Y.-T., Yang, G., Zhang, A., & Miao, Z. (2016) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.6b00055 · Cited by 248 · see citing works
Jin, M. H., & Oh, D. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.07.002 · Cited by 246 · see citing works
Mutational signatures are jointly shaped by DNA damage and repair
Volkova, N. V., Meier, B., González‐Huici, V., Bertolini, S., González, S., Vöhringer, H. S., Abascal, F., Martincorena, I., Campbell, P. J., Gartner, A., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-15912-7 · Cited by 223 · see citing works
Capalbo, A., Hoffmann, E. R., Cimadomo, D., Ubaldi, F. M., & Rienzi, L. F. (2017) · Human Reproduction Update · doi:10.1093/humupd/dmx026 · Cited by 221 · see citing works
STING enhances cell death through regulation of reactive oxygen species and DNA damage
Hayman, T. J., Baro, M., MacNeil, T., Phoomak, C., Aung, T. N., Cui, W., Leach, K., Iyer, R. P., Challa, S., Sandoval-Schaefer, T., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-22572-8 · Cited by 210 · see citing works
Gourley, C., Balmañà, J., Ledermann, J. A., Serra, V., Dent, R. A., Loibl, S., Pujade-Lauraine, É., & Boulton, S. J. (2019) · Journal of Clinical Oncology · doi:10.1200/jco.18.02050 · Cited by 193 · see citing works
Regulated cell death and adaptive stress responses
Galluzzi, L., Bravo-San Pedro, J. M., Kepp, O., & Kroemer, G. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2209-y · Cited by 177 · see citing works
DNA Damage Response in Cancer Therapy and Resistance: Challenges and Opportunities
Jurkovičová, D., Neophytou, C. M., Gašparović, A. Č., & Gonçalves, A. C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232314672 · Cited by 170 · see citing works
Inhibition of Topoisomerase (DNA) I (TOP1): DNA Damage Repair and Anticancer Therapy
Xu, Y., & Her, C. (2015) · Biomolecules · doi:10.3390/biom5031652 · Cited by 164 · see citing works
Melatonin: A pleiotropic molecule that modulates DNA damage response and repair pathways
Majidinia, M., Sadeghpour, A., Mehrzadi, S., Reiter, R. J., Khatami, N., & Yousefi, B. (2017) · Journal of Pineal Research · doi:10.1111/jpi.12416 · Cited by 164 · see citing works
Schirris, Y., Gavves, E., Nederlof, I., Horlings, H. M., & Teuwen, J. (2022) · Medical Image Analysis · doi:10.1016/j.media.2022.102464 · Cited by 164 · see citing works
Evaluating the molecule-based prediction of clinical drug responses in cancer
Ding, Z., Zu, S., & Gu, J. (2016) · Bioinformatics · doi:10.1093/bioinformatics/btw344 · Cited by 155 · see citing works
The RNA Splicing Response to DNA Damage
Shkreta, L., & Chabot, B. (2015) · Biomolecules · doi:10.3390/biom5042935 · Cited by 154 · see citing works
A new wave of innovations within the DNA damage response
Li, Q., Qian, W., Zhang, Y., Hu, L., Chen, S., & Xia, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01548-8 · Cited by 152 · see citing works
Davalli, P., Marverti, G., Lauriola, A., & D’Arca, D. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/2389523 · Cited by 151 · see citing works
Advances in Deubiquitinating Enzyme Inhibition and Applications in Cancer Therapeutics
Antao, A. M., Tyagi, A., Kim, K.-S., & Ramakrishna, S. (2020) · Cancers · doi:10.3390/cancers12061579 · Cited by 150 · see citing works
DNA damage response and resistance of cancer stem cells
Abad, E., Graifer, D., & Lyakhovich, A. (2020) · Cancer Letters · doi:10.1016/j.canlet.2020.01.008 · Cited by 146 · see citing works
Targeted Therapies for Ovarian Cancer
Grunewald, T., & Ledermann, J. A. (2016) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2016.12.001 · Cited by 145 · see citing works
The molecular landscape of ETMR at diagnosis and relapse
Lambo, S., Gröbner, S. N., Rausch, T., Waszak, S. M., Schmidt, C., Gorthi, A., Romero, J. C., Mauermann, M., Brabetz, S., Krausert, S., et al. (2019) · Nature · doi:10.1038/s41586-019-1815-x · Cited by 143 · see citing works
Wang, Z., Xu, Z., & Zhu, G. (2016) · Angewandte Chemie International Edition · doi:10.1002/anie.201608936 · Cited by 141 · see citing works
Targeting DNA damage repair in small cell lung cancer and the biomarker landscape
Sen, T., Gay, C. M., & Byers, L. A. (2018) · Translational Lung Cancer Research · doi:10.21037/tlcr.2018.02.03 · Cited by 137 · see citing works
canSAR: an updated cancer research and drug discovery knowledgebase
Tym, J. E., Mitsopoulos, C., Coker, E. A., Razaz, P., Schierz, A. C., Antolín, A. A., & Al‐Lazikani, B. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv1030 · Cited by 135 · see citing works
Self-citationBioinformatics in translational drug discovery
Wooller, S. K., Benstead-Hume, G., Chen, X., Ali, Y., & Pearl, F. M. G. (2017) · Bioscience Reports · doi:10.1042/bsr20160180 · Cited by 134 · see citing works
Self-citationVariant classification in precision oncology
Leichsenring, J., Horak, P., Kreutzfeldt, S., Heining, C., Christopoulos, P., Volckmar, A., Neumann, O., Kirchner, M., Ploeger, C., Budczies, J., et al. (2019) · International Journal of Cancer · doi:10.1002/ijc.32358 · Cited by 130 · see citing works
Role of Rad51 and DNA repair in cancer: A molecular perspective
Laurini, E., Marson, D., Fermeglia, A., Aulić, S., Fermeglia, M., & Pricl, S. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107492 · Cited by 128 · see citing works
Cerrato, A., Morra, F., & Celetti, A. (2016) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-016-0456-2 · Cited by 127 · see citing works
Shenoy, T., Boysen, G., Wang, M. Y., Xu, Q. Z., Guo, W., Koh, F. M., Wang, C., Zhang, L. Z., Wang, Y., Gil, V., et al. (2017) · Annals of Oncology · doi:10.1093/annonc/mdx165 · Cited by 125 · see citing works
canSAR: update to the cancer translational research and drug discovery knowledgebase
Coker, E. A., Mitsopoulos, C., Tym, J. E., Komianou, A., Kannas, C. C., Micco, P. D., Villasclaras-Fernández, E. D., Özer, B., Antolín, A. A., Workman, P., et al. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky1129 · Cited by 121 · see citing works
Self-citationKarimian, A., Majidinia, M., Baghi, H. B., & Yousefi, B. (2017) · DNA repair · doi:10.1016/j.dnarep.2017.01.003 · Cited by 120 · see citing works
Wang, C., Yin, R. H., Dai, J., Gu, Y., Cui, S., Ma, H., Zhang, Z., Huang, J., Qin, N., Jiang, T., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-04492-2 · Cited by 115 · see citing works
Targeting DNA repair, DNA metabolism and replication stress as anti‐cancer strategies
Puigvert, J. C., Sanjiv, K., & Helleday, T. (2015) · FEBS Journal · doi:10.1111/febs.13574 · Cited by 114 · see citing works
Ubiquitin-specific protease 7 sustains DNA damage response and promotes cervical carcinogenesis
Su, D., Ma, S., Shan, L., Wang, Y., Wang, Y., Cao, C., Liu, B., Yang, C., Wang, L., Tian, S., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci120518 · Cited by 114 · see citing works
The rise and fall of poly(ADP-ribose): An enzymatic perspective
Pascal, J. M., & Ellenberger, T. (2015) · DNA repair · doi:10.1016/j.dnarep.2015.04.008 · Cited by 107 · see citing works
Repair of 8-oxoG:A mismatches by the MUTYH glycosylase: Mechanism, metals and medicine
Banda, D. M., Nuñez, N. N., Burnside, M. A., Bradshaw, K. M., & David, S. S. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.01.008 · Cited by 103 · see citing works
Stress management by autophagy: Implications for chemoresistance
Huang, Z., Zhou, L., Chen, Z., Nice, E. C., & Huang, C. (2016) · International Journal of Cancer · doi:10.1002/ijc.29990 · Cited by 101 · see citing works
Khoury, A., Deo, K. M., & Aldrich-Wright, J. R. (2020) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2020.111070 · Cited by 100 · see citing works
DNA repair in the trinucleotide repeat disorders
Jones, L., Houlden, H., & Tabrizi, S. J. (2016) · The Lancet Neurology · doi:10.1016/s1474-4422(16)30350-7 · Cited by 99 · see citing works
Tyrosyl–DNA phosphodiesterases: rescuing the genome from the risks of relaxation
Kawale, A. S., & Povirk, L. F. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx1219 · Cited by 99 · see citing works
Manic, G., Signore, M., Sistigu, A., Russo, G., Corradi, F., Siteni, S., Musella, M., Vitale, S., De Angelis, M. L., Pallocca, M., et al. (2018) · Gut · doi:10.1136/gutjnl-2016-312623 · Cited by 98 · see citing works
Cellular senescence in gastrointestinal diseases: from pathogenesis to therapeutics
Frey, N., Venturelli, S., Zender, L., & Bitzer, M. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.146 · Cited by 97 · see citing works
SIRT6 coordinates with CHD4 to promote chromatin relaxation and DNA repair
Hou, T., Cao, Z., Zhang, J., Tang, M., Tian, Y., Li, Y., Lu, X., Chen, Y., Wang, H., Wei, F., et al. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkaa006 · Cited by 96 · see citing works
The central role of DNA damage and repair in CAG repeat diseases
Massey, T. H., & Jones, L. (2018) · Disease Models & Mechanisms · doi:10.1242/dmm.031930 · Cited by 95 · see citing works
Genomic signatures reveal DNA damage response deficiency in colorectal cancer brain metastases
Sun, J., Wang, C., Zhang, Y., Xu, L., Fang, W. J., Zhu, Y., Zheng, Y., Chen, X., Xie, X., Hu, X., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-10987-3 · Cited by 94 · see citing works
canSAR: update to the cancer translational research and drug discovery knowledgebase
Mitsopoulos, C., Micco, P. D., Villasclaras-Fernández, E. D., Dolciami, D., Holt, E., Mica, I. L., Coker, E. A., Tym, J. E., Campbell, J., Che, K. H., et al. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkaa1059 · Cited by 94 · see citing works
Self-citationDeficiency of nucleotide excision repair is associated with mutational signature observed in cancerPreprint
Jager, M., Blokzijl, F., Kuijk, E., Bertl, J., Vougioukalaki, M., Janssen, R., Besselink, N. J. M., Boymans, S., de Ligt, J., Pedersen, J. S., et al. (2019) · Genome Research · doi:10.1101/gr.246223.118 · Cited by 94 · see citing works
Nones, K., Johnson, J., Newell, F., Patch, A. M., Thorne, H., Kazakoff, S. H., de Luca, X. M., Parsons, M. T., Ferguson, K., Reid, L. E., et al. (2019) · Annals of Oncology · doi:10.1093/annonc/mdz132 · Cited by 93 · see citing works
“No evidence of biallelic inactivation in 52 HR-related genes [12] were identified in this case (supplementary Tables S3–S6, available at Annals of Oncology online).”
BackgroundProteins from the DNA Damage Response: Regulation, Dysfunction, and Anticancer Strategies
Molinaro, C., Martoriati, A., & Cailliau, K. (2021) · Cancers · doi:10.3390/cancers13153819 · Cited by 93 · see citing works
Dufey, E., Pedro, J. M. B., Eggers, C., González-Quiroz, M., Urra, H., Sagredo, A. I., Sepúlveda, D., Pihán, P., Carreras‐Sureda, A., Hazari, Y., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-15694-y · Cited by 92 · see citing works
DNA repair and damage pathways in breast cancer development and therapy
Majidinia, M., & Yousefi, B. (2017) · DNA repair · doi:10.1016/j.dnarep.2017.03.009 · Cited by 91 · see citing works
Kirsch, D. G., Diehn, M., Kesarwala, A. H., Maity, A. M., Morgan, M. A., Schwarz, J. K., Bristow, R. G., Demaria, S., Eke, I., Griffin, R. J., et al. (2017) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djx231 · Cited by 91 · see citing works
DNA damage responses in cancer stem cells: Implications for cancer therapeutic strategies
Wang, Q. (2015) · World Journal of Biological Chemistry · doi:10.4331/wjbc.v6.i3.57 · Cited by 90 · see citing works
Cytoplasmic RAP1 mediates cisplatin resistance of non-small cell lung cancer
Xiao, L., Lan, X., Shi, X., Zhao, K., Wang, D., Wang, X., Li, F., Huang, H., & Liu, J. (2017) · Cell Death and Disease · doi:10.1038/cddis.2017.210 · Cited by 89 · see citing works
Cell cycle dysregulation in cancer
Glaviano, A., Singh, S. K., Lee, E. H. C., Okina, E., Lam, H. Y., Carbone, D., Reddy, E. P., O’Connor, M. J., Koff, A., Singh, G., et al. (2024) · Pharmacological Reviews · doi:10.1016/j.pharmr.2024.100030 · Cited by 88 · see citing works
Zhang, K., Keymeulen, S., Nelson, R. A., Tong, T. R. S.-W., Yuan, Y., Yun, X., Liu, Z., Lopez, J., Raz, D. J., & Kim, J. Y. (2017) · American Journal Of Pathology · doi:10.1016/j.ajpath.2017.09.011 · Cited by 87 · see citing works
Polyphenols: Major regulators of key components of DNA damage response in cancer
Majidinia, M., Bishayee, A., & Yousefi, B. (2019) · DNA repair · doi:10.1016/j.dnarep.2019.102679 · Cited by 87 · see citing works
Bady, P., Kurscheid, S., Delorenzi, M., Gorlia, T., van den Bent, M. J., Hoang‐Xuan, K., Vauléon, É., Gijtenbeek, A., Enting, R. H., Thiessen, B. A., et al. (2018) · Acta Neuropathologica · doi:10.1007/s00401-018-1810-6 · Cited by 86 · see citing works
Park, S., Lee, H., Lee, B., Lee, S., Sun, J., Park, W., Ahn, J. S., Ahn, M., & Park, K. (2019) · Journal of Thoracic Oncology · doi:10.1016/j.jtho.2019.05.014 · Cited by 86 · see citing works
Synthetic Lethality and Cancer – Penetrance as the Major Barrier
Ryan, C. J., Bajrami, I., & Lord, C. J. (2018) · Trends in cancer · doi:10.1016/j.trecan.2018.08.003 · Cited by 86 · see citing works
Multifunctional Magnetoliposomes for Sequential Controlled Release
Salvatore, A., Montis, C., Berti, D., & Baglioni, P. (2016) · ACS Nano · doi:10.1021/acsnano.6b03194 · Cited by 83 · see citing works
Nanoparticles for siRNA-Based Gene Silencing in Tumor Therapy
Babu, A., Muralidharan, R., Amreddy, N., Mehta, M., Munshi, A., & Ramesh, R. (2016) · IEEE Transactions on NanoBioscience · doi:10.1109/tnb.2016.2621730 · Cited by 83 · see citing works
DNA damage response regulation by microRNAs as a therapeutic target in cancer
Majidinia, M., & Yousefi, B. (2016) · DNA repair · doi:10.1016/j.dnarep.2016.09.003 · Cited by 82 · see citing works
MiRNA-Based Therapies for Lung Cancer: Opportunities and Challenges?
Yang, H. K., Liu, Y., Chen, L., Zhao, J., Guo, M., Zhao, X., Wen, Z., He, Z., Chen, C., & Xu, L. (2023) · Biomolecules · doi:10.3390/biom13060877 · Cited by 81 · see citing works
Du, M., Gu, D., Xin, J., Peters, U., Song, M., Cai, G., Li, S., Ben, S., Meng, Y., Chu, H., et al. (2023) · Cell Reports Medicine · doi:10.1016/j.xcrm.2023.100974 · Cited by 80 · see citing works
Long, J., Fang, W. Y., Chang, L., Gao, W. H., Shen, Y., Jia, M. Y., Zhang, Y. X., Wang, Y., Dou, H. B., Zhang, W. J., et al. (2017) · Leukemia · doi:10.1038/leu.2017.130 · Cited by 78 · see citing works
Genomic hallmarks and therapeutic implications of G0 cell cycle arrest in cancer
Wiecek, A. J., Cutty, S. J., Kornai, D., Parreno-Centeno, M., Gourmet, L. E., Tagliazucchi, G. M., Jacobson, D. H., Zhang, P., Xiong, L., Bond, G. L., et al. (2023) · Genome biology · doi:10.1186/s13059-023-02963-4 · Cited by 78 · see citing works
Synthetic lethal strategies for the development of cancer therapeutics
Ngoi, N. Y. L., Gallo, D., Torrado, C., Nardo, M., Durocher, D., & Yap, T. A. (2024) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-024-00966-z · Cited by 78 · see citing works
Mirza‐Aghazadeh‐Attari, M., Darband, S. G., Kaviani, M., Mihanfar, A., Aghazadeh-Attari, J., Yousefi, B., & Majidinia, M. (2018) · DNA repair · doi:10.1016/j.dnarep.2018.07.005 · Cited by 77 · see citing works
Chen, R., Wang, G., Zheng, Y., Hua, Y., & Cai, Z. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14064 · Cited by 76 · see citing works
The Effects of Localized Heat on the Hallmarks of Cancer
Hannon, G., Tansi, F. L., Hilger, I., & Prina‐Mello, A. (2021) · Advanced Therapeutics · doi:10.1002/adtp.202000267 · Cited by 76 · see citing works
Non-Coding RNAs and Resistance to Anticancer Drugs in Gastrointestinal Tumors
Hahne, J. C., & Valeri, N. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00226 · Cited by 73 · see citing works
Ooki, A., Osumi, H., Yoshino, K., & Yamaguchi, K. (2024) · Gastric Cancer · doi:10.1007/s10120-024-01523-4 · Cited by 72 · see citing works
The Synergistic Effect of PARP Inhibitors and Immune Checkpoint Inhibitors
Wu, Z., Cui, P., Tao, H., Zhang, S., Ma, J., Liu, Z., Wang, J., Qian, Y., Chen, S., Huang, Z., et al. (2021) · Clinical Medicine Insights Oncology · doi:10.1177/1179554921996288 · Cited by 71 · see citing works
The spectrum of APOBEC3 activity: From anti-viral agents to anti-cancer opportunities
Green, A. M., & Weitzman, M. D. (2019) · DNA repair · doi:10.1016/j.dnarep.2019.102700 · Cited by 70 · see citing works
Genomic analysis of DNA repair genes and androgen signaling in prostate cancer
Jividen, K., Kedzierska, K., Yang, C., Szlachta, K. A., Ratan, A., & Paschal, B. M. (2018) · BMC Cancer · doi:10.1186/s12885-018-4848-x · Cited by 67 · see citing works
Genetic modifiers of Mendelian disease: Huntington’s disease and the trinucleotide repeat disorders
Holmans, P., Massey, T. H., & Jones, L. (2017) · Human Molecular Genetics · doi:10.1093/hmg/ddx261 · Cited by 65 · see citing works
Cdk5 links with DNA damage response and cancer
Liu, W., Li, J., Song, Y., Li, Y., Jia, Y., & Zhao, H. (2017) · Molecular Cancer · doi:10.1186/s12943-017-0611-1 · Cited by 64 · see citing works
Kashyap, T., Argueta, C. E., Unger, T. J., Klebanov, B., Debler, S., Senapedis, W. T., Crochiere, M. L., Lee, M. S., Kauffman, M. G., Shacham, S., et al. (2018) · Oncotarget · doi:10.18632/oncotarget.25637 · Cited by 64 · see citing works
CHK1 inhibitor sensitizes resistant colorectal cancer stem cells to nortopsentin
Franco, S. D., Parrino, B., Gaggianesi, M., Pantina, V. D., Bianca, P., Nicotra, A., Mangiapane, L. R., Iacono, M. L., Ganduscio, G., Veschi, V., et al. (2021) · iScience · doi:10.1016/j.isci.2021.102664 · Cited by 63 · see citing works
- Authors
- Pearl, L. H., Schierz, A. C., Ward, S. E., Al-Lazikani, B., & Pearl, F. M. G.
- Affiliations
- University of Sussex (GB)
- Institute of Cancer Research (GB)
- Corresponding author
- Pearl, Frances M. G.
- Venue
- Nature Reviews Cancer
- Published
- 2015-02-24
- Volume
- 15
- Issue
- 3
- Pages
- 166-180
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- OpenAlex
- W2065087624
- Cited by
- 587
- References
- 112
- Citations by year
- 2026: 22 · 2025: 42 · 2024: 66 · 2023: 56 · 2022: 57 · 2021: 66 · 2020: 59 · 2019: 49 · 2018: 49 · 2017: 60 · 2016: 45 · 2015: 16
- FWCI
- 5.49
- Type
- journal article
- Language
- en
- Open access
- green
- figshare.com
- Licence
- Locations
- Nature reviews. Cancer (publishedVersion)
- PubMed (publishedVersion)
- Sussex Research Online (University of Sussex) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
- Funders
- Cancer Research UK (C309/A11566, 11566, C302/A14532, 14532)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Keywords
- DNA damage response, synthetic lethality, targeted cancer therapy, therapeutic target, genome stability, cancer genomics
- MeSH terms
- DNA Damage, DNA Repair, Humans, Neoplasms
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