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Lgr5 marks cycling, yet long-lived, hair follicle stem cells

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Lgr6 Marks Stem Cells in the Hair Follicle That Generate All Cell Lineages of the Skin

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Exploring the Genomes of Cancer Cells: Progress and Promise

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Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6

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R-Spondin2 Is a Secreted Activator of Wnt/β-Catenin Signaling and Is Required for Xenopus Myogenesis

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Wilms Tumor Suppressor WTX Negatively Regulates WNT/ß-Catenin Signaling

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The Three Subfamilies of Leucine-Rich Repeat-Containing G Protein-Coupled Receptors (LGR): Identification of LGR6 and LGR7 and the Signaling Mechanism for LGR7

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R-Spondin Family Members Regulate the Wnt Pathway by a Common Mechanism

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Comparing the DNA Hypermethylome with Gene Mutations in Human Colorectal Cancer

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Methylation of Cancer-Stem-Cell-Associated Wnt Target Genes Predicts Poor Prognosis in Colorectal Cancer Patients

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R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6

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Mouse Cristin/R-spondin Family Proteins Are Novel Ligands for the Frizzled 8 and LRP6 Receptors and Activate β-Catenin-dependent Gene Expression

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Bursicon, the insect cuticle-hardening hormone, is a heterodimeric cystine knot protein that activates G protein-coupled receptor LGR2

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R-Spondin Proteins: A Novel Link to β-catenin Activation

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New G-protein-coupled receptor crystal structures: insights and limitations

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Crystal structures of the extracellular domain of LRP6 and its complex with DKK1

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Regulation of Lrp6 phosphorylation

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Neonatal Lethality of LGR5 Null Mice Is Associated with Ankyloglossia and Gastrointestinal Distension

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R-spondin1 Is a High Affinity Ligand for LRP6 and Induces LRP6 Phosphorylation and β-Catenin Signaling

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Identification of overexpression of orphan G protein-coupled receptor GPR49 in human colon and ovarian primary tumors

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Receptors coupled to heterotrimeric G proteins of the G12 family

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Drosophila molting neurohormone bursicon is a heterodimer and the natural agonist of the orphan receptor DLGR2

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Wnt Antagonists Bind through a Short Peptide to the First β-Propeller Domain of LRP5/6

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Convergence of Mutation and Epigenetic Alterations Identifies Common Genes in Cancer That Predict for Poor Prognosis

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G-Protein-Coupled Receptor GPR49 is Up-regulated in Basal Cell Carcinoma and Promotes Cell Proliferation and Tumor Formation

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Leucine-Rich Repeat-Containing, G Protein-Coupled Receptor 4 Null Mice Exhibit Intrauterine Growth Retardation Associated with Embryonic and Perinatal Lethality

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Distinct High-Profile Methylated Genes in Colorectal Cancer

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Lgr4 is required for Paneth cell differentiation and maintenance of intestinal stem cells ex vivo

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Structural and Functional Studies of LRP6 Ectodomain Reveal a Platform for Wnt Signaling

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LGR5 Is a Negative Regulator of Tumourigenicity, Antagonizes Wnt Signalling and Regulates Cell Adhesion in Colorectal Cancer Cell Lines

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Cellular signaling and biological functions of R-spondins

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Up-regulation of GPR48 Induced by Down-regulation of p27 Kip1 Enhances Carcinoma Cell Invasiveness and Metastasis

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Hyperinduction of Wnt Activity: A New Paradigm for the Treatment of Colorectal Cancer?

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Rich Tapestry of G Protein-Coupled Receptor Signaling and Regulatory Mechanisms

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Mutations in the RSPO1 Coding Region Are Not the Main Cause of Canine SRY-Negative XX Sex Reversal in Several Breeds

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Genomic analyses of the evolution of LGR genes.

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Matching Receptome Genes with Their Ligands for Surveying Paracrine/Autocrine Signaling Systems

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An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

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International Union of Basic and Clinical Pharmacology. LXXXVIII. G Protein-Coupled Receptor List: Recommendations for New Pairings with Cognate Ligands

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PDGFRα + pericryptal stromal cells are the critical source of Wnts and RSPO3 for murine intestinal stem cells in vivo

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Maresin 1 activates LGR6 receptor promoting phagocyte immunoresolvent functions

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Organoids for Drug Discovery and Personalized Medicine

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Lgr5-Expressing Cells Are Sufficient and Necessary for Postnatal Mammary Gland Organogenesis

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Homeostasis of the sebaceous gland and mechanisms of acne pathogenesis

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The structural basis of R-spondin recognition by LGR5 and RNF43Preprint

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Wnt Signaling in Vertebrate Neural Development and Function

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Wnt/β-Catenin Signaling and Obesity

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Targeting LGR5 in Colorectal Cancer: therapeutic gold or too plastic?

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The R-spondin family of proteins: Emerging regulators of WNT signaling

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Structural basis for R-spondin recognition by LGR4/5/6 receptorsPreprint

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Neuroendocrinology and neurobiology of sebaceous glands

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Local Control of Intestinal Stem Cell Homeostasis by Enteroendocrine Cells in the Adult Drosophila Midgut

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Mammary Development and Breast Cancer: A Wnt Perspective

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Novel Insights into the Bovine Polled Phenotype and Horn Ontogenesis in Bovidae

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Lgr6 marks nail stem cells and is required for digit tip regeneration

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R-spondin1 is a novel hormone mediator for mammary stem cell self-renewalPreprint

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Stem Cell Signaling Pathways in the Small Intestine

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Frizzleds as GPCRs – More Conventional Than We Thought!

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LGR5 receptor promotes cell–cell adhesion in stem cells and colon cancer cells via the IQGAP1–Rac1 pathway

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HGF/R-spondin1 rescues liver dysfunction through the induction of Lgr5+ liver stem cells

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Analysis of LGR4 Receptor Distribution in Human and Mouse Tissues

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Ex Vivo Organoid Cultures Reveal the Importance of the Tumor Microenvironment for Maintenance of Colorectal Cancer Stem Cells

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R-spondins engage heparan sulfate proteoglycans to potentiate WNT signaling

Dubey, R., van Kerkhof, P., Jordens, I., Malinauskas, T., Pusapati, G. V., McKenna, J. K., Li, D., Carette, J. E., Ho, M., Siebold, C., et al. (2020) · eLife · doi:10.7554/elife.54469 · Cited by 64

Constitutive Internalization of the Leucine-rich G Protein-coupled Receptor-5 (LGR5) to the Trans-Golgi Network

Snyder, J. C., Rochelle, L. K., Lyerly, H. K., Caron, M. G., & Barak, L. S. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.447540 · Cited by 62

Lgr6 is a stem cell marker in mouse skin squamous cell carcinoma

Huang, P., Kandyba, E. E., Jabouille, A., Sjölund, J., Kumar, A., Halliwill, K. D., McCreery, M. Q., Delrosario, R., Kang, H. C., Wong, C. E., et al. (2017) · Nature Genetics · doi:10.1038/ng.3957 · Cited by 59

BMP9 Reduces Bone Loss in Ovariectomized Mice by Dual Regulation of Bone Remodeling

Zhou, Y., Yang, Y., Jing, Y., Yuan, T.-J., Sun, L., Tao, B., Liu, J., & Zhao, H. (2020) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3957 · Cited by 59

Mismatch Repair Proteins Initiate Epigenetic Alterations during Inflammation-Driven Tumorigenesis

Maiuri, A. R., Peng, M., Podicheti, R., Sriramkumar, S., Kamplain, C. M., Rusch, D. B., Shields, C. E. D., Sears, C. L., & O’Hagan, H. M. (2017) · Cancer Research · doi:10.1158/0008-5472.can-17-0056 · Cited by 57

Silencing LGR6 Attenuates Stemness and Chemoresistance via Inhibiting Wnt/β-Catenin Signaling in Ovarian Cancer

Ruan, X., Liu, A., Zhong, M., Wei, J., Zhang, W., Rong, Y., Liu, W., Li, M., Qing, X., Chen, G., et al. (2019) · Molecular Therapy — Oncolytics · doi:10.1016/j.omto.2019.04.002 · Cited by 56

Leucine-rich repeat-containing G protein-coupled receptor 5 regulates epithelial cell phenotype and survival of hepatocellular carcinoma cells

Fukuma, M., Tanese, K., Effendi, K., Yamazaki, K., Masugi, Y., Suda, M., & Sakamoto, M. (2012) · Experimental Cell Research · doi:10.1016/j.yexcr.2012.10.011 · Cited by 52

Exploring the Wnt Pathway as a Therapeutic Target for Prostate Cancer

Koushyar, S., Méniel, V. S., Phesse, T. J., & Pearson, H. B. (2022) · Biomolecules · doi:10.3390/biom12020309 · Cited by 48

R-spondin signaling as a pivotal regulator of tissue development and homeostasis

Nagano, K. (2019) · Japanese Dental Science Review · doi:10.1016/j.jdsr.2019.03.001 · Cited by 47

Maresin-1 resolution with RORα and LGR6

Im, D. (2020) · Progress in Lipid Research · doi:10.1016/j.plipres.2020.101034 · Cited by 47

LGR5 is Expressed by Ewing Sarcoma and Potentiates Wnt/β-Catenin Signaling

Scannell, C. A., Pedersen, E. A., Mosher, J. T., Krook, M. A., Nicholls, L. A., Wilky, B. A., Loeb, D. M., & Lawlor, E. R. (2013) · Frontiers in Oncology · doi:10.3389/fonc.2013.00081 · Cited by 46

Hunting for the function of orphan GPCRs – beyond the search for the endogenous ligand

Ahmad, R., Wojciech, S., & Jockers, R. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12942 · Cited by 45

Epidermal expression of L gr6 is dependent on nerve endings and S chwann cells

Liao, X., & Nguyen, H. (2014) · Experimental Dermatology · doi:10.1111/exd.12340 · Cited by 44

LGR4: A New Receptor Member in Endocrine and Metabolic Diseases

Zhang, N., Yuan, M., & Wang, J. (2023) · Endocrine Reviews · doi:10.1210/endrev/bnad003 · Cited by 43

LGR6 promotes osteogenesis by activating the Wnt/β-catenin signaling pathway

Liu, S.-L., Zhou, Y., Tang, D.-B., Zhou, N., Zheng, W., Tang, Z.-H., Duan, C., Zheng, L., & Chen, J. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.08.122 · Cited by 42

Normal hematopoiesis and hematologic malignancies: Role of canonical Wnt signaling pathway and stromal microenvironment

Etet, P. F. S., Vecchio, L., Kamga, P. B., Nukenine, E. N., Krampera, M., & Kamdje, A. H. N. (2012) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2012.08.002 · Cited by 40

Novel Regulation of Wnt Signaling at the Proximal Membrane Level

Jiang, X., & Cong, F. (2016) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2016.06.003 · Cited by 36

Wnt and Vitamin D at the Crossroads in Solid Cancer

González‐Sancho, J. M., Larriba, M. J., & Múñoz, A. (2020) · Cancers · doi:10.3390/cancers12113434 · Cited by 35

LGR6 Promotes Tumor Proliferation and Metastasis through Wnt/β-Catenin Signaling in Triple-Negative Breast Cancer

Kong, Y., Ou, X., Li, X., Zeng, Y., Gao, G., Lyu, N., & Liu, P. (2020) · Molecular Therapy — Oncolytics · doi:10.1016/j.omto.2020.06.020 · Cited by 34

A novel function of R-spondin1 in regulating estrogen receptor expression independent of Wnt/β-catenin signaling

Geng, A., Wu, T. H., Cai, C., Song, W., Wang, J., Yu, Q. C., & Zeng, Y. A. (2020) · eLife · doi:10.7554/elife.56434 · Cited by 34

Identification of the Prognostic Signatures of Glioma With Different PTEN Status

Zhang, P., Meng, X., Liu, L., Li, S., Li, Y., Ali, S., Li, S., Xiong, J., Liu, X., Li, S., et al. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.633357 · Cited by 32

Maresin 1 Alleviates Diabetic Kidney Disease via LGR6‐Mediated cAMP‐SOD2‐ROS Pathway

Li, X., Xu, B.-T., Wu, J. T., Pu, Y., Wan, S., Zeng, Y., Wang, M., Luo, L., Zhang, F., Jiang, Z., et al. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/7177889 · Cited by 32

The role of R-spondin 1 through activating Wnt/β-catenin in the growth, survival and migration of ovarian cancer cells

Liu, Q., Zhao, Y., Xing, H., Li, L., Li, R., Dai, J., Li, Q., & Fang, S. (2018) · Gene · doi:10.1016/j.gene.2018.11.098 · Cited by 31

Development and Maintenance of Epidermal Stem Cells in Skin Adnexa

Mokrý, J., & Pisal, R. V. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249736 · Cited by 30

Roles of nAChR and Wnt signaling in intestinal stem cell function and inflammation

Takahashi, T. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.106260 · Cited by 28

Mouse LGR6 regulates osteogenesis in vitro and in vivo through differential ligand use

Khedgikar, V., Charles, J. F., & Lehoczky, J. A. (2021) · Bone · doi:10.1016/j.bone.2021.116267 · Cited by 28

Fine-mapping quantitative trait loci affecting murine external ear tissue regeneration in the LG/J by SM/J advanced intercross line

Cheverud, J. M., Lawson, H. A., Bouckaert, K., Kossenkov, A. V., Showe, L. C., Cort, L., Blankenhorn, E. P., Bedelbaeva, K., Gourevitch, D., Zhang, Y., et al. (2014) · Heredity · doi:10.1038/hdy.2013.133 · Cited by 27

LGR6 promotes the progression of gastric cancer through PI3K/AKT/mTOR pathway

Ke, J., Ma, P., Chen, J., Qin, J., & Qian, H. (2018) · OncoTargets and Therapy · doi:10.2147/ott.s149303 · Cited by 27

Suppression of Wnt/β-Catenin Signaling Is Associated with Downregulation of Wnt1, PORCN, and Rspo2 in Alzheimer’s Disease

Macyczko, J. R., Wang, N., Zhao, J., Ren, Y., Lü, W., Ikezu, T. C., Zhao, N., Liu, C., Bu, G., & Li, Y. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-03065-1 · Cited by 25

microRNA-513c suppresses the proliferation of human glioblastoma cells by repressing low-density lipoprotein receptor-related protein 6

Xu, J., Sun, T., & Hu, X. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.3913 · Cited by 24

R-Spondin-2 Is Upregulated in Idiopathic Pulmonary Fibrosis and Affects Fibroblast Behavior

Munguía-Reyes, A., Balderas-Martínez, Y. I., Becerril, C., Checa, M., Ramı́rez, R., Ortiz, B., Meléndez-Zajgla, J., Pardo, A., & Selman, M. (2018) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2017-0115oc · Cited by 24

Established and In-trial GPCR Families in Clinical Trials: A Review for Target Selection

Saikia, S., Bordoloi, M., & Sarmah, R. (2018) · Current Drug Targets · doi:10.2174/1389450120666181105152439 · Cited by 23

Molecular mechanisms of alveolar epithelial cell senescence and idiopathic pulmonary fibrosis: a narrative review

Tu, M., Wei, T., Jia, Y., Wang, Y., & Wu, J. (2022) · Journal of Thoracic Disease · doi:10.21037/jtd-22-886 · Cited by 22

WNT11, a new gene associated with early onset osteoporosis, is required for osteoblastogenesis

da Silva, C. C., Édouard, T., Fradin, M., Aubert‐Mucca, M., Ricquebourg, M., Raman, R., Salles, J., Charon, V., Guggenbuhl, P., Müller, M., et al. (2021) · Human Molecular Genetics · doi:10.1093/hmg/ddab349 · Cited by 21

Wnt-associated adult stem cell marker Lgr6 is required for osteogenesis and fracture healing

Doherty, L., Wan, M., Peterson, A., Youngstrom, D. W., King, J. S., Kalajzić, I., Hankenson, K. D., & Sanjay, A. (2022) · Bone · doi:10.1016/j.bone.2023.116681 · Cited by 21

In a Class of Their Own – RXFP1 and RXFP2 are Unique Members of the LGR Family

Petrie, E. J., Lagaida, S., Sethi, A., Bathgate, R. A. D., & Gooley, P. R. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00137 · Cited by 21

DNA methyltransferase inhibition reduces inflammation-induced colon tumorigenesis

Maiuri, A. R., Savant, S. S., Podicheti, R., Rusch, D. B., & O’Hagan, H. M. (2019) · Epigenetics · doi:10.1080/15592294.2019.1634986 · Cited by 21

Amphiregulin mediates the hormonal regulation on Rspondin-1 expression in the mammary gland

Cai, C., Geng, A., Wang, M., Yang, L. C., Yu, Q. C., & Zeng, Y. A. (2019) · Developmental Biology · doi:10.1016/j.ydbio.2019.10.006 · Cited by 20

Evidence for Lgr6 as a Novel Marker of Osteoblastic Progenitors in Mice

Khedgikar, V., & Lehoczky, J. A. (2018) · JBMR Plus · doi:10.1002/jbm4.10075 · Cited by 20

LGRs in Skeletal Tissues: An Emerging Role for Wnt‐Associated Adult Stem Cell Markers in Bone

Doherty, L., & Sanjay, A. (2020) · JBMR Plus · doi:10.1002/jbm4.10380 · Cited by 20

LGR5 constitutively activates NF‐κB signaling to regulate the growth of intestinal crypts

Lai, S., Cheng, R., Gao, D., Chen, Y., & Deng, C. (2020) · The FASEB Journal · doi:10.1096/fj.202001329r · Cited by 20

Disruption of a Hedgehog-Foxf1-Rspo2 signaling axis leads to tracheomalacia and a loss of Sox9+ tracheal chondrocytes

Nasr, T., Holderbaum, A. M., Chaturvedi, P., Agarwal, K., Kinney, J. L., Daniels, K., Trisno, S. L., Ustiyan, V., Shannon, J. M., Wells, J. M., et al. (2020) · Disease Models & Mechanisms · doi:10.1242/dmm.046573 · Cited by 20

Down-regulation of LGR6 promotes bone fracture recovery using bone marrow stromal cells

Cui, Y., Huang, R.-C., Wang, Y., Zhu, L., & Zhang, X. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.12.109 · Cited by 20

Multiple Roles for Cholinergic Signaling from the Perspective of Stem Cell Function

Takahashi, T. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020666 · Cited by 19

CITED4 gene silencing in colorectal cancer cells modulates adherens/tight junction gene expression and reduces cell proliferation

Rogers, M. A., Kalter, V., Marcias, G., Zapatka, M., Barbus, S., & Lichter, P. (2015) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-015-2011-5 · Cited by 19

The Lgr5 transgene is expressed specifically in glycinergic amacrine cells in the mouse retina

Sukhdeo, K., Koch, C. E., Miller, T. E., Zhou, H., Rivera, M., Yan, K. K.-L., Cepko, C. L., Lathia, J. D., & Rich, J. N. (2013) · Experimental Eye Research · doi:10.1016/j.exer.2013.11.003 · Cited by 18

Downregulation of Lgr6 inhibits proliferation and invasion and increases apoptosis in human colorectal cancer

Wang, F., Dai, C., Zhang, L., Bing, C., Qin, J., & Liu, Y. (2018) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2018.3633 · Cited by 18

Molecular determinants of WNT9b responsiveness in nephron progenitor cells

Dickinson, K., Hammond, L. C., Karner, C. M., Hastie, N. D., Carroll, T. J., & Goodyer, P. (2019) · PLoS ONE · doi:10.1371/journal.pone.0215139 · Cited by 18

Rethinking WNT signalling

Lehoczky, J. A., & Tabin, C. J. (2018) · Nature · doi:10.1038/d41586-018-04820-y · Cited by 18

Integrative Analysis of LGR5/6 Gene Variants, Gut Microbiota Composition and Osteoporosis Risk in Elderly Population

Di, D., Li, C., Dai, Y., Wei, M., Wang, S., Song, W., Zhou, H., Cui, Y., Zhang, R., Huang, Q., et al. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.765008 · Cited by 17

Association of genetic variants in migraineurs with and without restless legs syndrome

Lin, G., Lin, Y., Liang, C., Lee, J., Tsai, C., Hung, K., Luo, W., Tsai, C., Hsu, Y., Ho, T., et al. (2020) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.51186 · Cited by 16

A novel autoantibody test for the detection of pre-neoplastic lung lesions

Lowe, F., Shen, W., Zu, J., Li, J., Wang, H., Zhang, X., & Zhong, L. (2014) · Molecular Cancer · doi:10.1186/1476-4598-13-78 · Cited by 16

Increased LGR6 Expression Sustains Long-Term Wnt Activation and Acquisition of Senescence in Epithelial Progenitors in Chronic Lung Diseases

Cortesi, E. E., Meeusen, B., Vanstapel, A., Verleden, S. E., Vanaudenaerde, B. M., Wuyts, W. A., Janssens, W., Janssens, V., Roskams, T., & Ventura, J. (2021) · Cells · doi:10.3390/cells10123437 · Cited by 16

The Stem Cell-Expressed Receptor Lgr5 Possesses Canonical and Functionally Active Molecular Determinants Critical to β-arrestin-2 Recruitment

Snyder, J. C., Rochelle, L. K., Barak, L. S., & Caron, M. G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0084476 · Cited by 16

Discovery of polypeptide ligand‐receptor pairs based on their co‐evolution

Hsueh, A. J. W., & Feng, Y. (2020) · The FASEB Journal · doi:10.1096/fj.202000779r · Cited by 15

Digit Tip Injuries: Current Treatment and Future Regenerative Paradigms

Miller, T. J., Deptula, P. L., Buncke, G. M., & Maan, Z. N. (2019) · Stem Cells International · doi:10.1155/2019/9619080 · Cited by 15

Characterizing the cellular attachment receptor for Langat virus

Rodrigues, R., Danskog, K., Överby, A. K., & Arnberg, N. (2019) · PLoS ONE · doi:10.1371/journal.pone.0217359 · Cited by 14

Drug Conjugates of Antagonistic R-Spondin 4 Mutant for Simultaneous Targeting of Leucine-Rich Repeat-Containing G Protein-Coupled Receptors 4/5/6 for Cancer Treatment

Cui, J., Toh, Y., Park, S.-H., Yu, W., Tu, J., Wu, L., Li, L., Jacob, J., Pan, S., Carmon, K. S., et al. (2021) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.1c00395 · Cited by 14

Intrinsic disorder in spondins and some of their interacting partners

Alowolodu, O., Johnson, G., Alashwal, L., Addou, I., Zhdanova, I. V., & Uversky, V. N. (2016) · Intrinsically Disordered Proteins · doi:10.1080/21690707.2016.1255295 · Cited by 13

Class A Orphans (version 2019.5) in the IUPHAR/BPS Guide to Pharmacology Database

Alexander, S. P. H., Battey, J., Benson, H. E., Benya, R. V., Bonner, T. I., Davenport, A. P., Eguchi, S., Harmar, A. J., Holliday, N. D., Jensen, R. T., et al. (2019) · IUPHAR/BPS Guide to Pharmacology CITE · doi:10.2218/gtopdb/f16/2019.5 · Cited by 12

An "R‐spondin code" for multimodal signaling ON‐OFF states

Niehrs, C., Seidl, C., & Lee, H. (2024) · BioEssays · doi:10.1002/bies.202400144 · Cited by 10

LGR5 enhances the osteoblastic differentiation of MC3T3‑E1 cells through the Wnt/β‑catenin pathway

Yu, W. H., Xie, C., Chen, F., Cheng, P. F., Yang, L., & Pan, X. (2021) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2021.10321 · Cited by 10

Impaired Mitochondria Promote Aging-Associated Sebaceous Gland Dysfunction and Pathology

Ahmed, N. S., Foote, J. B., & Singh, K. K. (2022) · American Journal Of Pathology · doi:10.1016/j.ajpath.2022.07.006 · Cited by 10

Overexpression of NT-3 in the hippocampus suppresses the early phase of the adult neurogenic process

Kasakura, N., Murata, Y., Shindo, A., Kitaoka, S., Furuyashiki, T., Suzuki, K., & Segi‐Nishida, E. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1178555 · Cited by 9

Antitumor Activity of a Pyrrolobenzodiazepine Antibody–Drug Conjugate Targeting LGR5 in Preclinical Models of Neuroblastoma

Tu, J., Toh, Y., Aldana, A. M., Wen, J. J., Wu, L., Jacob, J., Li, L., Pan, S., Carmon, K. S., & Liu, Q. J. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16070943 · Cited by 9

Lgr6+ stem cells and their progeny in mouse epidermis under regimens of exogenous skin carcinogenesis, and their absence in ensuing skin tumors

van de Glind, G. C., Rebel, H. G., Out‐Luiting, J. J., Zoutman, W. H., Tensen, C. P., & de Gruijl, F. R. (2016) · Oncotarget · doi:10.18632/oncotarget.13436 · Cited by 9

Class A Orphans (version 2020.5) in the IUPHAR/BPS Guide to Pharmacology Database

Alexander, S. P. H., Battey, J., Benson, H. E., Benya, R. V., Bonner, T. I., Davenport, A. P., Singh, K. D., Eguchi, S., Harmar, A. J., Holliday, N. D., et al. (2020) · IUPHAR/BPS Guide to Pharmacology CITE · doi:10.2218/gtopdb/f16/2020.5 · Cited by 8

G protein-coupled receptor LGR6 is an independent risk factor for colon adenocarcinoma

Wang, W., Ding, S., Hejun, Z., Li, J., Zhang, H., & Zhang, H. (2018) · Frontiers of Medicine · doi:10.1007/s11684-018-0633-0 · Cited by 8

LGR4 is essential for R-spondin1-mediated suppression of food intake via pro-opiomelanocortin

Otsuka, A., Jinguji, A., Maejima, Y., Kasahara, Y., Shimomura, K., Hidema, S., & Nishimori, K. (2019) · Bioscience Biotechnology and Biochemistry · doi:10.1080/09168451.2019.1591266 · Cited by 8

Tackling the complexities of orphan GPCR ligand discovery with rationally assisted approaches

So, S. S., Ngo, T., Keov, P., Smith, N. J., & Kufareva, I. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816228-6.00016-7 · Cited by 8

R-spondin-1 induces Axin degradation via the LRP6-CK1ε axis

Tan, L., Yan, M., Su, Z., Wang, H., Li, H., Zhao, X., Liu, S., Zhang, L., Sun, Q., & Lu, D. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-023-01456-y · Cited by 7

LGR6 is a prognostic biomarker for less differentiated tumors in lymph nodes of colon cancer patients

Eltorky, H. A. E., AbdelMageed, M. A., Ismail, H. T. H., Zahran, F. M., Guirgis, A. A., Olsson, L., Lindmark, G. E., Hammarström, M., Hammarström, S., & Sitohy, B. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1393075 · Cited by 7

Class A Orphans in GtoPdb v.2023.1

Alexander, S. P. H., Battey, J., Benson, H. E., Benya, R. V., Bonner, T. I., Davenport, A. P., Singh, K. D., Eguchi, S., Harmar, A. J., Holliday, N. D., et al. (2023) · IUPHAR/BPS Guide to Pharmacology CITE · doi:10.2218/gtopdb/f16/2023.1 · Cited by 6

From genome‐wide association to biological explanation

Steensel, M. A. M. V. (2019) · British Journal of Dermatology · doi:10.1111/bjd.18462 · Cited by 6

WNT enhancing signals in pancreatic cancer are transmitted by LGR6

Wang, J., Koch, D. T., Hofmann, F. O., Härtwig, D., Beirith, I., Janssen, K., Bazhin, A. V., Nieß, H., Werner, J., Renz, B. W., et al. (2023) · Aging · doi:10.18632/aging.205101 · Cited by 5

R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/β-catenin signaling

Carmon, K. S., Gong, X. W., Lin, Q., Thomas, A., & Liu, Q. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1106083108 · Cited by 894

R-Spondin Potentiates Wnt/β-Catenin Signaling through Orphan Receptors LGR4 and LGR5

Ruffner, H., Sprunger, J., Charlat, O., Leighton-Davies, J. R., Grosshans, B. L., Salathe, A., Zietzling, S., Beck, V., Therier, M., Isken, A., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040976 · Cited by 172

Abstract 4900: Functional and mechanism analysis of LGR4 in human lung cancer cells.

Gong, X. W., Xiong, W., Yi, J., Carmon, K. S., & Liu, Q. (2013) · Cancer Research · doi:10.1158/1538-7445.am2013-4900

Abstract 2714: Expression and functional analysis of LGR4 in normal and cancer cells of human colon.

Yi, J., Xiong, W., Gong, X. W., & Liu, Q. (2013) · Cancer Research · doi:10.1158/1538-7445.am2013-2714

R-Spondin1/LGR5 Activates TGFβ Signaling and Suppresses Colon Cancer Metastasis

Zhou, X., Geng, L., Wang, D., Yi, H., Talmon, G. A., & Wang, J. (2017) · Cancer Research · doi:10.1158/0008-5472.can-17-0219 · Cited by 65