Gene expression study of monocytes/macrophages during early foreign body reaction and identification of potential precursors of myofibroblasts
Open accessAbstract
Foreign body reaction (FBR), initiated by adherence of macrophages to biomaterials, is associated with several complications. Searching for mechanisms potentially useful to overcome these complications, we have established the signaling role of monocytes/macrophages in the development of FBR and the presence of CD34(+) cells that potentially differentiate into myofibroblasts. Therefore, CD68(+) cells were in vitro activated with fibrinogen and also purified from the FBR after 3 days of implantation in rats. Gene expression profiles showed a switch from monocytes and macrophages attracted by fibrinogen to activated macrophages and eventually wound-healing macrophages. The immature FBR also contained a subpopulation of CD34(+) cells, which could be differentiated into myofibroblasts. This study showed that macrophages are the clear driving force of FBR, dependent on milieu, and myofibroblast deposition and differentiation.
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Macrophages release pro-inflammatory actors such as TNFα, IL-1b, IL-6, and IL-8.
“These macrophages also mediate the core of the inflammatory response, releasing pro-inflammatory actors such as TNFα (tumor necrosis factor α), and interleukins IL-1b, IL-6, and IL-8 (Jones et al., 2007; Mesure et al., 2010).”
From Foreign Body Reaction to Implanted Biomaterials and Its Impact in Nerve Neuroprosthetics (2021) · cites this paper as Mesure et al., 2010
The Results section (“FBR gene response”; page not provided) reports that foreign-body-reaction macrophages show increased expression of TNFα, IL-1β, and IL-6 and signal through these factors. The Discussion links this response to cytokine release, but our copy does not identify IL-8 among the factors, and the study’s gene-expression findings do not directly establish release of every listed cytokine. (LLM, conf=0.88)
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- Authors
- Mesure, L., De Visscher, G., Vranken, I., Lebacq, A., & Flameng, W.
- Affiliations
- KU Leuven (BE)
- ORCID
- Vranken, Ilse
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2010-09-23
- Volume
- 5
- Issue
- 9
- Pages
- e12949
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC2944875
- OpenAlex
- W1974581595
- Cited by
- 40
- References
- 38
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 3 · 2023: 3 · 2022: 5 · 2021: 2 · 2020: 4 · 2019: 2 · 2018: 3 · 2017: 2 · 2016: 3 · 2015: 3 · 2014: 3 · 2012: 1
- FWCI
- 1.00
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Funders
- Vlaamse regering
- Topics
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Health Sciences › Medicine › Surgery › Orthopaedic implants and arthroplasty
- Keywords
- foreign body reaction, macrophages, monocytes, myofibroblasts, CD34+ cells, fibrinogen, gene expression profiling, biomaterial implantation, macrophage activation, CD68, cell differentiation
- MeSH terms
- Animals, Cell Differentiation, Cells, Cultured, Disease Models, Animal, Fibrinogen, Foreign-Body Reaction, Humans, Macrophages, Male, Monocytes, Gene Expression, Rats, Wistar, Gene Expression Profiling, Rats, Myofibroblasts
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