Blockade of VEGFR2 and Not VEGFR1 Can Limit Diet-Induced Fat Tissue Expansion: Role of Local versus Bone Marrow-Derived Endothelial Cells
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BACKGROUND: We investigated if new vessel formation in fat involves the contribution of local tissue-derived endothelial cells (i.e., angiogenesis) or bone marrow-derived cells (BMDCs, i.e. vasculogenesis) and if antiangiogenic treatment by blockade of vascular endothelial growth factor (VEGF) receptors can prevent diet-induced obesity (DIO). METHODOLOGY/PRINCIPAL FINDINGS: We performed restorative bone marrow transplantation into wild-type mice using transgenic mice expressing green fluorescent protein (GFP) constitutively (driven by beta-actin promoter) or selectively in endothelial cells (under Tie2 promoter activation) as donors. The presence of donor BMDCs in recipient mice was investigated in fat tissue vessels after DIO using in vivo and ex vivo fluorescence microscopy. We investigated the roles of VEGF receptors 1 and 2 (VEGFR1/VEGFR2) by inducing DIO in mice and treating them with blocking monoclonal antibodies. We found only marginal (less than 1%) incorporation of BMDCs in fat vessels during DIO. When angiogenesis was inhibited by blocking VEGFR2 in mice with DIO, treated mice had significantly lower body weights than control animals. In contrast, blocking VEGFR1 had no discernable effect on the weight gain during DIO. CONCLUSIONS/SIGNIFICANCE: Formation of new vessels in fat tissues during DIO is largely due to angiogenesis rather than de novo vasculogenesis. Antiangiogenic treatment by blockade of VEGFR2 but not VEGFR1 may limit adipose tissue expansion.
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Blockade of VEGF-R2, but not VEGF-R1, restricts AT expansion and thus prevents the progression of DIO.
“Blockade of VEGF-R2, but not VEGF-R1, restricts AT expansion and thus prevents the progression of DIO (81)”
From Adipose tissue remodeling and obesity (2011) · cites this paper as [81]
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- Authors
- Tam, J., Duda, D. G., Perentes, J. Y., Quadri, R. S., Fukumura, D., & Jain, R. K.
- Affiliations
- Harvard University (US)
- Corresponding author
- Fukumura, Dai
- Jain, Rakesh K.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2009-03-31
- Volume
- 4
- Issue
- 3
- Pages
- e4974
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC2659427
- OpenAlex
- W2079330089
- Cited by
- 99
- References
- 36
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 6 · 2022: 6 · 2021: 4 · 2020: 3 · 2019: 4 · 2018: 7 · 2017: 4 · 2016: 7 · 2015: 4 · 2014: 10 · 2013: 18 · 2012: 5
- FWCI
- 3.09
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- IRIS (submittedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- SERVAL (Université de Lausanne) (submittedVersion, other-oa)
- Funders
- National Institutes of Health
- National Cancer Institute (R01CA115767, R01 CA 85140, T32CA073479, R01CA085140, R01CA096915, R24CA085140, R01-CA96915, P01CA080124, R01CA126642, P01-CA-80124)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- VEGFR2, VEGFR1, angiogenesis, vasculogenesis, diet-induced obesity, adipose tissue expansion, endothelial cells, bone marrow-derived cells, anti-angiogenic therapy, VEGF receptor blockade, adipose tissue vascularization, bone marrow transplantation
- MeSH terms
- Adipose Tissue, Animals, Body Weight, Bone Marrow Cells, Diet, Mice, Transgenic, Obesity, Bone Marrow Transplantation, Neovascularization, Physiologic, Vascular Endothelial Growth Factor Receptor-1, Vascular Endothelial Growth Factor Receptor-2, Endothelial Cells, Cell Proliferation, Mice
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