Cited by 119Advanced Neuroimaging Techniques and ApplicationsDementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

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Multiple Indices of Diffusion Identifies White Matter Damage in Mild Cognitive Impairment and Alzheimer’s Disease

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O'Dwyer, Laurence, Lamberton, Franck, Bokde, Arun L. W., Ewers, Michael, Faluyi, Yetunde O., Tanner, Colby, Mazoyer, Bernard, O'Neill, Des, Bartley, Máiréad, Collins, D. Rónán, Coughlan, Tara, Prvulovic, David, Hampel, Harald·2011·PLoS ONE

DOI 10.1371/journal.pone.0021745PMC PMC3128090

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Abstract

The study of multiple indices of diffusion, including axial (DA), radial (DR) and mean diffusion (MD), as well as fractional anisotropy (FA), enables WM damage in Alzheimer's disease (AD) to be assessed in detail. Here, tract-based spatial statistics (TBSS) were performed on scans of 40 healthy elders, 19 non-amnestic MCI (MCIna) subjects, 14 amnestic MCI (MCIa) subjects and 9 AD patients. Significantly higher DA was found in MCIna subjects compared to healthy elders in the right posterior cingulum/precuneus. Significantly higher DA was also found in MCIa subjects compared to healthy elders in the left prefrontal cortex, particularly in the forceps minor and uncinate fasciculus. In the MCIa versus MCIna comparison, significantly higher DA was found in large areas of the left prefrontal cortex. For AD patients, the overlap of FA and DR changes and the overlap of FA and MD changes were seen in temporal, parietal and frontal lobes, as well as the corpus callosum and fornix. Analysis of differences between the AD versus MCIna, and AD versus MCIa contrasts, highlighted regions that are increasingly compromised in more severe disease stages. Microstructural damage independent of gross tissue loss was widespread in later disease stages. Our findings suggest a scheme where WM damage begins in the core memory network of the temporal lobe, cingulum and prefrontal regions, and spreads beyond these regions in later stages. DA and MD indices were most sensitive at detecting early changes in MCIa.

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Authors: O'Dwyer, L., Lamberton, F., Bokde, A. L. W., Ewers, M., Faluyi, Y. O., Tanner, C., Mazoyer, B., O'Neill, D., Bartley, M., Collins, D. R., Coughlan, T., Prvulovic, D., & Hampel, H.
Affiliations: Centre National de la Recherche Scientifique (FR)
Trinity College Dublin (IE)
San Francisco VA Medical Center (US)
Cambridgeshire and Peterborough NHS Foundation Trust (GB)
Goethe University Frankfurt (DE)
ORCID: Lamberton, Franck
Bokde, Arun L. W.
Ewers, Michael
Mazoyer, Bernard
Hampel, Harald
Venue: PLoS ONE
Publisher: Public Library of Science (PLoS)
Published: 2011-06-30
Volume: 6
Issue: 6
Pages: e21745
ISSN: 1932-6203 (ISSN-L)
DOI: 10.1371/journal.pone.0021745
PMC: PMC3128090
OpenAlex: W2111813385
Cited by: 119
References: 86
Citations by year: 2026: 1 · 2025: 5 · 2024: 2 · 2023: 9 · 2022: 5 · 2021: 6 · 2020: 7 · 2019: 7 · 2018: 4 · 2017: 10 · 2016: 8 · 2015: 10 · 2014: 10 · 2013: 19 · 2012: 14
FWCI: 10.77
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (unspecified)
Locations: PLoS ONE (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Arrow@dit (Dublin Institute of Technology) (submittedVersion, cc-by-nc-sa)
HAL (submittedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Publication Server of Goethe University Frankfurt am Main (Goethe University Frankfurt) (submittedVersion, cc-by)
Funders: Irish Research Council for Science, Engineering and Technology
Science Foundation Ireland (08/IN.1/B1846)
Irish Research Council
Topics: Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Keywords: white matter injury, mild cognitive impairment, Alzheimer's disease, diffusion MRI, axial diffusion, radial diffusion, fractional anisotropy, tract-based spatial statistics, posterior cingulum, precuneus, prefrontal cortex, uncinate fasciculus, forceps minor, fornix, corpus callosum, temporal lobe, memory networks, disease progression
MeSH terms: Aged, Alzheimer Disease, Female, Humans, Male, Middle Aged, Diffusion Magnetic Resonance Imaging, Cognitive Dysfunction

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Multiple Indices of Diffusion Identifies White Matter Damage in Mild Cognitive Impairment and Alzheimer’s Disease

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