Neurons in the Amygdala with Response-Selectivity for Anxiety in Two Ethologically Based Tests
Open accessAbstract
The amygdala is a key area in the brain for detecting potential threats or dangers, and further mediating anxiety. However, the neuronal mechanisms of anxiety in the amygdala have not been well characterized. Here we report that in freely-behaving mice, a group of neurons in the basolateral amygdala (BLA) fires tonically under anxiety conditions in both open-field and elevated plus-maze tests. The firing patterns of these neurons displayed a characteristic slow onset and progressively increased firing rates. Specifically, these firing patterns were correlated to a gradual development of anxiety-like behaviors in the open-field test. Moreover, these neurons could be activated by any impoverished environment similar to an open-field; and introduction of both comfortable and uncomfortable stimuli temporarily suppressed the activity of these BLA neurons. Importantly, the excitability of these BLA neurons correlated well with levels of anxiety. These results demonstrate that this type of BLA neuron is likely to represent anxiety and/or emotional values of anxiety elicited by anxiogenic environmental stressors.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Tonic activity in a subset of BLA neurons tracks with anxiety-like behavior in the EPM and OFT.
“For instance, tonic activity in a subset of BLA neurons has been shown to track with anxiety-like behavior in the EPM and OFT79.”
From Resolving the neural circuits of anxiety (2015) · cites this paper as [79]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
LeDoux, J. E. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.155 · Cited by 8,444 · see citing works
Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat
Pellow, S., Chopin, P., File, S. E., & Briley, M. (1985) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(85)90031-7 · Cited by 5,822 · see citing works
The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review.
Prut, L., & Belzung, C. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01272-x · Cited by 3,190 · see citing works
The open-field test: A critical review.
WALSH, R. N., & Cummins, R. A. (1976) · Psychological Bulletin · doi:10.1037/0033-2909.83.3.482 · Cited by 2,389 · see citing works
The Emotional Brain, Fear, and the Amygdala
LeDoux, J. (2003) · Cellular and Molecular Neurobiology · doi:10.1023/a:1025048802629 · Cited by 1,818 · see citing works
Tests for emotionality in rats and mice: A review
Archer, J. (1973) · Animal Behaviour · doi:10.1016/s0003-3472(73)80065-x · Cited by 1,577 · see citing works
Neuronal signalling of fear memory
Maren, S., & Quirk, G. J. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1535 · Cited by 1,428 · see citing works
Hall, C. S. (1934) · Journal of comparative psychology · doi:10.1037/h0071444 · Cited by 1,365 · see citing works
Ethological and temporal analyses of anxiety-like behavior: The elevated plus-maze model 20 years on
Carobrez, A. P., & Bertoglio, L. J. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.04.017 · Cited by 993 · see citing works
Measuring normal and pathological anxiety-like behaviour in mice: a review
Belzung, C., & Griebel, G. (2001) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00291-1 · Cited by 912 · see citing works
Ethologically-based animal models of anxiety disorders.
Lister, R. (1990) · Pharmacology and Therapeutics · doi:10.1016/0163-7258(90)90021-s · Cited by 894 · see citing works
Role of the bed nucleus of the stria terminalis versus the amygdala in fear, stress, and anxiety
Walker, D. L., Toufexis, D. J., & Davis, M. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01282-2 · Cited by 838 · see citing works
Neurotransmission in the rat amygdala related to fear and anxiety
Davis, M., Rainnie, D., & Cassell, M. (1994) · Trends in Neurosciences · doi:10.1016/0166-2236(94)90106-6 · Cited by 771 · see citing works
Thigmotaxis as a test for anxiolytic activity in rats
Treit, D., & Fundytus, M. E. (1988) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(88)90413-3 · Cited by 681 · see citing works
Etkin, A., Klemenhagen, K. C., Dudman, J. T., Rogan, M. T., Hen, R., Kandel, E. R., & Joy Hirsch, C. (2004) · Neuron · doi:10.1016/j.neuron.2004.12.006 · Cited by 679 · see citing works
Are different parts of the extended amygdala involved in fear versus anxiety?
Davis, M. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00288-1 · Cited by 545 · see citing works
A multiple-test study of anxiety-related behaviours in six inbred rat strains
Ramos, A., Berton, O., Mormède, P., & Chaouloff, F. (1997) · Behavioural Brain Research · doi:10.1016/s0166-4328(96)00164-7 · Cited by 493 · see citing works
Neuroimaging studies of amygdala function in anxiety disorders
RAUCH, S. L., SHIN, L. M., & WRIGHT, C. I. (2003) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2003.tb07096.x · Cited by 463 · see citing works
Animal models of ‘anxiety’: Where next?
Rodgers, R. J. (1997) · Behavioural Pharmacology · doi:10.1097/00008877-199711000-00003 · Cited by 437 · cited 2× · see citing works
“, thigmotaxis, defecation) that are commonly used to estimate anxiety [14], [16].”
BackgroundThe Role of the Central Nucleus of the Amygdala in Mediating Fear and Anxiety in the Primate
Kalin, N. H., Shelton, S. E., & Davidson, R. J. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.0292-04.2004 · Cited by 406 · see citing works
Nishijo, H., Ono, T., & Nishino, H. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-10-03570.1988 · Cited by 333 · see citing works
Regulation of anxiety by GABAA receptors in the rat amygdala
Sanders, S., & Shekhar, A. (1995) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(95)00153-n · Cited by 319 · see citing works
Induction of Fos immunoreactivity in the brain by exposure to the elevated plus-maze
Silveira, M. C. L., Sandner, G., & Graeff, F. G. (1993) · Behavioural Brain Research · doi:10.1016/0166-4328(93)90028-o · Cited by 231 · see citing works
Boyce‐Rustay, J. M., & Holmes, A. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301039 · Cited by 209 · see citing works
Adamec, R. E., Burton, P., Shallow, T., & Budgell, J. (1998) · Physiology & Behavior · doi:10.1016/s0031-9384(98)00226-1 · Cited by 171 · see citing works
Ohl, F. (2005) · Handbook of experimental pharmacology · doi:10.1007/3-540-28082-0_2 · Cited by 164 · see citing works
Clément, Y. (1998) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(97)00058-4 · Cited by 155 · see citing works
Wilson, F. A. W., & Rolls, E. T. (1993) · Experimental Brain Research · doi:10.1007/bf00229353 · Cited by 144 · see citing works
Music Versus Distraction for Procedural Pain and Anxiety in Patients With Cancer
Kwekkeboom, K. L. (2003) · Oncology nursing forum · doi:10.1188/03.onf.433-440 · Cited by 129 · see citing works
Johnstone, K. A., & Page, A. C. (2003) · Behaviour Research and Therapy · doi:10.1016/s0005-7967(03)00137-2 · Cited by 114 · see citing works
Large-scale neural ensemble recording in the brains of freely behaving mice
Lin, L., Chen, G., Xie, K., Zaia, K. A., Zhang, S., & Tsien, J. Z. (2006) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2005.12.032 · Cited by 108 · see citing works
Self-citationSajdyk, T. J., & Shekhar, A. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00594-5 · Cited by 107 · see citing works
Truitt, W. A., Johnson, P. L., Dietrich, A. D., Fitz, S. D., & Shekhar, A. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.01.083 · Cited by 98 · see citing works
Hale, M. W., Bouwknecht, J. A., Spiga, F., Shekhar, A., & Lowry, C. A. (2006) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2006.09.001 · Cited by 84 · see citing works
Wu, L., Ko, S. W., Toyoda, H., Zhao, M., Xu, H., Vadakkan, K. I., Ren, M., Knifed, E., Shum, F. W. F., Quan, J., et al. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000167 · Cited by 82 · see citing works
Mitra, R., Ferguson, D., & Sapolsky, R. M. (2009) · Molecular Psychiatry · doi:10.1038/mp.2009.9 · Cited by 70 · see citing works
Recent Advances in the Understanding and Treatment of Anxiety Disorders
Shearer, S. L. (2007) · Primary Care Clinics in Office Practice · doi:10.1016/j.pop.2007.05.002 · Cited by 53 · see citing works
Wunderlich, G. R., Raymond, R., DeSousa, N. J., Nobrega, J. X. E., & Vaccarino, F. J. (2002) · Psychopharmacology · doi:10.1007/s00213-002-1181-4 · Cited by 37 · see citing works
Stephens, D. N. (1997) · Behavioural Pharmacology · doi:10.1097/00008877-199711000-00004 · Cited by 4 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Resolving the neural circuits of anxiety
Calhoon, G. G., & Tye, K. M. (2015) · Nature Neuroscience · doi:10.1038/nn.4101 · Cited by 766 · see citing works
Anxiety Cells in a Hippocampal-Hypothalamic Circuit
Jimenez, J., Su, K., Goldberg, A., Luna, V. M., Biane, J. S., Ordek, G., Zhou, P., Ong, S. K., Wright, M. A., Zweifel, L. S., et al. (2018) · Neuron · doi:10.1016/j.neuron.2018.01.016 · Cited by 606 · see citing works
BLA to vHPC inputs modulate anxiety-related behaviors
Felix-Ortiz, A. C., Beyeler, A., Seo, C., Leppla, C. A., Wildes, C. P., & Tye, K. M. (2013) · Neuron · doi:10.1016/j.neuron.2013.06.016 · Cited by 592 · see citing works
Amygdala inputs to the ventral hippocampus bidirectionally modulate social behavior
Felix-Ortiz, A. C., & Tye, K. M. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.4257-13.2014 · Cited by 473 · see citing works
From Structure to Behavior in Basolateral Amygdala-Hippocampus Circuits
Yang, Y., & Wang, J. (2017) · Frontiers in Neural Circuits · doi:10.3389/fncir.2017.00086 · Cited by 301 · see citing works
Álvarez-Crespo, M., Skibicka, K. P., Farkas, I., Molnár, C. S., Egecioglu, E., Hrabovszky, E., Liposits, Z., & Dickson, S. L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046321 · Cited by 166 · see citing works
Putting Together Pieces of the Lateral Septum: Multifaceted Functions and Its Neural Pathways
Rizzi-Wise, C. A., & Wang, D. V. (2021) · eNeuro · doi:10.1523/eneuro.0315-21.2021 · Cited by 152 · see citing works
Self-citationAsan, E., Steinke, M. R., & Lesch, K. (2013) · Histochemistry and Cell Biology · doi:10.1007/s00418-013-1081-1 · Cited by 138 · see citing works
Sabihi, S., Dong, S. M., Maurer, S., Goodpaster, C. M., & Leuner, B. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.06.024 · Cited by 84 · see citing works
Novaes, L. S., dos Santos, N. B., Batalhote, R. F. P. F., Malta, M. B., Camarini, R., Scavone, C., & Munhoz, C. D. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.10.026 · Cited by 81 · see citing works
Bonn, M., Schmitt, A. G., Lesch, K., Bockstaele, E. J. V., & Asan, E. (2012) · Brain Structure and Function · doi:10.1007/s00429-012-0406-5 · Cited by 65 · see citing works
Jacinto, L., Cerqueira, J., & Sousa, N. (2016) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2016.00171 · Cited by 61 · see citing works
Erbin in Amygdala Parvalbumin-Positive Neurons Modulates Anxiety-like Behaviors
Luo, Z.-Y., Huang, L., Lin, S., Yin, Y., Jie, W., Hu, N.-Y., Hu, Y.-Y., Guan, Y., Liu, J., You, Q.-L., et al. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.10.021 · Cited by 58 · see citing works
Self-citationASIC1a Activation Enhances Inhibition in the Basolateral Amygdala and Reduces Anxiety
Pidoplichko, V. I., Aroniadou‐Anderjaska, V., Prager, E. M., Figueiredo, T. H., Almeida-Suhett, C. P., Miller, S. L., & Braga, M. F. M. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.4009-13.2014 · Cited by 52 · see citing works
Representation of Fear of Heights by Basolateral Amygdala Neurons
Liu, J., Lin, L., & Wang, D. V. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.0483-20.2020 · Cited by 57 · see citing works
Self-citationChegini, H., Nasehi, M., & Zarrindast, M. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.12.007 · Cited by 52 · see citing works
Demaestri, C., Brenhouse, H. C., & Honeycutt, J. A. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.12.005 · Cited by 42 · see citing works
Abou‐El‐Hassan, H., Rezende, R. M., Izzy, S., Gabriely, G., Yahya, T., Tatematsu, B. K., Habashy, K. J., Lopes, J. R., de Oliveira, G. L. V., Maghzi, A., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-39857-9 · Cited by 45 · see citing works
Bidirectional Influence of Limbic GIRK Channel Activation on Innate Avoidance Behavior
Vo, B. N., Marron Fernandez de Velasco, E., Rose, T. R., Oberle, H., Luo, H., Hopkins, C. R., & Wickman, K. (2021) · The Journal of Neuroscience · doi:10.1523/jneurosci.2787-20.2021 · Cited by 33 · see citing works
Islam, M. B. A. R., Davis, B. T., Kando, M. J., Mao, Q., Procissi, D., Weiss, C., & Schwulst, S. J. (2021) · Experimental Neurology · doi:10.1016/j.expneurol.2021.113714 · Cited by 33 · see citing works
Diaz, M. R., Jotty, K., Locke, J. L., Jones, S. R., & Valenzuela, C. F. (2014) · Frontiers in Pediatrics · doi:10.3389/fped.2014.00046 · Cited by 32 · see citing works
Hühne-Landgraf, A., Volkmann, P., Stephan, M., Rossner, M. J., & Landgraf, D. (2020) · Genes Brain & Behavior · doi:10.1111/gbb.12661 · Cited by 30 · see citing works
Przybysz, K. R., Werner, D. F., & Diaz, M. R. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.01.036 · Cited by 29 · see citing works
Neural Oscillations in Aversively Motivated Behavior
Totty, M. S., & Maren, S. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.936036 · Cited by 26 · see citing works
Winne, J., Ciralli, B., Malfatti, T., Brisa, E., Doerl, J. G., Nogueira, I., Leão, K. E., & Leão, R. N. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113175 · Cited by 26 · see citing works
Functional coupling of Tmem74 and HCN1 channels regulates anxiety-like behavior in BLA neurons
Shao, L.-X., Jiang, Q., Liu, X., Gong, D.-M., Yin, Y., Wu, G., Sun, N.-H., Wang, C.-K., Chen, Q., Yu, C., et al. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0402-8 · Cited by 23 · see citing works
Varlinskaya, E. I., Johnson, J. M., Przybysz, K. R., Terrence Deak, B., & Diaz, M. R. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.109812 · Cited by 24 · see citing works
Santos-Soto, I. J., Chorna, N., Carballeira, N. M., Vélez-Bartolomei, J. G., Méndez-Merced, A. T., Chornyy, A. P., & de Ortı́z, S. P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0081459 · Cited by 21 · see citing works
Reactivity to conditioned threat cues is distinct from exploratory drive in the elevated plus maze
Hilton, J. R., Simpson, S. R., Sherman, E. R., Raby‐Smith, W., Azvine, K., Arribas, M., Zhou, J., Deiana, S., Hengerer, B., & Cahill, E. (2022) · European Journal of Neuroscience · doi:10.1111/ejn.15870 · Cited by 17 · see citing works
Trujillo, V., Valentim‐Lima, E., Mencalha, R., Carbalan, Q. S. R., Dos‐Santos, R. C., Felintro, V., Girardi, C. E. N., Rorato, R. C., Lustrino, D., Reis, L. C., et al. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-02181-0 · Cited by 17 · see citing works
Wang, A.-L., Chao, O., Yang, Y.-M., Trossbach, S. V., Müller, C., Korth, C., Huston, J., & Silva, M. A. D. S. (2019) · Pharmacology, Biochemistry and Behavior · doi:10.1016/j.pbb.2019.02.005 · Cited by 15 · see citing works
Tsang, V. W. K., Young, D., During, M. J., & Birch, N. P. (2014) · PLoS ONE · doi:10.1371/journal.pone.0091050 · Cited by 17 · see citing works
Cai, C.-Y., Tao, Y., Zhou, Y., Yang, D., Qin, C., Bian, X.-L., Xian, J.-Y., Cao, B., Chang, L., Wu, H., et al. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.04.049 · Cited by 16 · see citing works
Tran, L., & Keele, N. B. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.01.053 · Cited by 16 · see citing works
Gioia, D. A., Alexander, N., & McCool, B. A. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00424 · Cited by 16 · see citing works
Prefrontal Cortical Control of Anxiety: Recent Advances
Mack, N. R., Deng, S., Yang, S.-S., Shu, Y., & Gao, W. (2022) · The Neuroscientist · doi:10.1177/10738584211069071 · Cited by 14 · see citing works
Uzuneser, T. C., Szkudlarek, H. J., Jones, M., Nashed, M. G., Clement, T., Wang, H., Ojima, I., Rushlow, W. J., & Laviolette, S. R. (2022) · Cerebral Cortex · doi:10.1093/cercor/bhac220 · Cited by 15 · see citing works
Kaur, M., Sharma, A., John, P. J., & Bhatnagar, P. (2024) · NeuroToxicology · doi:10.1016/j.neuro.2024.10.008 · Cited by 16 · see citing works
Weber, A. J., Adamson, A. B., Greathouse, K. M., Andrade, J. P., Freeman, C. D., Seo, J. V., Rae, R. J., Walker, C. K., & Herskowitz, J. H. (2021) · Molecular Brain · doi:10.1186/s13041-021-00878-4 · Cited by 15 · see citing works
Sex-specific transgenerational effects of morphine exposure on reward and affective behaviors
Brynildsen, J. K., Sanchez, V., Yohn, N. L., Carpenter, M. D., & Blendy, J. A. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112842 · Cited by 14 · see citing works
Electroconvulsive shocks decrease α2-adrenoceptor binding in the Flinders rat model of depression.
Lillethorup, T., Iversen, P., Fontain, J., Wegener, G., Doudet, D., & Landau, A. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2014.12.003 · Cited by 15 · see citing works
Kangarlu-Haghighi, K., Oryan, S., Nasehi, M., & Zarrindast, M. (2015) · EXCLI Journal : Experimental and Clinical Sciences · doi:10.17179/excli2015-201 · Cited by 15 · see citing works
Model of theta frequency perturbations and contextual fear memory
Castegnetti, G., Bush, D., & Bach, D. R. (2021) · Hippocampus · doi:10.1002/hipo.23307 · Cited by 11 · see citing works
Pidoplichko, V. I., Aroniadou‐Anderjaska, V., Figueiredo, T. H., Wilbraham, C., & Braga, M. F. M. (2021) · Brain Research · doi:10.1016/j.brainres.2021.147628 · Cited by 12 · see citing works
Apland, J. P., Aroniadou‐Anderjaska, V., Figueiredo, T. H., Pidoplichko, V. I., Rossetti, K., & Braga, M. F. M. (2018) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.117.245969 · Cited by 12 · see citing works
Plant-Derived Extracts in the Neuroscience of Anxietyon Animal Models: Biases and Comments
Chirumbolo, S. (2011) · International Journal of Neuroscience · doi:10.3109/00207454.2011.635829 · Cited by 11 · see citing works
Gioia, D. A., & McCool, B. A. (2017) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13343 · Cited by 11 · see citing works
Nerve injury alters restraint-induced activation of the basolateral amygdala in male rats
Kang, J. W. M., Mor, D., & Keay, K. A. (2021) · Brain Structure and Function · doi:10.1007/s00429-021-02235-6 · Cited by 10 · see citing works
Reis, F. M., Novaes, L. S., dos Santos, N. B., Ferreira-Rosa, K. C., Perfetto, J. G., Baldo, M. V. C., Munhoz, C. D., & Canteras, N. S. (2022) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2022.105757 · Cited by 10 · see citing works
Diab, A. M., Qi, J., Shahin, I., Milligan, C., & Fawcett, J. P. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.09.026 · Cited by 8 · see citing works
The regulative role and mechanism of BNST in anxiety disorder
Xie, M., Xiong, Y., & Wang, H. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1437476 · Cited by 7 · see citing works
Faraji, N., Shiravi, A., Bahari, Z., Shirvani, H., & Meftahi, G. H. (2020) · Neurochemical Journal · doi:10.1134/s1819712420010079 · Cited by 7 · see citing works
Xiong, R., Li, B., Yu, H., Fan, T., Yu, H., Yang, Y., Wang, J., Pi, G., & Yang, X. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-240298 · Cited by 6 · see citing works
Kesmati, M., Mard‐Soltani, M., & Khajehpour, L. (2013) · Europe PMC (PubMed Central) · doi:10.5681/apb.2014.006 · Cited by 6 · see citing works
Contesse, T., Gomes-Ribeiro, J., Royon, L., Fofo, H., Braine, A., Glangetas, C., Zhang, S., Barbano, M. F., Soiza‐Reilly, M., Georges, F. E., et al. (2025) · Biological Psychiatry · doi:10.1016/j.biopsych.2025.04.007 · Cited by 5 · see citing works
Neonatal vocalization rate predicts future prosocial behavior in C57 BL/6J mice
Binder, M. S., Cauley, E. B., Cofsky, E. N. I., & Lemler, M. O. (2025) · Behavioural Brain Research · doi:10.1016/j.bbr.2025.115560 · Cited by 4 · see citing works
Gamble, M. E., Montero, M., Silberstein, D. N., Deak, T., Varlinskaya, E. I., & Diaz, M. R. (2025) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2025.1570951 · Cited by 4 · see citing works
Kalitin, K. Y., Спасов, А. А., & Mukha, O. Y. (2024) · Research Results in Pharmacology · doi:10.18413/rrpharmacology.10.400 · Cited by 4 · see citing works
Kaur, M., Sharma, A., John, P. J., & Bhatnagar, P. (2023) · Research Square · doi:10.21203/rs.3.rs-3073756/v1 · Cited by 4 · see citing works
Anterior cingulate cortex monitors action state and action content in complex associative learningPreprint
Huang, W., Hall, A. F., Kawalec, N., Opalka, A. N., Liu, J., & Wang, D. V. (2025) · eLife · doi:10.7554/elife.105774 · Cited by 5 · see citing works
Self-citationDiaz, M. R., Barney, T. M., Marsland, P., & Terrence Deak, B. (2025) · Neuropharmacology · doi:10.1016/j.neuropharm.2025.110304 · Cited by 3 · see citing works
Coding of “Home Cage” by PFC Neurons
Yan, R., & Zhou, Q. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.09.042 · Cited by 3 · see citing works
Intra-amygdala circuits of sleep disruption-induced anxiety in female micePreprint
Peng, B., Foilb, A. R., Manasian, Y., Li, Y., Deng, X., Meloni, E. G., Ressler, K. J., Carlezon, W. A., & Bolshakov, V. Y. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.05.19.594863 · Cited by 3 · see citing works
Felintro, V., Trujillo, V., Dos‐Santos, R. C., Almeida, C. D. S., Reis, L. C., da Rocha, F. F., & Mecawi, A. S. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1062211 · Cited by 2 · see citing works
Monteiro, R. F. M., Nascimento, M. V. L., Lima, K. T., Cardoso, V. S. L., Almeida, J. R. G., Costa, W. J. T. N., Valente‐Amaral, A., Teixeira, B. J. B., Santos‐Barbosa, L., Shirakura, V. T., et al. (2025) · Fundamental and Clinical Pharmacology · doi:10.1111/fcp.70049 · Cited by 2 · see citing works
The Role of Ventral Hippocampal Projections to the Amygdala on Anxiety Behavior
Bakir, S. (2015) · TSpace (University of Toronto) · Cited by 1 · see citing works
Gu, B. (2015) · DukeSpace (Duke University) · Cited by 1 · see citing works
Polli, F. S. (2014) · Americanae (AECID Library)
Szelenyi, E. R., Fisenne, D., Knox, J. E., Harris, J. A., Gornet, J., Palaniswamy, R., Kim, Y., Venkataraju, K. U., & Osten, P. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/458992 · Cited by 2 · see citing works
Novaes, L. S. (2019) · doi:10.11606/t.42.2019.tde-18022019-144217
Kainate receptor auxiliary subunits NETO1 and NETO2 in anxiety and fear-related behaviors
Mennesson, M. (2019) · Työväentutkimus Vuosikirja
Noradrenergic regulation of the basolateral amygdala
Skelly, M. J., Snyder, A. E., & Silberman, Y. (2020) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-12-815134-1.00009-x
Noorani, S. K., Hojati, V., Ardeshiri, M. R., & Akbari, E. (2021) · DOAJ (DOAJ: Directory of Open Access Journals)
Anxiety and Trauma-Related Disorders
Jia, C., Li, H., & Tye, K. M. (2025) · Oxford University Press eBooks · doi:10.1093/med/9780197640654.003.0039
Evolutionary Clustering Detection of Similarity in Neuronal Spike Patterns
Lu, H., Liu, Z., & Song, Y. (2014) · Lecture notes in computer science · doi:10.1007/978-3-319-12436-0_62
Huang, W., Hall, A. F., Kawalec, N., Opalka, A. N., LIU, J. T., & Wang, D. V. (2026) · eLife · doi:10.7554/elife.105774.2
Self-citation
- Authors
- Wang, D. V., Wang, F., Liu, J., Zhang, L., Wang, Z., & Lin, L.
- Affiliations
- East China Normal University (CN)
- Corresponding author
- Lin, Longnian
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2011-04-11
- Volume
- 6
- Issue
- 4
- Pages
- e18739
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3073991
- OpenAlex
- W1972585935
- Cited by
- 78
- References
- 39
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 5 · 2023: 5 · 2022: 5 · 2021: 9 · 2020: 8 · 2019: 6 · 2018: 5 · 2017: 5 · 2016: 3 · 2015: 4 · 2014: 7 · 2013: 5 · 2012: 2
- FWCI
- 2.43
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Funders
- National Natural Science Foundation of China (30570584)
- Shanghai Municipal Education Commission
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- basolateral amygdala, anxiety, open field test, elevated plus maze, anxiety-like behavior, neuronal excitability, emotional value, freely moving mice
- MeSH terms
- Action Potentials, Amygdala, Animals, Anxiety, Behavior, Animal, Environmental Exposure, Ethology, Male, Mice, Inbred C57BL, Neurons, Maze Learning, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review