Angiogenesis and obesity
Abstract
Development of obesity is associated with substantial modulation of adipose tissue structure, involving adipogenesis, angiogenesis, and extracellular matrix remodelling. These processes require proteolytic activity, provided mainly by the fibrinolytic (plasminogen/plasmin), matrix metalloproteinase, and ADAM/ADAMTS systems. In early-stage development of adipose tissue, adipogenesis is tightly associated with angiogenesis. Thus, adipose tissue explants trigger blood vessel formation, and in turn adipose tissue endothelial cells promote pre-adipocyte differentiation. Modulation of angiogenesis and of proteolytic systems may have the potential to impair adipose tissue development.
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The newly formed vascular network is crucial for adipogenesis and adipose tissue expansion.
“The newly formed vascular network is crucial for adipogenesis and AT expansion (64,65).”
From Adipose tissue remodeling and obesity (2011) · cites this paper as [65]
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- Authors
- Lijnen, H. R.
- Affiliations
- KU Leuven (BE)
- Corresponding author
- Lijnen, H. R.
- Venue
- Cardiovascular Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-02-19
- Volume
- 78
- Issue
- 2
- Pages
- 286-293
- ISSN
- 0008-6363 (ISSN-L)
- OpenAlex
- W2099398050
- Cited by
- 206
- References
- 117
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 6 · 2023: 9 · 2022: 9 · 2021: 9 · 2020: 5 · 2019: 13 · 2018: 15 · 2017: 8 · 2016: 8 · 2015: 15 · 2014: 20 · 2013: 22 · 2012: 10
- FWCI
- 1.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cardiovascular Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- angiogenesis, obesity, adipose tissue, adipogenesis, extracellular matrix remodeling, proteolysis, fibrinolysis, plasmin system, matrix metalloproteinases, ADAMTS, Adam, preadipocyte differentiation
- MeSH terms
- Adipose Tissue, Animals, Humans, Obesity, Peptide Hydrolases, Protease Inhibitors, Signal Transduction, Adipocytes, Neovascularization, Physiologic, Anti-Obesity Agents, Angiogenesis Inhibitors, Angiogenic Proteins, Endothelial Cells, Adipokines
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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