Podocalyxin Is a Novel Polysialylated Neural Adhesion Protein with Multiple Roles in Neural Development and Synapse Formation
Open accessAbstract
Neural development and plasticity are regulated by neural adhesion proteins, including the polysialylated form of NCAM (PSA-NCAM). Podocalyxin (PC) is a renal PSA-containing protein that has been reported to function as an anti-adhesin in kidney podocytes. Here we show that PC is widely expressed in neurons during neural development. Neural PC interacts with the ERM protein family, and with NHERF1/2 and RhoA/G. Experiments in vitro and phenotypic analyses of podxl-deficient mice indicate that PC is involved in neurite growth, branching and axonal fasciculation, and that PC loss-of-function reduces the number of synapses in the CNS and in the neuromuscular system. We also show that whereas some of the brain PC functions require PSA, others depend on PC per se. Our results show that PC, the second highly sialylated neural adhesion protein, plays multiple roles in neural development.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The plasticity resulting from polysialic acid expression appears to be important for neuronal migration and for reorganization following injury.
“The ' plasticity ' resulting from polysialic acid expression appears to be important for neuronal migration as well as reorganization following injury (546 -554).”
From Biological roles of glycans (2017) · cites this paper as [551]
The Discussion (page not specified) says that removing polysialic acid disrupts tangential neuronal migration, supporting the migration part of the claim. It does not address reorganization following injury, so that part is unsupported by our copy. (LLM, conf=0.86)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The Molecular Biology of Axon Guidance
Tessier‐Lavigne, M., & Goodman, C. S. (1996) · Science · doi:10.1126/science.274.5290.1123 · Cited by 3,295 · see citing works
A simple method for organotypic cultures of nervous tissue
Stoppini, L., Buchs, P., & Muller, D. (1991) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(91)90128-m · Cited by 3,097 · see citing works
Cremer, H., Lange, R., Christoph, A., Plomann, M., Vopper, G., Roes, J., Brown, R. W., Baldwin, S. A., Kraemer, P. J., Scheff, S. W., et al. (1994) · Nature · doi:10.1038/367455a0 · Cited by 1,007 · see citing works
Tbr1 regulates differentiation of the preplate and layer 6
Hevner, R. F., Shi, L., Justice, N., Hsueh, Y.-P., Sheng, M., Smiga, S., Bulfone, A., Goffinet, A. M., Campagnoni, A. T., & Rubenstein, J. L. R. (2001) · Neuron · doi:10.1016/s0896-6273(01)00211-2 · Cited by 857 · see citing works
Maness, P. F., & Schachner, M. (2006) · Nature Neuroscience · doi:10.1038/nn1827 · Cited by 850 · see citing works
PSA-NCAM is required for activity-induced synaptic plasticity.
Muller, D., Wang, C., Skibo, G. G., Toni, N., Cremer, H., Calaora, V., Rougon, G., & Kiss, J. Z. (1996) · Neuron · doi:10.1016/s0896-6273(00)80174-9 · Cited by 625 · see citing works
The Neural Cell Adhesion Molecule NCAM Is an Alternative Signaling Receptor for GDNF Family Ligands
Paratcha, G., Ledda, F., & Ibáñez, C. F. (2003) · Cell · doi:10.1016/s0092-8674(03)00435-5 · Cited by 624 · see citing works
Cell adhesion molecules: signalling functions at the synapse
Dalva, M. B., McClelland, A. C., & Kayser, M. S. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2075 · Cited by 620 · see citing works
Multiple roles of eph receptors and ephrins in neural development
Wilkinson, D. G. (2001) · Nature reviews. Neuroscience · doi:10.1038/35058515 · Cited by 614 · see citing works
Effects of brain-derived neurotrophic factor on optic axon branching and remodelling in vivo
Cohen-Cory, S., & Fraser, S. E. (1995) · Nature · doi:10.1038/378192a0 · Cited by 580 · see citing works
Glycans and neural cell interactions
KLEENE, R. B., & Schachner, M. (2004) · Nature reviews. Neuroscience · doi:10.1038/nrn1349 · Cited by 518 · see citing works
Tomasiewicz, H. G., Ono, K., Yee, D., Thompson, C., Goridis, C., Rutishauser, U. S., & Magnuson, T. (1993) · Neuron · doi:10.1016/0896-6273(93)90228-j · Cited by 475 · see citing works
A role for Cajal–Retzius cells and reelin in the development of hippocampal connections
Del Río, J. A., Heimrich, B., Borrell, V., Förster, E., Drakew, A., Alcántara, S., Nakajima, K., Miyata, T., Ogawa, M., Mikoshiba, K., et al. (1997) · Nature · doi:10.1038/385070a0 · Cited by 472 · see citing works
Self-citationCastellani, V., Chédotal, A., Schachner, M., Faivre‐Sarrailh, C., & Rougon, G. N. (2000) · Neuron · doi:10.1016/s0896-6273(00)00033-7 · Cited by 425 · see citing works
Ono, K., Tomasiewicz, H. G., Magnuson, T., & Rutishauser, U. S. (1994) · Neuron · doi:10.1016/0896-6273(94)90028-0 · Cited by 414 · see citing works
Novel functions of the CD34 family
Nielsen, J. S., & McNagny, K. M. (2008) · Journal of Cell Science · doi:10.1242/jcs.037507 · Cited by 379 · see citing works
Self-citationModulation of an NCAM-Related Adhesion Molecule with Long-Term Synaptic Plasticity in Aplysia
Mayford, M. R., Barzilai, A., Keller, F., Schacher, S., & Kandel, E. R. (1992) · Science · doi:10.1126/science.1585176 · Cited by 371 · see citing works
Anuria, Omphalocele, and Perinatal Lethality in Mice Lacking the Cd34-Related Protein Podocalyxin
Doyonnas, R., Kershaw, D. B., Duhme, C., Merkens, H., Chelliah, S., Graf, T., & McNagny, K. M. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.1.13 · Cited by 336 · see citing works
Self-citationRegulation of repulsion versus adhesion by different splice forms of an Eph receptor
Holmberg, J., Clarke, D. L., & Frisén, J. (2000) · Nature · doi:10.1038/35041577 · Cited by 335 · see citing works
Stoeckli, E. T., & Landmesser, L. T. (1995) · Neuron · doi:10.1016/0896-6273(95)90264-3 · Cited by 327 · see citing works
Eckhardt, M., Bukalo, O., Chazal, G., Wang, L., Goridis, C., Schachner, M., Gerardy‐Schahn, R., Cremer, H., & Dityatev, A. E. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-14-05234.2000 · Cited by 315 · see citing works
Weinhold, B., Seidenfaden, R., Röckle, I., Mühlenhoff, M., Schertzinger, F., Conzelmann, S., Marth, J. D., Gerardy-Schahn, R., & Hildebrandt, H. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m511097200 · Cited by 298 · see citing works
NCAM Is Essential for Axonal Growth and Fasciculation in the Hippocampus
Cremer, H., Chazal, G., Goridis, C., & Represa, A. (1997) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.1996.0588 · Cited by 294 · see citing works
Rho GTPases regulate distinct aspects of dendritic arbor growth in Xenopus central neurons in vivo
Li, Z., Aelst, L. V., & Cline, H. T. (2000) · Nature Neuroscience · doi:10.1038/72920 · Cited by 293 · see citing works
Dent, E. W., Barnes, A. M., Tang, F., & Kalil, K. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.4963-03.2004 · Cited by 290 · see citing works
Lee, T., Winter, C. G., Marticke, S., Lee, A. M., & Luo, L. (2000) · Neuron · doi:10.1016/s0896-6273(00)80896-x · Cited by 287 · see citing works
Takeda, T., McQuistan, T. J., Orlando, R. A., & Farquhar, M. G. (2001) · Journal of Clinical Investigation · doi:10.1172/jci12539 · Cited by 265 · see citing works
Dityatev, A. E., Dityatev, A. E., Sytnyk, V., Delling, M., Toni, N., Nikonenko, I., Müller, D., & Schachner, M. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1702-04.2004 · Cited by 265 · see citing works
Yee, K. T., Simon, H. H., Tessier‐Lavigne, M., & O’Leary, D. D. M. (1999) · Neuron · doi:10.1016/s0896-6273(00)81116-2 · Cited by 262 · see citing works
Seki, T., & Rutishauser, U. S. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-10-03757.1998 · Cited by 262 · see citing works
Role of neurotrophins in central synapse formation and stabilization
Vicario‐Abejón, C., Owens, D. F., McKay, R. D. G., & Segal, M. (2002) · Nature reviews. Neuroscience · doi:10.1038/nrn988 · Cited by 247 · see citing works
Sassetti, C. M., Tangemann, K., Singer, M. S., Kershaw, D. B., & Rosen, S. D. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.187.12.1965 · Cited by 243 · see citing works
Cell biology of polysialic acid
Kiss, J. Z., & Rougon, G. N. (1997) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(97)80083-9 · Cited by 229 · see citing works
Cis and trans interactions of L1 with neuropilin‐1 control axonal responses to semaphorin 3A
Castellani, V., Angelis, E. D., Kenwrick, S. J., & Rougon, G. N. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf645 · Cited by 226 · see citing works
Alcántara, S., Ruiz, M., Castro, F. D., Soriano, E., & Sotelo, C. (2000) · Development · doi:10.1242/dev.127.7.1359 · Cited by 221 · see citing works
Self-citationDi Cristo, G., Chattopadhyaya, B., Kuhlman, S. J., Fu, Y., Bélanger, M.-C., Wu, C. Z., Rutishauser, U., Maffei, L., & Huang, Z. J. (2007) · Nature Neuroscience · doi:10.1038/nn2008 · Cited by 201 · see citing works
Takeda, T., Go, W. Y., Orlando, R. A., & Farquhar, M. G. (2000) · Molecular Biology of the Cell · doi:10.1091/mbc.11.9.3219 · Cited by 200 · see citing works
Bukalo, O., Fentrop, N., Lee, A. Y. W., Salmen, B., Law, J. W. S., Wotjak, C. T., Schweizer, M., Dityatev, A. E., & Schachner, M. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.3298-03.2004 · Cited by 184 · see citing works
Orlando, R. A., Takeda, T., Zak, B. M., Schmieder, S., Benoit, V. M., McQuistan, T. J., Furthmayr, H., & Farquhar, M. G. (2001) · Journal of the American Society of Nephrology · doi:10.1681/asn.v1281589 · Cited by 177 · see citing works
Dityatev, A. E., Dityatev, A. E., & Schachner, M. (2000) · Neuron · doi:10.1016/s0896-6273(00)81151-4 · Cited by 173 · see citing works
Somasiri, A. M., Nielsen, J. S., Makretsov, N. A., McCoy, M. L., Prentice, L., Gilks, C. B., Chia, S., Gelmon, K. A., Kershaw, D. B., Huntsman, D. D., et al. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-0240 · Cited by 157 · see citing works
Self-citationMolecular Cloning and Characterization of Human Podocalyxin-like Protein
Kershaw, D. B., Beck, S. G., Wharram, B. L., Wiggins, J. E., Goyal, M., Thomas, P. E., & Wiggins, R. C. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.25.15708 · Cited by 147 · see citing works
Netrin signaling leading to directed growth cone steering
Round, J. E., & Stein, E. (2007) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2007.01.003 · Cited by 140 · see citing works
Senkov, O., Sun, M., Weinhold, B., Gerardy‐Schahn, R., Schachner, M., & Dityatev, A. E. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0878-06.2006 · Cited by 140 · see citing works
Podocalyxin activates RhoA and induces actin reorganization through NHERF1 and Ezrin in MDCK cells
Schmieder, S., Nagai, M., Orlando, R. A., Takeda, T., & Farquhar, M. G. (2004) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000135968.49899.e8 · Cited by 137 · see citing works
McNagny, K. M., Pettersson, I., Rossi, F. M. V., Flamme, I., Shevchenko, A., Mann, M., & Graf, T. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.138.6.1395 · Cited by 133 · see citing works
Self-citationTang, F., & Kalil, K. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0871-05.2005 · Cited by 127 · see citing works
Angata, K., Huckaby, V., Ranscht, B., Terskikh, A. V., Marth, J. D., & Fukuda, M. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00205-07 · Cited by 124 · see citing works
Hara, T., Nakano, Y.-K., Tanaka, M., Tamura, K., Sekiguchi, T., Minehata, K., Copeland, N. G., Jenkins, N. A., Okabe, M., Kogo, H., et al. (1999) · Immunity · doi:10.1016/s1074-7613(00)80132-6 · Cited by 112 · see citing works
Dekan, G., Gabel, C., & Farquhar, M. G. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.12.5398 · Cited by 96 · see citing works
Moscoso, L. M., Cremer, H., & Sanes, J. R. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-04-01465.1998 · Cited by 91 · see citing works
Kershaw, D. B., Thomas, P. E., Wharram, B. L., Goyal, M., Wiggins, J. E., Whiteside, C. I., & Wiggins, R. C. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.49.29439 · Cited by 88 · see citing works
Semaphorins in development and adult brain: Implication for neurological diseases
Mann, F., Chauvet, S., & Rougon, G. N. (2007) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2007.02.011 · Cited by 80 · see citing works
The Role of L1 in Axon Pathfinding and Fasciculation
Wiencken‐Barger, A. E. (2003) · Cerebral Cortex · doi:10.1093/cercor/bhg110 · Cited by 78 · see citing works
Podocalyxin in Rat Platelets and Megakaryocytes
Miettinen, A., Solin, M., Reivinen, J., Juvonen, E., Väisänen, R., & Holthöfer, H. (1999) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65328-x · Cited by 67 · see citing works
Takeda, T. (2003) · Clinical and Experimental Nephrology · doi:10.1007/s10157-003-0257-8 · Cited by 63 · see citing works
Development of the olivocerebellar system: migration and formation of cerebellar maps
Sotelo, C., & Chédotal, A. (2005) · Progress in brain research · doi:10.1016/s0079-6123(04)48001-7 · Cited by 50 · see citing works
Pathfinding Errors of Corticospinal Axons in Neural Cell Adhesion Molecule-Deficient Mice
Rolf, B., Bastmeyer, M., Schachner, M., & Bartsch, U. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-19-08357.2002 · Cited by 48 · see citing works
FASt remodeling of synapses in Drosophila
Packard, M. C., Mathew, D., & Budnik, V. (2003) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2003.09.008 · Cited by 41 · see citing works
Pattern of expression of the podocalyxin gene in the mouse brain during development
Vitureira, N., McNagny, K. M., Soriano, E., & Burgaya, F. (2004) · Gene Expression Patterns · doi:10.1016/j.modgep.2004.10.002 · Cited by 39 · see citing works
Self-citationSoriano, E., del Rı́o, J. A., Martinez-Guijarro, F. J., Ferrer, I., & López, C. (1991) · Journal of Histochemistry & Cytochemistry · doi:10.1177/39.11.1918930 · Cited by 14 · see citing works
Self-citationA collection of cDNAs enriched in upper cortical layers of the embryonic mouse brain
Garcı́a-Frigola, C., Burgaya, F., Calbet, M., López‐Doménech, G., de Lecea, L., & Soriano, E. (2004) · Molecular Brain Research · doi:10.1016/j.molbrainres.2003.12.014 · Cited by 10 · see citing works
Self-citationProduction and characterization of murine monoclonal antibodies against human podocalyxin
Rodrı́guez, R. B., Butta, N. V., Larrucea, S., Alonso‐Martín, S., & Parrilla, R. (2006) · Tissue Antigens · doi:10.1111/j.1399-0039.2006.00692.x · Cited by 9 · see citing works
Removal of PSA causes aberrant mossy fiber innervation and ectopic synaptogenesis in the hippocampus
Seki, T., Rutishauser, U. S., & Arai, Y. (1998) · Neuroscience Research · doi:10.1016/s0168-0102(98)82250-5 · Cited by 3 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [20]Kershaw D Thomas P Wharram M Goyal J Wiggins C 1995 Molecular cloning, expression and characterization of podocalyxin-like protein 1 from rabbit as a transmembrane preotein of glomerular podocytes and vascular endothelium. J Biol Chem 270 29439 29446 7493982
Cited by
Sorted by citations
Varki, A. (2017) · Glycobiology · doi:10.1093/glycob/cww086 · Cited by 2,635 · see citing works
“The "plasticity" resulting from polysialic acid expression appears to be important for neuronal migration as well as reorganization following injury (546) (547) (548) (549) (550) (551) (552) (553) (554) .”
BackgroundFreedman, B., Brooks, C. R., Lam, A. Q., Fu, H., Morizane, R., Agrawal, V., Saad, A. F., Li, M. K., Hughes, M. R., Werff, R. V., et al. (2015) · Nature Communications · doi:10.1038/ncomms9715 · Cited by 785 · see citing works
Self-citationNievergelt, C. M., Maihofer, A. X., Klengel, T., Atkinson, E. G., Chen, C.-Y., Choi, K. W., Coleman, J. R. I., Dalvie, S., Duncan, L. E., Gelernter, J., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-12576-w · Cited by 635 · see citing works
Keratan sulfate, a complex glycosaminoglycan with unique functional capability
Caterson, B., & Melrose, J. (2018) · Glycobiology · doi:10.1093/glycob/cwy003 · Cited by 256 · see citing works
Notaras, M., Lodhi, A., Dündar, F., Collier, P., Sayles, N. M., Tilgner, H., Greening, D., & Colak, D. (2022) · Molecular Psychiatry · doi:10.1038/s41380-021-01316-6 · Cited by 150 · see citing works
Hogan, M. C., Johnson, K. L., Zenka, R. M., Charlesworth, M. C., Madden, B. J., Mahoney, D. W., Oberg, A. L., Huang, B. Q., Leontovich, A. A., Nesbitt, L. L., et al. (2013) · Kidney International · doi:10.1038/ki.2013.422 · Cited by 114 · see citing works
Juvenile parkinsonism: Differential diagnosis, genetics, and treatment
Niemann, N., & Jankovic, J. J. (2019) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2019.06.025 · Cited by 112 · see citing works
López‐Doménech, G., Serrat, R., Mirra, S., D’Aniello, S., Somorjai, I., Abad, A., Vitureira, N., García‐Arumí, E., Alonso, M. T., Rodríguez-Prados, M., et al. (2012) · Nature Communications · doi:10.1038/ncomms1829 · Cited by 106 · see citing works
Self-citationVaquero, J., Ho-Bouldoires, T. H. N., Clapéron, A., & Fouassier, L. (2017) · Oncogene · doi:10.1038/onc.2016.462 · Cited by 101 · see citing works
Why Is N-Glycolylneuraminic Acid Rare in the Vertebrate Brain?
Davies, L. R. L., & Varki, A. (2013) · Topics in Current Chemistry · doi:10.1007/128_2013_419 · Cited by 80 · see citing works
Nácher, J., Guirado, R., & Castillo-Gómez, E. (2013) · Neurochemical Research · doi:10.1007/s11064-013-0977-4 · Cited by 75 · see citing works
Amo, L., Tamayo-Orbegozo, E., Maruri, N., Eguizábal, C., Zenarruzabeitia, O., n, M. R., Arrieta, A., Santos, S. D. M., Monge, J., Vesga, M. Á., et al. (2014) · Frontiers in Oncology · doi:10.3389/fonc.2014.00245 · Cited by 73 · see citing works
Zhang, J., Zhu, Z., Wu, H., Yu, Z., Rong, Z., Luo, Z., Xu, Y., Huang, K., Qiu, Z., & Huang, C. (2018) · Gastric Cancer · doi:10.1007/s10120-018-0833-y · Cited by 71 · see citing works
Melrose, J. (2018) · Journal of Neurochemistry · doi:10.1111/jnc.14652 · Cited by 71 · see citing works
A familiar stranger: CD34 expression and putative functions in SVF cells of adipose tissue
Scherberich, A. (2013) · World Journal of Stem Cells · doi:10.4252/wjsc.v5.i1.1 · Cited by 68 · see citing works
Podocalyxin in Normal Tissue and Epithelial Cancer
Tran, N. L., Wang, Y., & Nie, G. (2021) · Cancers · doi:10.3390/cancers13122863 · Cited by 61 · see citing works
BDNF repairs podocyte damage by microRNA ‐mediated increase of actin polymerization
Li, M., Armelloni, S., Zennaro, C., Wei, C., Corbelli, A., Ikehata, M., Berra, S., Giardino, L., Mattinzoli, D., Watanabe, S., et al. (2014) · The Journal of Pathology · doi:10.1002/path.4484 · Cited by 59 · see citing works
The Dendritic Spines of Interneurons Are Dynamic Structures Influenced by PSA-NCAM Expression
Guirado, R., Pérez-Rando, M., Sanchez-Matarredona, D., Castillo-Gómez, E., Liberia, T., Rovira-Esteban, L., Varea, E., Crespo, C., Blasco‐Ibáñez, J. M., & Nácher, J. (2013) · Cerebral Cortex · doi:10.1093/cercor/bht156 · Cited by 58 · see citing works
Notaras, M. J., Lodhi, A., Fang, H., Greening, D. W., & Colak, D. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01664-5 · Cited by 52 · see citing works
Binder, Z. A., Siu, I., Eberhart, C. G., Rhys, C. M. J. A., Bai, R.-Y., Staedtke, V., Zhang, H., Smoll, N. R., Piantadosi, S., Piccirillo, S. G. M., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0075945 · Cited by 43 · see citing works
Horrillo, A., Porras, G., Ayuso, M. S., & González‐Manchón, C. (2016) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2016.04.006 · Cited by 42 · see citing works
Sudhaman, S., Prasad, K., Behari, M., Muthane, U. B., Juyal, R. C., & Thelma, B. K. (2016) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2015-103459 · Cited by 41 · see citing works
Zhai, L., Gu, J., Yang, D., Hu, W., Wang, W., & Ye, S. (2016) · Journal of Diabetes · doi:10.1111/1753-0407.12437 · Cited by 41 · see citing works
Li, M., Armelloni, S., Ikehata, M., Corbelli, A., Pesaresi, M., Calvaresi, N., Giardino, L., Mattinzoli, D., Nisticò, F., Andreoni, S., et al. (2011) · The Journal of Pathology · doi:10.1002/path.2923 · Cited by 37 · see citing works
Zhai, L., Gu, J., Yang, D., Wang, W., & Ye, S. (2015) · Journal of Diabetes Research · doi:10.1155/2015/231825 · Cited by 33 · see citing works
Podocalyxin Regulates Murine Lung Vascular Permeability by Altering Endothelial Cell Adhesion
DeBruin, E., Hughes, M. R., Sina, C., Liu, A., Cait, J., Jian, Z., Lopez, M., Lo, B. C., Abraham, T., & McNagny, K. M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0108881 · Cited by 32 · see citing works
Self-citationKaufman, M. L., Park, K. U., Goodson, N., Chew, S., Bersie, S. M., Jones, K. L., Lamba, D. A., & Brzezinski, J. A. (2019) · Developmental Biology · doi:10.1016/j.ydbio.2019.05.016 · Cited by 32 · see citing works
Loss of podocalyxin causes a novel syndromic type of congenital nephrotic syndrome
Kang, H. G., Lee, M., Lee, K. B., Hughes, M. R., Kwon, B. S., Lee, S., McNagny, K. M., Ahn, Y. H., Ko, J. M., Ha, I. S., et al. (2017) · Experimental & Molecular Medicine · doi:10.1038/emm.2017.227 · Cited by 31 · see citing works
Self-citationTownshend, R. F., Shao, Y., Wang, S., Cortez, C. L., Esfahani, S. N., Spence, J. R., O’Shea, K. S., Fu, J., Gumucio, D. L., & Taniguchi, K. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.588941 · Cited by 30 · see citing works
Borg, D., Hedner, C., Nodin, B., Larsson, A. H., Johnsson, A., Eberhard, J., & Jirström, K. (2016) · BMC Clinical Pathology · doi:10.1186/s12907-016-0034-8 · Cited by 29 · see citing works
Özkan, S., Işıldar, B., Erçin, M., Gezginci-Oktayoğlu, S., Konukoğlu, D., Neşetoğlu, N., Öncül, M., & Koyutürk, M. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-03121-6 · Cited by 29 · see citing works
Fang, J., Wei, H., Yanyan, S., Zhang, X., Liu, W., Qintao, C., Wang, R., & Gong, Y. (2013) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-13-76 · Cited by 23 · see citing works
He, S., Du, W., Li, M., Yan, M., & Zheng, F. (2020) · BMC Cancer · doi:10.1186/s12885-020-07108-5 · Cited by 23 · see citing works
Brain-derived neurotrophic factor (BDNF): a multifaceted marker in chronic kidney disease
Afşar, B., & Afşar, R. E. (2022) · Clinical and Experimental Nephrology · doi:10.1007/s10157-022-02268-z · Cited by 22 · see citing works
Zhi, Q., Chen, H., Liu, F., Han, Y., Wan, D., Xu, Z., Kuang, Y., & Zhou, J. (2018) · Cancer Science · doi:10.1111/cas.13864 · Cited by 21 · see citing works
Fukasawa, H., Obayashi, H., Schmieder, S., Lee, J., Ghosh, P., & Farquhar, M. G. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.07.046 · Cited by 21 · see citing works
Podocalyxin-like protein 1 functions as an immunomodulatory molecule in breast cancer cells
Amo, L., Tamayo-Orbegozo, E., Maruri, N., Buqué, A., Solaun, M., Riñón, M., Arrieta, A., & Larrucea, S. (2015) · Cancer Letters · doi:10.1016/j.canlet.2015.06.029 · Cited by 21 · see citing works
Nievergelt, C. M., Maihofer, A. X., Klengel, T., Atkinson, E. G., Chen, C., Choi, K. W., Coleman, J. R. I., Dalvie, S., Duncan, L. E., Logue, M. W., et al. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/458562 · Cited by 24 · see citing works
Renal cell markers: lighthouses for managing renal diseases
Agarwal, S., Sudhini, Y. R., Polat, O. K., Reiser, J., & Altintas, M. M. (2021) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00182.2021 · Cited by 20 · see citing works
Podocyturia: why it may have added value in rare diseases
Sánchez-Niño, M. D., Pérez-Gómez, M. V., Rivas, L. V., Torrá, R., & Ortíz, A. (2018) · Clinical Kidney Journal · doi:10.1093/ckj/sfy081 · Cited by 19 · see citing works
Shoji, M., Takemoto, M., Kobayashi, K., Shoji, T., Mori, S., Sagara, J.-I., Kurosawa, H., Hirayama, Y., Sakamoto, K., Ishikawa, T., et al. (2018) · Scientific Reports · doi:10.1038/s41598-017-18647-6 · Cited by 19 · see citing works
Keratan Sulphate in the Tumour Environment
Hayes, A. J., & Melrose, J. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-40146-7_2 · Cited by 17 · see citing works
Podocyturia as an early diagnostic marker of preeclampsia: a literature review
Panek–Laszczyńska, K., Konieczny, A., Milewska, E., Dąbrowska, K., Bąchor, R., Witkiewicz, W., & Szewczuk, Z. (2017) · Biomarkers · doi:10.1080/1354750x.2017.1405283 · Cited by 16 · see citing works
Melrose, J. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26062554 · Cited by 15 · see citing works
Palma‐Gudiel, H., Yu, L., Huo, Z., Yang, J., Wang, Y., Gu, T., Gao, C., Jager, P. L. D., Jin, P., Bennett, D. A., et al. (2022) · Alzheimer s & Dementia · doi:10.1002/alz.12761 · Cited by 13 · see citing works
Melrose, J. (2024) · Journal of Neuroscience Research · doi:10.1002/jnr.25361 · Cited by 15 · see citing works
Podocalyxin in the Diagnosis and Treatment of Cancer
Kelly, M., Michael, R., Marcia, L., Erin, J., Snyder, K., Cipollone, J., Turvey, M. E., Poh, C., McColl, S. R., & Calvin, D. B. W. L. (2012) · InTech eBooks · doi:10.5772/24274 · Cited by 14 · see citing works
El‐Ashmawy, H. M., Selim, F. O., Hosny, T., & Almassry, H. N. (2019) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2019.04.003 · Cited by 14 · see citing works
Protective effect of pioglitazone on kidney injury in diabetic rats
Peng, X., Liang, P., Ou, S.-J., & Zu, X. (2014) · Asian Pacific Journal of Tropical Medicine · doi:10.1016/s1995-7645(14)60143-7 · Cited by 12 · see citing works
Endoglycan plays a role in axon guidance by modulating cell adhesion
Baeriswyl, T., Dumoulin, A., Schaettin, M., Tsapara, G., Niederkofler, V., Helbling, D., Avilés, E. C., Frei, J. A., Wilson, N. H., Gesemann, M., et al. (2021) · eLife · doi:10.7554/elife.64767 · Cited by 12 · see citing works
Paredes, C. C., Herrero-Turrión, M. J., & Merchán, M. Á. (2012) · Frontiers in Neural Circuits · doi:10.3389/fncir.2012.00086 · Cited by 12 · see citing works
Zhang, Z., Li, X., Liu, L., Sun, J., Wang, X., Zhao, Z., & Yang, Y. (2018) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2018/1913691 · Cited by 9 · see citing works
Huan, Y., Wei, J., Su, T., & Gao, Y. (2021) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2021.114064 · Cited by 9 · see citing works
Borg, D., Larsson, A. H., Hedner, C., Nodin, B., Johnsson, A., & Jirström, K. (2018) · Journal of Translational Medicine · doi:10.1186/s12967-018-1668-3 · Cited by 8 · see citing works
Keratan sulfate, an electrosensory neurosentient bioresponsive cell instructive glycosaminoglycan
Melrose, J. (2024) · Glycobiology · doi:10.1093/glycob/cwae014 · Cited by 7 · see citing works
Hsia, H., Tüshaus, J., Feng, X. M., Hofmann, L. I., Wefers, B., Marciano, D. K., Wurst, W., & Lichtenthaler, S. F. (2021) · The FASEB Journal · doi:10.1096/fj.202100475r · Cited by 7 · see citing works
Stoops, E. H., Hull, M. J., & Caplan, M. J. (2016) · Traffic · doi:10.1111/tra.12449 · Cited by 6 · see citing works
Yuan, D., Chen, H., Wang, S., Liu, F., Cheng, Y., & Jin, F. (2018) · Cancer Medicine · doi:10.1002/cam4.1765 · Cited by 6 · see citing works
Ramdin, S., Naicker, T., Baijnath, S., & Govender, N. (2023) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2023.03.012 · Cited by 6 · see citing works
Fan, X., Li, J., Gao, Y., Li, L., Zhang, H., & Bi, Z. (2025) · Molecular Medicine · doi:10.1186/s10020-025-01067-y · Cited by 5 · see citing works
Melrose, J. (2025) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00268.2025 · Cited by 5 · see citing works
Protein associations and protein–metabolite interactions with depressive symptoms and the p-factor
Whipp, A. M., Drouard, G., Rose, R. J., Pulkkinen, L., & Kaprio, J. A. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03362-y · Cited by 5 · see citing works
Podocytes: A new player for glutamate signaling
Armelloni, S., Li, M., Messa, P., & Rastaldi, M. P. (2012) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2012.09.014 · Cited by 5 · see citing works
The embryonic node functions as an instructive stem cell nichePreprint
Solovieva, T., Lu, H., Moverley, A. A., Plachta, N., & Stern, C. D. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.11.10.376913 · Cited by 5 · see citing works
Keratan Sulfate Is a Multifunctional Brain Glycosaminoglycan With Instructive Capabilities
Melrose, J. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70208 · Cited by 4 · see citing works
Amo, L., Díez‐García, J., Tamayo-Orbegozo, E., Maruri, N., & Larrucea, S. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.835527 · Cited by 4 · see citing works
CTCF-RNA interactions orchestrate cell-specific chromatin loop organization
Lucero, K., Han, S., Huang, P., Qiu, X., Mazzoni, E. O., & Reinberg, D. (2025) · Science Advances · doi:10.1126/sciadv.ady5507 · Cited by 6 · see citing works
Language Impairment Resulting from a de novo Deletion of 7q32.1q33
Jiménez-Romero, M. S., Barcos, M., Espejo-Portero, I., & Benítez‐Burraco, A. (2016) · Molecular Syndromology · doi:10.1159/000448208 · Cited by 3 · see citing works
Cairus, A., Brizolara, F., Kunizawa, H., Clouzet, V., Gonzalez, G., Alsina‐Llanes, M., Dellepiane, L., Fernández, S., García‐Carnelli, C., Umpiérrez, E., et al. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70153 · Cited by 2 · see citing works
Self-citationMelrose, J. (2026) · Journal of Neuroscience Research · doi:10.1002/jnr.70149 · Cited by 2 · see citing works
The role of serum podocalyxin levels in recurrent pregnancy loss
Yorgancı, A., Öztürk, F. H., Hançerlioğulları, N., Çandar, T., Çağlar, A. T., & Ozgu-Erdinc, A. S. (2021) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2021.03.021 · Cited by 2 · see citing works
An Update on the Psychiatric Genomics of Posttraumatic Stress Disorder (PTSD)
Norrholm, S. D. (2025) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2025.01.013 · Cited by 3 · see citing works
Okita, K., Tan, E., Satone, H., Kinoshita, S., Asakawa, S., Ojima, D., Yamazaki, H., Sakiyama, K., Takatani, T., Arakawa, O., et al. (2017) · Fisheries Science · doi:10.1007/s12562-017-1079-z · Cited by 2 · see citing works
Koike, T., Sato, T., Oe, S., Hayashi, S., Seki, R., Nakano, Y., Iwashita, H., Sato, Y., Hirahara, Y., & Kitada, M. (2024) · Brain Research · doi:10.1016/j.brainres.2024.149227 · Cited by 1 · see citing works
El ácido siálico, coraza de los seres vivos
Aguirre-Zapata, C., Pérez-Cervera, Y., & Salinas-Marín, R. (2023) · Revista Ciencia UANL · doi:10.29105/cienciauanl26.119-3 · Cited by 1 · see citing works
Serum Podocalyxin Levels as High Risk Markers for CVDs of Complication of Diabetes
Al-fatlawiy, H. D. A., & Ali, H. A. (2021) · Medico-Legal Update · doi:10.37506/mlu.v21i2.2900 · Cited by 1 · see citing works
DeBruin, E. (2013) · cIRcle (University of British Columbia) · doi:10.14288/1.0073108
Language impairment resulting from a de novo deletion of 7q32.1-q33: a case reportPreprint
Jiménez-Romero, M. S., Barcos, M., Espejo-Portero, I., & Benítez‐Burraco, A. (2016) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/047241
Serum podocalyxin levels in patients with obesity and carbohydrates disorders
Nedeva, I., Karamfilova, V., Vodenicharov, V., Gerganova, A., Velikova, T. V., & Assyov, Y. S. (2024) · Pharmacia · doi:10.3897/pharmacia.71.e132254
Jiang, K., Zhang, C., Shen, C., Fang, X., Huang, H., & Zheng, B. (2025) · Frontiers in Nephrology · doi:10.3389/fneph.2025.1576349
He, S., Du, W., Li, M., Yan, M., & Zheng, F. (2020) · Figshare · doi:10.6084/m9.figshare.12607345
Ozkan, S., Işıldar, B., Erçin, M., Gezginci-Oktayoğlu, S., Konukoglu, D., Neşetoğlu, N., Öncül, M., & Koyutürk, M. (2022) · Figshare · doi:10.6084/m9.figshare.20882210
Salamanca, A. F. D. (2025) · Revista de la Facultad de Ciencias de la Salud Universidad del Cauca · doi:10.47373/rfcs.2025.v27.2613
Clouzet, V., Rafael, A., Cairus, A., Gonzalez, G., Martínez, M., Prieto, J. P., & Vitureira, N. (2026) · Neurotoxicity Research · doi:10.1007/s12640-026-00817-y
Self-citationPODXL regulates the neuronal entry of α-synuclein aggregatesPreprint
Neupane, S., Šustić, L., Maraio, L., Bouris, V., Mariutti, G., Ribeiro, R., Yin, J.-A., Melki, R., Legname, G., Cecco, E. D., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.10.15.759470
Identification of Podocalyxin as a Candidate Gene in Focal Segmental Glomerulosclerosis
Shieh, E. (2015) · Digital Access to Scholarship at Harvard (DASH) (Harvard University)
- Authors
- Vitureira, N., Andrés, R., Pérez-Martínez, E., Martínez, A., Bribián, A., Blasi, J., Chelliah, S., López-Doménech, G., De Castro, F., Burgaya, F., McNagny, K., & Soriano, E.
- Affiliations
- Biomedical Research Networking Center on Neurodegenerative Diseases (ES)
- Institut d'Investigació Biomédica de Bellvitge (ES)
- University of British Columbia (CA)
- Corresponding author
- Soriano, Eduardo
- ORCID
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2010-08-10
- Volume
- 5
- Issue
- 8
- Pages
- e12003
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC2919383
- OpenAlex
- W2090048264
- Cited by
- 87
- References
- 64
- Citations by year
- 2026: 3 · 2025: 10 · 2024: 4 · 2023: 2 · 2022: 5 · 2021: 9 · 2020: 5 · 2019: 4 · 2018: 10 · 2017: 4 · 2016: 9 · 2015: 4 · 2014: 4 · 2013: 8 · 2012: 4
- FWCI
- 1.81
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (publishedVersion, cc-by)
- RECERCAT (Consorci de Serveis Universitaris de Catalunya) (publishedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- UCL Discovery (University College London) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- Funders
- Heart and Stroke Foundation of Canada
- “la Caixa” Foundation
- Michael Smith Health Research BC
- Canadian Institutes of Health Research
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Keywords
- podocalyxin, neural development, synaptogenesis, neurite outgrowth, axonal fasciculation, ERM proteins, RhoA, RhoG, neuromuscular synapse, sialylation, CD56
- MeSH terms
- Ezrin, Animals, Brain, Cytoskeletal Proteins, Female, Phosphoproteins, Pregnancy, Sialic Acids, Sialoglycoproteins, Synapses, Neurites, Sodium-Hydrogen Exchangers, Gene Expression Regulation, Developmental, Neural Cell Adhesion Molecules, GTP Phosphohydrolases, rho GTP-Binding Proteins, rhoA GTP-Binding Protein, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review