Chemical Magnetoreception: Bird Cryptochrome 1a Is Excited by Blue Light and Forms Long-Lived Radical-Pairs
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Cryptochromes (Cry) have been suggested to form the basis of light-dependent magnetic compass orientation in birds. However, to function as magnetic compass sensors, the cryptochromes of migratory birds must possess a number of key biophysical characteristics. Most importantly, absorption of blue light must produce radical pairs with lifetimes longer than about a microsecond. Cryptochrome 1a (gwCry1a) and the photolyase-homology-region of Cry1 (gwCry1-PHR) from the migratory garden warbler were recombinantly expressed and purified from a baculovirus/Sf9 cell expression system. Transient absorption measurements show that these flavoproteins are indeed excited by light in the blue spectral range leading to the formation of radicals with millisecond lifetimes. These biophysical characteristics suggest that gwCry1a is ideally suited as a primary light-mediated, radical-pair-based magnetic compass receptor.
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Cryptochromes from the migratory garden warbler form radicals with millisecond lifetimes under the influence of the blue spectral range.
“It seems a logical next step to more complex living creatures, especially since four different types of cryptochrome have been confirmed in the eyes of migratory birds [103] and cryptochromes from the migratory garden warbler form radicals with millisecond lifetimes under the influence of the blue spectral range [104].”
From The future of quantum biology (2018) · cites this paper as [104]
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Cites
Magnetic field effects in chemical kinetics and related phenomena
Steiner, U. E., & Ulrich, T. (1989) · Chemical Reviews · doi:10.1021/cr00091a003 · Cited by 1,660 · see citing works
HY4 gene of A. thaliana encodes a protein with characteristics of a blue-light photoreceptor
Ahmad, M., & Cashmore, A. R. (1993) · Nature · doi:10.1038/366162a0 · Cited by 1,270 · see citing works
A Model for Photoreceptor-Based Magnetoreception in Birds
Ritz, T., Adem, S., & Schulten, K. (2000) · Biophysical Journal · doi:10.1016/s0006-3495(00)76629-x · Cited by 1,176 · cited 4× · see citing works
“This led to the suggestion that photochemical reactions in the birds’ eyes could produce spin-correlated radical pairs as the primary sensor in a magnetic field-dependent signalling cascade [7,8], based on the fact that the recombination reactions of spin-correlated radical pairs are known to be magnetic field-sensiti…”
BackgroundInfluentialCryptochromes: Blue Light Receptors for Plants and Animals
Cashmore, A. R., Jarillo, J. A., Wu, Y., & Liu, D. (1999) · Science · doi:10.1126/science.284.5415.760 · Cited by 1,027 · see citing works
Trends in the Development of Baculovirus Expression Vectors
Luckow, V. A., & Summers, M. D. (1988) · Nature Biotechnology · doi:10.1038/nbt0188-47 · Cited by 1,016 · see citing works
Magnetic Compass of European Robins
Wiltschko, W., & Wiltschko, R. (1972) · Science · doi:10.1126/science.176.4030.62 · Cited by 752 · see citing works
Structure and function of DNA photolyase
Sancar, A. (1994) · Biochemistry · doi:10.1021/bi00167a001 · Cited by 663 · see citing works
Resonance effects indicate a radical-pair mechanism for avian magnetic compass
Ritz, T., Thalau, P., Phillips, J. B., Wiltschko, R., & Wiltschko, W. (2004) · Nature · doi:10.1038/nature02534 · Cited by 617 · cited 1× · see citing works
“The hypothesis that the avian magnetic compass is based on a radical pair mechanism is strongly supported by the observation that magnetic compass orientation of migratory birds can indeed be disturbed by weak radiofrequency magnetic fields with frequencies in the MHz range [17,18].”
BackgroundCrystal Structure of DNA Photolyase from Escherichia coli
Park, H.-W., Kim, S., Sancar, A., & Deisenhofer, J. (1995) · Science · doi:10.1126/science.7604260 · Cited by 585 · see citing works
Baculovirus Diversity and Molecular Biology
Blissard, G. W., & Rohrmann, G. F. (1990) · Annual Review of Entomology · doi:10.1146/annurev.en.35.010190.001015 · Cited by 535 · see citing works
Cryptochrome Blue Light Photoreceptors Are Activated through Interconversion of Flavin Redox States
Bouly, J., Schleicher, E., Dionisio‐Sese, M. L., Vandenbussche, F., Straeten, D. V. D., Bakrim, N., Meier, S., Batschauer, A., Galland, P., Bittl, R., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m609842200 · Cited by 450 · see citing works
Self-citationA Biomagnetic Sensory Mechanism Based on Magnetic Field Modulated Coherent Electron Spin Motion
Schulten, K., Swenberg, C. E., & Weller, A. (1978) · Zeitschrift für Physikalische Chemie · doi:10.1524/zpch.1978.111.1.001 · Cited by 430 · see citing works
Association of Flavin Adenine Dinucleotide with the Arabidopsis Blue Light Receptor CRY1
Lin, C., Robertson, D. E., Ahmad, M., Raibekas, A. A., Jörns, M. S., Dutton, P. L., & Cashmore, A. R. (1995) · Science · doi:10.1126/science.7638620 · Cited by 426 · see citing works
Intraprotein radical transfer during photoactivation of DNA photolyase
Aubert, C., Vos, M. H., Mathis, P., Eker, A. P. M., & Brettel, K. (2000) · Nature · doi:10.1038/35014644 · Cited by 416 · see citing works
Fluorescence and optical characteristics of reduced flavines and flavoproteins
Ghisla, S., Massey, V., Lhoste, J., & Mayhew, S. G. (1974) · Biochemistry · doi:10.1021/bi00700a029 · Cited by 387 · see citing works
Migrating Songbirds Recalibrate Their Magnetic Compass Daily from Twilight Cues
Cochran, W. W., Mouritsen, H., & Wikelski, M. C. (2004) · Science · doi:10.1126/science.1095844 · Cited by 383 · see citing works
Self-citationLin (2005) · Genome biology · doi:10.1186/gb-2005-6-5-220 · Cited by 351 · see citing works
Red light disrupts magnetic orientation of migratory birds
Wiltschko, W., Munro, U. H., FORD, H. A., & Wiltschko, R. (1993) · Nature · doi:10.1038/364525a0 · Cited by 314 · see citing works
Mouritsen, H., Janssen‐Bienhold, U., Liedvogel, M., Feenders, G., Stalleicken, J., Dirks, P., & Weiler, R. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405968101 · Cited by 304 · see citing works
Self-citationStructure of the photolyase-like domain of cryptochrome 1 from Arabidopsis thaliana
Brautigam, C. A., Smith, B. S., Ma, Z., Palnitkar, M., Tomchick, D. R., Machius, M., & Deisenhofer, J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0404851101 · Cited by 293 · see citing works
Light-induced electron transfer in a cryptochrome blue-light photoreceptor
Giovani, B., Byrdin, M., Ahmad, M., & Brettel, K. (2003) · Nature Structural & Molecular Biology · doi:10.1038/nsb933 · Cited by 274 · see citing works
Cryptochrome: The Second Photoactive Pigment in the Eye and Its Role in Circadian Photoreception
Sancar, A. (2000) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.69.1.31 · Cited by 263 · see citing works
Magnetoreception and its use in bird navigation
Mouritsen, H., & Ritz, T. (2005) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2005.06.003 · Cited by 228 · see citing works
Self-citationA new class of DNA photolyases present in various organisms including aplacental mammals.
Yasui, A., Eker, A. P., Yasuhira, S., Yajima, H., Kobayashi, T., Takao, M., & Oikawa, A. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06961.x · Cited by 219 · see citing works
Magnetic fields and radical reactions: recent developments and their role in nature
Brocklehurst, B. (2002) · Chemical Society Reviews · doi:10.1039/b107250c · Cited by 213 · see citing works
A Novel Photoreaction Mechanism for the Circadian Blue Light Photoreceptor Drosophila Cryptochrome
Berndt, A., Kottke, T., Breitkreuz, H., Dvorský, R., Hennig, S., Alexander, M., & Wolf, E. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m608872200 · Cited by 212 · see citing works
Steiner, U. E. (1984) · Berichte der Bunsengesellschaft für physikalische Chemie · doi:10.1002/bbpc.198400037 · Cited by 210 · see citing works
Magnetic Field Effects in Arabidopsis thaliana Cryptochrome-1
Solov’yov, I. A., Chandler, D. E., & Schulten, K. (2007) · Biophysical Journal · doi:10.1529/biophysj.106.097139 · Cited by 196 · see citing works
Möller, A., Sagasser, S., Wiltschko, W., & Schierwater, B. (2004) · Naturwissenschaften · doi:10.1007/s00114-004-0578-9 · Cited by 173 · see citing works
Magnetic compass orientation of migratory birds in the presence of a 1.315�MHz oscillating field
Thalau, P., Ritz, T., Stapput, K., Wiltschko, R., & Wiltschko, W. (2005) · Naturwissenschaften · doi:10.1007/s00114-004-0595-8 · Cited by 165 · see citing works
Night-vision brain area in migratory songbirds.
Mouritsen, H., Feenders, G., Liedvogel, M., Wada, K., & Jarvis, E. (2005) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0409575102 · Cited by 159 · see citing works
Self-citationWiltschko, W., & Wiltschko, R. (1995) · Journal of Comparative Physiology A · doi:10.1007/bf00192425 · Cited by 155 · see citing works
Cintolesi, F., Ritz, T., Kay, C. W. M., Timmel, C. R., & Hore, P. J. (2003) · Chemical Physics · doi:10.1016/s0301-0104(03)00320-3 · Cited by 146 · see citing works
Self-citationHenbest, K. B., Kukura, P., Rodgers, C. T., Hore, P. J., & Timmel, C. R. (2004) · Journal of the American Chemical Society · doi:10.1021/ja048220q · Cited by 136 · see citing works
Self-citationJörns, M. S., Sancar, G. B., & Sancar, A. (1984) · Biochemistry · doi:10.1021/bi00307a021 · Cited by 134 · see citing works
Byrdin, M., Eker, A. P. M., Vos, M. H., & Brettel, K. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1531645100 · Cited by 105 · see citing works
Biological sensing of small field differences by magnetically sensitive chemical reactions
Weaver, J. C., Vaughan, T. E., & Astumian, R. D. (2000) · Nature · doi:10.1038/35015128 · Cited by 97 · see citing works
Byrdin, M., Sartor, V., Eker, A. P. M., Vos, M. H., Aubert, C., Brettel, K., & Mathis, P. (2003) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2003.07.001 · Cited by 88 · see citing works
Migratory Birds Use Head Scans to Detect the Direction of the Earth's Magnetic Field
Mouritsen, H., Feenders, G., Liedvogel, M., & Kropp, W. (2004) · Current Biology · doi:10.1016/j.cub.2004.10.025 · Cited by 86 · see citing works
Self-citationOrigin of the Transient Electron Paramagnetic Resonance Signals in DNA Photolyase
Gindt, Y. M., Vollenbroek, E. G. M., Westphal, K., Sackett, H., Sancar, A., & Babcock, Ǵ. (1999) · Biochemistry · doi:10.1021/bi981191+ · Cited by 86 · see citing works
Weber, S., Kay, C. W. M., Mögling, H., MÖBIUS, K., Hitomi, K., & Todo, T. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.032469399 · Cited by 82 · see citing works
Lateralized activation of Cluster N in the brains of migratory songbirds
Liedvogel, M., Feenders, G., Wada, K., Troje, N. F., Jarvis, E. D., & Mouritsen, H. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05350.x · Cited by 70 · see citing works
Self-citationRadio Frequency Magnetic Field Effects on Electron-Hole Recombination
Woodward, J. R., Timmel, C. R., McLauchlan, K. A., & Hore, P. J. (2001) · Physical Review Letters · doi:10.1103/physrevlett.87.077602 · Cited by 62 · see citing works
Self-citationTimmel, C. R., Cintolesi, F., Brocklehurst, B., & Hore, P. J. (2001) · Chemical Physics Letters · doi:10.1016/s0009-2614(00)01436-6 · Cited by 59 · see citing works
Self-citationMelatonin is Crucial for the Migratory Orientation of Pied Flycatchers (Ficedula Hypoleuca Pallas)
Schneider, T. R., Thalau, H.-P., Semm, P., & Wiltschko, W. (1994) · Journal of Experimental Biology · doi:10.1242/jeb.194.1.255 · Cited by 52 · see citing works
A photochemically induced dynamic nuclear polarization study of denatured state of lysozyme
Broadhurst, R. W., Dobson, C. M., Hore, P. J., Radford, S. E., & Rees, M. L. (1991) · Biochemistry · doi:10.1021/bi00216a015 · Cited by 51 · see citing works
Self-citationLow-Field Optically Detected EPR Spectroscopy of Transient Photoinduced Radical Pairs
Rodgers, C. T., Henbest, K. B., Kukura, P., Timmel, C. R., & Hore, P. J. (2005) · The Journal of Physical Chemistry A · doi:10.1021/jp050765z · Cited by 42 · see citing works
Self-citationWiltschko, W., Möller, A., Gesson, M., Noll, C., & Wiltschko, R. (2004) · Journal of Experimental Biology · doi:10.1242/jeb.00873 · Cited by 40 · see citing works
Further investigation on the validity of Stokes–Einstein behaviour at the molecular level
Walser, R., Hess, B., Mark, A. E., & A, W. F. V. G. (2001) · Chemical Physics Letters · doi:10.1016/s0009-2614(00)01290-2 · Cited by 30 · see citing works
Hore, P. J., & Kaptein, R. (1983) · Biochemistry · doi:10.1021/bi00277a026 · Cited by 26 · see citing works
Self-citationJohnsen, S., Mattern, E., & Ritz, T. (2007) · Journal of Experimental Biology · doi:10.1242/jeb.007567 · Cited by 25 · see citing works
Flagged first, then by citations
3 of the 54 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- [9]Salikhov K Molin Y Sagdeev R Buchanenko A 1984 Spin polarization and magnetic field effects in radical reactions 22, Budapest Elsevier
- [23]Mouritsen H Janssen-Bienhold U Liedvogel M Feenders G Stalleicken J 2004 Cryptochrome and activity markers co-localize in bird retina during magnetic orientation. Proc Natl Acad Sci USA 101 14294 14299 15381765 PMC521149
Cited by
Sorted by citations
The cryptochromes: blue light photoreceptors in plants and animals
Chaves, I., Pokorny, R., Byrdin, M., Hoang, N., Ritz, T., Brettel, K., Essen, L.-O., van der Horst, G. T. J., Batschauer, A., & Ahmad, M. (2011) · Annual Review of Plant Biology · doi:10.1146/annurev-arplant-042110-103759 · Cited by 845 · see citing works
The Radical-Pair Mechanism of Magnetoreception
Hore, P. J., & Mouritsen, H. (2016) · Annual Review of Biophysics · doi:10.1146/annurev-biophys-032116-094545 · Cited by 813 · see citing works
Self-citationChemical magnetoreception in birds: The radical pair mechanism
Rodgers, C. T., & Hore, P. J. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711968106 · Cited by 542 · see citing works
Self-citationLong-distance navigation and magnetoreception in migratory animals
Mouritsen, H. (2018) · Nature · doi:10.1038/s41586-018-0176-1 · Cited by 536 · see citing works
Self-citationPlant photoreceptors: Multi-functional sensory proteins and their signaling networks
Paik, I., & Huq, E. (2019) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2019.03.007 · Cited by 379 · see citing works
Sustained Quantum Coherence and Entanglement in the Avian Compass
Gauger, E. M., Rieper, E., Morton, J. J. L., Benjamin, S. C., & Vedral, V. (2011) · Physical Review Letters · doi:10.1103/physrevlett.106.040503 · Cited by 357 · see citing works
The Cryptochrome Blue Light Receptors
Yu, X., Liu, H., John Klejnot, B., & Lin, C. (2010) · The Arabidopsis Book · doi:10.1199/tab.0135 · Cited by 337 · see citing works
(2008) · doi:10.1371/journal.pone.0001768 · Cited by 328 · see citing works
Self-citationMagnetic Compass of Birds Is Based on a Molecule with Optimal Directional Sensitivity
Ritz, T., Wiltschko, R., Hore, P. J., Rodgers, C. T., Stapput, K., Thalau, P., Timmel, C. R., & Wiltschko, W. (2009) · Biophysical Journal · doi:10.1016/j.bpj.2008.11.072 · Cited by 305 · see citing works
Self-citationVisual but not trigeminal mediation of magnetic compass information in a migratory bird
Zapka, M., Heyers, D., Hein, C. M., Engels, S., Schneider, N.-L., Hans, J. B., Weiler, S., Dreyer, D., Kishkinev, D., Wild, J. M., et al. (2009) · Nature · doi:10.1038/nature08528 · Cited by 296 · see citing works
Self-citationMarais, A., Adams, B., Ringsmuth, A. K., Ferretti, M., Gruber, J. M., Hendrikx, R., Schuld, M., Smith, S. L., Sinayskiy, I., Krüger, T. P. J., et al. (2018) · Journal of The Royal Society Interface · doi:10.1098/rsif.2018.0640 · Cited by 274 · see citing works
Cryptochromes—a potential magnetoreceptor: what do we know and what do we want to know?
Liedvogel, M., & Mouritsen, H. (2010) · Journal of The Royal Society Interface · doi:10.1098/rsif.2009.0411.focus · Cited by 231 · see citing works
Self-citationMagnetic field effects in chemical systems
Rodgers, C. T. (2009) · Pure and Applied Chemistry · doi:10.1351/pac-con-08-10-18 · Cited by 215 · see citing works
Günther, A., Einwich, A., Sjulstok, E., Feederle, R., Bolte, P., Koch, K.-W., Solov’yov, I. A., & Mouritsen, H. (2018) · Current Biology · doi:10.1016/j.cub.2017.12.003 · Cited by 204 · see citing works
Self-citationMüller, P., & Ahmad, M. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.228940 · Cited by 190 · see citing works
Avian Ultraviolet/Violet Cones Identified as Probable Magnetoreceptors
Nießner, C., Denzau, S., Gross, J. C., Peichl, L., Bischof, H., Fleissner, G., Wiltschko, W., & Wiltschko, R. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020091 · Cited by 184 · see citing works
Beel, B., Prager, K., Spexard, M., Sasso, S., Weiss, D., Müller, N., Heinnickel, M. L., Dewez, D., Ikoma, D., Grossman, A. R., et al. (2012) · The Plant Cell · doi:10.1105/tpc.112.098947 · Cited by 180 · see citing works
Magnetoreception through Cryptochrome May Involve Superoxide
Solov’yov, I. A., & Schulten, K. J. (2009) · Biophysical Journal · doi:10.1016/j.bpj.2009.03.048 · Cited by 157 · see citing works
Bensch, S., Grahn, M., MÜLLER, N., Gay, L., & Åkesson, S. (2009) · Molecular Ecology · doi:10.1111/j.1365-294x.2009.04210.x · Cited by 156 · see citing works
The magnetic retina: light-dependent and trigeminal magnetoreception in migratory birds
Mouritsen, H., & Hore, P. J. (2012) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2012.01.005 · Cited by 154 · see citing works
Self-citationDirect Observation of a Photoinduced Radical Pair in a Cryptochrome Blue‐Light Photoreceptor
Biskup, T., Schleicher, E., Okafuji, A., Link, G., Hitomi, K., Getzoff, E. D., & Weber, S. (2008) · Angewandte Chemie International Edition · doi:10.1002/anie.200803102 · Cited by 153 · see citing works
Self-citationThe Neural Basis of Long-Distance Navigation in Birds
Mouritsen, H., Heyers, D., & Güntürkün, O. (2015) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021115-105054 · Cited by 137 · see citing works
Self-citationRitz, T., Ahmad, M., Mouritsen, H., Wiltschko, R., & Wiltschko, W. (2010) · Journal of The Royal Society Interface · doi:10.1098/rsif.2009.0456.focus · Cited by 135 · see citing works
Self-citationMagnetic-field effect on the photoactivation reaction of Escherichia coli DNA photolyase
Henbest, K. B., Maeda, K., Hore, P. J., Joshi, M., Bacher, A., Bittl, R., Weber, S., Timmel, C. R., & Schleicher, E. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803620105 · Cited by 130 · see citing works
Self-citationGehring, W. J. (2012) · Wiley Interdisciplinary Reviews Developmental Biology · doi:10.1002/wdev.96 · Cited by 128 · see citing works
Effects of static magnetic fields in biology: role of free radicals
Okano, H. (2008) · Frontiers in bioscience · doi:10.2741/3141 · Cited by 129 · see citing works
Electron spin relaxation in cryptochrome-based magnetoreception
Kattnig, D. R., Solov’yov, I. A., & Hore, P. J. (2016) · Physical Chemistry Chemical Physics · doi:10.1039/c5cp06731f · Cited by 129 · see citing works
Self-citationA radical sense of direction: signalling and mechanism in cryptochrome magnetoreception
Dodson, C. A., Hore, P. J., & Wallace, M. I. (2013) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2013.07.002 · Cited by 129 · see citing works
Self-citationDecrypting Cryptochrome: Revealing the Molecular Identity of the Photoactivation Reaction
Solov’yov, I. A., Domratcheva, T. M., Shahi, A. R. M., & Schulten, K. J. (2012) · Journal of the American Chemical Society · doi:10.1021/ja3074819 · Cited by 121 · see citing works
Acuity of a Cryptochrome and Vision-Based Magnetoreception System in Birds
Solov’yov, I. A., Mouritsen, H., & Schulten, K. (2010) · Biophysical Journal · doi:10.1016/j.bpj.2010.03.053 · Cited by 119 · see citing works
Self-citationSjulstok, E., Olsen, J. M. H., & Solov’yov, I. A. (2015) · Scientific Reports · doi:10.1038/srep18446 · Cited by 116 · see citing works
Hogben, H. J., Efimova, O., Wagner-Rundell, N., Timmel, C. R., & Hore, P. J. (2009) · Chemical Physics Letters · doi:10.1016/j.cplett.2009.08.051 · Cited by 114 · see citing works
Self-citationPhylogenetic and Functional Classification of the Photolyase/Cryptochrome Family
Öztürk, N. (2016) · Photochemistry and Photobiology · doi:10.1111/php.12676 · Cited by 109 · see citing works
Phillips, J. B., Jorge, P. E., & Muheim, R. (2010) · Journal of The Royal Society Interface · doi:10.1098/rsif.2009.0459.focus · Cited by 110 · see citing works
Magnetoreception: activated cryptochrome 1a concurs with magnetic orientation in birds
Nießner, C., Denzau, S., Stapput, K., Ahmad, M., Peichl, L., Wiltschko, W., & Wiltschko, R. (2013) · Journal of The Royal Society Interface · doi:10.1098/rsif.2013.0638 · Cited by 109 · see citing works
Schwarze, S., Schneider, N.-L., Reichl, T., Dreyer, D., Lefeldt, N., Engels, S., Baker, N., Hore, P. J., & Mouritsen, H. (2016) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2016.00055 · Cited by 109 · see citing works
Self-citationEffects of nocturnal illumination on life-history decisions and fitness in two wild songbird species
de Jong, M., Ouyang, J. Q., Silva, A. D., van Grunsven, R. H. A., Kempenaers, B., Visser, M. E., & Spoelstra, K. (2015) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2014.0128 · Cited by 98 · see citing works
Vertebrate Cryptochromes are Vestigial Flavoproteins
Kutta, R. J., Archipowa, N., Johannissen, L. O., Jones, A. R., & Scrutton, N. S. (2017) · Scientific Reports · doi:10.1038/srep44906 · Cited by 96 · see citing works
Kirschvink, J. L., Michael Winklhofer, A., & Walker, M. M. (2010) · Journal of The Royal Society Interface · doi:10.1098/rsif.2009.0491.focus · Cited by 96 · see citing works
Lüdemann, G., Solov’yov, I. A., Kubař, T., & Elstner, M. (2014) · Journal of the American Chemical Society · doi:10.1021/ja510550g · Cited by 95 · see citing works
Phillips, J. B., Muheim, R., & Jorge, P. E. (2010) · Journal of Experimental Biology · doi:10.1242/jeb.020792 · Cited by 94 · see citing works
Fillmore, C. J. (1968) · The Knowledge Bank (The Ohio State University) · Cited by 92 · see citing works
True navigation in birds: from quantum physics to global migration
Holland, R. A. (2014) · Journal of Zoology · doi:10.1111/jzo.12107 · Cited by 91 · see citing works
Effect of magnetic fields on cryptochrome-dependent responses in Arabidopsis thaliana
Harris, S.-R., Henbest, K. B., Maeda, K., Pannell, J. R., Timmel, C. R., Hore, P. J., & Okamoto, H. (2009) · Journal of The Royal Society Interface · doi:10.1098/rsif.2008.0519 · Cited by 88 · see citing works
Self-citationRadical-Pair-Based Magnetoreception Amplified by Radical Scavenging: Resilience to Spin Relaxation
Kattnig, D. R. (2017) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.7b07672 · Cited by 80 · see citing works
Reaction Kinetics and Mechanism of Magnetic Field Effects in Cryptochrome
Solov’yov, I. A., & Schulten, K. (2011) · The Journal of Physical Chemistry B · doi:10.1021/jp209508y · Cited by 75 · see citing works
Magnetoreception in birds: the effect of radio-frequency fields
Wiltschko, R., Thalau, P., Gehring, D., Nießner, C., Ritz, T., & Wiltschko, W. (2014) · Journal of The Royal Society Interface · doi:10.1098/rsif.2014.1103 · Cited by 72 · see citing works
Magnetic field effects in flavoproteins and related systems
Evans, E. W., Dodson, C. A., Maeda, K., Biskup, T., Wedge, C. J., & Timmel, C. R. (2013) · Interface Focus · doi:10.1098/rsfs.2013.0037 · Cited by 69 · see citing works
Self-citationBolte, P., Bleibaum, F., Einwich, A., Günther, A., Liedvogel, M., Heyers, D., Depping, A., Wöhlbrand, L., Rabus, R., Janssen‐Bienhold, U., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0147819 · Cited by 72 · see citing works
Self-citationXu, C., Yin, X., Lv, Y., Wu, C., Zhang, Y., & Song, T. (2011) · Advances in Space Research · doi:10.1016/j.asr.2011.12.004 · Cited by 69 · see citing works
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Ritz, T. (2011) · Procedia Chemistry · doi:10.1016/j.proche.2011.08.034 · Cited by 67 · see citing works
Avian magnetite-based magnetoreception: a physiologist's perspective
Cadiou, H., & McNaughton, P. A. (2010) · Journal of The Royal Society Interface · doi:10.1098/rsif.2009.0423.focus · Cited by 68 · see citing works
Wu, H., Scholten, A., Einwich, A., Mouritsen, H., & Koch, K. (2020) · Scientific Reports · doi:10.1038/s41598-020-64429-y · Cited by 66 · see citing works
Self-citationHein, C. M., Zapka, M., Heyers, D., Kutzschbauch, S., Schneider, N.-L., & Mouritsen, H. (2009) · Journal of The Royal Society Interface · doi:10.1098/rsif.2009.0376.focus · Cited by 66 · see citing works
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Nießner, C., Denzau, S., Malkemper, E. P., Gross, J. C., Burda, H., Winklhofer, M., & Peichl, L. (2016) · Scientific Reports · doi:10.1038/srep21848 · Cited by 65 · see citing works
Leberecht, B., Kobylkov, D., Karwinkel, T., Döge, S., Burnus, L., Wong, S. Y., Apte, S., Haase, K., Musielak, I., Chetverikova, R., et al. (2022) · Journal of Comparative Physiology A · doi:10.1007/s00359-021-01537-8 · Cited by 61 · see citing works
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Zapka, M., Heyers, D., Liedvogel, M., Jarvis, E. D., & Mouritsen, H. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07311.x · Cited by 61 · see citing works
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Juutilainen, J., Herrala, M., Luukkonen, J., Naarala, J., & Hore, P. J. (2018) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2018.0590 · Cited by 62 · see citing works
Self-citationHolland, R. A., & Helm, B. (2013) · Journal of The Royal Society Interface · doi:10.1098/rsif.2012.1047 · Cited by 57 · see citing works
Photoactivation of the cryptochrome/photolyase superfamily
Wang, J., Du, X., Pan, W., Wang, X., & Wu, W. (2014) · Journal of Photochemistry and Photobiology C Photochemistry Reviews · doi:10.1016/j.jphotochemrev.2014.12.001 · Cited by 56 · see citing works
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Voigt, C. C., Roeleke, M., Marggraf, L. C., Pētersons, G., & Voigt‐Heucke, S. L. (2017) · PLoS ONE · doi:10.1371/journal.pone.0177748 · Cited by 56 · see citing works
Lau, J. C. S., Rodgers, C. T., & Hore, P. J. (2012) · Journal of The Royal Society Interface · doi:10.1098/rsif.2012.0374 · Cited by 52 · see citing works
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Engels, S., Hein, C. M., Lefeldt, N., Prior, H., & Mouritsen, H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043271 · Cited by 52 · see citing works
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Holland, R. A. (2010) · Journal of The Royal Society Interface · doi:10.1098/rsif.2010.0159 · Cited by 52 · see citing works
Cailliez, F., Müller, P., Firmino, T. D. R., Pernot, P., & de la Lande, A. (2016) · Journal of the American Chemical Society · doi:10.1021/jacs.5b10938 · Cited by 51 · see citing works
Nießner, C., Gross, J. C., Denzau, S., Peichl, L., Fleissner, G., Wiltschko, W., & Wiltschko, R. (2016) · PLoS ONE · doi:10.1371/journal.pone.0150377 · Cited by 51 · see citing works
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Worster, S. B., Mouritsen, H., & Hore, P. J. (2017) · Journal of The Royal Society Interface · doi:10.1098/rsif.2017.0405 · Cited by 46 · see citing works
Self-citationBolte, P., Einwich, A., Seth, P. K., Chetverikova, R., Heyers, D., Wojahn, I., Janssen‐Bienhold, U., Feederle, R., Hore, P. J., Dedek, K., et al. (2021) · Ethology Ecology & Evolution · doi:10.1080/03949370.2020.1870571 · Cited by 48 · see citing works
Self-citationLeberecht, B., Wong, S. Y., Satish, B., Döge, S., Hindman, J., Venkatraman, L., Apte, S., Haase, K., Musielak, I., Dautaj, G., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2301153120 · Cited by 47 · see citing works
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Cassone, V. M., Paulose, J. K., Whitfield‐Rucker, M. G., & Peters, J. L. (2009) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2009.01.003 · Cited by 47 · see citing works
Kobylkov, D., Wynn, J., Michael Winklhofer, A., Chetverikova, R., Xu, J., Hiscock, H. G., Hore, P. J., & Mouritsen, H. (2019) · Journal of The Royal Society Interface · doi:10.1098/rsif.2019.0716 · Cited by 47 · see citing works
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Karki, N., Vergish, S., & Zoltowski, B. D. (2021) · Protein Science · doi:10.1002/pro.4124 · Cited by 45 · see citing works
Xu, C., Lv, Y., Chen, C., Zhang, Y., & Wei, S. (2014) · Advances in Space Research · doi:10.1016/j.asr.2014.01.033 · Cited by 46 · see citing works
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Ritz, T., Yoshii, T., Foerster, C., & Ahmad, M. (2010) · Communicative & Integrative Biology · doi:10.4161/cib.3.1.9865 · Cited by 45 · see citing works
Burger, T., Lucová, M., Moritz, R. E., Oelschläger, H., Druga, R., Burda, H., Wiltschko, W., Wiltschko, R., & Němec, P. (2010) · Journal of The Royal Society Interface · doi:10.1098/rsif.2009.0551 · Cited by 44 · see citing works
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Xu, C., Wei, S., Lü, Y., Zhang, Y., Chen, C., & Song, T. (2013) · Bioelectromagnetics · doi:10.1002/bem.21788 · Cited by 44 · see citing works
Very weak oscillating magnetic field disrupts the magnetic compass of songbird migrants
Pakhomov, A. Y., Bojarinova, J., Cherbunin, R. V., Chetverikova, R., Grigoryev, P. S., Kavokin, K. V., Kobylkov, D., Lubkovskaja, R., & Chernetsov, N. (2017) · Journal of The Royal Society Interface · doi:10.1098/rsif.2017.0364 · Cited by 43 · see citing works
Mitsui, H., Maeda, T., Chiaki, Y., Tsuji, Y., Watari, R., Kubo, Y., Okano, K., & Okano, T. (2015) · Biochemistry · doi:10.1021/bi501441u · Cited by 40 · see citing works
Eumetazoan Cryptochrome Phylogeny and Evolution
Haug, M. F., Gesemann, M., Lazović, V., & Neuhauss, S. C. F. (2015) · Genome Biology and Evolution · doi:10.1093/gbe/evv010 · Cited by 40 · see citing works
The radical pair mechanism and the avian chemical compass: Quantum coherence and entanglement
Zhang, Y., Berman, G. P., & Kais, S. (2015) · International Journal of Quantum Chemistry · doi:10.1002/qua.24943 · Cited by 40 · see citing works
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Stoneham, A. M., Gauger, E. M., Porfyrakis, K., Benjamin, S. C., & Lovett, B. W. (2012) · Biophysical Journal · doi:10.1016/j.bpj.2012.01.007 · Cited by 39 · see citing works
Direct Interaction of Avian Cryptochrome 4 with a Cone Specific G-Protein
Görtemaker, K., Yee, C., Bartölke, R., Behrmann, H., Voß, J.-O., Schmidt, J., Xu, J., Solovyeva, V., Leberecht, B., Behrmann, E., et al. (2022) · Cells · doi:10.3390/cells11132043 · Cited by 38 · see citing works
Self-citationMagnetoreception systems in birds: A review of current research
Kishkinev, D., & Chernetsov, N. (2015) · Biology Bulletin Reviews · doi:10.1134/s2079086415010041 · Cited by 36 · see citing works
Shirdel, J., Zirak, P., Penzkofer, А., Breitkreuz, H., & Wolf, E. (2008) · Chemical Physics · doi:10.1016/j.chemphys.2008.06.006 · Cited by 36 · see citing works
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Smith, K. T., Bhullar, B.-A. S., Köhler, G., & Habersetzer, J. (2018) · Current Biology · doi:10.1016/j.cub.2018.02.021 · Cited by 35 · see citing works
Molecular dynamics simulations disclose early stages of the photo-activation of cryptochrome 4
Kattnig, D. R., Nielsen, C., & Solov’yov, I. A. (2018) · New Journal of Physics · doi:10.1088/1367-2630/aad70f · Cited by 35 · see citing works
Light-dependent magnetic compass in Iberian green frog tadpoles
Diego‐Rasilla, F. J., Luengo, R. M., & Phillips, J. B. (2010) · Die Naturwissenschaften · doi:10.1007/s00114-010-0730-7 · Cited by 34 · see citing works
Vieira, J., Jones, A. R., Danon, A., Sakuma, M., Hoang, N., Robles, D., Tait, S., Heyes, D. J., Picot, M., Yoshii, T., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031867 · Cited by 34 · see citing works
The Diversity of Photosensitivity and its Implications for Light Pollution
Alaasam, V., Kernbach, M. E., Miller, C. R., & Ferguson, S. M. (2021) · Integrative and Comparative Biology · doi:10.1093/icb/icab156 · Cited by 34 · see citing works
Sensitivity and entanglement in the avian chemical compass
Zhang, Y., Berman, G. P., & Kais, S. (2014) · Physical Review E · doi:10.1103/physreve.90.042707 · Cited by 32 · see citing works
Mouritsen, H. (2013) · Springer eBooks · doi:10.1007/978-3-642-10769-6_20 · Cited by 32 · see citing works
Self-citationMultiscale description of avian migration: from chemical compass to behaviour modeling
Pedersen, J. B., Nielsen, C., & Solov’yov, I. A. (2016) · Scientific Reports · doi:10.1038/srep36709 · Cited by 32 · see citing works
Yukawa, H., Kono, H., Ishiwata, H., Igarashi, R., Takakusagi, Y., Arai, S., Hirano, Y., Suhara, T., & Baba, Y. (2025) · Chemical Society Reviews · doi:10.1039/d4cs00650j · Cited by 34 · see citing works
Magnetoreception in birds and its use for long-distance migration
Mouritsen, H. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819770-7.00040-2 · Cited by 31 · see citing works
Self-citationGrüning, G., Wong, S. Y., Gerhards, L., Schuhmann, F., Kattnig, D. R., Hore, P. J., & Solov’yov, I. A. (2022) · Journal of the American Chemical Society · doi:10.1021/jacs.2c06233 · Cited by 31 · see citing works
Self-citationMouritsen, H. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-407160-5.00008-7 · Cited by 29 · see citing works
Self-citationThe magnetic map sense and its use in fine-tuning the migration programme of birds
Heyers, D., Elbers, D., Bulte, M., Bairlein, F., & Mouritsen, H. (2017) · Journal of Comparative Physiology A · doi:10.1007/s00359-017-1164-x · Cited by 29 · see citing works
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Schroeder, C., Werner, K., Otten, H., Krätzig, S., Schwalbe, H., & Essen, L. (2008) · ChemBioChem · doi:10.1002/cbic.200800280 · Cited by 28 · see citing works
Magnetic activation in the brain of the migratory northern wheatear (Oenanthe oenanthe)
Elbers, D., Bulte, M., Bairlein, F., Mouritsen, H., & Heyers, D. (2017) · Journal of Comparative Physiology A · doi:10.1007/s00359-017-1167-7 · Cited by 28 · see citing works
Self-citation
- Authors
- Liedvogel, M., Maeda, K., Henbest, K., Schleicher, E., Simon, T., Timmel, C. R., Hore, P. J., & Mouritsen, H.
- Affiliations
- Carl von Ossietzky Universität Oldenburg (DE)
- University of Oxford (GB)
- Freie Universität Berlin (DE)
- Corresponding author
- Liedvogel, Miriam
- Maeda, Kiminori
- Henbest, Kevin
- Schleicher, Erik
- Simon, Thomas
- Timmel, Christiane R.
- Hore, P. J.
- Mouritsen, Henrik
- ORCID
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2007-10-31
- Volume
- 2
- Issue
- 10
- Pages
- e1106
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC2040520
- OpenAlex
- W2163169468
- Cited by
- 183
- References
- 54
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 7 · 2023: 6 · 2022: 7 · 2021: 11 · 2020: 9 · 2019: 3 · 2018: 12 · 2017: 12 · 2016: 14 · 2015: 11 · 2014: 11 · 2013: 8 · 2012: 11
- FWCI
- 7.68
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Max Planck Digital Library (submittedVersion, other-oa)
- Figshare (submittedVersion, cc-by)
- Lund University Publications (Lund University) (submittedVersion)
- Refubium (Universitätsbibliothek der Freien Universität Berlin) (submittedVersion, cc-by)
- Funders
- Carl von Ossietzky Universität Oldenburg
- Royal Society
- EMF Biological Research Trust
- Deutsche Forschungsgemeinschaft (FOR 526, MO 1408/1-2, FOR 701)
- Volkswagen Foundation
- Engineering and Physical Sciences Research Council (GR/T05424/01)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Electromagnetic Fields and Biological Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Electron Spin Resonance Studies
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- radical pairs, blue light absorption, flavoprotein, magnetic compass orientation, bird migration, garden warbler, transient absorption spectroscopy, recombinant protein expression
- MeSH terms
- Animals, Birds, Cell Line, Cloning, Molecular, Flavoproteins, Free Radicals, Insecta, Light, Magnetics, Models, Biological, Magnetic Resonance Spectroscopy, Recombinant Proteins, Ultraviolet Rays, Protein Structure, Tertiary, Animal Migration, Cryptochromes
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