The Bile Acid Receptor GPBAR-1 (TGR5) Modulates Integrity of Intestinal Barrier and Immune Response to Experimental Colitis

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

Morris, G. M., Huey, R., Lindstrom, W., Sanner, M. F., Belew, R. K., Goodsell, D. S., & Olson, A. J. (2009) · Journal of Computational Chemistry · doi:10.1002/jcc.21256 · Cited by 26,294

Comparative Protein Modelling by Satisfaction of Spatial Restraints

Šali, A., & Blundell, T. L. (1993) · Journal of Molecular Biology · doi:10.1006/jmbi.1993.1626 · Cited by 12,977

Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes

MANTOVANI, A., SOZZANI, S., LOCATI, M., ALLAVENA, P., & SICA, A. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(02)02302-5 · Cited by 5,528

Comparative Protein Structure Modeling of Genes and Genomes

Martí-Renom, M. A., Stuart, A. C., Fiser, A., Sánchez, R., Melo, F., & Šali, A. (2000) · Annual Review of Biophysics and Biomolecular Structure · doi:10.1146/annurev.biophys.29.1.291 · Cited by 3,169

Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation

Watanabe, M., Houten, S. M., Mataki, C., Christoffolete, M. A., Kim, B. W., Sato, H., Messaddeq, N., Harney, J. W., Ezaki, O., Kodama, T., et al. (2006) · Nature · doi:10.1038/nature04330 · Cited by 2,220

A G Protein-coupled Receptor Responsive to Bile Acids

Kawamata, Y., Fujii, R., Hosoya, M., Harada, M., Yoshida, H., Miwa, M., Fukusumi, S., Habata, Y., Itoh, T., Shintani, Y., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209706200 · Cited by 1,628

Main-chain Bond Lengths and Bond Angles in Protein Structures

Laskowski, R. A., Moss, D. S., & Thornton, J. M. (1993) · Journal of Molecular Biology · doi:10.1006/jmbi.1993.1351 · Cited by 1,217

Identification of membrane-type receptor for bile acids (M-BAR)

Maruyama, T., Miyamoto, Y., Nakamura, T., Tamai, Y., Okada, H., Sugiyama, E., Nakamura, T., Itadani, H., & Tanaka, K. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)02550-0 · Cited by 993

Bile acids promote glucagon-like peptide-1 secretion through TGR5 in a murine enteroendocrine cell line STC-1

Katsuma, S., Hirasawa, A., & Tsujimoto, G. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.01.139 · Cited by 789

The bile acid receptor FXR is a modulator of intestinal innate immunity

Vavassori, P., Mencarelli, A., Renga, B., Distrutti, E., & Fiorucci, S. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803978 · Cited by 655

Bile Acids and the Potential Role in Primary Biliary Cirrhosis

Yang, H., & Duan, Z. (2016) · Digestion · doi:10.1159/000452300 · Cited by 35

Regulation of mononuclear phagocyte function by the microbiota at mucosal sites

Scott, N. A., & Mann, E. R. (2019) · Immunology · doi:10.1111/imm.13155 · Cited by 35

Contributions of bile acids to gastrointestinal physiology as receptor agonists and modifiers of ion channels

Keely, S. J., Urso, A., Ilyaskin, A. V., Korbmacher, C., Bunnett, N. W., Poole, D. P., & Carbone, S. (2021) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00125.2021 · Cited by 37

Interplay between gut microbiota and bile acids in diarrhoea-predominant irritable bowel syndrome: a review

Hou, J.-J., Wang, X., Wang, Y.-M., & Wang, B.-M. (2021) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2021.2018401 · Cited by 36

Gut Microbiota Metabolites: Unveiling Their Role in Inflammatory Bowel Diseases and Fibrosis

Bernardi, F., D’Amico, F., Bencardino, S., Faggiani, I., Fanizza, J., Zilli, A., Parigi, T. L., Allocca, M., Danese, S., & Furfaro, F. (2024) · Pharmaceuticals · doi:10.3390/ph17030347 · Cited by 39

What We Know So Far about the Metabolite-Mediated Microbiota-Intestinal Immunity Dialogue and How to Hear the Sound of This Crosstalk

Caffaratti, C., Plazy, C., Méry, G., Tidjani, A.-R., Fiorini, F., Thiroux, S., Toussaint, B., Hannani, D., & Gouëllec, A. L. (2021) · Metabolites · doi:10.3390/metabo11060406 · Cited by 36

Corrigendum: Inflammatory and Microbiota-Related Regulation of the Intestinal Epithelial Barrier

Barbara, G., Barbaro, M. R., Fuschi, D., Palombo, M., Falangone, F., Cremon, C., Marasco, G., & Stanghellini, V. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.790387 · Cited by 41

Controversies in the Mechanism of Total Parenteral Nutrition Induced Pathology

Kumar, J., & Teckman, J. H. (2015) · Children · doi:10.3390/children2030358 · Cited by 33

Bile acid activated receptors are targets for regulation of integrity of gastrointestinal mucosa

Distrutti, E., Santucci, L., Cipriani, S., Renga, B., Schiaroli, E., Ricci, P., Donini, A., & Fiorucci, S. (2015) · Journal of Gastroenterology · doi:10.1007/s00535-015-1041-8 · Cited by 33

Xenobiotic Receptor-Mediated Regulation of Intestinal Barrier Function and Innate Immunity

Ranhotra, H. S., Flannigan, K. L., Brave, M., Mukherjee, S., Lukin, D. J., Hirota, S. A., & Mani, S. (2016) · Nuclear Receptor Research · doi:10.11131/2016/101199 · Cited by 37

Bile acid activated receptors: Integrating immune and metabolic regulation in non-alcoholic fatty liver disease

Biagioli, M., & Fiorucci, S. (2021) · Liver Research · doi:10.1016/j.livres.2021.08.003 · Cited by 33

Pathophysiology and Clinical Management of Bile Acid Diarrhea

Marasco, G., Cremon, C., Barbaro, M. R., Falangone, F., Montanari, D., Capuani, F., Mastel, G., Stanghellini, V., & Barbara, G. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11113102 · Cited by 33

Bile acids, bioactive signalling molecules in interoceptive gut‐to‐brain communication

Joyce, S. A., & O'Malley, D. (2022) · The Journal of Physiology · doi:10.1113/jp281727 · Cited by 32

Approaches to discern if microbiome associations reflect causation in metabolic and immune disorders

Basic, M., Dardevet, D. P., Abuja, P. M., Bolsega, S., Bornes, S., Caesar, R., Calabrese, F. M., Collino, M., Angelis, M. D., Gérard, P., et al. (2022) · Gut Microbes · doi:10.1080/19490976.2022.2107386 · Cited by 35

Interactions between noroviruses, the host, and the microbiota

Walker, F. C., & Baldridge, M. T. (2019) · Current Opinion in Virology · doi:10.1016/j.coviro.2019.04.001 · Cited by 31

Molecular Pathogenesis of Colitis-associated Colorectal Cancer: Immunity, Genetics, and Intestinal Microecology

Yin, Y., Wan, J., Yu, J., & Wu, K. (2023) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izad081 · Cited by 35

Interkingdom signaling between gastrointestinal hormones and the gut microbiome

Zhao, X., Qiu, Y., Liang, L., & Fu, X. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2456592 · Cited by 33

Hepatoprotective impact of the bile acid receptor TGR5

Merlen, G., Bidault, V., Kahale, N., Glénisson, M., Bedoya, J. U., Doignon, I., Garcin, I., Humbert, L., Rainteau, D. P., & Tordjmann, T. (2020) · Liver International · doi:10.1111/liv.14427 · Cited by 29

Administration of a mixture of triterpenoids from yeyachun and phenolic acids from danshen ameliorates carbon tetrachloride-induced liver fibrosis in mice by the regulation of intestinal flora

Tan, Y., Li, Y., Zhou, F., Guo, J., Wang, T., Shi, Y., Yang, Y., Lu, J., & Pei, G. (2020) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2020.04.007 · Cited by 30

Deoxycholic Acid and Lithocholic Acid Alleviate Liver Injury and Inflammation in Mice with Klebsiella pneumoniae-Induced Liver Abscess and Bacteremia

Zheng, Y., Yue, C., Zhang, H., Chen, H., Liu, Y., & Li, J. (2021) · Journal of Inflammation Research · doi:10.2147/jir.s298495 · Cited by 32

Fermented products and bioactive food compounds as a tool to activate autophagy and promote the maintenance of the intestinal barrier function

Kocot, A. M., & Wróblewska, B. (2021) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2021.11.014 · Cited by 28

Diet as a modifiable factor in tumorigenesis: Focus on microbiome-derived bile acid metabolites and short-chain fatty acids

Ahmad, F., Saha, P., Singh, V., Wahid, M., Mandal, R. K., Mishra, B. N., Fagoonee, S., & Haque, S. (2022) · Food Chemistry · doi:10.1016/j.foodchem.2022.135320 · Cited by 31

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Biagioli, M., Marchianò, S., di Giorgio, C., Roselli, R., Bordoni, M., Bellini, R., Fiorillo, B., Sepe, V., Catalanotti, B., Cassiano, C., et al. (2023) · Hepatology · doi:10.1002/hep.32787 · Cited by 28

Overview of the microbiota in the gut-liver axis in viral B and C hepatitis

Neag, M. A., Mitre, A. O., Cătinean, A., & Buzoianu, A. D. (2021) · World Journal of Gastroenterology · doi:10.3748/wjg.v27.i43.7446 · Cited by 27

Activation of GPBAR1 attenuates vascular inflammation and atherosclerosis in a mouse model of NAFLD-related cardiovascular disease

Biagioli, M., Marchianò, S., Giorgio, C. D., Bordoni, M., Urbani, G., Bellini, R., Massa, C., Khan, R. S. U., Roselli, R., Monti, M. C., et al. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115900 · Cited by 28

Stimulation of G Protein–Coupled Bile Acid Receptor Enhances Vascular Endothelial Barrier Function via Activation of Protein Kinase A and Rac1

Kida, T., Omori, K., Hori, M., Ozaki, H., & Murata, T. (2013) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.113.209288 · Cited by 27

Bile acid receptor TGR5 overexpression is associated with decreased intestinal mucosal injury and epithelial cell proliferation in obstructive jaundice

Ji, C., Xie, X., Yin, J., Qi, W., Chen, L., Bai, Y., Wang, N., Zhao, D., Jiang, X., & Jiang, H. (2016) · Translational research · doi:10.1016/j.trsl.2016.12.001 · Cited by 29

TGR5 Protects Against Colitis in Mice, but Vertical Sleeve Gastrectomy Increases Colitis Severity

Garibay, D., Zaborska, K. E., Shanahan, M. T., Zheng, Q., Kelly, K. M., Montrose, D. C., Dannenberg, A. J., Miller, A. D., Sethupathy, P., & Cummings, B. P. (2019) · Obesity Surgery · doi:10.1007/s11695-019-03707-9 · Cited by 25

The Interaction of Gut Microbiota and Heart Failure with Preserved Ejection Fraction: From Mechanism to Potential Therapies

Yu, W., Jiang, Y., Xu, H., & Zhou, Y. (2023) · Biomedicines · doi:10.3390/biomedicines11020442 · Cited by 26

Microbial metabolites and immunotherapy: Basic rationale and clinical indications

Kovtonyuk, L. V., & McCoy, K. D. (2023) · Seminars in Immunology · doi:10.1016/j.smim.2023.101755 · Cited by 25

Bile salt signaling and bile salt-based therapies in cardiometabolic disease

Groenen, C., Nguyen, T.-A., Paulusma, C. C., & van de Graaf, S. F. J. (2024) · Clinical Science · doi:10.1042/cs20230934 · Cited by 25

Bile acid–gut microbiota crosstalk in irritable bowel syndrome

Gu, Y., Li, L., Yang, M., Liu, T., Song, X., Qin, X., Xu, X. J., Liu, J., Wang, B., & Cao, H. (2022) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2022.2058353 · Cited by 26

Antimicrobial promotion of pig growth is associated with tissue-specific remodeling of bile acid signature and signaling

Ipharraguerre, I. R., Pastor, J. J., Gavaldà‐Navarro, A., Villarroya, F., & Mereu, A. (2018) · Scientific Reports · doi:10.1038/s41598-018-32107-9 · Cited by 26

Cholestatic liver diseases: An era of emerging therapies

Samant, H. V., Manatsathit, W., Dies, D. F., Shokouh-Amiri, H. M., Zibari, G. B., Boktor, M., & Alexander, J. S. (2019) · World Journal of Clinical Cases · doi:10.12998/wjcc.v7.i13.1571 · Cited by 25

Taurolithocholic acid but not tauroursodeoxycholic acid rescues phagocytosis activity of bone marrow‐derived macrophages under inflammatory stress

Wu, S., Romero‐Ramírez, L., & Mey, J. (2021) · Journal of Cellular Physiology · doi:10.1002/jcp.30619 · Cited by 23

Gut Dysbiosis and Blood-Brain Barrier Alteration in Hepatic Encephalopathy: From Gut to Brain

Shahbazi, A., Sepehrinezhad, A., Vahdani, E., Jamali, R., Ghasempour, M., Massoudian, S., Negah, S. S., & Larsen, F. S. (2023) · Biomedicines · doi:10.3390/biomedicines11051272 · Cited by 25

Aberrant Gut-To-Brain Signaling in Irritable Bowel Syndrome - The Role of Bile Acids

Dhonnabháín, R. N., Xiao, Q., & O’Malley, D. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.745190 · Cited by 25

Deciphering the role of gut metabolites in non-alcoholic fatty liver disease

Ralli, T., Saifi, Z., Tyagi, N., Vidyadhari, A., Aeri, V., & Kohli, K. (2022) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2022.2142091 · Cited by 22

The microbial metabolite urolithin A reduces Clostridioides difficile toxin expression and toxin-induced epithelial damage

Ghosh, S., Erickson, D., Chua, M. J., Collins, J., & Jala, V. R. (2024) · mSystems · doi:10.1128/msystems.01255-23 · Cited by 21

Bile Acids-Based Therapies for Primary Sclerosing Cholangitis: Current Landscape and Future Developments

Fiorucci, S., Urbani, G., Giorgio, C. D., Biagioli, M., & Distrutti, E. (2024) · Cells · doi:10.3390/cells13191650 · Cited by 22

Bile acid 7α-dehydroxylating bacteria accelerate injury-induced mucosal healing in the colon

Jalil, A., Perino, A., Dong, Y., Imbach, J., Volet, C., Oton, E. V., Demagny, H., Plantade, L., Gallart‐Ayala, H., Ivanišević, J., et al. (2025) · EMBO Molecular Medicine · doi:10.1038/s44321-025-00202-w · Cited by 25

Review of yeast culture concerning the interactions between gut microbiota and young ruminant animals

Liu, S., Yang, L., Zhang, Y., Chen, H., Li, X., Xu, Z., Du, R. F., Li, X., Ma, J., & Liu, D. (2024) · Frontiers in Veterinary Science · doi:10.3389/fvets.2024.1335765 · Cited by 26

Chenodeoxycholic acid requires activation of EGFR, EPAC, and Ca2+ to stimulate CFTR-dependent Cl− secretion in human colonic T84 cells

Domingue, J. C., Ao, M., Sarathy, J., & Rao, M. C. (2016) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00168.2016 · Cited by 21

GLP-1 Mediates Regulation of Colonic ACE2 Expression by the Bile Acid Receptor GPBAR1 in Inflammation

Biagioli, M., Marchianò, S., Roselli, R., Giorgio, C. D., Bellini, R., Bordoni, M., Distrutti, E., Catalanotti, B., Zampella, A., Graziosi, L., et al. (2022) · Cells · doi:10.3390/cells11071187 · Cited by 22

Inflammatory-Dependent Bidirectional Effect of Bile Acids on NLRP3 Inflammasome and Its Role in Ameliorating CPT-11-Induced Colitis

Liao, C., Wang, D., Qin, S., Zhang, Y., Chen, J., Xu, R., Xu, F., & Zhang, P. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.677738 · Cited by 22

Influence of the gut microbiota on endometriosis: Potential role of chenodeoxycholic acid and its derivatives

Li, Y., Wang, K., Ding, J., Sun, S., Ni, Z., & Yu, C. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.954684 · Cited by 21

Mini-review: microbiota have potential to prevent PEDV infection by improved intestinal barrier

Yang, S., Liu, G., Savelkoul, H. F. J., Jansen, C. A., & Li, B. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1230937 · Cited by 20

Atorvastatin protects against liver and vascular damage in a model of diet induced steatohepatitis by resetting FXR and GPBAR1 signaling

Marchianò, S., Biagioli, M., Roselli, R., Zampella, A., Giorgio, C. D., Bordoni, M., Bellini, R., Morretta, E., Monti, M. C., Distrutti, E., et al. (2021) · The FASEB Journal · doi:10.1096/fj.202101397r · Cited by 20

TGR5 ligands as potential therapeutics in inflammatory diseases

Pols, T. W. H., Eggink, H. M., & Soeters, M. R. (2014) · International Journal of Interferon Cytokine and Mediator Research · doi:10.2147/ijicmr.s40102 · Cited by 21

No Gut No Gain! Enteral Bile Acid Treatment Preserves Gut Growth but Not Parenteral Nutrition–Associated Liver Injury in a Novel Extensive Short Bowel Animal Model

Villalona, G. A., Price, A., Blomenkamp, K., Manithody, C., Saxena, S., Ratchford, T. L., Westrich, M., Kakarla, V., Pochampally, S., Phillips, W., et al. (2018) · Journal of Parenteral and Enteral Nutrition · doi:10.1002/jpen.1167 · Cited by 21

Effects of bile acid metabolism on intestinal health of livestock and poultry

Jia, H., & Dong, N. (2024) · Journal of Animal Physiology and Animal Nutrition · doi:10.1111/jpn.13969 · Cited by 19

Roles of Bile Acid-Activated Receptors in Monocytes-Macrophages and Dendritic Cells

Jia, H., He, X., Jiang, T., & Kong, F. (2025) · Cells · doi:10.3390/cells14120920 · Cited by 21

Farnesoid X Receptor in Mice Prevents Severe Liver Immunopathology During Lymphocytic Choriomeningitis Virus Infection

Honke, N., Shaabani, N., Hardt, C., Krings, C., Häussinger, D., Lang, P. A., Lang, K. S., & Keitel, V. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000456168 · Cited by 18

The gut microbiota and its metabolites: novel therapeutic targets for inflammatory bowel disease

Shen, X. Z., Li, Y., Wang, D., & Sun, K. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1690279 · Cited by 25

Self-assembled nanoaggregates based on polyaspartamide graft copolymers for pH-controlled release of doxorubicin

Thuy, V. T. T., Lim, C. W., Park, J. H., Ahn, C., & Kim, D. (2015) · Journal of Materials Chemistry B · doi:10.1039/c4tb01930j · Cited by 18

Role of Bile Acids and Gut Microbiota in Parenteral Nutrition Associated Injury

Manithody, C., van Nispen, J., Murali, V., Jain, S., Ashish, S., Armstrong, A. T., & Ajay, J. (2020) · Journal of Human Nutrition · doi:10.36959/487/286 · Cited by 18

Activation of the bile acid receptor GPBAR 1 protects against gastrointestinal injury caused by non‐steroidal anti‐inflammatory drugs and aspirin in mice

Cipriani, S., Mencarelli, A., Bruno, A. M., Renga, B., Distrutti, E., Santucci, L., Baldelli, F., & Fiorucci, S. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.02128.x · Cited by 18

Liver GPBAR1 Associates With Immune Dysfunction in Primary Sclerosing Cholangitis and Its Activation Attenuates Cholestasis in Abcb4−/− Mice

Giorgio, C. D., Urbani, G., Marchianò, S., Biagioli, M., Bordoni, M., Bellini, R., Massa, C., Lachi, G., Cari, L., Morretta, E., et al. (2025) · Liver International · doi:10.1111/liv.16235 · Cited by 19

Microbial bile acid modifications: current understandings, key problems, and future perspectives

Zhang, H., Wen, J., Liu, X., Feng, Y., Liu, X., & Ning, K. (2025) · Science China Life Sciences · doi:10.1007/s11427-025-3019-2 · Cited by 20

Bile acid receptor agonists in primary biliary cholangitis: Regulation of the cholangiocyte secretome and downstream T cell differentiation

Etherington, R. E., Millar, B. J. M., Innes, B. A., Jones, D. E., Kirby, J. A., & Brain, J. G. (2019) · FASEB BioAdvances · doi:10.1096/fba.2018-00046 · Cited by 16

Pharmaceutical Activation or Genetic Absence of ClC-2 Alters Tight Junctions During Experimental Colitis

Jin, Y., Pridgen, T. A., & Blikslager, A. T. (2015) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000550 · Cited by 17

Emerging concepts and shifting paradigms for understanding the microbial basis of inflammatory bowel diseases

Kennedy, M. S., & Chang, E. B. (2025) · Journal of Clinical Investigation · doi:10.1172/jci193969 · Cited by 17

Gastro-intestinal tract: The leading role of mucosal immunity

Steinert, A., Radulovic, K., & Niess, J. H. (2016) · Swiss Medical Weekly · doi:10.4414/smw.2016.14293 · Cited by 17

Bile acids and liver carcinogenesis: TGR5 as a novel piece in the puzzle?

Péan, N., Doignon, I., & Tordjmann, T. (2013) · Clinics And Research in Hepatology and Gastroenterology · doi:10.1016/j.clinre.2012.12.005 · Cited by 17

Bile acid receptors link nutrient sensing to metabolic regulation

Li, J., & Li, T. (2017) · Liver Research · doi:10.1016/j.livres.2017.04.001 · Cited by 16

FXR/TGR5 mediates inflammasome activation and host resistance to bacterial infection

Kang, J., Kim, M., & Yim, M. (2021) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2021.101051 · Cited by 16

Bile acid modulation of host immunity

Anh, N. B., Yang, X., & Hang, H. C. (2025) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.70014 · Cited by 16

Serum Bile Acid Metabolites Predict the Therapeutic Effect of Mesalazine in Patients with Ulcerative Colitis

Sun, Q., Tang, Y., Dai, L., Tang, Z., Zhou, W., Wu, T., & Ji, G. (2023) · Journal of Proteome Research · doi:10.1021/acs.jproteome.2c00820 · Cited by 15

Taurodeoxycholate ameliorates DSS-induced colitis in mice

Zou, Y., Ghaderpour, A., Munkhbileg, B., Seo, S., & Seong, S. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110628 · Cited by 15

Essential roles of bile acid receptors FXR and TGR5 as metabolic regulators

Jacinto, S. H., & Fang, S. (2014) · Animal Cells and Systems · doi:10.1080/19768354.2014.987318 · Cited by 15

Duodenal bile acids as determinants of intestinal mucosal homeostasis and disease

Keely, S., & Talley, N. J. (2020) · Neurogastroenterology & Motility · doi:10.1111/nmo.13854 · Cited by 15

Cannabidiol-Treated Ovariectomized Mice Show Improved Glucose, Energy, and Bone Metabolism With a Bloom in Lactobacillus

Sui, K., Tveter, K. M., Bawagan, F. G., Buckendahl, P., Martinez, S. A., Jaffri, Z. H., MacDonell, A. T., Wu, Y., Duran, R. M., Shapses, S. A., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.900667 · Cited by 16

Blueberry extract alleviated lipopolysaccharide‐induced inflammation responses in mice through activating the FXR / TGR5 signaling pathway and regulating gut microbiota

Zhou, S., Li, Y., Hu, L., Qin, W., Cao, Y., Tang, Z., Li, H., Hu, X., Fang, Z., Li, S., et al. (2023) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.12560 · Cited by 14

Bile acid metabolites enhance expression of cathelicidin antimicrobial peptide in airway epithelium through activation of the TGR5-ERK1/2 pathway

Myszor, I. T., Lapka, K., Hermannsson, K., Rekha, R., Bergman, P., & Gudmundsson, G. H. (2024) · Scientific Reports · doi:10.1038/s41598-024-57251-3 · Cited by 12

Pulsatilla decoction alleviates DSS-induced UC by activating FXR-ASBT pathways to ameliorate disordered bile acids homeostasis

Xiao, Y., Jia, Y., Liu, W., Niu, C., Mai, Z., Dong, J., Zhang, X.-S., Yuan, Z., Ji, P., Wei, Y., et al. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1399829 · Cited by 14

Modulation of gut microbiota by Mantequilla and Melipona honeys decrease low-grade inflammation caused by high fructose corn syrup or sucrose in rats

Coutiño-Hernández, D., Sánchez‐Tapia, M., Leal-Vega, F. J., Bobadilla-del-Valle, M., Ledezma, H., Cervantes, R., Pedraza‐Chaverrí, J., Granados‐Portillo, O., Díaz, D., Antunes‐Ricardo, M., et al. (2021) · Food Research International · doi:10.1016/j.foodres.2021.110856 · Cited by 14

Fecal microbiota from children with vitamin A deficiency impair colonic barrier function in germ-free mice: The possible role of alterative bile acid metabolites

Feng, D., Chen, B., Zeng, B., Xiao, L., Yan, J., Yang, T., Zhu, J., Li, T., Wang, L., Wei, H., et al. (2021) · Nutrition · doi:10.1016/j.nut.2021.111274 · Cited by 14

Bile Acid-Induced Liver Injury in Cholestasis

Li, T., & Chiang, J. Y. L. (2017) · Springer eBooks · doi:10.1007/978-3-319-53774-0_7 · Cited by 14

Bile acid alterations associated with indolent course of inflammatory bowel disease

Liu, C., Zhan, S., Li, N., Tu, T., Lin, J., Li, M., Chen, M., Zeng, Z., & Zhuang, X. (2023) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365521.2023.2200518 · Cited by 13

Development of dual GPBAR1 agonist and RORγt inverse agonist for the treatment of inflammatory bowel diseases

Biagioli, M., Giorgio, C. D., Morretta, E., Bellini, R., Massa, C., Urbani, G., Bordoni, M., Marchianò, S., Lachi, G., Sepe, V., et al. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107403 · Cited by 14

Interplay of Nutrients and Microbial Metabolites in Intestinal Immune Homeostasis: Distinct and Common Mechanisms of Immune Regulation in the Small Bowel and Colon

Perrigoue, J., Das, A., & Mora, J. R. (2014) · Nestlé Nutrition Institute Workshop series · doi:10.1159/000360685 · Cited by 13

Oral pathogens meet the gut microbiome: new mechanistic insights on systemic disease

Gan, G., Chen, R., Zheng, P., Long, K., Ma, K. K., Sulaiman, J. E., & Huang, X. (2026) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2025.1673512 · Cited by 16

Intestinal crosstalk between bile acids and microbiota in irritable bowel syndrome

Deng, X., Xiao, L., Luo, M., Xie, P., & Xiong, L. (2023) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.16159 · Cited by 16

Increased circulating total bile acid levels were associated with organ failure in patients with acute pancreatitis

Xie, X., Dong, J., Lu, G., Gao, K., Li, X., Mao, W., Chen, F., Tong, Z., Li, B., & Li, W. (2020) · BMC Gastroenterology · doi:10.1186/s12876-020-01243-w · Cited by 11

Chinese Medicine Formula Siwu-Yin Inhibits Esophageal Precancerous Lesions by Improving Intestinal Flora and Macrophage Polarization

Shi, H., Chen, X.-Y., Chen, X., Wu, Z., Li, J.-Y., Sun, Y.-Q., Shi, D.-X., & Li, J. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.812386 · Cited by 12

GPBAR1 Activation by C6-Substituted Hyodeoxycholane Analogues Protect against Colitis

Marino, S. D., Finamore, C., Biagioli, M., Carino, A., Marchianò, S., Roselli, R., Giorgio, C. D., Bordoni, M., Leva, F. S. D., Novellino, E., et al. (2020) · ACS Medicinal Chemistry Letters · doi:10.1021/acsmedchemlett.9b00636 · Cited by 12

The link between gut microbiota and multiple sclerosis from the perspective of barrier function

Ren, J., Niu, Z., Wang, J., Guo, J., Hao, H.-J., Gao, F., Liu, R., & Wang, Z. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1652796 · Cited by 13

Fermented bile acids improved growth performance and intestinal health by altering metabolic profiles and intestinal microbiome in Micropterus salmoides

Guo, Q., Liú, W., Zhao, L., Sui, Y., Zhao, H., Liu, Y., Mu, C., & Wang, X. (2024) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2024.109593 · Cited by 11

Intestinal metabolites in colitis-associated carcinogenesis: Building a bridge between host and microbiome

Fan, Y., Li, Y., Gu, X., Chen, N., Chen, Y., Fang, C., Wang, Z., Yin, Y., Deng, H., & Dai, L. (2025) · Chinese Medical Journal · doi:10.1097/cm9.0000000000003430 · Cited by 11

Exploring the bioactivity of pentacyclic triterpenoids as potential antimycobacterial nutraceutics: Insights through comparative biomolecular modelling

Tolufashe, G. F., Lawal, M. M., Govender, K. K., Shode, F. O., & Singh, T. (2021) · Journal of Molecular Graphics and Modelling · doi:10.1016/j.jmgm.2021.107900 · Cited by 11

Beyond lipids: Novel mechanisms for parenteral nutrition–associated liver disease

Wichman, B. E., Nilson, J., Govindan, S., Chen, A., Jain, A., Arun, V., Derdoy, J., Krebs, J., & Jain, A. K. (2022) · Nutrition in Clinical Practice · doi:10.1002/ncp.10830 · Cited by 11

Saponins from Camellia sinensis Seeds Stimulate GIP Secretion in Mice and STC-1 Cells via SGLT1 and TGR5

Zhu, H., Wang, K., Chen, S., Kang, J., Guo, N., Chen, H., Liu, J., Wu, Y., He, P., Tu, Y., et al. (2022) · Nutrients · doi:10.3390/nu14163413 · Cited by 11

Gegen-Qinlian decoction alleviates anxiety-like behaviors in methamphetamine-withdrawn mice by regulating Akkermansia and metabolism in the colon

Lu, X., Fan, Y., Peng, Y., Pan, W., Du, D., Xu, X., Li, N., He, T., Nie, J., Shi, P., et al. (2023) · Chinese Medicine · doi:10.1186/s13020-023-00794-w · Cited by 12

Phillygenin ameliorates tight junction proteins reduction, fibrosis, and apoptosis in mice with chronic colitis via TGR5-mediated PERK-eIF2α-Ca2+ pathway

Xue, H., Li, P., Guo, J., Chen, T., Li, S.-F., & Zhang, L. (2024) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2024.101042 · Cited by 11

A Narrative Review: Immunometabolic Interactions of Host–Gut Microbiota and Botanical Active Ingredients in Gastrointestinal Cancers

Li, S., Feng, W., Wu, J., Cui, H., Wang, Y., Liang, T., An, J., Chen, W., Guo, Z., & Lei, H. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25169096 · Cited by 10

Bile Acids in Control of the Gut-Liver-Axis

Hild, B., Heinzow, H. S., Schmidt, H., & Maschmeier, M. (2021) · Zeitschrift für Gastroenterologie · doi:10.1055/a-1330-9644 · Cited by 10

Reprint of: Role of enteric neurotransmission in host defense and protection of the gastrointestinal tract

Sharkey, K. A., & Savidge, T. (2014) · Autonomic Neuroscience · doi:10.1016/j.autneu.2014.03.004 · Cited by 11

Clinical evidence linking osteoporosis and the gut microbiome in postmenopausal females: A systematic review

Lee, K. J., Kim, H., & Wang, J. (2025) · Bone · doi:10.1016/j.bone.2025.117644 · Cited by 9

Bile salt hydrolase activity as a rational target for MASLD therapy

Jones, E. V., Wang, Y., Wei, W., Reed, J. C., Chaudhari, S. N., Li, D. K., Boursier, J., Lang, S., Demir, M., Diehl, A. M., et al. (2026) · Gut Microbes · doi:10.1080/19490976.2025.2608437 · Cited by 12

The Symbiosis Between Lactobacillus acidophilus and Inulin: Metabolic Benefits in an Obese Murine Model

Rangel-Torres, B. E., García-Montoya, I. A., Rodríguez‐Tadeo, A., & Jiménez-Vega, F. (2022) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-022-10012-y · Cited by 9

The Bile Acid Receptor GPBAR1 Regulates the M1/M2 Phenotype of Intestinal Macrophages and Activation of GPBAR1 Rescues Mice from Murine Colitis

Biagioli, M., Carino, A., Cipriani, S., Francisci, D., Marchianò, S., Scarpelli, P., Sorcini, D., Zampella, A., & Fiorucci, S. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1700183 · Cited by 327

GPBAR1 (TGR5) Ligation Protects Against Colitis Development by Regulating Leukocyte Traffinking and Promoting a IL-10 Dependent Shift in the M1/M2 Phenotype

Biagioli, M., Cipriani, S., Sorcini, D., Carino, A., Marchianò, S., Zampella, A., Distrutti, E., Santucci, L., Baldelli, F., & Fiorucci, S. (2017) · Gastroenterology · doi:10.1016/s0016-5085(17)30783-7 · Cited by 1

A microbial derived bile acid acts as GPBAR1 agonist and RORγt inverse agonist and reverses inflammation in inflammatory bowel diseasePreprint

Biagioli, M., Giorgio, C. D., Massa, C., Marchianò, S., Bellini, R., Bordoni, M., Urbani, G., Roselli, R., Lachi, G., Morretta, E., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.04.08.588556 · Cited by 2

P324 A bile acid receptor atlas in immune cells and the human gastrointestinal epithelial barrier

Mobbs, C. L., Helps, T., Keely, S. J., Walters, J., & McLean, M. H. (2026) · E-Posters · doi:10.1136/gutjnl-2026-bsg.436

Ghrelin ameliorates intestinal barrier dysfunction in experimental colitis by inhibiting the activation of nuclear factor-kappa B

Cheng, J., Zhang, L., Dai, W., Mao, Y., Li, S., Wang, J., Li, H., Guo, C., & Fan, X. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.01.083 · Cited by 37