Hyperleptinemia Is Required for the Development of Leptin Resistance

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Effects of Recombinant Leptin Therapy in a Child with Congenital Leptin Deficiency

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Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity

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Trophic Action of Leptin on Hypothalamic Neurons That Regulate Feeding

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Should We Consider Neurodegeneration by Itself or in a Triangulation with Neuroinflammation and Demyelination? The Example of Multiple Sclerosis and Beyond

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Sex-specific effects of prepubertal stress and high-fat diet on leptin signaling in rats

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The Divergent Effect of Maternal Protein Restriction during Pregnancy and Postweaning High-Fat Diet Feeding on Blood Pressure and Adiposity in Adult Mouse Offspring

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A General Method for Insertion of Functional Proteins within Proteins via Combinatorial Selection of Permissive Junctions

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The influence of parental high-fat high-sugar diet on the gut-brain axis in male offspring

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Beyond the Scale: Exploring the Endocannabinoid System’s Impact on Obesity

Akurati, S., & Hanlon, E. C. (2024) · Current Diabetes Reports · doi:10.1007/s11892-024-01562-2 · Cited by 13

UCP1-independent glucose-lowering effect of leptin in type 1 diabetes: only in conditions of hypoleptinemia

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Sicyos angulatus Prevents High-Fat Diet-Induced Obesity and Insulin Resistance in Mice

Choi, J. H., Noh, J., Kim, Y., Kim, J.-H., Kang, E., Choi, D., Choi, J. H., An, J., Oh, W. K., & Lee, C.-H. (2020) · International Journal of Medical Sciences · doi:10.7150/ijms.42247 · Cited by 10

Anti-obesity and hypolipidemic effects of chufa (Cyperus esculentus L.) in mice fed a high-fat diet

Moon, M. K., Ahn, J., Lee, H., & Ha, T. Y. (2012) · Food Science and Biotechnology · doi:10.1007/s10068-012-0042-0 · Cited by 10

Leptin: 30 Years Later

Ahima, R. S., & Flier, J. S. (2025) · Annual Review of Physiology · doi:10.1146/annurev-physiol-042324-100259 · Cited by 10

High sucrose consumption decouples intrinsic and synaptic excitability of AgRP neurons without altering body weight

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Changes in Expression of the Genes for the Leptin Signaling in Hypothalamic-Pituitary Selected Areas and Endocrine Responses to Long-Term Manipulation in Body Weight and Resistin in Ewes

Zieba, D. A., Biernat, W., Szczęsna, M., Kirsz, K., Barć, J., & Misztal, T. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21124238 · Cited by 10

Canine extrahepatic biliary disease

Jaffey, J. A. (2021) · Journal of Small Animal Practice · doi:10.1111/jsap.13468 · Cited by 9

Leptin

Matarese, G., Procaccini, C., Pucino, V., & Christos, M. (2014) · Springer eBooks · doi:10.1007/978-3-319-09915-6 · Cited by 10

Effects of Erythrocyte Membrane Polyunsaturated Fatty Acids in Overweight, Obese, and Morbidly Obese Korean Women

Choi, H., & Yim, J. (2017) · Journal of Cancer Prevention · doi:10.15430/jcp.2017.22.3.182 · Cited by 8

The chemical chaperon 4-phenyl butyric acid restored high-fat diet- induced hippocampal insulin content and insulin receptor level reduction along with spatial learning and memory deficits in male rats

Binayi, F., Zardooz, H., Ghasemi, R., Hedayati, M., Askari, S., Pouriran, R., & Sahraei, M. (2021) · Physiology & Behavior · doi:10.1016/j.physbeh.2021.113312 · Cited by 8

Leptin, Obesity, and Leptin Resistance

Münzberg, H., & Heymsfield, S. B. (2014) · Springer eBooks · doi:10.1007/978-3-319-09915-6_6 · Cited by 11

The hyperleptinemia state can downregulate cardiorespiratory fitness and energy expenditure in obese women

Sanches, R. B., Poli, V. F. S., Fidalgo, J. P. N., Andrade-Silva, S. G., Cerrone, L. A., Oyama, L. M., Dâmaso, A. R., dos Santos, R. V. T., & Caranti, D. A. (2017) · Physiology & Behavior · doi:10.1016/j.physbeh.2017.10.029 · Cited by 7

High Fat Feeding in Rats Alters Respiratory Parameters by a Mechanism That Is Unlikely to Be Mediated by Carotid Body Type I Cells

Rakoczy, R. J., Pye, R. L., Fayyad, T. H., Santin, J. M., Barr, B. L., & Wyatt, C. N. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-91137-3_17 · Cited by 7

Teasaponin improves leptin sensitivity in the prefrontal cortex of obese mice

Yu, Y., Wu, Y., Szabo, A., Wang, S., Yu, S., Wang, Q., & Huang, X. (2015) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201500205 · Cited by 7

Restoration of Lepr in β cells of Lepr null mice does not prevent hyperinsulinemia and hyperglycemia

D'souza, A. M., & Kieffer, T. J. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2017.04.003 · Cited by 8

Does elevated bilirubin aid weight control by preventing development of hypothalamic leptin resistance?

DiNicolantonio, J. J., McCarty, M. F., & O’Keefe, J. H. (2019) · Open Heart · doi:10.1136/openhrt-2018-000897 · Cited by 7

Natural Products From Plants Targeting Leptin Resistance for the Future Development of Anti-Obesity Agents

Liu, Y., & Gong, F. (2025) · Phytotherapy Research · doi:10.1002/ptr.8415 · Cited by 6

Neuroendocrinology and the Genetics of Obesity

Ruggiero-Ruff, R. E., & Coss, D. (2025) · Endocrinology · doi:10.1210/endocr/bqaf121 · Cited by 6

Obesity and chronic leptin resistance foster insulin resistance

Dey, S., Murmu, N., Böse, M., Ghosh, S., & Giri, B. (2021) · BLDE University Journal of Health Sciences · doi:10.4103/bjhs.bjhs_29_20 · Cited by 9

Molecular profile and response to energy deficit of leptin-receptor neurons in the lateral hypothalamus

Kakava-Georgiadou, N., Drkelic, V., Garner, K. M., Luijendijk, M. C. M., Başak, O., & Adan, R. A. H. (2022) · Scientific Reports · doi:10.1038/s41598-022-16492-w · Cited by 6

Biomarkers, Obesity, and Cardiovascular Diseases

Meza, M. N., & Carrillo, J. A.-B. (2016) · InTech eBooks · doi:10.5772/62555 · Cited by 7

16/8 intermittent fasting in mice protects from diet‐induced obesity by increasing leptin sensitivity and postprandial thermogenesis

Arruda, A. C., Santos, R. B., Freitas‐Lima, L. C., Budu, A., Perilhão, M. S., Wasinski, F., Arthur, G. D. M., Guzmán, R. R., Gomes, G., Pesquero, J. B., et al. (2025) · Acta Physiologica · doi:10.1111/apha.70036 · Cited by 5

Physical Activity and Sedentary Behavior Influences on Executive Function in Daily Living

Baker, B., & Castelli, D. M. (2020) · Cognitive science and technology · doi:10.1007/978-3-030-34784-0_9 · Cited by 5

Nil-Surin Rice Bran Hydrolysates Improve Lipid Metabolism and Hepatic Steatosis by Regulating Secretion of Adipokines and Expression of Lipid-Metabolism Genes

Boonloh, K., Thanaruksa, R., Proongkhong, T., Thawornchinsombut, S., & Pannangpetch, P. (2022) · Journal of Medicinal Food · doi:10.1089/jmf.2021.k.0170 · Cited by 5

Allograft inflammatory factor-1-like is a situational regulator of leptin levels, hyperphagia, and obesity

Parikh, D., Jayakumar, S., Oliveira‐Paula, G. H., Almonte, V. M., Riascos‐Bernal, D. F., & Sibinga, N. E. S. (2022) · iScience · doi:10.1016/j.isci.2022.105058 · Cited by 5

Onset of leptin resistance shows temporal differences related to dose or pulsed treatment

Strehler, K. Y. E., Matheny, M. E., Kirichenko, N., Sakarya, Y., Bruce, E. B., Toklu, H. Z., Carter, C. S., Morgan, D., Tümer, N., & Scarpace, P. J. (2016) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2016.03.026 · Cited by 5

Bardoxolone methyl prevents obesity and hypothalamic dysfunction

Camer, D., Yu, Y., Szabo, A., Wang, H., Dinh, C. H. L., & Huang, X. (2016) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2016.07.013 · Cited by 5

Hematopoietic Stem Cell-Derived Adipocytes Modulate Adipose Tissue Cellularity, Leptin Production and Insulin Responsiveness in Female Mice

Gavin, K. M., Sullivan, T. M., Maltzahn, J. K., Jackman, M. R., Libby, A. E., MacLean, P. S., Kohrt, W. M., Majka, S. M., & Klemm, D. J. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.844877 · Cited by 5

Obesity-driven hunger: From pathophysiology to intervention

Azemi, A. K., Mutalub, Y. B., Abdulwahab, M., Rasool, A. H. G., Mustapha, S., Suhaimi, S. Q. A., & Mokhtar, S. S. (2025) · Obesity Medicine · doi:10.1016/j.obmed.2025.100588 · Cited by 6

Leptin and melanocortin signalling in the response to infection

Fan, R. R., Beckham, J. D., & Rajagopalan, K. N. (2025) · Nature Reviews Endocrinology · doi:10.1038/s41574-025-01184-y · Cited by 4

Elevated adiponectin but varied response in circulating leptin levels to falciparum malaria in type 2 diabetics and non-diabetic controls

Acquah, S., Eghan, B., & Boampong, J. N. (2016) · Biomedical Journal · doi:10.1016/j.bj.2016.09.003 · Cited by 4

In vivo Protein Interference: Oral Administration of Recombinant Yeast-Mediated Partial Leptin Reduction for Obesity Control

Yue, F., Du, L., Wang, R., Han, B., Zhang, X., Yao, Z., Zhang, W., Cai, C., Zhang, Z., & Xu, K. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.923656 · Cited by 4

Effects of Piper sarmentosum on Metabolic Syndrome and Its Related Complications: A Review of Preclinical Evidence

Ekeuku, S. O., Azlina, M. F. N., & Chin, K. (2021) · Applied Sciences · doi:10.3390/app11219860 · Cited by 5

Brain Related Gut Peptides – A Review

Manoharan, N., Jayamurali, D., Parasuraman, R., & Govindarajulu, S. N. (2022) · Protein and Peptide Letters · doi:10.2174/0929866529666220920150127 · Cited by 4

Regional specific effect of saturated vs unsaturated fat on leptin receptor signalling in mice brain areas regulating feeding

Fernández-Felipe, J., López, L. L., Cano, V., Sánchez-Hita, E., Sanz-Martos, A. B., Chowen, J. A., Olmo, N. D., Ruiz‐Gayo, M., & Merino, B. (2022) · Neuroscience Letters · doi:10.1016/j.neulet.2022.136996 · Cited by 4

Brief Report: Plasma Leptin and Mealtime Feeding Behaviors Among Children with Autism Spectrum Disorder: A Pilot Study

Dhaliwal, K. K., Avedzi, H. M., Richard, C., Zwaigenbaum, L., & Haqq, A. M. (2022) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-022-05581-4 · Cited by 4

Characterization of a novel genetically obese mouse model demonstrating early onset hyperphagia and hyperleptinemia

Nakahara, K., Bannai, M., Maruyama, K., SUZUKI, Y., Okame, R., & Murakami, N. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00540.2012 · Cited by 4

Current Progress in Adipose Tissue Biology: Implications in Obesity and Its Comorbidities

Meiliana, A., Dewi, N. M., & Wijaya, A. (2020) · The Indonesian Biomedical Journal · doi:10.18585/inabj.v12i2.1171 · Cited by 3

Cord Leptin is Associated with Neuropsychomotor Development in Childhood

Karakosta, P., Margetaki, K., Fthenou, E., Kampouri, M., Kyriklaki, A., Koutra, K., Chalkiadaki, G., Roumeliotaki, T., Vafeiadi, M., Kogevinas, M., et al. (2019) · Obesity · doi:10.1002/oby.22571 · Cited by 3

Evidence-based assisted reproduction in obese women

Narice, B. F., & Metwally, M. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-817919-2.00014-0 · Cited by 3

The Selfish Immune System when the Immune System Overrides the ‘Selfish’ Brain

Pruimboom, L. (2020) · DergiPark (Istanbul University) · Cited by 3

Umami taste—a novel mechanism driving food intake and obesity

Beutler, L. R. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00445-0 · Cited by 3

Smooth Muscle Cells from a Rat Model of Obesity and Hyperleptinemia Are Partially Resistant to Leptin-Induced Reactive Oxygen Species Generation

López-Acosta, O., Cristóbal-García, M., Cardoso-Saldaña, G. C., Carvajal, K., & El‐Hafidi, M. (2023) · Antioxidants · doi:10.3390/antiox12030728 · Cited by 3

Calorie restriction-mediated restoration of hypothalamic signal transducer and activator of transcription 3 (STAT3) phosphorylation is not effective for lowering the body weight set point in IRS-2 knockout obese mice

Senda, S., Inoue, A., Mahmood, A., Suzuki, R., Kamei, N., Kubota, N., Watanabe, T., Aoyama, M., Nawaz, A., Ohkuma, Y., et al. (2015) · Diabetology International · doi:10.1007/s13340-015-0205-3 · Cited by 2

A histomorphometric study on the effects of antiretroviral therapy (ART) combined with a high-calorie diet (HCD) on aortic perivascular adipose tissue (PVAT)

Nel, S., Strijdom, H., Genis, A., Everson, F., Wijk, R. V., & Kotzé, S. H. (2017) · Acta Histochemica · doi:10.1016/j.acthis.2017.05.009 · Cited by 2

Role of Glucagon-Like Peptide-1 in Appetite Regulation in Patients with Morbid Obesity and Leptin Resistance

Algon, A. A. A., Almulla, A. F., Najm, A. H., & Keshwan, R. A. (2019) · International Journal of Peptide Research and Therapeutics · doi:10.1007/s10989-019-09864-w · Cited by 2

Leptin Receptors Are Not Required for Roux-en-Y Gastric Bypass Surgery to Normalize Energy and Glucose Homeostasis in Rats

Hankir, M. K., Rotzinger, L., Nordbeck, A., Corteville, C., Dischinger, U., Knop, J., Hoffmann, A., Otto, C., & Seyfried, F. (2021) · Nutrients · doi:10.3390/nu13051544 · Cited by 3

Regulation of Food Intake After Surgery and the Gut-Brain Axis

Tewari, N., & Lobo, D. N. (2019) · Springer eBooks · doi:10.1007/978-3-030-16554-3_1 · Cited by 2

Role of bioactive lipids in obesity

Salsinha, A. S., Rodríguez-Alcalá, L. M., Pimentel, L. L., & Pintado, M. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-824043-4.00012-9 · Cited by 2

NUCLEAR RETENTION OF LEPTIN/UPD2 REGULATES ORGANISMAL RESILIENCE TO NUTRIENT EXTREMESPreprint

Poling, M. E., Sullivan, C. E., Madan, A., Kelly, K., Brent, A. E., Dubrulle, J., Raghavan, P., & Rajan, A. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.01.29.428913 · Cited by 2

Effects of the combination of intermittent fasting and physical exercise on autophagic and leptin pathway in the hypothalamus of obese mice

Oliveira, L. D. C. (2022) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.17.2022.tde-06022023-105659 · Cited by 2

A Subcortical Feeding Circuit Linking Interoception to Jaw movementPreprint

Kosse, C., Ivanov, J., Knight, Z. A., Pellegrino, K., & Friedman, J. M. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.10.11.561735 · Cited by 2

High-Amylose Maize Resistant Starch Type 2 (HAM-RS2) Intake, Body Composition, and Satiety in Overweight Adults

Patterson, M. A. (2014) · Cited by 2

Changes in hippocampal volume, synaptic plasticity and amylin sensitivity in an animal model of type 2 diabetes are associated with increased vulnerability to amyloid-beta in advancing age

Tarhan, M., Hartl, T., Shchyglo, O., Colitti-Klausnitzer, J., Kuhla, A., Breuer, T. M., & Manahan‐Vaughan, D. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1373477 · Cited by 2

Methodological considerations and implications for appetite and feeding behaviour research in PKU; Current knowledge, practical application and future perspectives

Green, B. (2025) · Rare · doi:10.1016/j.rare.2025.100060 · Cited by 3

Comparison of the characteristics of non-alcoholic fatty liver disease in C57BL/6J-Leprem1hwl/Korl and C57BLKS/J-Leprdb/J mice

Lee, S., Min, J. K., Kim, M. J., Yun, S., Seo, M. K., & Lee, J. K. (2025) · EXPERIMENTAL ANIMALS · doi:10.1538/expanim.24-0100 · Cited by 1

Effects of aerobic exercise and antioxidant micronutrients on leptin levels in pregnancy: a sub-analysis from a double-blinded randomised controlled trial

Suárez‐Ortegón, M. F., Ortega, J. G., Echeverri, I., Mateus, J. C., & Mosquera, M. (2025) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637486.2025.2525905 · Cited by 1

Systemic and Local Leptin Resistance in Patients with Cardiovascular Diseases

Gruzdeva, O. V., Gorbatovskaya, E., Dyleva, Y. A., Dolmatova, S., Romanova, A., Fanaskova, E. V., Tarasov, R. S., Stasev, A., & Барбараш, О. Л. (2025) · Diagnostics · doi:10.3390/diagnostics15212772 · Cited by 1

Crosstalk Between Leptin and Adiponectin in Colorectal Cancer: Molecular Mechanisms and Oncogenic Pathways

Slavova, S., Kiselova-Kaneva, Y. D., Ivanova, D. G., & Vankova, D. G. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27041789 · Cited by 1

Leptin-driven microglial activation in fibromyalgia: mechanistic insights and therapeutic implications

Abdelrheem, N. M., Ahmed, M. A. E., Mohamed, A. F., Shalaby, H. N., & Sayed, N. S. E. (2026) · International Immunopharmacology · doi:10.1016/j.intimp.2026.116657 · Cited by 1

Altered leptin signaling and attenuated cardiac vagal activity in rats with type 2 diabetes

Evans, A. J., Tu, H., Li, Y., Shabaltiy, B., Whitney, L., Carpenter, K., & Li, Y.-L. (2025) · Frontiers in Physiology · doi:10.3389/fphys.2025.1547901 · Cited by 1

Neuroimmunometabolism as a regulator of obesity

Sweeney, C. A. P., & Domingos, A. I. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-15447-8.00011-8 · Cited by 1

Leptin Inhibit the Effect of Pioglitazone in Reducing MMP-9 and MMP-13 of IL-1β-Induced Chondrocytes

Normasari, R., & Murniati, A. (1970) · Journal of Agromedicine and Medical Sciences · doi:10.19184/ams.v1i2.1954 · Cited by 1

Functional paradox of leptin and adiponectin in diabetes patients and controls in the Cape Coast Metropolis of Ghana

Acquah, S., Boampong, J. N., & Eghan, B. A. (2017) · Medical Journal of Dr D Y Patil University · doi:10.4103/mjdrdypu.mjdrdypu_271_16 · Cited by 1

Obesity and Stress: The Melanocortin Connection

Singhal, S., & Hill, J. W. (2018) · Springer eBooks · doi:10.1007/978-3-319-89506-2_11 · Cited by 1

Estresse crônico associado à dieta hipercalórica em ratos Wistar : parâmetros ponderais e bioquímicos

de Macedo, I. C. (2010) · Americanae (AECID Library) · Cited by 1

Is there a critical time window for weight loss intervention?

Li, X. (2013) · Nutrition Bulletin · doi:10.1111/nbu.12025

Efecto de la sobrenutrición neonatal en la respuesta aguda a la leptina en los periodos prepuberal y peripuberal

González, D. (2014) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)

Molecular and Physiological Adaptations to Weight Perturbation in Mice

Ravussin, Y. (2011) · doi:10.7916/d8hq45w5

The influence of obesity on structure, biochemistry and function of brain regions involved in cognition

Bocarsly, M. E. (2013)

The immunological consequences of obesity on primary and secondary immune defenses to the 2009 pandemic H1N1 influenza virus

Milner, J. J. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/c8p3-s268

Polimorfismos dos genes CD40, ICAM-1, VCAM, E-selectina, LIGHT, RAGE e CX3CR1 relacionados com inflamação e sua associação à obesidade

Braga, A. A. (2014) · doi:10.11606/d.9.2014.tde-26052015-143307

Effects of insulin gene dosage on body weight and glucose homeostasis

Mehran, A. E. (2015) · cIRcle (University of British Columbia) · doi:10.14288/1.0167270

Kinases and Mitochondrial Cycling

Carreras, M. C., & Poderoso, J. J. (2012) · Oxidative stress and disease · doi:10.1201/b12308-13

Appetite and metabolic responses to acute and moderate-term dairy snack consumption in young people

Green, B. (2015) · Northumbria Research Link (Northumbria University)

Maternal High Fat Feeding: Impact of Female Offspring Body Composition and Bone Health

Castelli, L. M. (2014) · Brock University Digital Repository (Brock University)

Is body weight “homeostatically” regulated?<_ufe:lines xmlns:_ufe="http://www.arbortext.com/namespace/Styler/UserFormattingElements" xml:base="-5mm"> </_ufe:lines>—a clue from Rcan2

Li, S., Gong, Q.-Q., & Sun, X. (2017) · Scientia Sinica Vitae · doi:10.1360/n052016-00308

Leptin is Not Associate with Maternal Fat Mass on the Third Trimester of Pregnancy

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