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Cited by 20Probiotics and Fermented FoodsGenetics, Aging, and Longevity in Model OrganismsImmune responses and vaccinations

Long-term administration of pDC stimulative lactic acid bacteria, Lactococcus lactis strain Plasma, prevents immune-senescence and decelerates individual senescence

Tsuji, Ryohei, Komano, Yuta, Ohshio, Konomi, Ishii, Naoaki, Kanauchi, Osamu·2018·Experimental Gerontology
DOI 10.1016/j.exger.2018.06.028
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Abstract

Aging is accompanied by the decline in immune function, resulting in increasing susceptibility to infectious diseases and tumorigenesis. In our previous reports, we showed that Lactococcus lactis subsp. lactis strain Plasma (LC-Plasma) stimulated plasmacytoid dendritic cells (pDCs), which play an important role in viral infection, and oral administration of LC-Plasma showed prophylactic effects against viral infection both in mice and humans. However, the effects of long-term administration of LC-Plasma are not known. In this study, we investigated the effect of long-term oral administration of LC-Plasma on IFN-α induction activity and individual senescence in the senescence-accelerated mice strains Prone 1 (SAMP1) and Prone 10 (SAMP10). LC-Plasma administration promoted IFN-α induction activity and increased the naïve T cell ratio in SAMP1 mice. In SAMP10 mice, in addition to preventing a decrease in the naïve T cell ratio, aging-associated skin thinning was suppressed histologically and the expression of representative tight junction genes, such as Claudin-1 and Zo-1, was increased. Furthermore, age-related muscle weight loss tended to be suppressed in the LC-Plasma group and expression of the muscle degeneration gene FoxO-1 was significantly suppressed. Related to these phenotypes, the senescence score in the LC-Plasma group was significantly decreased at 47 weeks of age compared with that in the control group. Taken together, long-term oral administration of LC-Plasma could prevent immune-senescence and other senescence phenotypes at the organ level. Therefore, LC-Plasma is suggested to be a useful functional food material for decelerating individual senescence.

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  • Some probiotic extracts have the potential to improve aging skin.

    “For example, probiotic fermentation can enhance the skin anti-photo-aging activity of Agastache rugosa leaves, and some probiotic extracts also have the potential to improve aging skin. [131,132].”

    From Diet and Skin Aging—From the Perspective of Food Nutrition (2020) · cites this paper as [131]

  • Dietary probiotics and their products can alleviate skin aging.

    “Some studies have reported that dietary probiotics and their products can also alleviate skin aging.”

    From Diet and Skin Aging—From the Perspective of Food Nutrition (2020) · cites this paper as [131]

  • Probiotic fermentation can enhance the skin anti-photo-aging activity of Agastache rugosa leaves.

    “For example, probiotic fermentation can enhance the skin anti-photo-aging activity of Agastache rugosa leaves, and some probiotic extracts also have the potential to improve aging skin. [131,132].”

    From Diet and Skin Aging—From the Perspective of Food Nutrition (2020) · cites this paper as [131]

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Authors
Tsuji, R., Komano, Y., Ohshio, K., Ishii, N., & Kanauchi, O.
Affiliations
  • Kirin (Japan) (JP)
  • Tokai University (JP)
Corresponding author
Tsuji, Ryohei
ORCID
Venue
Experimental Gerontology
Publisher
Elsevier BV
Published
2018-10
Volume
111
Pages
10-16
ISSN
0531-5565 (ISSN-L)
DOI
10.1016/j.exger.2018.06.028
OpenAlex
W2811014959
Cited by
20
References
48
Citations by year
2026: 1 · 2025: 4 · 2024: 5 · 2023: 1 · 2021: 5 · 2020: 1 · 2019: 2 · 2018: 1
FWCI
2.12
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Experimental Gerontology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Keywords
lactic acid bacteria, plasmacytoid dendritic cells, immunosenescence, aging, senescence-accelerated mice, SAMP1, naive T cells, skin thinning, tight junction genes, muscle atrophy, FOXO1, functional foods, oral administration
MeSH terms
Immunosenescence, Forkhead Box Protein O1, Administration, Oral, Aging, Animals, Cells, Cultured, Dendritic Cells, Interferons, Male, Lactococcus lactis, Time Factors, Gene Expression, Models, Animal, Mice, Claudin-1, Zonula Occludens-1 Protein

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