Cited by 129Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchGenetic Associations and Epidemiology

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Genome-Wide Association Study of CSF Levels of 59 Alzheimer's Disease Candidate Proteins: Significant Associations with Proteins Involved in Amyloid Processing and Inflammation

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Kauwe, John S. K., Bailey, Matthew H., Ridge, Perry G., Perry, Rachel, Wadsworth, Mark E., Hoyt, Kaitlyn L., Staley, Lyndsay A., Karch, Celeste M., Harari, Oscar, Cruchaga, Carlos, Ainscough, Benjamin J., Bales, Kelly, Pickering, Eve H., Bertelsen, Sarah, the Alzheimer's Disease Neuroimaging Initiative, Fagan, Anne M., Holtzman, David M., Morris, John C., Goate, Alison M.·2014·PLoS Genetics

DOI 10.1371/journal.pgen.1004758PMC PMC4207667

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Abstract

Cerebrospinal fluid (CSF) 42 amino acid species of amyloid beta (Aβ42) and tau levels are strongly correlated with the presence of Alzheimer's disease (AD) neuropathology including amyloid plaques and neurodegeneration and have been successfully used as endophenotypes for genetic studies of AD. Additional CSF analytes may also serve as useful endophenotypes that capture other aspects of AD pathophysiology. Here we have conducted a genome-wide association study of CSF levels of 59 AD-related analytes. All analytes were measured using the Rules Based Medicine Human DiscoveryMAP Panel, which includes analytes relevant to several disease-related processes. Data from two independently collected and measured datasets, the Knight Alzheimer's Disease Research Center (ADRC) and Alzheimer's Disease Neuroimaging Initiative (ADNI), were analyzed separately, and combined results were obtained using meta-analysis. We identified genetic associations with CSF levels of 5 proteins (Angiotensin-converting enzyme (ACE), Chemokine (C-C motif) ligand 2 (CCL2), Chemokine (C-C motif) ligand 4 (CCL4), Interleukin 6 receptor (IL6R) and Matrix metalloproteinase-3 (MMP3)) with study-wide significant p-values (p<1.46×10-10) and significant, consistent evidence for association in both the Knight ADRC and the ADNI samples. These proteins are involved in amyloid processing and pro-inflammatory signaling. SNPs associated with ACE, IL6R and MMP3 protein levels are located within the coding regions of the corresponding structural gene. The SNPs associated with CSF levels of CCL4 and CCL2 are located in known chemokine binding proteins. The genetic associations reported here are novel and suggest mechanisms for genetic control of CSF and plasma levels of these disease-related proteins. Significant SNPs in ACE and MMP3 also showed association with AD risk. Our findings suggest that these proteins/pathways may be valuable therapeutic targets for AD. Robust associations in cognitively normal individuals suggest that these SNPs also influence regulation of these proteins more generally and may therefore be relevant to other diseases.

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D Peterson, 2013, Variants in PPP3R1 and MAPT are associated with more rapid functional decline in Alzheimer's disease: The Cache County Dementia Progression Study, Alzheimers Dement, 10, 366, 10.1016/j.jalz.2013.02.010 · DOI · Paper page
G Abecasis, 2007, Metal—Meta Analysis Helper, Center for Statistical Genetics

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Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing
Alzheimer Disease Genetics Consortium (ADGC), Kunkle, B. W., The European Alzheimer’s Disease Initiative (EADI), Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE), Genetic and Environmental Risk in AD/Defining Genetic, P. A. E. R. F. A. D. C. (., Grenier-Boley, B., Sims, R., Bis, J. C., Damotte, V., Naj, A. C., et al. (2019) · Nature Genetics · doi:10.1038/s41588-019-0358-2 · Cited by 2,946
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Authors: Kauwe, J. S. K., Bailey, M. H., Ridge, P. G., Perry, R., Wadsworth, M. E., Hoyt, K. L., Staley, L. A., Karch, C. M., Harari, O., Cruchaga, C., Ainscough, B. J., Bales, K., Pickering, E. H., Bertelsen, S., Initiative, T. A. D. N., Fagan, A. M., Holtzman, D. M., Morris, J. C., & Goate, A. M.
Affiliations: Brigham Young University (US)
Washington University in St. Louis (US)
Pfizer (United States) (US)
Corresponding author: Goate, Alison M.
ORCID: Kauwe, John S. K.
Bailey, Matthew H.
Ridge, Perry G.
Wadsworth, Mark E.
Karch, Celeste M.
Harari, Oscar
Cruchaga, Carlos
Ainscough, Benjamin J.
Bertelsen, Sarah
Fagan, Anne M.
Holtzman, David M.
Morris, John C.
Goate, Alison M.
Venue: PLoS Genetics
Publisher: Public Library of Science (PLoS)
Published: 2014-10-23
Volume: 10
Issue: 10
Pages: e1004758
ISSN: 1553-7390 (ISSN-L)
1553-7404
DOI: 10.1371/journal.pgen.1004758
PMC: PMC4207667
OpenAlex: W2028156288
Cited by: 125
References: 106
Citations by year: 2026: 3 · 2025: 7 · 2024: 8 · 2023: 13 · 2022: 8 · 2021: 16 · 2020: 13 · 2019: 11 · 2018: 9 · 2017: 14 · 2016: 15 · 2015: 7 · 2014: 1
FWCI: 8.20
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (unspecified)
Locations: PLoS Genetics (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Digital Commons@Becker (Washington University School of Medicine) (submittedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Figshare (submittedVersion, cc-by)
Funders: U.S. Department of Defense (U01 AG024904, W81XWH, W81XWH-12-2-, W81XWH1220012, AG024904)
Foundation for the National Institutes of Health (W81XWH-12-2-0012, U01AG024904, Grant U01 AG024904, UL1TR000448, U24 AG021886, AG024904, U01 AG016976, N01-AG-12100)
Alzheimer's Association (U01 AG016976, U01 AG032984, AG05681, U01 AG024904, ADGC-10–196728, U24AG021886, AG033193, MNIRG-11-205368, W81XWH-12-2-0012)
Bristol-Myers Squibb (U01 AG024904, AG024904, W81XWH-12-2-0012)
Eli Lilly and Company (U01 AG024904, AG024904, W81XWH-12-2-0012)
Pfizer (AG024904, W81XWH-12-2-0012, U01 AG024904)
Biogen (W81XWH-12-2-0012, U01 AG024904, AG024904)
University of Southern California (W81XWH-12-2-0012, U01 AG024904)
BrightFocus Foundation (A2013359S)
Brigham Young University
F. Hoffmann-La Roche (W81XWH-12-2-0012, AG024904, U01 AG024904)
Medpace (U01 AG024904)
Meso Scale Diagnostics (U01 AG024904, AG024904, W81XWH-12-2-0012)
Synarc (U01 AG024904)
Alzheimer's Disease Neuroimaging Initiative (W81XWH-12-2–0012, U01 AG032984, U01AG024904, AG024904, W81XWH-12-2-, Department of Defense award number W81XWH-12-2-0012)
BioClinica (U01 AG024904, W81XWH-12-2-0012, AG024904)
Institute of Clinical and Translational Sciences (UL1TR000448)
Novartis Pharmaceuticals Corporation (W81XWH-12-2-0012, U01 AG024904, AG024904)
Northern California Institute for Research and Education (U01 AG024904, W81XWH-12-2-0012)
Wellcome Trust (082604/2/07/Z, 082604, GR082604MA)
Development of Innovative Strategies for a Transdisciplinary approach to ALZheimer's disease
Institut National de la Santé et de la Recherche Médicale
Bundesministerium für Bildung und Forschung (01GI0102, 01GI0711, 01GI0420)
Erasmus Medisch Centrum
Eisai (W81XWH-12-2-0012, U01 AG024904, AG024904)
Servier (AG024904, W81XWH-12-2-0012, U01 AG024904)
Hjartavernd (N01-AG-1-2100)
Centre hospitalier régional universitaire de Lille
IXICO (AG024904, W81XWH-12-2-0012, U01 AG024904)
National Institutes of Health (n01ag12100-57-0-2, 3u01ag024904-10s2, MNIRG-11-205368, N01-AG-1-2100, W81XWH, UL1TR000448, W81XWH-12-2-0012, NIA AG081220, AG016976, U01-AG024904, AG05681, Grant U01 AG024904, TR000448, AG024904, AG 03991)
Genentech (W81XWH-12-2-0012, AG024904, U01 AG024904)
University of California, San Diego
Canadian Institutes of Health Research (U01 AG024904, W81XWH-12-2-0012)
Medical Research Council (MR/L501517/1, 503480, U01 AG024904, MR/L010305/1, MR/K013041/1, G0300429)
National Institute on Aging (U01-AG-024904, AG 016976, R01AG042611, AG03991, W81XWH-12-2–0012, N01-AG12100, R01 AG035053, AG 024904, AG081220, U01AG016976, NIA AG081220, AG 05681, U01AG032984, AG033193, P 50 AG05681, AG026276, AG032984, P50AG005681, P01 AG0 3991, P01AG003991, R01AG033193, AG021886, P01AG026276, U24AG021886)
National Heart, Lung, and Blood Institute (HL-105756, TR000448, R01HL105756, AG033193)
National Cancer Institute (T32CA113275)
National Institute of Biomedical Imaging and Bioengineering (W81XWH-12-2-0012, U01 AG024904, AG024904)
National Center for Advancing Translational Sciences (TR000448)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords: Alzheimer's disease, cerebrospinal fluid biomarkers, amyloid processing, inflammation, angiotensin-converting enzyme, IL-6 receptor, matrix metalloproteinase-3, MCP-1, carbon tetrachloride, chemokines, single nucleotide polymorphisms, genetic association, endophenotypes, therapeutic target
MeSH terms: Alzheimer Disease, Blood Proteins, Female, Humans, Male, Renin, Amyloid beta-Peptides, tau Proteins, Receptors, Lipoprotein, Chemokine CCL2, Matrix Metalloproteinase 3, Receptors, Interleukin-6, Polymorphism, Single Nucleotide, Nerve Growth Factor, Chemokine CCL4, Genome-Wide Association Study

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Genome-Wide Association Study of CSF Levels of 59 Alzheimer's Disease Candidate Proteins: Significant Associations with Proteins Involved in Amyloid Processing and Inflammation

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