Cited by 87Axon Guidance and Neuronal SignalingNeurogenesis and neuroplasticity mechanismsCell Adhesion Molecules Research

Podocalyxin Is a Novel Polysialylated Neural Adhesion Protein with Multiple Roles in Neural Development and Synapse Formation

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Vitureira, Nathalia, Andrés, Rosa, Pérez-Martínez, Esther, Martínez, Albert, Bribián, Ana, Blasi, Juan, Chelliah, Shierley, López-Doménech, Guillermo +4 more·2010·PLoS ONE

Abstract

Neural development and plasticity are regulated by neural adhesion proteins, including the polysialylated form of NCAM (PSA-NCAM). Podocalyxin (PC) is a renal PSA-containing protein that has been reported to function as an anti-adhesin in kidney podocytes. Here we show that PC is widely expressed in neurons during neural development. Neural PC interacts with the ERM protein family, and with NHERF1/2 and RhoA/G. Experiments in vitro and phenotypic analyses of podxl-deficient mice indicate that PC is involved in neurite growth, branching and axonal fasciculation, and that PC loss-of-function reduces the number of synapses in the CNS and in the neuromuscular system. We also show that whereas some of the brain PC functions require PSA, others depend on PC per se. Our results show that PC, the second highly sialylated neural adhesion protein, plays multiple roles in neural development.

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Crossref · 10.1371/journal.pone.0012003

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  • The plasticity resulting from polysialic acid expression appears to be important for neuronal migration and for reorganization following injury.

    “The ' plasticity ' resulting from polysialic acid expression appears to be important for neuronal migration as well as reorganization following injury (546 -554).”

    From Biological roles of glycans (2017) · cites this paper as [551]

    The Discussion (page not specified) says that removing polysialic acid disrupts tangential neuronal migration, supporting the migration part of the claim. It does not address reorganization following injury, so that part is unsupported by our copy. (LLM, conf=0.86)

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Research works printed but not linked: 1

  1. [20]Kershaw D Thomas P Wharram M Goyal J Wiggins C 1995 Molecular cloning, expression and characterization of podocalyxin-like protein 1 from rabbit as a transmembrane preotein of glomerular podocytes and vascular endothelium. J Biol Chem 270 29439 29446 7493982

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Authors
Vitureira, N., Andrés, R., Pérez-Martínez, E., Martínez, A., Bribián, A., Blasi, J., Chelliah, S., López-Doménech, G., De Castro, F., Burgaya, F., McNagny, K., & Soriano, E.
Affiliations
  • Biomedical Research Networking Center on Neurodegenerative Diseases (ES)
  • Institut d'Investigació Biomédica de Bellvitge (ES)
  • University of British Columbia (CA)
Corresponding author
Soriano, Eduardo
Venue
PLoS ONE
Published
2010-08-10
Volume
5
Issue
8
Pages
e12003
ISSN
1932-6203 (ISSN-L)
OpenAlex
W2090048264
Cited by
87
References
64
Citations by year
2026: 3 · 2025: 10 · 2024: 4 · 2023: 2 · 2022: 5 · 2021: 9 · 2020: 5 · 2019: 4 · 2018: 10 · 2017: 4 · 2016: 9 · 2015: 4 · 2014: 4 · 2013: 8 · 2012: 4
FWCI
1.81
Type
journal article
Language
en
Open access
Locations
  • PLoS ONE (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (publishedVersion, cc-by)
  • RECERCAT (Consorci de Serveis Universitaris de Catalunya) (publishedVersion, other-oa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • UCL Discovery (University College London) (submittedVersion)
  • Figshare (submittedVersion, cc-by)
Funders
  • Heart and Stroke Foundation of Canada
  • “la Caixa” Foundation
  • Michael Smith Health Research BC
  • Canadian Institutes of Health Research
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
Keywords
podocalyxin, neural development, synaptogenesis, neurite outgrowth, axonal fasciculation, ERM proteins, RhoA, RhoG, neuromuscular synapse, sialylation, CD56
MeSH terms
Ezrin, Animals, Brain, Cytoskeletal Proteins, Female, Phosphoproteins, Pregnancy, Sialic Acids, Sialoglycoproteins, Synapses, Neurites, Sodium-Hydrogen Exchangers, Gene Expression Regulation, Developmental, Neural Cell Adhesion Molecules, GTP Phosphohydrolases, rho GTP-Binding Proteins, rhoA GTP-Binding Protein, Mice

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